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Volumn 136, Issue 2, 2006, Pages 404-408

Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: A randomized, double-blind, crossover trial

Author keywords

Bioavailability; Citrus antioxidant; Hesperetin 7 glucoside; Hesperidin; Randomized crossover study

Indexed keywords

AGLYCONE; FLAVONOID; GLUCOSIDE; HESPERIDIN; RHAMNOSE;

EID: 32444451694     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.2.404     Document Type: Article
Times cited : (293)

References (27)
  • 1
    • 0343247685 scopus 로고    scopus 로고
    • Antioxidant flavonols and coronary heart disease risk
    • Hertog MG, Feskens EJ, Kromhout D. Antioxidant flavonols and coronary heart disease risk. [letter] Lancet. 1997;349:699.
    • (1997) Lancet , vol.349 , pp. 699
    • Hertog, M.G.1    Feskens, E.J.2    Kromhout, D.3
  • 2
    • 19544378483 scopus 로고    scopus 로고
    • Polyphenols: Dietary components with established benefits to health?
    • Kroon P, Williamson G. Polyphenols: dietary components with established benefits to health? J Sci Food Agric. 2005;85:1239-40.
    • (2005) J Sci Food Agric , vol.85 , pp. 1239-1240
    • Kroon, P.1    Williamson, G.2
  • 3
    • 9744222928 scopus 로고    scopus 로고
    • Potential synergy of phytochemicals in cancer prevention: Mechanism of action
    • Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr. 2004;134:3479S-85.
    • (2004) J Nutr , vol.134
    • Liu, R.H.1
  • 4
    • 0038653437 scopus 로고    scopus 로고
    • Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice
    • Chiba H, Uehara M, Wu J, Wang X, Masuyama R, Suzuki K, Kanazawa K, Ishimi Y. Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J Nutr. 2003;133:1892-7.
    • (2003) J Nutr , vol.133 , pp. 1892-1897
    • Chiba, H.1    Uehara, M.2    Wu, J.3    Wang, X.4    Masuyama, R.5    Suzuki, K.6    Kanazawa, K.7    Ishimi, Y.8
  • 5
    • 0035667114 scopus 로고    scopus 로고
    • Chemistry and pharmacology of the citrus bioflavonoid hesperidin
    • Garg A, Garg S, Zaneveld LJ, Singla AK. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res. 2001;15:655-69.
    • (2001) Phytother Res , vol.15 , pp. 655-669
    • Garg, A.1    Garg, S.2    Zaneveld, L.J.3    Singla, A.K.4
  • 7
    • 0035150315 scopus 로고    scopus 로고
    • Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice
    • Erlund I, Meririnne E, Alfthan G, Aro A. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. J Nutr. 2001;131:235-41.
    • (2001) J Nutr , vol.131 , pp. 235-241
    • Erlund, I.1    Meririnne, E.2    Alfthan, G.3    Aro, A.4
  • 8
    • 0037327340 scopus 로고    scopus 로고
    • Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice
    • Manach C, Morand C, Gil-Izquierdo A, Bouteloup-Demange C, Rémésy C. Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr. 2003;57:235-42.
    • (2003) Eur J Clin Nutr , vol.57 , pp. 235-242
    • Manach, C.1    Morand, C.2    Gil-Izquierdo, A.3    Bouteloup-Demange, C.4    Rémésy, C.5
  • 10
    • 3142621340 scopus 로고    scopus 로고
    • The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides
    • Arts IC, Sesink AL, Faassen-Peters M, Hollman PC. The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. Br J Nutr. 2004;91:841-7.
    • (2004) Br J Nutr , vol.91 , pp. 841-847
    • Arts, I.C.1    Sesink, A.L.2    Faassen-Peters, M.3    Hollman, P.C.4
  • 12
    • 0034491103 scopus 로고    scopus 로고
    • Quercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasma
    • Morand C, Manach C, Crespy V, Rémésy C. Quercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasma. Free Radic Res. 2000;33:667-76.
    • (2000) Free Radic Res , vol.33 , pp. 667-676
    • Morand, C.1    Manach, C.2    Crespy, V.3    Rémésy, C.4
  • 13
    • 0034054933 scopus 로고    scopus 로고
    • Bioavailabilities of quercetin-3-glucoside and quercetin-4′- glucoside do not differ in humans
    • Olthof MR, Hollman PC, Vree TB, Katan MB. Bioavailabilities of quercetin-3-glucoside and quercetin-4′-glucoside do not differ in humans. J Nutr. 2000;130:1200-3.
    • (2000) J Nutr , vol.130 , pp. 1200-1203
    • Olthof, M.R.1    Hollman, P.C.2    Vree, T.B.3    Katan, M.B.4
  • 16
    • 0034029902 scopus 로고    scopus 로고
    • Identification and quantification of flavonoids in human urine samples by column-switching liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry
    • Nielsen SE, Freese R, Cornett C, Dragsted LO. Identification and quantification of flavonoids in human urine samples by column-switching liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry. Anal Chem. 2000;72:1503-9.
    • (2000) Anal Chem , vol.72 , pp. 1503-1509
    • Nielsen, S.E.1    Freese, R.2    Cornett, C.3    Dragsted, L.O.4
  • 17
    • 0032502861 scopus 로고    scopus 로고
    • Column-switching high-performance liquid chromatographic assay for the determination of quercetin in human urine with ultraviolet absorbance detection
    • Nielsen SE, Dragsted LO. Column-switching high-performance liquid chromatographic assay for the determination of quercetin in human urine with ultraviolet absorbance detection. J Chromatogr B Biomed Sci Appl. 1998;707:81-9.
    • (1998) J Chromatogr B Biomed Sci Appl , vol.707 , pp. 81-89
    • Nielsen, S.E.1    Dragsted, L.O.2
  • 19
    • 0037219688 scopus 로고    scopus 로고
    • Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    • Nemeth K, Plumb GW, Berrin JG, Juge N, Jacob R, Naim HY, Williamson G, Swallow DM, Kroon PA. Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr. 2003;42:29-42.
    • (2003) Eur J Nutr , vol.42 , pp. 29-42
    • Nemeth, K.1    Plumb, G.W.2    Berrin, J.G.3    Juge, N.4    Jacob, R.5    Naim, H.Y.6    Williamson, G.7    Swallow, D.M.8    Kroon, P.A.9
  • 20
    • 0032566518 scopus 로고    scopus 로고
    • Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity
    • Day AJ, DuPont MS, Ridley S, Rhodes M, Rhodes MJ, Morgan MR, Williamson G. Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett. 1998;436:71-5.
    • (1998) FEBS Lett , vol.436 , pp. 71-75
    • Day, A.J.1    DuPont, M.S.2    Ridley, S.3    Rhodes, M.4    Rhodes, M.J.5    Morgan, M.R.6    Williamson, G.7
  • 21
    • 0033734729 scopus 로고    scopus 로고
    • Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway
    • Gee JM, DuPont MS, Day AJ, Plumb GW, Williamson G, Johnson IT. Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway. J Nutr. 2000;130:2765-71.
    • (2000) J Nutr , vol.130 , pp. 2765-2771
    • Gee, J.M.1    DuPont, M.S.2    Day, A.J.3    Plumb, G.W.4    Williamson, G.5    Johnson, I.T.6
  • 22
    • 0023548365 scopus 로고
    • Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans
    • Bokkenheuser VD, Shackleton CH, Winter J. Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans. Biochem J. 1987;248:953-6.
    • (1987) Biochem J , vol.248 , pp. 953-956
    • Bokkenheuser, V.D.1    Shackleton, C.H.2    Winter, J.3
  • 24
    • 0037377562 scopus 로고    scopus 로고
    • Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: The role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter
    • Day AJ, Gee JM, DuPont MS, Johnson IT, Williamson G. Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Biochem Pharmacol. 2003;65:1199-206.
    • (2003) Biochem Pharmacol , vol.65 , pp. 1199-1206
    • Day, A.J.1    Gee, J.M.2    DuPont, M.S.3    Johnson, I.T.4    Williamson, G.5
  • 26
    • 0034494884 scopus 로고    scopus 로고
    • Respective bioavailability of quercetin aglycone and its glycosides in a rat model
    • Morand C, Manach C, Crespy V, Rémésy C. Respective bioavailability of quercetin aglycone and its glycosides in a rat model. Biofactors. 2000;12:169-74.
    • (2000) Biofactors , vol.12 , pp. 169-174
    • Morand, C.1    Manach, C.2    Crespy, V.3    Rémésy, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.