Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States

Cancer Epidemiology Biomarkers and Prevention

Volumn 19, Issue 2, 2010, Pages 537-546

  Yong, Mellissa ^a   Schwartz, Stephen M ^a   Atkinson, Charlotte ^c   Makar, Karen W ^a   Thomas, Sushma S ^a   Newton, Katherine M ^a,b   Aiello Bowles, Erin J ^b   Holt, Victoria L ^a   Leisenring, Wendy M ^a   Lampe, Johanna W ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b GROUP HEALTH RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE; SEX HORMONE; SULFOTRANSFERASE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME MECHANISM; FEMALE; GENE; GENETIC POLYMORPHISM; GENOMICS; GENOTYPE; GLUCURONIDATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAMMOGRAPHY; MULTIGENE FAMILY; PREMENOPAUSE; PRIORITY JOURNAL; SULFATION; SULT1A1 GENE; SULT1E1 GENE; UGT1A GENE; UGT2B GENE; UNITED STATES;

ADULT; BREAST; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUCURONOSYLTRANSFERASE; HUMANS; MAMMOGRAPHY; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PREMENOPAUSE; SULFOTRANSFERASES;

EID: 76149117207     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-09-0898     Document Type: Article

References (40)

1. Cancer facts and figures - 2009. Atlanta (GA): American Cancer Society; 2009.
2. Kelsey JL, Gammon MD, John EM. Reproductive factors and breast cancer. Epidemiol Rev 1993;15:36-47.
3. Eliassen AH, Missmer SA, Tworoger SS, et al. Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. J Natl Cancer Inst 2006;98:1406-15.
4. Bergkvist L, Tabar L, Bergstrom R, Adami HO. Epidemiologic determinants of the mammographic parenchymal pattern. A populationbased study within a mammographic screening program. Am J Epidemiol 1987;126:1075-81.
5. Boyd NF, Lockwood GA, Byng JW, Tritchler DL, Yaffe MJ. Mammographic densities and breast cancer risk. Cancer Epidemiol Biomarkers Prev 1998;7:1133-44.
6. de Waard F, Rombach JJ, Collette HJA, Slotboom B. Breast cancer risk associated with reproductive factors and breast parenchymal patterns. J Natl Cancer Inst 1984;72:1277-82.
7. Meech R, Mackenzie PI. Structure and function of uridine diphosphate glucuronosyltransferases. Clin Exp Pharmacol Physiol 1997; 24:907-15.
8. Falany CN. Enzymology of human cytosolic sulfotransferases. FASEB J 1997;11:206-16.
9. Atkinson C, Newton KM, Bowles EJ, Yong M, Lampe JW. Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to daidzein-metabolizing phenotypes among premenopausal women in the United States. Am J Clin Nutr 2008;87: 679-87.
10. Atkinson C, Newton KM, Aiello Bowles EJ, et al. Daidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States. Breast Cancer Res Treat 2009;116:587-94.
11. Adjei AA, Thomae BA, Prondzinski JL, Eckloff BW, Wieben ED, Weinshilboum RM. Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics. Br J Pharmacol 2003;139:1373-82.
12. Lampe JW, Bigler J, Horner NK, Potter JD. UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations. Pharmacogenetics 1999;9:341-9.
13. Thomas SS, Li SS, Lampe JW, Potter JD, Bigler J. Genetic variability, haplotypes, and htSNPs for exons 1 at the human UGT1A locus. Hum Mutat 2006;27:717.
14. Lampe JW, Bigler J, Bush AC, Potter JD. Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4 (D458E), UGT2B7(H268Y), and UGT2B15(D85Y). Cancer Epidemiol Biomarkers Prev 2000;9:329-33.
15. Raftogianis R, Wood TC, Weinshilboum RM. Human phenol sulfotransferases SULT1A2 and SULT1A1: genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations. Biochem Pharmacol 1999;58:605-16.
16. Gallagher CJ, Muscat JE, Hicks AN, et al. The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer. Cancer Epidemiol Biomarkers Prev 2007;16:823-8.
17. Lin DY, Zeng D. Likelihood-based inference on haplotype effects in genetic association studies. J Am Stat Assoc 2006;101:89-104.
18. Sillanpää P, Kataja V, Eskelinen M, et al. Sulfotransferase 1A1 genotype as a potential modifier of breast cancer risk among premenopausal women. Pharmacogenet Genom 2005;15:749-752.
19. Carlini EJ, Raftogianis RB, Wood TC, et al. Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects. Pharmacogenetics 2001; 11:57-68.
20. Habel LA, Capra AM, Oestreicher N, et al. Mammographic density in a multiethnic cohort. Menopause 2007;14:891-9.
21. Nagar S, Walther S, Blanchard R. Sulfotransferase (SULT) 1A1 polymorphic variants *1, *2, and *3 are associated with altered enzymatic activity, cellular phenotype and protein degradation. Mol Pharmacol 2006;69:2084-92.
22. Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. 2-Hydroxyestrone: the 'good' estrogen. J Endocrinol 1996;150:S259-65.
23. Fishman J, Martucci C. Biological properties of 16α-hydroxyestrone: implications in estrogen physiology and pathophysiology. J Clin Endocrinol Metab 1980;51:611-5.
24. Riza E, dos Santos Silva I, De Stavola B, et al. Urinary estrogen metabolites and mammographic parenchymal patterns in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2001;10:627-34.
25. Muti P, Bradlow HL, Micheli A, et al. Estrogen metabolism and risk of breast cancer: a prospective study of the 2:16α-hydroxyestrone ratio in premenopausal and postmenopausal women. Epidemiology 2000; 11:635-40.
26. Hui Y, Yasuda S, Liu M-Y, We Y-Y, Liu M-C. On the sulfation and methylation of catecholestrogens in human mammary epithelial cells and breast cancer cells. Biol Pharm Bull 2008;31:769-73.
27. Spink BC, Katz BH, Hussain MM, et al. SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells. Carcinogenesis 2000;21:1947-57.
28. Yang G, Gao YT, Cai QY, Shu XO, Cheng JR, Zheng W. Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones. Breast Cancer Res Treat 2005;94:63-70.
29. Bosma P, Chowdhury JR, Bakker C, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995;333:1171-5.
30. Monaghan G, Ryan M, Seddon R, Hume R, Burchell B. Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome. Lancet 1996;347:578-81.
31. Beutler E, Gelbart T, Demina A. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci U S A 1998;95:8170-4.
32. Senafi SB, Clarke DJ, Burchell B. Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-gluronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation. Biochem J 1994;303:233-40.
33. Haiman CA, Hankinson SE, De Vivo I, et al. Polymorphisms in steroid hormone pathway genes and mammographic density. Breast Cancer Res Treat 2003;77:27-36.
34. Peters WHM, te Morsche RHM, Roelofs HMJ. Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome. J Hepatol 2003;38:3-8.
35. Lankisch TO, Behrens G, Ehmer U, et al. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy - an extended haplotype of genetic variants increases risk in indinavir treatment. J Hepatol 2009;50:1010-8.
36. Bélanger A, Pelletier G, Labrie F, Barbier O, Chouinard S. Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans. Trends Endocrinol Metab 2003;14:473-9.
37. Thibaudeau J, Lépine J, Tojcic J, et al. Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone. Cancer Res 2006;66:125-33.
38. Greendale GA, Palla S, Ursin G, et al. The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density Study. Am J Epidemiol 2005;162: 826-34.
39. Gestl SA, Green MD, Shearer DA, Frauenhoffer E, Tephly TR, Weisz J. Expression of UGT2B7, a UDP-glucuronosyltransferase implicated in the metabolism of 4-hydroxyestrone and all-trans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers. Am J Pathol 2002;160:1467-79.
40. Feigelson HS, Henderson BE. Future possibilities in the prevention of breast cancer: role of genetic variation in breast cancer prevention. Breast Cancer Res 2000;2:277-82.