Lead diversification. Application to existing drug molecules: Mifepristone 1 and antalarmin 8

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 723-728

  Abid Masood, M ^a   Farrant, Elizabeth ^a   Morao, Inaki ^a   Bazin, Marc ^a   Perez, Manuel ^a   Bunnage, Mark E ^a   Fancy, Sally Ann ^a   Peakman, Torren ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Antalarmin; Biomimetic; Lead diversification; Metalloporphyrin; Mifepristone

Indexed keywords

ANTALARMIN; CARBON; CYCLOSPORIN A; HYDROGEN; LEAD; METALLOPORPHYRIN; MIFEPRISTONE; TACROLIMUS;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL BOND; CHEMICAL MODIFICATION; CHLORINATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; LEAD DIVERSIFICATION; LIVER MICROSOME; MOLECULE; OXIDATION; STRUCTURE ACTIVITY RELATION;

BIOMIMETICS; CARBON; CHEMISTRY, PHARMACEUTICAL; CHLORINE; DRUG DESIGN; HUMANS; HYDROGEN; INHIBITORY CONCENTRATION 50; METALLOPORPHYRINS; METALS; MICROSOMES, LIVER; MIFEPRISTONE; MODELS, CHEMICAL; OXYGEN; PYRIMIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84655169277     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.066     Document Type: Article

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