Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program

Journal of Medicinal Chemistry

Volumn 59, Issue 5, 2016, Pages 1818-1829

  Zhang, Ting ^a   Liu, Yong ^a   Yang, Xianshu ^a   Martin, Gary E ^a   Yao, Huifang ^a   Shang, Jackie ^a   Bugianesi, Randal M ^a   Ellsworth, Kenneth P ^a   Sonatore, Lisa M ^a   Nizner, Peter ^a   Sherer, Edward C ^a   Hill, Susan E ^a   Knemeyer, Ian W ^a   Geissler, Wayne M ^a   Dandliker, Peter J ^a   Helmy, Roy ^a   Wood, Harold B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 9A INHIBITOR; BLOOD CLOTTING INHIBITOR; UNCLASSIFIED DRUG; BLOOD CLOTTING FACTOR 9A; FIBRINOLYTIC AGENT; LIGAND;

ARTICLE; AUTOMATED LIGAND IDENTIFICATION SYSTEM AFFINITY SELECTION; BINDING AFFINITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ASSAY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOMATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; RAT;

ANIMALS; AUTOMATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FACTOR IXA; FIBRINOLYTIC AGENTS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84960859067     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01293     Document Type: Article

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