Generation of statin drug metabolites through electrochemical and enzymatic oxidations

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 18, 2013, Pages 6009-6018

  Khera, Smriti ^a,b   Hu, Na ^a,c  

^a AMGEN INC   (United States)

^b AGILENT TECHNOLOGIES   (United States)

^c MICHIGAN TECHNOLOGICAL UNIVERSITY   (United States)

Author keywords

CYP102A1; Electrochemistry; Electrochemistry mass spectrometry (EC MS); Lovastatin; Metabolite generation; Simvastatin

Indexed keywords

CHOLESTEROL-LOWERING EFFECTS; CYP102A1; DRUG-DRUG INTERACTIONS; HYPERCHOLESTEROLEMIA; LOVASTATIN; PHARMACEUTICAL DISCOVERY; SIMVASTATIN; STRUCTURAL CHARACTERIZATION;

BIOMOLECULES; DRUG INTERACTIONS; ELECTROCHEMICAL OXIDATION; ELECTROCHEMISTRY; IODINE; SPECTROMETRY;

METABOLITES;

CYTOCHROME P450; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; MEVINOLIN; SIMVASTATIN;

CHEMISTRY; CONFERENCE PAPER; ELECTROCHEMICAL ANALYSIS; GENETICS; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION;

ANTICHOLESTEREMIC AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROCHEMICAL TECHNIQUES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MUTATION; OXIDATION-REDUCTION; SIMVASTATIN;

BACTERIA (MICROORGANISMS);

EID: 84879794236     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7021-z     Document Type: Conference Paper

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