Emerging technologies for metabolite generation and structural diversification

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 20, 2013, Pages 5471-5483

  Cusack, Kevin P ^a   Koolman, Hannes F ^a   Lange, Udo E W ^a   Peltier, Hillary M ^a   Piel, Isabel ^a   Vasudevan, Anil ^a  

^a ABBVIE INC   (United States)

Author keywords

Biomimetic oxidation; Catalytic transformation; Cytochrome P450; Electrochemistry; Enzymatic transformation; Fluorination; Metabolism; Metalloporphyrin; Microbial metabolism

Indexed keywords

1,4 BIS(4 METHOXYPHENYL) 3 (3 PHENYLPROPYL) 2 AZETIDINONE; ACRONINE; ALKENE; ARTEMISININ; BORNAPRINE; CARBAMAZEPINE; CODEINE; CYTOCHROME P450; DASATINIB; DICLOFENAC; DRUG METABOLITE; EZETIMIBE; FLUOROURACIL; LIDOCAINE; LORCASERIN; LOSARTAN; MEXILETINE; QUINIDINE; TEGAFUR; TESTOSTERONE; VERAPAMIL;

BIOCATALYST; CYCLOPROPANATION; DRUG METABOLISM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TRANSFORMATION; ELECTROCHEMISTRY; ELECTROSPRAY; FLUORINATION; HYDROXYLATION; MICROFLUIDICS; OXIDATION; OXIDATION REDUCTION POTENTIAL; REVIEW; STRUCTURE ANALYSIS;

BIOMIMETIC OXIDATION; CATALYTIC TRANSFORMATION; CYTOCHROME P450; ELECTROCHEMISTRY; ENZYMATIC TRANSFORMATION; FLUORINATION; FXTIYMYTRIFRKL-RFGMYIJVSA-K; LPGJQKSJOQRXJT-YOAFYNBBSA-N; METABOLISM; METALLOPORPHYRIN; MICROBIAL METABOLISM; OETMRHBYSHRNMU-UHFFFAOYSA-N; QAGYKUNXZHXKMR-HKWSIXNMSA-N; SAMJTHBMAUMJNB-UHFFFAOYSA-N; SINGGCIFJHSECQ-PFVZUNBHSA-N; VDBQDONUIAOUOC-SKXVCGILSA-N; WPRSCLYSKGPDBZ-UHFFFAOYSA-N;

BIOMIMETIC MATERIALS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROCHEMICAL TECHNIQUES; HUMANS; RECOMBINANT PROTEINS; STEREOISOMERISM;

EID: 84884282045     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.003     Document Type: Review

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