Preparation of human drug metabolites using fungal peroxygenases

Biochemical Pharmacology

Volumn 82, Issue 7, 2011, Pages 789-796

  Poraj Kobielska, Marzena ^a   Kinne, Matthias ^a   Ullrich, René ^a   Scheibner, Katrin ^b   Kayser, Gernot ^a   Hammel, Kenneth E ^c,d   Hofrichter, Martin ^a  

^a International Graduate School Zittau   (Germany)

^b Lausitz University of Applied Sciences   (Germany)

^c FOREST PRODUCTS LABORATORY   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Cytochrome P450; Hydroxylation; N Dealkylation; O Dealkylation; Peroxidase; Peroxygenation

Indexed keywords

ACETANILIDE; ALIPHATIC COMPOUND; AMINOPHENAZONE; AROMATIC COMPOUND; AROMATIC PEROXYGENASE; CARBAMAZEPINE; CHLORPROMAZINE; CORTODOXONE; DEUTERIUM; DEXTRORPHAN; DICLOFENAC; DRUG METABOLITE; ETHINYLESTRADIOL; FELBAMATE; FUNGAL ENZYME; GEMFIBROZIL; HYDROGEN PEROXIDE; IBUPROFEN; KETOPROFEN; LIDOCAINE; METOPROLOL; NAPROXEN; OMEPRAZOLE; OSELTAMIVIR; PHENACETIN; PROPRANOLOL; SILDENAFIL; SULFADIAZINE; TAMOXIFEN; TOLBUTAMIDE; UNCLASSIFIED DRUG;

AGROCYBE AEGERITA; ARTICLE; BIOCATALYSIS; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; COPRINELLUS RADIANS; DEALKYLATION; DEETHYLATION; DRUG HYDROXYLATION; DRUG OXIDATION; DRUG PURITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME KINETICS; ENZYME RELEASE; FUNGUS; ISOMER; MASS SPECTROMETRY; OXYGENATION; PEROXYGENATION; PRIORITY JOURNAL;

AGARICALES; AGROCYBE; DEALKYLATION; HYDROGEN PEROXIDE; HYDROXYLATION; KINETICS; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; OXYGEN ISOTOPES; PHARMACEUTICAL PREPARATIONS; STEREOISOMERISM;

EID: 80051795192     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.06.020     Document Type: Article

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