Metabolite generation via microbial biotransformations with actinomycetes: Rapid screening for active strains and biosynthesis of important human metabolites of two development-stage compounds, 5-[(5S,9R)-9-(4-cyanophenyl)-3- (3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non7-yl-methyl] -3-thiophenecarboxylic acid (BMS-587101) and dasatinib

Drug Metabolism and Disposition

Volumn 36, Issue 4, 2008, Pages 721-730

  Li, Wenying ^a   Josephs, Jonathan L ^a   Skiles, Gary L ^a,b   Humphreys, W Griffith ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [(9 (4 CYANOPHENYL) 3 (3,5 DICHLOROPHENYL) 1 METHYL 2,4 DIOXO 1,3,7 TRIAZASPIRO[4.4]NON8 EN 7 YL)METHYL]THIOPHENE 3 CARBOXYLIC ACID; 5 [9 (4 CYANOPHENYL) 3 (3,5 DICHLOROPHENYL) 1 METHYL 2,4 DIOXO 1,3,7 TRIAZASPIRO[4.4]NON7 YL METHYL] 3 THIOPHENECARBOXYLIC ACID; BMS 587101; CARBOXYLIC ACID DERIVATIVE; CYTOCHROME P450; DASATINIB; DICLOFENAC; DRUG METABOLITE; SPIRO COMPOUND; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ACTINOBACTERIA; ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SCREENING; DRUG SYNTHESIS; FUNGAL STRAIN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAMMAL; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SCALE UP; TECHNIQUE;

ACTINOBACTERIA; ANIMALS; BIOTRANSFORMATION; DRUGS, INVESTIGATIONAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MICROSOMES, LIVER; PYRIMIDINES; RATS; SPIRO COMPOUNDS; SWINE; THIAZOLES; THIOPHENES;

ACTINOBACTERIA (CLASS); MAMMALIA;

EID: 41549109840     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.019570     Document Type: Article

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