Regioselectivity in palladium-catalyzed C-H activation/oxygenation reactions

Organic Letters

Volumn 7, Issue 19, 2005, Pages 4149-4152

  Kalyani, Dipannita ^a   Sanford, Melanie S ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 25444475266     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol051486x     Document Type: Article

References (41)

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34. 1H NMR spectroscopy). See Supporting Information for full details.
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38. 0-catalyzed reactions and similar arguments have been invoked in these systems (see refs 8 and 9).
39. 2 to form the diacetoxylated product at similar rates. Therefore, the observed selectivity appears to be inherent to the C-H activation reaction of 18 (rather than resulting from selective consumption of one of the regioisomers after it is formed).
40. The regioselectivity of transition metal-mediated C-H activation reactions is frequently dominated by steric effects. For example, see ref 5d,g and refs 8-10.
41. Chemistry of Organofluorine Compounds 2; Hudlicky, M., Pavlath, A. E., Eds.; American Chemical Society: Washington, DC, 1995.