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Volumn 84, Issue 7, 2009, Pages 613-624

Opioid metabolism

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTIHISTAMINIC AGENT; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBAMAZEPINE; CODEINE; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DIHYDROCODEINE; DIHYDROMORPHINE; FENTANYL; HYDROCODONE; HYDROMORPHONE; METHADONE; MORPHINE; MORPHINE 3 GLUCURONIDE; NALOXONE; NALTREXONE; NARCOTIC ANALGESIC AGENT; OXYCODONE; OXYMORPHONE; SEROTONIN UPTAKE INHIBITOR; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG; CYTOCHROME P450; PRODRUG;

EID: 67650736252     PISSN: 00256196     EISSN: None     Source Type: Journal    
DOI: 10.4065/84.7.613     Document Type: Review
Times cited : (576)

References (116)
  • 1
    • 84900643268 scopus 로고    scopus 로고
    • World Health Organization. Cancer Pain Relief: With a Guide to Opioid Availability. 2nd ed.Geneva, Switzerland: WHO Office of Publication; 1996.
    • World Health Organization. Cancer Pain Relief: With a Guide to Opioid Availability. 2nd ed.Geneva, Switzerland: WHO Office of Publication; 1996.
  • 2
    • 2542492932 scopus 로고    scopus 로고
    • Practice guidelines for acute pain management in the perioperative setting: An updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management
    • Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management. Anesthesiology. 2004;100(6):1573-1581.
    • (2004) Anesthesiology , vol.100 , Issue.6 , pp. 1573-1581
  • 3
    • 0036087972 scopus 로고    scopus 로고
    • The management of persistent pain in older persons
    • AGS Panel on Persistent Pain in Older Persons
    • AGS Panel on Persistent Pain in Older Persons. The management of persistent pain in older persons. J Am Geriatr Soc. 2002;50(6)(suppl): S205-S224.
    • (2002) J Am Geriatr Soc , vol.50 , Issue.6 SUPPL.
  • 5
    • 0033554190 scopus 로고    scopus 로고
    • Epidemiological features of chronic low-back pain
    • Andersson GB. Epidemiological features of chronic low-back pain. Lancet. 1999;354(9178):581-585.
    • (1999) Lancet , vol.354 , Issue.9178 , pp. 581-585
    • Andersson, G.B.1
  • 6
    • 0036812566 scopus 로고    scopus 로고
    • Opioid rotation in the treatment of joint pain: A review of 67 cases
    • Grilo RM, Bertin P, Scotto di Fazano C, et al. Opioid rotation in the treatment of joint pain: a review of 67 cases. Joint Bone Spine. 2002;69(5):491-494.
    • (2002) Joint Bone Spine , vol.69 , Issue.5 , pp. 491-494
    • Grilo, R.M.1    Bertin, P.2    Scotto di Fazano, C.3
  • 7
    • 0033229732 scopus 로고    scopus 로고
    • Opioid rotation for cancer pain: Rationale and clinical aspects
    • Mercadante S. Opioid rotation for cancer pain: rationale and clinical aspects. Cancer. 1999;86(9):1856-1866.
    • (1999) Cancer , vol.86 , Issue.9 , pp. 1856-1866
    • Mercadante, S.1
  • 8
    • 33746925643 scopus 로고    scopus 로고
    • Mercadante S, Bruera E. Opioid switching: a systematic and critical review. Cancer Treat Rev. 2006 Jun;32(4):304-315. Epub 2006 Apr 19.
    • Mercadante S, Bruera E. Opioid switching: a systematic and critical review. Cancer Treat Rev. 2006 Jun;32(4):304-315. Epub 2006 Apr 19.
  • 9
    • 0342313732 scopus 로고    scopus 로고
    • Opioid substitution to improve the effectiveness of chronic noncancer pain control: A chart review
    • Quang-Cantagrel ND, Wallace MS, Magnuson SK. Opioid substitution to improve the effectiveness of chronic noncancer pain control: a chart review. Anesth Analg. 2000;90(4):933-937.
    • (2000) Anesth Analg , vol.90 , Issue.4 , pp. 933-937
    • Quang-Cantagrel, N.D.1    Wallace, M.S.2    Magnuson, S.K.3
  • 10
    • 84900575072 scopus 로고    scopus 로고
    • Duragesic fentanyl transdermal system, package insert, Titusville, NJ: Janssen Pharmaceuticals, Inc; 2008
    • Duragesic (fentanyl transdermal system) [package insert]. Titusville, NJ: Janssen Pharmaceuticals, Inc; 2008.
  • 11
    • 85031362403 scopus 로고    scopus 로고
    • OxyContin oxycodone HCl controlled-release tablets, package insert, Stamford, CT: Purdue Pharma LP; 2007
    • OxyContin (oxycodone HCl controlled-release tablets) [package insert]. Stamford, CT: Purdue Pharma LP; 2007.
  • 12
    • 0031894377 scopus 로고    scopus 로고
    • The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268)
    • Coffman BL, King CD, Rios GR, Tephly TR. The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268). Drug Metab Dispos. 1998;26(1):73-77.
    • (1998) Drug Metab Dispos , vol.26 , Issue.1 , pp. 73-77
    • Coffman, B.L.1    King, C.D.2    Rios, G.R.3    Tephly, T.R.4
  • 13
    • 85031357078 scopus 로고    scopus 로고
    • Codeine Contin (codeine controlled-release tablets) [product monograph]. Pickering, Ontario, Canada: Purdue Pharma; 2006.
    • Codeine Contin (codeine controlled-release tablets) [product monograph]. Pickering, Ontario, Canada: Purdue Pharma; 2006.
  • 14
    • 84900592479 scopus 로고    scopus 로고
    • Hydrocodone [package insert, Corona, CA: Watson Laboratories; 2004
    • Hydrocodone [package insert]. Corona, CA: Watson Laboratories; 2004.
  • 15
    • 85031351278 scopus 로고    scopus 로고
    • Methadone hydrochloride tablets [package insert, Hazelwood, MO: Mallinckrodt, Inc; 2004
    • Methadone hydrochloride tablets [package insert]. Hazelwood, MO: Mallinckrodt, Inc; 2004.
  • 16
    • 84900588918 scopus 로고    scopus 로고
    • Ultram ER tramadol hydrochloride, package insert, Raritan, NJ: Ortho-McNeil; 2008
    • Ultram ER (tramadol hydrochloride) [package insert]. Raritan, NJ: Ortho-McNeil; 2008.
  • 17
    • 84900661221 scopus 로고    scopus 로고
    • Dilaudid-HP injection 10 mg (hydromorphone hydrochloride) full prescribing information. North Chicago, IL: Abbott Laboratories; 2008.
    • Dilaudid-HP injection 10 mg (hydromorphone hydrochloride) full prescribing information. North Chicago, IL: Abbott Laboratories; 2008.
  • 18
    • 85031361180 scopus 로고    scopus 로고
    • OPANA ER oxymorphone hydrochloride extended-release tablets, package insert, Chadds Ford, PA: Endo Pharmaceuticals Inc; 2008
    • OPANA ER (oxymorphone hydrochloride extended-release tablets) [package insert]. Chadds Ford, PA: Endo Pharmaceuticals Inc; 2008.
  • 19
    • 0032903876 scopus 로고    scopus 로고
    • Methadone N-demethylation in human liver microsomes: Lack of stereoselectivity and involvement of CYP3A4
    • Foster DJ, Somogyi AA, Bochner F. Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4. Br J Clin Pharmacol. 1999;47(4):403-412.
    • (1999) Br J Clin Pharmacol , vol.47 , Issue.4 , pp. 403-412
    • Foster, D.J.1    Somogyi, A.A.2    Bochner, F.3
  • 20
    • 33947412998 scopus 로고    scopus 로고
    • Totah RA, Allen KE, Sheffels P, Whittington D, Kharasch ED. Enantiomeric metabolic interactions and stereoselective human methadone metabolism. J Pharmacol Exp Ther. 2007 Apr;321(1):389-399. Epub 2007 Jan 26.
    • Totah RA, Allen KE, Sheffels P, Whittington D, Kharasch ED. Enantiomeric metabolic interactions and stereoselective human methadone metabolism. J Pharmacol Exp Ther. 2007 Apr;321(1):389-399. Epub 2007 Jan 26.
  • 21
    • 0038193696 scopus 로고    scopus 로고
    • Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro
    • Wang JS, DeVane CL. Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro. Drug Metab Dispos. 2003;31(6):742-747.
    • (2003) Drug Metab Dispos , vol.31 , Issue.6 , pp. 742-747
    • Wang, J.S.1    DeVane, C.L.2
  • 22
    • 42449123284 scopus 로고    scopus 로고
    • Interindividual variability of methadone response: Impact of genetic polymorphism
    • Li Y, Kantelip JP, Gerritsen-van Schieveen P, Davani S. Interindividual variability of methadone response: impact of genetic polymorphism. Mol Diagn Ther. 2008;12(2):109-124.
    • (2008) Mol Diagn Ther , vol.12 , Issue.2 , pp. 109-124
    • Li, Y.1    Kantelip, J.P.2    Gerritsen-van Schieveen, P.3    Davani, S.4
  • 23
    • 33845533592 scopus 로고    scopus 로고
    • ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment
    • Crettol S, Déglon JJ, Besson J, et al. ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment. Clin Pharmacol Ther. 2006;80(6):668-681.
    • (2006) Clin Pharmacol Ther , vol.80 , Issue.6 , pp. 668-681
    • Crettol, S.1    Déglon, J.J.2    Besson, J.3
  • 24
    • 36549059303 scopus 로고    scopus 로고
    • Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring
    • Zhou SF, Xue CC, Yu XQ, Li C, Wang G. Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring. Ther Drug Monit. 2007;29(6):687-710.
    • (2007) Ther Drug Monit , vol.29 , Issue.6 , pp. 687-710
    • Zhou, S.F.1    Xue, C.C.2    Yu, X.Q.3    Li, C.4    Wang, G.5
  • 25
    • 45249121177 scopus 로고    scopus 로고
    • Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
    • Zhou SF. Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab. 2008;9(4):310-322.
    • (2008) Curr Drug Metab , vol.9 , Issue.4 , pp. 310-322
    • Zhou, S.F.1
  • 26
    • 35348867597 scopus 로고    scopus 로고
    • Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins
    • Girennavar B, Jayaprakasha GK, Patil BS. Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins. J Food Sci. 2007;72(8):C417-C421.
    • (2007) J Food Sci , vol.72 , Issue.8
    • Girennavar, B.1    Jayaprakasha, G.K.2    Patil, B.S.3
  • 27
    • 39149134628 scopus 로고    scopus 로고
    • Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver
    • Huber WW, Rossmanith W, Grusch M, et al. Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver. Food Chem Toxicol. 2008;46(4):1230-1238.
    • (2008) Food Chem Toxicol , vol.46 , Issue.4 , pp. 1230-1238
    • Huber, W.W.1    Rossmanith, W.2    Grusch, M.3
  • 29
    • 0018900001 scopus 로고
    • A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population
    • Evans DA, Mahgoub A, Sloan TP, Idle JR, Smith RL. A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. J Med Genet. 1980;17(2):102-105.
    • (1980) J Med Genet , vol.17 , Issue.2 , pp. 102-105
    • Evans, D.A.1    Mahgoub, A.2    Sloan, T.P.3    Idle, J.R.4    Smith, R.L.5
  • 30
    • 0032436459 scopus 로고    scopus 로고
    • Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone
    • Heiskanen T, Olkkola KT, Kalso E. Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. Clin Pharmacol Ther. 1998;64(6):603-611.
    • (1998) Clin Pharmacol Ther , vol.64 , Issue.6 , pp. 603-611
    • Heiskanen, T.1    Olkkola, K.T.2    Kalso, E.3
  • 31
    • 0026506140 scopus 로고    scopus 로고
    • Bertilsson L, Lou YQ, Du YL, et al. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin [published correction appears in Clin Pharmacol Ther. 1994;55(6):648]. Clin Pharmacol Ther. 1992;51(4):388-397.
    • Bertilsson L, Lou YQ, Du YL, et al. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin [published correction appears in Clin Pharmacol Ther. 1994;55(6):648]. Clin Pharmacol Ther. 1992;51(4):388-397.
  • 32
    • 0031960328 scopus 로고    scopus 로고
    • Ultrarapid metabolism of sparteine: Frequency of alleles with duplicated CYP2D6 genes in a Danish population as determined by restriction fragment length polymorphism and long polymerase chain reaction
    • Bathum L, Johansson I, Ingelman-Sundberg M, Hørder M, Brosen K. Ultrarapid metabolism of sparteine: frequency of alleles with duplicated CYP2D6 genes in a Danish population as determined by restriction fragment length polymorphism and long polymerase chain reaction. Pharmacogenetics. 1998;8(2):119-123.
    • (1998) Pharmacogenetics , vol.8 , Issue.2 , pp. 119-123
    • Bathum, L.1    Johansson, I.2    Ingelman-Sundberg, M.3    Hørder, M.4    Brosen, K.5
  • 33
    • 0007293059 scopus 로고    scopus 로고
    • Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene
    • Løvlie R, Daly AK, Molven A, Idle JR, Steen VM. Ultrarapid metabolizers of debrisoquine: characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene. FEBS Lett. 1996;392(1):30-34.
    • (1996) FEBS Lett , vol.392 , Issue.1 , pp. 30-34
    • Løvlie, R.1    Daly, A.K.2    Molven, A.3    Idle, J.R.4    Steen, V.M.5
  • 34
    • 0026091975 scopus 로고
    • Metoprolol oxidation polymorphism in a Korean population: Comparison with native Japanese and Chinese populations
    • Sohn DR, Shin SG, Park CW, Kusaka M, Chiba K, Ishizaki T. Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations. Br J Clin Pharmacol. 1991;32(4): 504-507.
    • (1991) Br J Clin Pharmacol , vol.32 , Issue.4 , pp. 504-507
    • Sohn, D.R.1    Shin, S.G.2    Park, C.W.3    Kusaka, M.4    Chiba, K.5    Ishizaki, T.6
  • 35
    • 0030432585 scopus 로고    scopus 로고
    • Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
    • Aklillu E, Persson I, Bertilsson L, Johansson I, Rodrigues F, Ingelman-Sundberg M. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther. 1996;278(1):441-446.
    • (1996) J Pharmacol Exp Ther , vol.278 , Issue.1 , pp. 441-446
    • Aklillu, E.1    Persson, I.2    Bertilsson, L.3    Johansson, I.4    Rodrigues, F.5    Ingelman-Sundberg, M.6
  • 37
    • 0026004805 scopus 로고
    • Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects
    • Relling MV, Cherrie J, Schell MJ, Petros WP, Meyer WH, Evans WE. Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects. Clin Pharmacol Ther. 1991;50(3):308-313.
    • (1991) Clin Pharmacol Ther , vol.50 , Issue.3 , pp. 308-313
    • Relling, M.V.1    Cherrie, J.2    Schell, M.J.3    Petros, W.P.4    Meyer, W.H.5    Evans, W.E.6
  • 38
    • 0029853664 scopus 로고    scopus 로고
    • A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: Association with diminished debrisoquine hydroxylase activity
    • Masimirembwa C, Persson I, Bertilsson L, Hasler J, Ingelman-Sundberg M. A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity. Br J Clin Pharmacol. 1996;42(6):713-719.
    • (1996) Br J Clin Pharmacol , vol.42 , Issue.6 , pp. 713-719
    • Masimirembwa, C.1    Persson, I.2    Bertilsson, L.3    Hasler, J.4    Ingelman-Sundberg, M.5
  • 40
    • 10044297116 scopus 로고    scopus 로고
    • Genetic predictors of the clinical response to opioid analgesics: Clinical utility and future perspectives
    • Lötsch J, Skarke C, Liefhold J, Geisslinger G. Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives. Clin Pharmacokinet. 2004;43(14):983-1013.
    • (2004) Clin Pharmacokinet , vol.43 , Issue.14 , pp. 983-1013
    • Lötsch, J.1    Skarke, C.2    Liefhold, J.3    Geisslinger, G.4
  • 41
    • 36348941795 scopus 로고    scopus 로고
    • Foster A, Mobley E, Wang Z. Complicated pain management in a CYP450 2D6 poor metabolizer. Pain Pract. 2007 Dec;7(4):352-356. Epub 2007 Nov 6.
    • Foster A, Mobley E, Wang Z. Complicated pain management in a CYP450 2D6 poor metabolizer. Pain Pract. 2007 Dec;7(4):352-356. Epub 2007 Nov 6.
  • 42
    • 33745652413 scopus 로고    scopus 로고
    • Susce MT, Murray-Carmichael E, de Leon J. Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Sep 30;30(7):1356-1358. Epub 2006 Apr 24.
    • Susce MT, Murray-Carmichael E, de Leon J. Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Sep 30;30(7):1356-1358. Epub 2006 Apr 24.
  • 43
    • 84900650298 scopus 로고    scopus 로고
    • Kadian morphine sulfate extended-release capsules, package insert, Piscataway, NJ: Alpharma; 2008
    • Kadian (morphine sulfate extended-release capsules) [package insert]. Piscataway, NJ: Alpharma; 2008.
  • 44
    • 0033645752 scopus 로고    scopus 로고
    • Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: Ethnic diversity of alleles and potential clinical significance
    • Bhasker CR, McKinnon W, Stone A, et al. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. Pharmacogenetics. 2000; 10(8):679-685.
    • (2000) Pharmacogenetics , vol.10 , Issue.8 , pp. 679-685
    • Bhasker, C.R.1    McKinnon, W.2    Stone, A.3
  • 45
    • 34249937715 scopus 로고    scopus 로고
    • Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine
    • Hara Y, Nakajima M, Miyamoto K, Yokoi T. Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine. Drug Metab Pharmacokinet. 2007;22(2):103-112.
    • (2007) Drug Metab Pharmacokinet , vol.22 , Issue.2 , pp. 103-112
    • Hara, Y.1    Nakajima, M.2    Miyamoto, K.3    Yokoi, T.4
  • 46
    • 0141631451 scopus 로고    scopus 로고
    • Identification of CYP3A4 and CYP2C8 as the major cytochrome P450s responsible for morphine N-demethylation in human liver microsomes
    • Projean D, Morin PE, Tu TM, Ducharme J. Identification of CYP3A4 and CYP2C8 as the major cytochrome P450s responsible for morphine N-demethylation in human liver microsomes. Xenobiotica. 2003;33(8):841-854.
    • (2003) Xenobiotica , vol.33 , Issue.8 , pp. 841-854
    • Projean, D.1    Morin, P.E.2    Tu, T.M.3    Ducharme, J.4
  • 47
    • 14944354806 scopus 로고    scopus 로고
    • Modulation of UDP- glucuronosyltransferase function by cytochrome P450: Evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4
    • Epub Dec 20
    • Takeda S, Ishii Y, Iwanaga M, et al. Modulation of UDP- glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4. Mol Pharmacol. 2005;67(3):665-672. Epub 2004 Dec 20.
    • (2004) Mol Pharmacol. 2005 , vol.67 , Issue.3 , pp. 665-672
    • Takeda, S.1    Ishii, Y.2    Iwanaga, M.3
  • 48
    • 26444523430 scopus 로고    scopus 로고
    • Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: Differential effects of CYP1A2, CYP2C9 and CYP3A4
    • Takeda S, Ishii Y, Mackenzie PI, et al. Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4. Biol Pharm Bull. 2005; 28(10):2026-2027.
    • (2005) Biol Pharm Bull , vol.28 , Issue.10 , pp. 2026-2027
    • Takeda, S.1    Ishii, Y.2    Mackenzie, P.I.3
  • 49
    • 39749110077 scopus 로고    scopus 로고
    • UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease
    • Darbari DS, van Schaik RH, Capparelli EV, Rana S, McCarter R, van den Anker J. UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease. Am J Hematol. 2008;83(3):200-202.
    • (2008) Am J Hematol , vol.83 , Issue.3 , pp. 200-202
    • Darbari, D.S.1    van Schaik, R.H.2    Capparelli, E.V.3    Rana, S.4    McCarter, R.5    van den Anker, J.6
  • 50
    • 1542286160 scopus 로고    scopus 로고
    • A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity
    • Duguay Y, Báár C, Skorpen F, Guillemette C. A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity. Clin Pharmacol Ther. 2004;75(3):223-233.
    • (2004) Clin Pharmacol Ther , vol.75 , Issue.3 , pp. 223-233
    • Duguay, Y.1    Báár, C.2    Skorpen, F.3    Guillemette, C.4
  • 51
    • 0036266930 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1α is a causal factor responsible for interindividual differences in the expression of UDP-glucuronosyltransferase 2B7 mRNA in human livers
    • Toide K, Takahashi Y, Yamazaki H, et al. Hepatocyte nuclear factor-1α is a causal factor responsible for interindividual differences in the expression of UDP-glucuronosyltransferase 2B7 mRNA in human livers. Drug Metab Dispos. 2002;30(6):613-615.
    • (2002) Drug Metab Dispos , vol.30 , Issue.6 , pp. 613-615
    • Toide, K.1    Takahashi, Y.2    Yamazaki, H.3
  • 52
    • 0035367176 scopus 로고    scopus 로고
    • Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: A prospective study
    • Mercadante S, Casuccio A, Fulfaro F, et al. Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study. J Clin Oncol. 2001;19(11):2898-2904.
    • (2001) J Clin Oncol , vol.19 , Issue.11 , pp. 2898-2904
    • Mercadante, S.1    Casuccio, A.2    Fulfaro, F.3
  • 53
    • 43549121967 scopus 로고    scopus 로고
    • Evidence that morphine is metabolized to hydromorphone but not to oxymorphone
    • Cone EJ, Caplan YH, Moser F, Robert T, Black D. Evidence that morphine is metabolized to hydromorphone but not to oxymorphone. J Anal Toxicol. 2008;32(4):319-323.
    • (2008) J Anal Toxicol , vol.32 , Issue.4 , pp. 319-323
    • Cone, E.J.1    Caplan, Y.H.2    Moser, F.3    Robert, T.4    Black, D.5
  • 54
    • 33646178983 scopus 로고    scopus 로고
    • Evidence of morphine metabolism to hydromorphone in pain patients chronically treated with morphine
    • Cone EJ, Heit HA, Caplan YH, Gourlay D. Evidence of morphine metabolism to hydromorphone in pain patients chronically treated with morphine. J Anal Toxicol. 2006;30(1):1-5.
    • (2006) J Anal Toxicol , vol.30 , Issue.1 , pp. 1-5
    • Cone, E.J.1    Heit, H.A.2    Caplan, Y.H.3    Gourlay, D.4
  • 55
    • 43749100932 scopus 로고    scopus 로고
    • The detection of hydromorphone in urine specimens with high morphine concentrations
    • McDonough PC, Levine B, Vorce S, Jufer RA, Fowler D. The detection of hydromorphone in urine specimens with high morphine concentrations. J Forensic Sci. 2008;53(3):752-754.
    • (2008) J Forensic Sci , vol.53 , Issue.3 , pp. 752-754
    • McDonough, P.C.1    Levine, B.2    Vorce, S.3    Jufer, R.A.4    Fowler, D.5
  • 56
    • 1542359666 scopus 로고    scopus 로고
    • CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes
    • Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA. CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004;57(3): 287-297.
    • (2004) Br J Clin Pharmacol , vol.57 , Issue.3 , pp. 287-297
    • Hutchinson, M.R.1    Menelaou, A.2    Foster, D.J.3    Coller, J.K.4    Somogyi, A.A.5
  • 58
    • 0033819965 scopus 로고    scopus 로고
    • Identification of hydrocodone in human urine following controlled codeine administration
    • Oyler JM, Cone EJ, Joseph RE Jr, Huestis MA. Identification of hydrocodone in human urine following controlled codeine administration. J Anal Toxicol. 2000;24(7):530-535.
    • (2000) J Anal Toxicol , vol.24 , Issue.7 , pp. 530-535
    • Oyler, J.M.1    Cone, E.J.2    Joseph Jr, R.E.3    Huestis, M.A.4
  • 59
    • 0034893705 scopus 로고    scopus 로고
    • Metabolism of methadone and levo-α- acetyl-methadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): Potential contribution of intestinal metabolism to presystemic clearance and bioactivation
    • Oda Y, Kharasch ED. Metabolism of methadone and levo-α- acetyl-methadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. J Pharmacol Exp Ther. 2001;298(3):1021-1032.
    • (2001) J Pharmacol Exp Ther , vol.298 , Issue.3 , pp. 1021-1032
    • Oda, Y.1    Kharasch, E.D.2
  • 60
    • 36148963655 scopus 로고    scopus 로고
    • Rational use and interpretation of urine drug testing in chronic opioid therapy
    • Reisfield GM, Salazar E, Bertholf RL. Rational use and interpretation of urine drug testing in chronic opioid therapy. Ann Clin Lab Sci. 2007;37(4):301-314.
    • (2007) Ann Clin Lab Sci , vol.37 , Issue.4 , pp. 301-314
    • Reisfield, G.M.1    Salazar, E.2    Bertholf, R.L.3
  • 61
    • 0031405796 scopus 로고    scopus 로고
    • Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine
    • Dalén P, Frengell C, Dahl ML, Sjöqvist F. Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine. Ther Drug Monit. 1997;19(5):543-544.
    • (1997) Ther Drug Monit , vol.19 , Issue.5 , pp. 543-544
    • Dalén, P.1    Frengell, C.2    Dahl, M.L.3    Sjöqvist, F.4
  • 62
    • 11144221180 scopus 로고    scopus 로고
    • Gasche Y, Daali Y, Fathi M, et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism [published correction appears in N Engl J Med. 2005;352(6):638]. N Engl J Med. 2004;351(27):2827-2831.
    • Gasche Y, Daali Y, Fathi M, et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism [published correction appears in N Engl J Med. 2005;352(6):638]. N Engl J Med. 2004;351(27):2827-2831.
  • 63
    • 0031746749 scopus 로고    scopus 로고
    • Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation
    • Eckhardt K, Li S, Ammon S, Schänzle G, Mikus G, Eichelbaum M. Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation. Pain. 1998;76(1-2):27-33.
    • (1998) Pain , vol.76 , Issue.1-2 , pp. 27-33
    • Eckhardt, K.1    Li, S.2    Ammon, S.3    Schänzle, G.4    Mikus, G.5    Eichelbaum, M.6
  • 64
    • 33748918495 scopus 로고    scopus 로고
    • Opioids used in primary care for the management of pain: A pharmacologic, pharmacotherapeutic, and pharmacodynamic overview
    • Boswell MV, Cole BE, eds, 7th ed. New York, NY: CRC Press/Taylor & Francis Group;
    • Barkin RL, Iusco AM, Barkin SJ. Opioids used in primary care for the management of pain: a pharmacologic, pharmacotherapeutic, and pharmacodynamic overview. In: Boswell MV, Cole BE, eds. Weiner's Pain Management: A Practical Guide for Clinicians. 7th ed. New York, NY: CRC Press/Taylor & Francis Group; 2006:789-804.
    • (2006) Weiner's Pain Management: A Practical Guide for Clinicians , pp. 789-804
    • Barkin, R.L.1    Iusco, A.M.2    Barkin, S.J.3
  • 65
    • 0026557354 scopus 로고
    • Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide
    • Hucks D, Thompson PI, McLoughlin L, et al. Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide. Br J Cancer. 1992;65(1):122-126.
    • (1992) Br J Cancer , vol.65 , Issue.1 , pp. 122-126
    • Hucks, D.1    Thompson, P.I.2    McLoughlin, L.3
  • 66
    • 0036897440 scopus 로고    scopus 로고
    • Unwanted effects of morphine-6-glucoronide and morphine
    • Cann C, Curran J, Milner T, Ho B. Unwanted effects of morphine-6-glucoronide and morphine. Anaesthesia. 2002;57(12):1200-1203.
    • (2002) Anaesthesia , vol.57 , Issue.12 , pp. 1200-1203
    • Cann, C.1    Curran, J.2    Milner, T.3    Ho, B.4
  • 68
    • 0034053670 scopus 로고    scopus 로고
    • Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites
    • Smith MT. Neuroexcitatory effects of morphine and hydromorphone: evidence implicating the 3-glucuronide metabolites. Clin Exp Pharmacol Physiol. 2000;27(7):524-528.
    • (2000) Clin Exp Pharmacol Physiol , vol.27 , Issue.7 , pp. 524-528
    • Smith, M.T.1
  • 69
    • 0035876325 scopus 로고    scopus 로고
    • Hydromorphone-3-glucuronide: A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide
    • Wright AW, Mather LE, Smith MT. Hydromorphone-3-glucuronide: a more potent neuro-excitant than its structural analogue, morphine-3-glucuronide. Life Sci. 2001;69(4):409-420.
    • (2001) Life Sci , vol.69 , Issue.4 , pp. 409-420
    • Wright, A.W.1    Mather, L.E.2    Smith, M.T.3
  • 70
    • 0032102417 scopus 로고    scopus 로고
    • Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation
    • Wright AW, Nocente ML, Smith MT. Hydromorphone-3-glucuronide: biochemical synthesis and preliminary pharmacological evaluation. Life Sci. 1998;63(5):401-411.
    • (1998) Life Sci , vol.63 , Issue.5 , pp. 401-411
    • Wright, A.W.1    Nocente, M.L.2    Smith, M.T.3
  • 71
    • 0345530952 scopus 로고    scopus 로고
    • Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients
    • Klepstad P, Borchgrevink PC, Dale O, et al. Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients. Palliat Med. 2003;17:679-687.
    • (2003) Palliat Med , vol.17 , pp. 679-687
    • Klepstad, P.1    Borchgrevink, P.C.2    Dale, O.3
  • 72
    • 0037251596 scopus 로고    scopus 로고
    • Plasma concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide and their relationship with analgesia and side effects in patients with cancer-related pain
    • Quigley C, Joel S, Patel N, Baksh A, Slevin M. Plasma concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide and their relationship with analgesia and side effects in patients with cancer-related pain. Palliat Med. 2003;17(2):185-190.
    • (2003) Palliat Med , vol.17 , Issue.2 , pp. 185-190
    • Quigley, C.1    Joel, S.2    Patel, N.3    Baksh, A.4    Slevin, M.5
  • 73
    • 0034060094 scopus 로고    scopus 로고
    • Insidious intoxication after morphine treatment in renal failure: Delayed onset of morphine-6-glucuronide action
    • Angst MS, Buhrer M, Lötsch J. Insidious intoxication after morphine treatment in renal failure: delayed onset of morphine-6-glucuronide action. Anesthesiology. 2000;92(5):1473-1476.
    • (2000) Anesthesiology , vol.92 , Issue.5 , pp. 1473-1476
    • Angst, M.S.1    Buhrer, M.2    Lötsch, J.3
  • 75
    • 0027248094 scopus 로고
    • The pharmacokinetics of morphine and morphine glucuronides in kidney failure
    • Osborne R, Joel S, Grebenik K, Trew D, Slevin M. The pharmacokinetics of morphine and morphine glucuronides in kidney failure. Clin Pharmacol Ther. 1993;54(2):158-167.
    • (1993) Clin Pharmacol Ther , vol.54 , Issue.2 , pp. 158-167
    • Osborne, R.1    Joel, S.2    Grebenik, K.3    Trew, D.4    Slevin, M.5
  • 76
    • 0022532772 scopus 로고
    • Morphine intoxication in renal failure: The role of morphine-6-glucuronide
    • Osborne RJ, Joel SP, Slevin ML. Morphine intoxication in renal failure: the role of morphine-6-glucuronide. Br Med J (Clin Res Ed). 1986;292(6535): 1548-1549.
    • (1986) Br Med J (Clin Res Ed) , vol.292 , Issue.6535 , pp. 1548-1549
    • Osborne, R.J.1    Joel, S.P.2    Slevin, M.L.3
  • 77
    • 47249099319 scopus 로고    scopus 로고
    • CYP2D6 polymorphism in relation to tramadol metabolism: A study of Faroese patients
    • Halling J, Weihe P, Brosen K. CYP2D6 polymorphism in relation to tramadol metabolism: a study of Faroese patients. Ther Drug Monit. 2008; 30(3):271-275.
    • (2008) Ther Drug Monit , vol.30 , Issue.3 , pp. 271-275
    • Halling, J.1    Weihe, P.2    Brosen, K.3
  • 78
    • 0033901486 scopus 로고    scopus 로고
    • Affinity, potency and efficacy of tramadol and its metabolites at the cloned human μ-opioid receptor
    • Gillen C, Haurand M, Kobelt DJ, Wnendt S. Affinity, potency and efficacy of tramadol and its metabolites at the cloned human μ-opioid receptor. Naunyn Schmiedebergs Arch Pharmacol. 2000;362(2):116-121.
    • (2000) Naunyn Schmiedebergs Arch Pharmacol , vol.362 , Issue.2 , pp. 116-121
    • Gillen, C.1    Haurand, M.2    Kobelt, D.J.3    Wnendt, S.4
  • 79
    • 0026585612 scopus 로고
    • Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro
    • Driessen B, Reimann W. Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro. Br J Pharmacol. 1992;105(1):147-151.
    • (1992) Br J Pharmacol , vol.105 , Issue.1 , pp. 147-151
    • Driessen, B.1    Reimann, W.2
  • 80
    • 0027511794 scopus 로고
    • Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro
    • Driessen B, Reimann W, Giertz H. Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro. Br J Pharmacol. 1993;108(3):806-811.
    • (1993) Br J Pharmacol , vol.108 , Issue.3 , pp. 806-811
    • Driessen, B.1    Reimann, W.2    Giertz, H.3
  • 81
    • 33646183072 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites
    • Lalovic B, Kharasch E, Hoffer C, Risler L, Liu-Chen LY, Shen DD. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clin Pharmacol Ther. 2006;79(5):461-479.
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.5 , pp. 461-479
    • Lalovic, B.1    Kharasch, E.2    Hoffer, C.3    Risler, L.4    Liu-Chen, L.Y.5    Shen, D.D.6
  • 82
    • 0029813838 scopus 로고    scopus 로고
    • Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes: Role of CYP3A4
    • Feierman DE, Lasker JM. Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes: role of CYP3A4. Drug Metab Dispos. 1996;24(9):932-939.
    • (1996) Drug Metab Dispos , vol.24 , Issue.9 , pp. 932-939
    • Feierman, D.E.1    Lasker, J.M.2
  • 83
    • 27844528953 scopus 로고    scopus 로고
    • Pharmacology of methadone and its isomers
    • Inturrisi CE. Pharmacology of methadone and its isomers. Minerva Anestesiol. 2005;71(7-8):435-437.
    • (2005) Minerva Anestesiol , vol.71 , Issue.7-8 , pp. 435-437
    • Inturrisi, C.E.1
  • 84
    • 33846016606 scopus 로고    scopus 로고
    • A case of serotonin syndrome and mutism associated with methadone
    • Bush E, Miller C, Friedman I. A case of serotonin syndrome and mutism associated with methadone. J Palliat Med. 2006;9(6):1257-1259.
    • (2006) J Palliat Med , vol.9 , Issue.6 , pp. 1257-1259
    • Bush, E.1    Miller, C.2    Friedman, I.3
  • 85
    • 50049116470 scopus 로고    scopus 로고
    • Myoclonus associated with high-dose parenteral methadone
    • Ito S, Liao S. Myoclonus associated with high-dose parenteral methadone. J Palliat Med. 2008;11(6):838-841.
    • (2008) J Palliat Med , vol.11 , Issue.6 , pp. 838-841
    • Ito, S.1    Liao, S.2
  • 87
    • 40549092967 scopus 로고    scopus 로고
    • CYP2D6 ultrarapid metabolism and morphine/codeine ratios in blood: Was it codeine or heroin?
    • He YJ, Brockmöller J, Schmidt H, Roots I, Kirchheiner J. CYP2D6 ultrarapid metabolism and morphine/codeine ratios in blood: was it codeine or heroin? J Anal Toxicol. 2008;32(2):178-182.
    • (2008) J Anal Toxicol , vol.32 , Issue.2 , pp. 178-182
    • He, Y.J.1    Brockmöller, J.2    Schmidt, H.3    Roots, I.4    Kirchheiner, J.5
  • 88
    • 34547644659 scopus 로고    scopus 로고
    • Kirchheiner J, Schmidt H, Tzvetkov M, et al. Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J. 2007 Aug;7(4):257-265. Epub 2006 Jul 4.
    • Kirchheiner J, Schmidt H, Tzvetkov M, et al. Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J. 2007 Aug;7(4):257-265. Epub 2006 Jul 4.
  • 89
    • 0025879251 scopus 로고
    • Forensic drug testing for opiates, III: Urinary excretion rates of morphine and codeine following codeine administration
    • Cone EJ, Welch P, Paul BD, Mitchell JM. Forensic drug testing for opiates, III: Urinary excretion rates of morphine and codeine following codeine administration. J Anal Toxicol. 1991;15(4):161-166.
    • (1991) J Anal Toxicol , vol.15 , Issue.4 , pp. 161-166
    • Cone, E.J.1    Welch, P.2    Paul, B.D.3    Mitchell, J.M.4
  • 90
    • 0016251752 scopus 로고
    • A study of codeine metabolism
    • Solomon MD. A study of codeine metabolism. Clin Toxicol. 1974;7(3): 255-257.
    • (1974) Clin Toxicol , vol.7 , Issue.3 , pp. 255-257
    • Solomon, M.D.1
  • 91
    • 0020603409 scopus 로고
    • Gas chromatographic study of the urinary codeine-to-morphine ratios in controlled codeine consumption and in mass screening for opiate drugs
    • Dutt MC, Lo DS, Ng DL, Woo SO. Gas chromatographic study of the urinary codeine-to-morphine ratios in controlled codeine consumption and in mass screening for opiate drugs. J Chromatogr. 1983;267(1):117-124.
    • (1983) J Chromatogr , vol.267 , Issue.1 , pp. 117-124
    • Dutt, M.C.1    Lo, D.S.2    Ng, D.L.3    Woo, S.O.4
  • 92
    • 0020511246 scopus 로고
    • Simultaneous determination of codeine and morphine in urine and blood by HPLC
    • Posey BL, Kimble SN. Simultaneous determination of codeine and morphine in urine and blood by HPLC. J Anal Toxicol. 1983;7(5):241-245.
    • (1983) J Anal Toxicol , vol.7 , Issue.5 , pp. 241-245
    • Posey, B.L.1    Kimble, S.N.2
  • 93
    • 0033063491 scopus 로고    scopus 로고
    • A pilot study to determine the usefulness of the urinary excretion of methadone and its primary metabolite (EDDP) as potential markers of compliance in methadone detoxification programs
    • George S, Braithwaite RA. A pilot study to determine the usefulness of the urinary excretion of methadone and its primary metabolite (EDDP) as potential markers of compliance in methadone detoxification programs. J Anal Toxicol. 1999;23(2):81-85.
    • (1999) J Anal Toxicol , vol.23 , Issue.2 , pp. 81-85
    • George, S.1    Braithwaite, R.A.2
  • 94
    • 0003549757 scopus 로고    scopus 로고
    • Levine B, ed, 2nd ed. Washington, DC: AACC Press;
    • Levine B, ed. Principles of Forensic Toxicology. 2nd ed. Washington, DC: AACC Press; 2003:385.
    • (2003) Principles of Forensic Toxicology , pp. 385
  • 95
    • 0033046088 scopus 로고    scopus 로고
    • Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects
    • Caraco Y, Sheller J, Wood AJ. Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects. J Pharmacol Exp Ther. 1999;290(1):413-422.
    • (1999) J Pharmacol Exp Ther , vol.290 , Issue.1 , pp. 413-422
    • Caraco, Y.1    Sheller, J.2    Wood, A.J.3
  • 96
    • 48249143187 scopus 로고    scopus 로고
    • Regarding CYP450 2D6 poor metabolizers [letter]
    • Ahdieh H. Regarding CYP450 2D6 poor metabolizers [letter]. Pain Pract. 2008;8(4):329.
    • (2008) Pain Pract , vol.8 , Issue.4 , pp. 329
    • Ahdieh, H.1
  • 97
    • 48249100116 scopus 로고    scopus 로고
    • Foster A. In response to Dr. Ahdieh [published online ahead of print May 26, 2008]. Pain Pract. doi10.1111/j.1533-2500.2008.00218-2.x.
    • Foster A. In response to Dr. Ahdieh [published online ahead of print May 26, 2008]. Pain Pract. doi10.1111/j.1533-2500.2008.00218-2.x.
  • 99
    • 0024389395 scopus 로고
    • Hepatic extraction of morphine is impaired in cirrhosis
    • Crotty B, Watson KJ, Desmond PV, et al. Hepatic extraction of morphine is impaired in cirrhosis. Eur J Clin Pharmacol. 1989;36(5):501-506.
    • (1989) Eur J Clin Pharmacol , vol.36 , Issue.5 , pp. 501-506
    • Crotty, B.1    Watson, K.J.2    Desmond, P.V.3
  • 100
    • 0020466945 scopus 로고
    • Fentanyl pharmacokinetics in anaesthetized patients with cirrhosis
    • Haberer JP, Schoeffler P, Couderc E, Duvaldestin P. Fentanyl pharmacokinetics in anaesthetized patients with cirrhosis. Br J Anaesth. 1982;54(12): 1267-1270.
    • (1982) Br J Anaesth , vol.54 , Issue.12 , pp. 1267-1270
    • Haberer, J.P.1    Schoeffler, P.2    Couderc, E.3    Duvaldestin, P.4
  • 102
    • 0021910427 scopus 로고
    • Longitudinal studies on the rate of decline in renal function with age
    • Lindeman RD, Tobin J, Shock NW. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc. 1985;33(4):278-285.
    • (1985) J Am Geriatr Soc , vol.33 , Issue.4 , pp. 278-285
    • Lindeman, R.D.1    Tobin, J.2    Shock, N.W.3
  • 103
    • 0017230772 scopus 로고
    • The effect of age on creatinine clearance in men: A cross-sectional and longitudinal study
    • Rowe JW, Andres R, Tobin JD, Norris AH, Shock NW. The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. J Gerontol. 1976;31(2):155-163.
    • (1976) J Gerontol , vol.31 , Issue.2 , pp. 155-163
    • Rowe, J.W.1    Andres, R.2    Tobin, J.D.3    Norris, A.H.4    Shock, N.W.5
  • 104
    • 0022608327 scopus 로고
    • Effects of aging on the renal glomerulus
    • Anderson S, Brenner BM. Effects of aging on the renal glomerulus. Am J Med. 1986;80(3):435-442.
    • (1986) Am J Med , vol.80 , Issue.3 , pp. 435-442
    • Anderson, S.1    Brenner, B.M.2
  • 105
    • 0026694304 scopus 로고
    • The influence of renal function on the renal clearance of morphine and its glucuronide metabolites in intensive-care patients
    • Milne RW, Nation RL, Somogyi AA, Bochner F, Griggs WM. The influence of renal function on the renal clearance of morphine and its glucuronide metabolites in intensive-care patients. Br J Clin Pharmacol. 1992;34(1): 53-59.
    • (1992) Br J Clin Pharmacol , vol.34 , Issue.1 , pp. 53-59
    • Milne, R.W.1    Nation, R.L.2    Somogyi, A.A.3    Bochner, F.4    Griggs, W.M.5
  • 106
    • 0032890987 scopus 로고    scopus 로고
    • Pharmacokinetics of morphine and its glucuronides following intravenous administration of morphine in patients undergoing continuous ambulatory peritoneal dialysis
    • Pauli-Magnus C, Hofmann U, Mikus G, Kuhlmann U, Mettang T. Pharmacokinetics of morphine and its glucuronides following intravenous administration of morphine in patients undergoing continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant. 1999;14(4):903-909.
    • (1999) Nephrol Dial Transplant , vol.14 , Issue.4 , pp. 903-909
    • Pauli-Magnus, C.1    Hofmann, U.2    Mikus, G.3    Kuhlmann, U.4    Mettang, T.5
  • 108
    • 0001189368 scopus 로고    scopus 로고
    • Morphine poisoning in chronic kidney failure: Morphine-6-glucuronide as a pharmacologically active morphine metabolite
    • in German
    • Dubs A, Wiedemeier P, Caduff B. Morphine poisoning in chronic kidney failure: morphine-6-glucuronide as a pharmacologically active morphine metabolite [in German]. Dtsch Med Wochenschr. 1999;124(30):896-898.
    • (1999) Dtsch Med Wochenschr , vol.124 , Issue.30 , pp. 896-898
    • Dubs, A.1    Wiedemeier, P.2    Caduff, B.3
  • 109
    • 0029076403 scopus 로고
    • Hydromorphone metabolite accumulation in renal failure [letter]
    • Babul N, Darke AC, Hagen N. Hydromorphone metabolite accumulation in renal failure [letter]. J Pain Symptom Manage. 1995;10(3):184-186.
    • (1995) J Pain Symptom Manage , vol.10 , Issue.3 , pp. 184-186
    • Babul, N.1    Darke, A.C.2    Hagen, N.3
  • 112
    • 7044245703 scopus 로고    scopus 로고
    • Opioids in renal failure and dialysis patients
    • Dean M. Opioids in renal failure and dialysis patients. J Pain Symptom Manage. 2004;28(5):497-504.
    • (2004) J Pain Symptom Manage , vol.28 , Issue.5 , pp. 497-504
    • Dean, M.1
  • 113
    • 0030762608 scopus 로고    scopus 로고
    • Fentanyl pharmacokinetics in patients undergoing renal transplantation
    • Koehntop DE, Rodman JH. Fentanyl pharmacokinetics in patients undergoing renal transplantation. Pharmacotherapy. 1997;17(4):746-752.
    • (1997) Pharmacotherapy , vol.17 , Issue.4 , pp. 746-752
    • Koehntop, D.E.1    Rodman, J.H.2
  • 115
    • 0024385442 scopus 로고
    • Studies on morphine disposition: Influence of renal failure on the kinetics of morphine and its metabolites
    • Sear JW, Hand CW, Moore RA, McQuay HJ. Studies on morphine disposition: influence of renal failure on the kinetics of morphine and its metabolites. Br J Anaesth. 1989;62(1):28-32.
    • (1989) Br J Anaesth , vol.62 , Issue.1 , pp. 28-32
    • Sear, J.W.1    Hand, C.W.2    Moore, R.A.3    McQuay, H.J.4
  • 116
    • 34548443321 scopus 로고    scopus 로고
    • The use of opioid analgesia in end-stage renal disease patients managed without dialysis: Recommendations for practice
    • Murtagh FE, Chai MO, Donohoe P, Edmonds PM, Higginson IJ. The use of opioid analgesia in end-stage renal disease patients managed without dialysis: recommendations for practice. J Pain Palliat Care Pharmacother. 2007;21(2):5-16.
    • (2007) J Pain Palliat Care Pharmacother , vol.21 , Issue.2 , pp. 5-16
    • Murtagh, F.E.1    Chai, M.O.2    Donohoe, P.3    Edmonds, P.M.4    Higginson, I.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.