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Chemistry - A European Journal

Volumn 21, Issue 42, 2015, Pages 15039-15047

Drug Oxidation by Cytochrome P450BM3: Metabolite Synthesis and Discovering New P450 Reaction Types

(6) Ren, Xinkun a Yorke, Jake A a Taylor, Emily a Zhang, Ting b Zhou, Weihong b Wong, Luet Lok a

a UNIVERSITY OF OXFORD (United Kingdom)

b NANKAI UNIVERSITY (China)

Author keywords

C H activation; cytochrome P450; decarboxylation; drug metabolism; protein engineering

Indexed keywords

ACTIVATION ANALYSIS; CARBOXYLATION; CATALYSTS; CHEMICAL ACTIVATION;

C-H ACTIVATION; CYTOCHROME P450; DECARBOXYLATION; DRUG METABOLISMS; PROTEIN ENGINEERING;

METABOLITES;

CHLORZOXAZONE; CYTOCHROME P450; DICLOFENAC; NAPROXEN; TESTOSTERONE;

CATALYSIS; CHEMISTRY; HUMAN; HYDROGEN BOND; KINETICS; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN ENGINEERING;

CATALYSIS; CHLORZOXAZONE; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; HUMANS; HYDROGEN BONDING; KINETICS; NAPROXEN; OXIDATION-REDUCTION; PROTEIN ENGINEERING; TESTOSTERONE;

EID: 84943817256 PISSN: 09476539 EISSN: 15213765 Source Type: Journal
DOI: 10.1002/chem.201502020 Document Type: Article

Times cited : (72)

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