Identification of quinone imine containing glutathione conjugates of diclofenac in rat bile

Chemical Research in Toxicology

Volumn 23, Issue 12, 2010, Pages 1947-1953

  Waldon, Daniel J ^a   Teffera, Yohannes ^a   Colletti, Adria E ^a   Liu, Jingzhou ^a   Zurcher, Danielle ^b   Copeland, Katrina W ^b   Zhao, Zhiyang ^a  

^a Drug Metabolism and Pharmacokinetics   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID CONJUGATE; BILE SALT; DICLOFENAC; DRUG METABOLITE; GLUTATHIONE; INDOPHENOL; TAUROCHOLIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BILE; BILE DUCT; BILE SECRETION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SYNTHESIS; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HOMEOSTASIS; MALE; MASS SPECTROMETRY; NONHUMAN; RAT;

ANIMALS; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICLOFENAC; GLUTATHIONE; IMINES; MALE; OXIDATION-REDUCTION; QUINONES; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 78650441316     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100296v     Document Type: Article

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