Recombinant human cytochrome P450 monooxygenases for drug metabolite synthesis

Biotechnology and Bioengineering

Volumn 106, Issue 5, 2010, Pages 699-706

  Schroer, Kirsten ^a   Kittelmann, Matthias ^a   Lütz, Stephan ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Biocatalysis; Cytochrome P450; Drug development

Indexed keywords

BIOCHEMISTRY; CLONING; METABOLITES;

BIOCATALYSIS; CYTOCHROME P450; DIVERSE APPLICATIONS; DRUG DEVELOPMENT; DRUG METABOLITES; HUMAN CYTOCHROME; HUMAN ISOFORMS; MONOOXYGENASES; WHOLE CELL;

METABOLISM;

AAG 561; CYTOCHROME P450; CYTOCHROME P450 17A1; CYTOCHROME P450 3A4; DRUG; DRUG METABOLITE; RECOMBINANT CYTOCHROME P450; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; ISOENZYME; MIXED FUNCTION OXIDASE; RECOMBINANT PROTEIN;

BACTERIAL CELL; DRUG METABOLISM; GENE OVEREXPRESSION; HUMAN; MICROSOME; MOLECULAR CLONING; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SYNTHESIS; WHOLE CELL; BACTERIA; BIOTECHNOLOGY; GENETICS; METABOLISM; MICROBIOLOGY; OXIDATION REDUCTION REACTION; PROCEDURES;

BACTERIA; BIOTECHNOLOGY; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; INDUSTRIAL MICROBIOLOGY; ISOENZYMES; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; PHARMACEUTICAL PREPARATIONS; RECOMBINANT PROTEINS; XENOBIOTICS;

EID: 77955359218     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22775     Document Type: Review

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