Enantioselective α-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3

Journal of the American Chemical Society

Volumn 128, Issue 18, 2006, Pages 6058-6059

  Landwehr, Marco ^a   Hochrein, Lisa ^a   Otey, Christopher R ^a   Kasrayan, Alex ^b   Bäckvall, Jan E ^b   Arnold, Frances H ^a  

^a California Institute of Technology   (United States)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYBUSPIRONE; ACETIC ACID DERIVATIVE; ALANINE; BUSPIRONE; CYTOCHROME P450; CYTOCHROME P450 BM 3; MANDELIC ACID DERIVATIVE; PHENYLALANINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACILLUS MEGATERIUM; CATALYSIS; CATALYST; CHEMICAL STRUCTURE; ENANTIOSELECTIVITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROXYLATION; REACTION ANALYSIS; STRUCTURAL BIOINFORMATICS;

BACTERIAL PROTEINS; BUSPIRONE; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; MIXED FUNCTION OXYGENASES; MUTAGENESIS, SITE-DIRECTED; PHENYLACETATES; STEREOISOMERISM;

EID: 33646505950     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja061261x     Document Type: Article

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