-
1
-
-
67649579669
-
Updated clinical classification of pulmonary hypertension
-
Simonneau G, Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 2009;54:S43-S54.
-
(2009)
J am Coll Cardiol
, vol.54
, pp. S43-S54
-
-
Simonneau, G.1
Robbins, I.M.2
Beghetti, M.3
Channick, R.N.4
Delcroix, M.5
Denton, C.P.6
-
2
-
-
84988934897
-
Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression
-
Austin ED, Menon S, Hemnes AR, Robinson LR, Talati M, Fox KL, et al. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ 2011;1:389-98.
-
(2011)
Pulm Circ
, vol.1
, pp. 389-398
-
-
Austin, E.D.1
Menon, S.2
Hemnes, A.R.3
Robinson, L.R.4
Talati, M.5
Fox, K.L.6
-
3
-
-
71949129187
-
Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure
-
Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF. Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol 2009;297:L1013-L1032.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
, pp. L1013-L1032
-
-
Stenmark, K.R.1
Meyrick, B.2
Galie, N.3
Mooi, W.J.4
McMurtry, I.F.5
-
4
-
-
71049187330
-
Alterations in oestrogen metabolism: Implications for higher penetrance of familial pulmonary arterial hypertension in females
-
Austin ED, Cogan JD, West JD, Hedges LK, Hamid R, Dawson EP, et al. Alterations in oestrogen metabolism: Implications for higher penetrance of familial pulmonary arterial hypertension in females. Eur Respir J 2009;34:1093-9.
-
(2009)
Eur Respir J
, vol.34
, pp. 1093-1099
-
-
Austin, E.D.1
Cogan, J.D.2
West, J.D.3
Hedges, L.K.4
Hamid, R.5
Dawson, E.P.6
-
5
-
-
77955953602
-
Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension
-
Humbert M, Sitbon O, Yaïci A, Montani D, O’Callaghan DS, Jaïs X, et al. Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension. Eur Respir J 2010;36:549-55.
-
(2010)
Eur Respir J
, vol.36
, pp. 549-555
-
-
Humbert, M.1
Sitbon, O.2
Yaïci, A.3
Montani, D.4
O’Callaghan, D.S.5
Jaïs, X.6
-
6
-
-
75249089553
-
Systematic review of trials using vasodilators in pulmonary arterial hypertension: Why a new approach is needed
-
Macchia A, Marchioli R, Tognoni G, Scarano M, Marfisi R, Tavazzi L, et al. Systematic review of trials using vasodilators in pulmonary arterial hypertension: Why a new approach is needed. Am Heart J 2010;159:245-57.
-
(2010)
Am Heart J
, vol.159
, pp. 245-257
-
-
Macchia, A.1
Marchioli, R.2
Tognoni, G.3
Scarano, M.4
Marfisi, R.5
Tavazzi, L.6
-
7
-
-
0032887861
-
Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation
-
Fagan KA, Tyler RC, Sato K, Fouty BW, Morris KG Jr, Huang PL, et al. Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation. Am J Physiol 1999;277:L472-8.
-
(1999)
Am J Physiol
, vol.277
, pp. L472-L478
-
-
Fagan, K.A.1
Tyler, R.C.2
Sato, K.3
Fouty, B.W.4
Morris, K.G.5
Huang, P.L.6
-
8
-
-
0029021148
-
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
-
Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995;377:239-42.
-
(1995)
Nature
, vol.377
, pp. 239-242
-
-
Huang, P.L.1
Huang, Z.2
Mashimo, H.3
Bloch, K.D.4
Moskowitz, M.A.5
Bevan, J.A.6
-
9
-
-
0032535435
-
Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase
-
Ohashi Y, Kawashima S, Hirata K, Yamashita T, Ishida T, Inoue N, et al. Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. J Clin Invest 1998;102:2061-71.
-
(1998)
J Clin Invest
, vol.102
, pp. 2061-2071
-
-
Ohashi, Y.1
Kawashima, S.2
Hirata, K.3
Yamashita, T.4
Ishida, T.5
Inoue, N.6
-
10
-
-
0345707647
-
Regulatory effects of iNOS on acute lung inflammatory responses in mice
-
Speyer CL, Neff TA, Warner RL, Guo RF, Sarma JV, Riedemann NC, et al. Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol 2003;163:2319-28.
-
(2003)
Am J Pathol
, vol.163
, pp. 2319-2328
-
-
Speyer, C.L.1
Neff, T.A.2
Warner, R.L.3
Guo, R.F.4
Sarma, J.V.5
Riedemann, N.C.6
-
11
-
-
24744464314
-
NOS 1 is required for allergen-induced expression of NOS 2 in mice
-
Iijima H, Tulic MK, Duguet A, Shan J, Carbonara P, Hamid Q, et al. NOS 1 is required for allergen-induced expression of NOS 2 in mice. Int Arch Allergy Immunol 2005;138:40-50.
-
(2005)
Int Arch Allergy Immunol
, vol.138
, pp. 40-50
-
-
Iijima, H.1
Tulic, M.K.2
Duguet, A.3
Shan, J.4
Carbonara, P.5
Hamid, Q.6
-
12
-
-
77952257220
-
PPHN: Is sildenafil the new nitric? A review of the literature
-
Spillers J. PPHN: Is sildenafil the new nitric? A review of the literature. Adv Neonatal Care 2010;10:69-74.
-
(2010)
Adv Neonatal Care
, vol.10
, pp. 69
-
-
Spillers, J.1
-
14
-
-
84871689771
-
Prolonged hypoxia augments L-citrulline transport by System A in the newborn piglet pulmonary circulation
-
Fike CD, Sidoryk-Wegrzynowicz M, Aschner M, Summar M, Prince LS, Cunningham G, et al. Prolonged hypoxia augments L-citrulline transport by System A in the newborn piglet pulmonary circulation. Cardiovasc Res 2012.
-
(2012)
Cardiovasc Res
-
-
Fike, C.D.1
Sidoryk-Wegrzynowicz, M.2
Aschner, M.3
Summar, M.4
Prince, L.S.5
Cunningham, G.6
-
15
-
-
17744381754
-
Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse
-
Nandi M, Miller A, Stidwill R, Jacques TS, Lam AA, Haworth S, et al. Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse. Circulation 2005;111:2086-90.
-
(2005)
Circulation
, vol.111
, pp. 2086-2090
-
-
Nandi, M.1
Miller, A.2
Stidwill, R.3
Jacques, T.S.4
Lam, A.A.5
Haworth, S.6
-
16
-
-
17744386526
-
Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension
-
Khoo JP, Zhao L, Alp NJ, Bendall JK, Nicoli T, Rockett K, et al. Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension. Circulation 2005;111:2126-33.
-
(2005)
Circulation
, vol.111
, pp. 2126-2133
-
-
Khoo, J.P.1
Zhao, L.2
Alp, N.J.3
Bendall, J.K.4
Nicoli, T.5
Rockett, K.6
-
17
-
-
0033694694
-
Nitric oxide synthase in pulmonary hypertension: Lessons from knockout mice
-
Fagan KA, McMurtry I, Rodman DM. Nitric oxide synthase in pulmonary hypertension: Lessons from knockout mice. Physiol Res 2000;49:539-48.
-
(2000)
Physiol Res
, vol.49
, pp. 539-548
-
-
Fagan, K.A.1
McMurtry, I.2
Rodman, D.M.3
-
18
-
-
2342613573
-
Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: A model of alveolar capillary dysplasia?
-
Han RN, Babaei S, Robb M, Lee T, Ridsdale R, Ackerley C, et al. Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: A model of alveolar capillary dysplasia? Circ Res 2004;94:1115-23.
-
(2004)
Circ Res
, vol.94
, pp. 1115-1123
-
-
Han, R.N.1
Babaei, S.2
Robb, M.3
Lee, T.4
Ridsdale, R.5
Ackerley, C.6
-
19
-
-
0345276632
-
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
-
Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003;9:1370-6.
-
(2003)
Nat Med
, vol.9
, pp. 1370-1376
-
-
Aicher, A.1
Heeschen, C.2
Mildner-Rihm, C.3
Urbich, C.4
Ihling, C.5
Technau-Ihling, K.6
-
20
-
-
29444450878
-
Defective lung vascular development in endothelial nitric oxide synthase-deficient mice
-
Han RN, Stewart DJ. Defective lung vascular development in endothelial nitric oxide synthase-deficient mice. Trends Cardiovasc Med 2006;16:29-34.
-
(2006)
Trends Cardiovasc Med
, vol.16
, pp. 29-34
-
-
Han, R.N.1
Stewart, D.J.2
-
22
-
-
0022931354
-
Thromboxane A2 and prostacyclin do not modulate pulmonary hemodynamics during exercise in sheep
-
Newman JH, Butka BJ, Brigham KL. Thromboxane A2 and prostacyclin do not modulate pulmonary hemodynamics during exercise in sheep. J Appl Physiol 1986;61:1706-11.
-
(1986)
J Appl Physiol
, vol.61
, pp. 1706-1711
-
-
Newman, J.H.1
Butka, B.J.2
Brigham, K.L.3
-
23
-
-
50949084538
-
Control of pulmonary vascular tone during exercise in health and pulmonary hypertension
-
Merkus D, de Beer VJ, Houweling B, Duncker DJ. Control of pulmonary vascular tone during exercise in health and pulmonary hypertension. Pharmacol Ther 2008;119:242-63.
-
(2008)
Pharmacol Ther
, vol.119
, pp. 242-263
-
-
Merkus, D.1
De Beer, V.J.2
Houweling, B.3
Duncker, D.J.4
-
24
-
-
0030816051
-
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
-
Murata T, Ushikubi F, Matsuoka T, Hirata M, Yamasaki A, Sugimoto Y, et al. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 1997;388:678-82.
-
(1997)
Nature
, vol.388
, pp. 678-682
-
-
Murata, T.1
Ushikubi, F.2
Matsuoka, T.3
Hirata, M.4
Yamasaki, A.5
Sugimoto, Y.6
-
25
-
-
0028360062
-
Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1
-
Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R, et al. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 1994;368:703-10.
-
(1994)
Nature
, vol.368
, pp. 703-710
-
-
Kurihara, Y.1
Kurihara, H.2
Suzuki, H.3
Kodama, T.4
Maemura, K.5
Nagai, R.6
-
26
-
-
0032762332
-
Disruption of ET-1 gene enhances pulmonary responses to methacholine via functional mechanism in knockout mice
-
Nagase T, Kurihara H, Kurihara Y, Aoki-Nagase T, Nagai R, Ouchi Y. Disruption of ET-1 gene enhances pulmonary responses to methacholine via functional mechanism in knockout mice. J Appl Physiol 1999;87:2020-4.
-
(1999)
J Appl Physiol
, vol.87
, pp. 2020-2024
-
-
Nagase, T.1
Kurihara, H.2
Kurihara, Y.3
Aoki-Nagase, T.4
Nagai, R.5
Ouchi, Y.6
-
27
-
-
5644247979
-
Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction
-
Amiri F, Virdis A, Neves MF, Iglarz M, Seidah NG, Touyz RM, et al. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation 2004;110:2233-40.
-
(2004)
Circulation
, vol.110
, pp. 2233-2240
-
-
Amiri, F.1
Virdis, A.2
Neves, M.F.3
Iglarz, M.4
Seidah, N.G.5
Touyz, R.M.6
-
28
-
-
43449111223
-
Vascular inflammation in absence of blood pressure elevation in transgenic murine model overexpressing endothelin-1 in endothelial cells
-
Amiri F, Paradis P, Reudelhuber TL, Schiffrin EL. Vascular inflammation in absence of blood pressure elevation in transgenic murine model overexpressing endothelin-1 in endothelial cells. J Hypertens 2008;26:1102-9.
-
(2008)
J Hypertens
, vol.26
, pp. 1102-1109
-
-
Amiri, F.1
Paradis, P.2
Reudelhuber, T.L.3
Schiffrin, E.L.4
-
29
-
-
0031916129
-
Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice
-
Clouthier DE, Hosoda K, Richardson JA, Williams SC, Yanagisawa H, Kuwaki T, et al. Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development 1998;125:813-24.
-
(1998)
Development
, vol.125
, pp. 813-824
-
-
Clouthier, D.E.1
Hosoda, K.2
Richardson, J.A.3
Williams, S.C.4
Yanagisawa, H.5
Kuwaki, T.6
-
30
-
-
0028639196
-
Targeted and natural (Piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice
-
Hosoda K, Hammer RE, Richardson JA, Baynash AG, Cheung JC, Giaid A, et al. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 1994;79:1267-76.
-
(1994)
Cell
, vol.79
, pp. 1267-1276
-
-
Hosoda, K.1
Hammer, R.E.2
Richardson, J.A.3
Baynash, A.G.4
Cheung, J.C.5
Giaid, A.6
-
31
-
-
0031940499
-
Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene
-
Yanagisawa H, Yanagisawa M, Kapur RP, Richardson JA, Williams SC, Clouthier DE, et al. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development 1998;125:825-36.
-
(1998)
Development
, vol.125
, pp. 825-836
-
-
Yanagisawa, H.1
Yanagisawa, M.2
Kapur, R.P.3
Richardson, J.A.4
Williams, S.C.5
Clouthier, D.E.6
-
33
-
-
0029145956
-
Voltage-gated K+ currents regulate resting membrane potential and [Ca2+]i in pulmonary arterial myocytes
-
Yuan XJ. Voltage-gated K+ currents regulate resting membrane potential and [Ca2+]i in pulmonary arterial myocytes. Circ Res 1995;77:370-8.
-
(1995)
Circ Res
, vol.77
, pp. 370-378
-
-
Yuan, X.J.1
-
34
-
-
0035430621
-
Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5
-
Archer SL, London B, Hampl V, Wu X, Nsair A, Puttagunta L, et al. Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5. Faseb J 2001;15:1801-3.
-
(2001)
Faseb J
, vol.15
, pp. 1801-1803
-
-
Archer, S.L.1
London, B.2
Hampl, V.3
Wu, X.4
Nsair, A.5
Puttagunta, L.6
-
35
-
-
0037461359
-
In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats
-
Pozeg ZI, Michelakis ED, McMurtry MS, Thébaud B, Wu XC, Dyck JR, et al. In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats. Circulation 2003;107:2037-44.
-
(2003)
Circulation
, vol.107
, pp. 2037-2044
-
-
Pozeg, Z.I.1
Michelakis, E.D.2
McMurtry, M.S.3
Thébaud, B.4
Wu, X.C.5
Dyck, J.R.6
-
36
-
-
20444483234
-
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension
-
McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, Harry G, et al. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest 2005;115:1479-91.
-
(2005)
J Clin Invest
, vol.115
, pp. 1479-1491
-
-
McMurtry, M.S.1
Archer, S.L.2
Altieri, D.C.3
Bonnet, S.4
Haromy, A.5
Harry, G.6
-
37
-
-
0028136565
-
Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels
-
Knaus HG, Garcia-Calvo M, Kaczorowski GJ, Garcia ML. Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels. J Biol Chem 1994;269:3921-4.
-
(1994)
J Biol Chem
, vol.269
, pp. 3921-3924
-
-
Knaus, H.G.1
Garcia-Calvo, M.2
Kaczorowski, G.J.3
Garcia, M.L.4
-
38
-
-
0026575435
-
Regulation of arterial tone by activation of calcium-dependent potassium channels
-
Brayden JE, Nelson MT. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science 1992;256:532-5.
-
(1992)
Science
, vol.256
, pp. 532-535
-
-
Brayden, J.E.1
Nelson, M.T.2
-
39
-
-
0029108913
-
Physiological roles and properties of potassium channels in arterial smooth muscle
-
Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 1995;268:C799-C822.
-
(1995)
Am J Physiol
, vol.268
, pp. C799-C822
-
-
Nelson, M.T.1
Quayle, J.M.2
-
40
-
-
0034687171
-
Vasoregulation by the beta1 subunit of the calcium-activated potassium channel
-
Brenner R, Peréz GJ, Bonev AD, Eckman DM, Kosek JC, Wiler SW, et al. Vasoregulation by the beta1 subunit of the calcium-activated potassium channel. Nature 2000;407:870-6.
-
(2000)
Nature
, vol.407
, pp. 870-876
-
-
Brenner, R.1
Peréz, G.J.2
Bonev, A.D.3
Eckman, D.M.4
Kosek, J.C.5
Wiler, S.W.6
-
41
-
-
0141612004
-
Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension
-
Amberg GC, Bonev AD, Rossow CF, Nelson MT, Santana LF. Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension. J Clin Invest 2003;112:717-24.
-
(2003)
J Clin Invest
, vol.112
, pp. 717-724
-
-
Amberg, G.C.1
Bonev, A.D.2
Rossow, C.F.3
Nelson, M.T.4
Santana, L.F.5
-
42
-
-
67650915097
-
Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism
-
Grimm PR, Irsik DL, Settles DC, Holtzclaw JD, Sansom SC. Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism. Proc Natl Acad Sci U S A 2009;106:11800-5.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 11800-11805
-
-
Grimm, P.R.1
Irsik, D.L.2
Settles, D.C.3
Holtzclaw, J.D.4
Sansom, S.C.5
-
43
-
-
33746829549
-
NADPH oxidase accounts for enhanced superoxide production and impaired endothelium-dependent smooth muscle relaxation in BKbeta1-/- mice
-
Oelze M, Warnholtz A, Faulhaber J, Wenzel P, Kleschyov AL, Coldewey M, et al. NADPH oxidase accounts for enhanced superoxide production and impaired endothelium-dependent smooth muscle relaxation in BKbeta1-/- mice. Arterioscler Thromb Vasc Biol 2006;26:1753-9.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 1753-1759
-
-
Oelze, M.1
Warnholtz, A.2
Faulhaber, J.3
Wenzel, P.4
Kleschyov, A.L.5
Coldewey, M.6
-
44
-
-
0034711349
-
Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure
-
Plüger S, Faulhaber J, Fürstenau M, Löhn M, Waldschütz R, Gollasch M, et al. Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure. Circ Res 2000;87:E53-E60.
-
(2000)
Circ Res
, vol.87
, pp. E53-E60
-
-
Plüger, S.1
Faulhaber, J.2
Fürstenau, M.3
Löhn, M.4
Waldschütz, R.5
Gollasch, M.6
-
45
-
-
21844461564
-
Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice
-
Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou XB, Sausbier U, et al. Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice. Circulation 2005;112:60-8.
-
(2005)
Circulation
, vol.112
, pp. 60-68
-
-
Sausbier, M.1
Arntz, C.2
Bucurenciu, I.3
Zhao, H.4
Zhou, X.B.5
Sausbier, U.6
-
46
-
-
79551470047
-
Large-conductance Ca2+-activated K+ channel beta1-subunit knockout mice are not hypertensive
-
Xu H, Garver H, Galligan JJ, Fink GD. Large-conductance Ca2+-activated K+ channel beta1-subunit knockout mice are not hypertensive. Am J Physiol Heart Circ Physiol 2011;300:H476-H485.
-
(2011)
Am J Physiol Heart Circ Physiol
, vol.300
, pp. H476-H485
-
-
Xu, H.1
Garver, H.2
Galligan, J.J.3
Fink, G.D.4
-
47
-
-
0242637581
-
Channel, TASK-1, in pulmonary artery smooth muscle cells
-
Gurney AM, Osipenko ON, MacMillan D, McFarlane KM, Tate RJ, Kempsill FE. Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells. Circ Res 2003;93:957-64.
-
(2003)
Circ Res
, vol.93
, pp. 957-964
-
-
Gurney, A.M.1
Osipenko, O.N.2
Macmillan, D.3
McFarlane, K.M.4
Tate, R.J.5
Kempsill, F.E.6
Two-Pore Domain, K.7
-
48
-
-
33646816053
-
Impact of TASK-1 in human pulmonary artery smooth muscle cells
-
Olschewski A, Li Y, Tang B, Hanze J, Eul B, Bohle RM, et al. Impact of TASK-1 in human pulmonary artery smooth muscle cells. Circ Res 2006;98:1072-80.
-
(2006)
Circ Res
, vol.98
, pp. 1072-1080
-
-
Olschewski, A.1
Li, Y.2
Tang, B.3
Hanze, J.4
Eul, B.5
Bohle, R.M.6
-
49
-
-
70349084966
-
Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells
-
Tang B, Li Y, Nagaraj C, Morty RE, Gabor S, Stacher E, et al. Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol 2009;41:476-83.
-
(2009)
Am J Respir Cell Mol Biol
, vol.41
, pp. 476-483
-
-
Tang, B.1
Li, Y.2
Nagaraj, C.3
Morty, R.E.4
Gabor, S.5
Stacher, E.6
-
50
-
-
79959747185
-
Contractile and electrophysiological properties of pulmonary artery smooth muscle are not altered in TASK-1 knockout mice
-
Manoury B, Lamalle C, Oliveira R, Reid J, Gurney AM. Contractile and electrophysiological properties of pulmonary artery smooth muscle are not altered in TASK-1 knockout mice. J Physiol 2011;589:3231-46.
-
(2011)
J Physiol
, vol.589
, pp. 3231-3246
-
-
Manoury, B.1
Lamalle, C.2
Oliveira, R.3
Reid, J.4
Gurney, A.M.5
-
51
-
-
0034999284
-
Upregulated TRP and enhanced capacitative Ca(2+) entry in human pulmonary artery myocytes during proliferation
-
Golovina VA, Platoshyn O, Bailey CL, Wang J, Limsuwan A, Sweeney M, et al. Upregulated TRP and enhanced capacitative Ca(2+) entry in human pulmonary artery myocytes during proliferation. Am J Physiol Heart Circ Physiol 2001;280:H746-H755.
-
(2001)
Am J Physiol Heart Circ Physiol
, vol.280
, pp. H746-H755
-
-
Golovina, V.A.1
Platoshyn, O.2
Bailey, C.L.3
Wang, J.4
Limsuwan, A.5
Sweeney, M.6
-
52
-
-
0035036473
-
Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstriction
-
McDaniel SS, Platoshyn O, Wang J, Yu Y, Sweeney M, Krick S, et al. Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 2001;280:L870-L880.
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.280
, pp. L870-L880
-
-
McDaniel, S.S.1
Platoshyn, O.2
Wang, J.3
Yu, Y.4
Sweeney, M.5
Krick, S.6
-
53
-
-
84858306938
-
New mechanisms of pulmonary arterial hypertension: Role of Ca(2)(+) signaling
-
Kuhr FK, Smith KA, Song MY, Levitan I, Yuan J ×. New mechanisms of pulmonary arterial hypertension: Role of Ca(2)(+) signaling. Am J Physiol Heart Circ Physiol 2012;302:H1546-H1562.
-
(2012)
Am J Physiol Heart Circ Physiol
, vol.302
, pp. H1546-H1562
-
-
Kuhr, F.K.1
Smith, K.A.2
Song, M.Y.3
Levitan, I.4
Yuan, J.×.5
-
54
-
-
0345305811
-
Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation
-
Moosmang S, Schulla V, Welling A, Feil R, Feil S, Wegener JW, et al. Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation. Embo J 2003;22:6027-34.
-
(2003)
Embo J
, vol.22
, pp. 6027-6034
-
-
Moosmang, S.1
Schulla, V.2
Welling, A.3
Feil, R.4
Feil, S.5
Wegener, J.W.6
-
55
-
-
77951296269
-
Short communication: Genetic ablation of L-type Ca2+ channels abolishes depolarization-induced Ca2+ release in arterial smooth muscle
-
Fernández-Tenorio M, González-Rodríguez P, Porras C, Castellano A, Moosmang S, Hofmann F, et al. Short communication: Genetic ablation of L-type Ca2+ channels abolishes depolarization-induced Ca2+ release in arterial smooth muscle. Circ Res 2010;106:1285-9.
-
(2010)
Circ Res
, vol.106
, pp. 1285-1289
-
-
Fernández-Tenorio, M.1
González-Rodríguez, P.2
Porras, C.3
Castellano, A.4
Moosmang, S.5
Hofmann, F.6
-
56
-
-
35448982353
-
Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1
-
Mederos
-
Dietrich A, Kalwa H, Storch U, Mederos y Schnitzler M, Salanova B, Pinkenburg O, et al. Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch 2007;455:465-77.
-
(2007)
Pflugers Arch
, vol.455
, pp. 465-477
-
-
Dietrich, A.1
Kalwa, H.2
Storch, U.3
Schnitzler, M.4
Salanova, B.5
Pinkenburg, O.6
-
57
-
-
0037067430
-
Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability
-
Tiruppathi C, Freichel M, Vogel SM, Paria BC, Mehta D, Flockerzi V, et al. Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ Res 2002;91:70-6.
-
(2002)
Circ Res
, vol.91
, pp. 70-76
-
-
Tiruppathi, C.1
Freichel, M.2
Vogel, S.M.3
Paria, B.C.4
Mehta, D.5
Flockerzi, V.6
-
58
-
-
20244375821
-
Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice
-
Freichel M, Suh SH, Pfeifer A, Schweig U, Trost C, Weissgerber P, et al. Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol 2001;3:121-7.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 121-127
-
-
Freichel, M.1
Suh, S.H.2
Pfeifer, A.3
Schweig, U.4
Trost, C.5
Weissgerber, P.6
-
59
-
-
70349432267
-
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo
-
Tsvilovskyy VV, Zholos AV, Aberle T, Philipp SE, Dietrich A, Zhu MX, et al. Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterol 2009;137:1415-24.
-
(2009)
Gastroenterol
, vol.137
, pp. 1415-1424
-
-
Tsvilovskyy, V.V.1
Zholos, A.V.2
Aberle, T.3
Philipp, S.E.4
Dietrich, A.5
Zhu, M.X.6
-
60
-
-
23344454472
-
Increased vascular smooth muscle contractility in TRPC6-/- mice
-
Dietrich A, Mederos Y Schnitzler M, Gollasch M, Gross V, Storch U, et al. Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol 2005;25:6980-9.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6980-6989
-
-
Dietrich, A.1
Mederos Y Schnitzler, M.2
Gollasch, M.3
Gross, V.4
Storch, U.5
-
61
-
-
34249084477
-
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange
-
Weissmann N, Dietrich A, Fuchs B, Kalwa H, Ay M, Dumitrascu R, et al. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc Natl Acad Sci U S A 2006;103:19093-8.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 19093-19098
-
-
Weissmann, N.1
Dietrich, A.2
Fuchs, B.3
Kalwa, H.4
Ay, M.5
Dumitrascu, R.6
-
62
-
-
0037155047
-
Transient receptor potential channels regulate myogenic tone of resistance arteries
-
Welsh DG, Morielli AD, Nelson MT, Brayden JE. Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 2002;90:248-50.
-
(2002)
Circ Res
, vol.90
, pp. 248-250
-
-
Welsh, D.G.1
Morielli, A.D.2
Nelson, M.T.3
Brayden, J.E.4
-
63
-
-
18044397693
-
TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries
-
Reading SA, Earley S, Waldron BJ, Welsh DG, Brayden JE. TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries. Am J Physiol Heart Circ Physiol 2005;288:H2055-H2061.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
, pp. H2055-H2061
-
-
Reading, S.A.1
Earley, S.2
Waldron, B.J.3
Welsh, D.G.4
Brayden, J.E.5
-
64
-
-
69249137915
-
TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure
-
Earley S, Pauyo T, Drapp R, Tavares MJ, Liedtke W, Brayden JE. TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. Am J Physiol Heart Circ Physiol 2009;297:H1096-H1102.
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.297
, pp. H1096-H1102
-
-
Earley, S.1
Pauyo, T.2
Drapp, R.3
Tavares, M.J.4
Liedtke, W.5
Brayden, J.E.6
-
65
-
-
0034646740
-
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
-
Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000;288:306-13.
-
(2000)
Science
, vol.288
, pp. 306-313
-
-
Caterina, M.J.1
Leffler, A.2
Malmberg, A.B.3
Martin, W.J.4
Trafton, J.5
Petersen-Zeitz, K.R.6
-
66
-
-
0342445418
-
Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta
-
Couse JF, Hewitt SC, Bunch DO, Sar M, Walker VR, Davis BJ, et al. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 1999;286:2328-31.
-
(1999)
Science
, vol.286
, pp. 2328-2331
-
-
Couse, J.F.1
Hewitt, S.C.2
Bunch, D.O.3
Sar, M.4
Walker, V.R.5
Davis, B.J.6
-
67
-
-
84928683408
-
Expression and physiological roles of TRP channels in smooth muscle cells
-
Guibert C, Ducret T, Savineau JP. Expression and physiological roles of TRP channels in smooth muscle cells. Adv Exp Med Biol 2011;704:687-706.
-
(2011)
Adv Exp Med Biol
, vol.704
, pp. 687-706
-
-
Guibert, C.1
Ducret, T.2
Savineau, J.P.3
-
68
-
-
68849107084
-
Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: Role in proliferation and migration
-
Potier M, Gonzalez JC, Motiani RK, Abdullaev IF, Bisaillon JM, Singer HA, et al. Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: Role in proliferation and migration. Faseb J 2009;23:2425-37.
-
(2009)
Faseb J
, vol.23
, pp. 2425-2437
-
-
Potier, M.1
Gonzalez, J.C.2
Motiani, R.K.3
Abdullaev, I.F.4
Bisaillon, J.M.5
Singer, H.A.6
-
69
-
-
84856766992
-
Targeting energetic metabolism: A new frontier in the pathogenesis and treatment of pulmonary hypertension
-
Tuder RM, Davis LA, Graham BB. Targeting energetic metabolism: A new frontier in the pathogenesis and treatment of pulmonary hypertension. Am J Respir Crit Care Med 2012;185:260-6.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 260-266
-
-
Tuder, R.M.1
Davis, L.A.2
Graham, B.B.3
-
70
-
-
0016799838
-
Characterization of the fawn-hooded rat as a model for hemostatic studies
-
Raymond SL, Dodds WJ. Characterization of the fawn-hooded rat as a model for hemostatic studies. Thromb Diath Haemorrh 1975;33:361-9.
-
(1975)
Thromb Diath Haemorrh
, vol.33
, pp. 361-369
-
-
Raymond, S.L.1
Dodds, W.J.2
-
72
-
-
0023007512
-
Spontaneous hypertension in the fawn
-
Kuijpers MH, de Jong W. Spontaneous hypertension in the fawn-hooded rat: A cardiovascular disease model. J Hypertens Suppl 1986;4:S41-S44.
-
(1986)
J Hypertens Suppl
, vol.4
, pp. S41-S44
-
-
Kuijpers, M.H.1
De Jong, W.2
-
73
-
-
0021274628
-
Spontaneous hypertension and hypertensive renal disease in the fawn-hooded rat
-
Kuijpers MH, Gruys E. Spontaneous hypertension and hypertensive renal disease in the fawn-hooded rat. Br J Exp Pathol 1984;65:181-90.
-
(1984)
Br J Exp Pathol
, vol.65
, pp. 181-190
-
-
Kuijpers, M.H.1
Gruys, E.2
-
74
-
-
0030725677
-
Pulmonary hypertension, family and environment
-
Gonzalez AM, Smith A, Emery C, Higenbottam T. Pulmonary hypertension, family and environment. J Hum Hypertens 1997;11:559-61.
-
(1997)
J Hum Hypertens
, vol.11
, pp. 559-561
-
-
Gonzalez, A.M.1
Smith, A.2
Emery, C.3
Higenbottam, T.4
-
76
-
-
0023820758
-
Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists
-
Wang P, Aulakh CS, Hill JL, Murphy DL. Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists. Psychopharmacology (Berl) 1988;94:558-62.
-
(1988)
Psychopharmacology (Berl)
, vol.94
, pp. 558-562
-
-
Wang, P.1
Aulakh, C.S.2
Hill, J.L.3
Murphy, D.L.4
-
77
-
-
0028677254
-
Increased mRNA for corticotrophin releasing hormone in the amygdala of fawn-hooded rats: A potential animal model of anxiety
-
Altemus M, Smith MA, Diep V, Aulakh CS, Murphy DL. Increased mRNA for corticotrophin releasing hormone in the amygdala of fawn-hooded rats: A potential animal model of anxiety. Anxiety 1994;1:251-7.
-
(1994)
Anxiety
, vol.1
, pp. 251-257
-
-
Altemus, M.1
Smith, M.A.2
Diep, V.3
Aulakh, C.S.4
Murphy, D.L.5
-
78
-
-
0027213606
-
Attenuation of hypercortisolemia in fawn-hooded rats by antidepressant drugs
-
Aulakh CS, Hill JL, Murphy DL. Attenuation of hypercortisolemia in fawn-hooded rats by antidepressant drugs. Eur J Pharmacol 1993;240:85-8.
-
(1993)
Eur J Pharmacol
, vol.240
, pp. 85-88
-
-
Aulakh, C.S.1
Hill, J.L.2
Murphy, D.L.3
-
79
-
-
0028134804
-
Functional and biochemical evidence for altered serotonergic function in the fawn-hooded rat strain
-
Aulakh CS, Tolliver T, Wozniak KM, Hill JL, Murphy DL. Functional and biochemical evidence for altered serotonergic function in the fawn-hooded rat strain. Pharmacol Biochem Behav 1994;49:615-20.
-
(1994)
Pharmacol Biochem Behav
, vol.49
, pp. 615-620
-
-
Aulakh, C.S.1
Tolliver, T.2
Wozniak, K.M.3
Hill, J.L.4
Murphy, D.L.5
-
80
-
-
33745155785
-
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
-
Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, et al. An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension. Circulation 2006;113:2630-41.
-
(2006)
Circulation
, vol.113
, pp. 2630-2641
-
-
Bonnet, S.1
Michelakis, E.D.2
Porter, C.J.3
Rade-Navarro, M.A.4
Thébaud, B.5
Bonnet, S.6
-
81
-
-
0037080541
-
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: Role of increased expression and activity of voltage-gated potassium channels
-
Michelakis ED, McMurtry MS, Wu XC, Dyck JR, Moudgil R, Hopkins TA, et al. Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: Role of increased expression and activity of voltage-gated potassium channels. Circulation 2002;105:244-50.
-
(2002)
Circulation
, vol.105
, pp. 244-250
-
-
Michelakis, E.D.1
McMurtry, M.S.2
Wu, X.C.3
Dyck, J.R.4
Moudgil, R.5
Hopkins, T.A.6
-
82
-
-
6344257102
-
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
-
McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, et al. Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 2004;95:830-40.
-
(2004)
Circ Res
, vol.95
, pp. 830-840
-
-
McMurtry, M.S.1
Bonnet, S.2
Wu, X.3
Dyck, J.R.4
Haromy, A.5
Hashimoto, K.6
-
83
-
-
77951220191
-
A proposed mitochondrial
-
Rehman J, Archer SL. A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: The Warburg model of pulmonary arterial hypertension. Adv Exp Med Biol 2010;661:171-85.
-
(2010)
Adv Exp Med Biol
, vol.661
, pp. 171-185
-
-
Rehman, J.1
Archer, S.L.2
-
84
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956;123:309-14.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
85
-
-
0001221508
-
On respiratory impairment in cancer cells
-
Warburg O. On respiratory impairment in cancer cells. Science 1956;124:269-70.
-
(1956)
Science
, vol.124
, pp. 269-270
-
-
Warburg, O.1
-
86
-
-
33846002728
-
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007;11:37-51.
-
(2007)
Cancer Cell
, vol.11
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
Haromy, A.4
Beaulieu, C.5
Thompson, R.6
-
87
-
-
84858180382
-
Lung (1)(8)F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension
-
Marsboom G, Wietholt C, Haney CR, Toth PT, Ryan JJ, Morrow E, et al. Lung (1)(8)F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. Am J Respir Crit Care Med 2012;185:670-9.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 670-679
-
-
Marsboom, G.1
Wietholt, C.2
Haney, C.R.3
Toth, P.T.4
Ryan, J.J.5
Morrow, E.6
-
88
-
-
33846614655
-
Alterations of cellular bioenergetics in pulmonary artery endothelial cells
-
Xu W, Koeck T, Lara AR, Neumann D, DiFilippo FP, Koo M, et al. Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proc Natl Acad Sci U S A 2007;104:1342-7.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 1342-1347
-
-
Xu, W.1
Koeck, T.2
Lara, A.R.3
Neumann, D.4
Difilippo, F.P.5
Koo, M.6
-
89
-
-
84856998882
-
Interstitial lung disease and pulmonary fibrosis in Hermansky-Pudlak syndrome type 2, an adaptor protein-3 complex disease
-
Gochuico BR, Huizing M, Golas GA, Scher CD, Tsokos M, Denver SD, et al. Interstitial lung disease and pulmonary fibrosis in Hermansky-Pudlak syndrome type 2, an adaptor protein-3 complex disease. Mol Med 2012;18:56-64.
-
(2012)
Mol Med
, vol.18
, pp. 56-64
-
-
Gochuico, B.R.1
Huizing, M.2
Golas, G.A.3
Scher, C.D.4
Tsokos, M.5
Denver, S.D.6
-
90
-
-
84862699122
-
Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling
-
Sethumadhavan S, Vasquez-Vivar J, Migrino RQ, Harmann L, Jacob HJ, Lazar J. Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling. J Biol Chem 2012.
-
(2012)
J Biol Chem
-
-
Sethumadhavan, S.1
Vasquez-Vivar, J.2
Migrino, R.Q.3
Harmann, L.4
Jacob, H.J.5
Lazar, J.6
-
91
-
-
0024573591
-
Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells
-
Badesch DB, Lee PD, Parks WC, Stenmark KR. Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells. Biochem Biophys Res Commun 1989;160:382-7.
-
(1989)
Biochem Biophys Res Commun
, vol.160
, pp. 382-387
-
-
Badesch, D.B.1
Lee, P.D.2
Parks, W.C.3
Stenmark, K.R.4
-
92
-
-
0025292977
-
Insulin
-
Dempsey EC, Stenmark KR, McMurtry IF, O’Brien RF, Voelkel NF, Badesch DB. Insulin-like growth factor I and protein kinase C activation stimulate pulmonary artery smooth muscle cell proliferation through separate but synergistic pathways. J Cell Physiol 1990;144:159-65.
-
(1990)
J Cell Physiol
, vol.144
, pp. 159-165
-
-
Dempsey, E.C.1
Stenmark, K.R.2
McMurtry, I.F.3
O’Brien, R.F.4
Voelkel, N.F.5
Badesch, D.B.6
-
93
-
-
34247282656
-
Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling
-
Crossno JT Jr, Garat CV, Reusch JE, Morris KG, Dempsey EC, McMurtry IF, et al. Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling. Am J Physiol Lung Cell Mol Physiol 2007;292:L885-L897.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.292
, pp. L885-L897
-
-
Crossno, J.T.1
Garat, C.V.2
Reusch, J.E.3
Morris, K.G.4
Dempsey, E.C.5
McMurtry, I.F.6
-
94
-
-
0027407536
-
Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension
-
Katayose D, Ohe M, Yamauchi K, Ogata M, Shirato K, Fujita H, et al. Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension. Am J Physiol 1993;264:L100-L106.
-
(1993)
Am J Physiol
, vol.264
, pp. L100-L106
-
-
Katayose, D.1
Ohe, M.2
Yamauchi, K.3
Ogata, M.4
Shirato, K.5
Fujita, H.6
-
95
-
-
0027295522
-
Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension
-
Arcot SS, Lipke DW, Gillespie MN, Olson JW. Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension. Biochem Pharmacol 1993;46:1086-91.
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 1086-1091
-
-
Arcot, S.S.1
Lipke, D.W.2
Gillespie, M.N.3
Olson, J.W.4
-
96
-
-
0035970577
-
Gene expression patterns in the lungs of patients with primary pulmonary hypertension: A gene microarray analysis
-
Geraci MW, Moore M, Gesell T, Yeager ME, Alger L, Golpon H, et al. Gene expression patterns in the lungs of patients with primary pulmonary hypertension: A gene microarray analysis. Circ Res 2001;88:555-62.
-
(2001)
Circ Res
, vol.88
, pp. 555-562
-
-
Geraci, M.W.1
Moore, M.2
Gesell, T.3
Yeager, M.E.4
Alger, L.5
Golpon, H.6
-
97
-
-
0038389113
-
Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth
-
Ameshima S, Golpon H, Cool CD, Chan D, Vandivier RW, Gardai SJ, et al. Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. Circ Res 2003;92:1162-9.
-
(2003)
Circ Res
, vol.92
, pp. 1162-1169
-
-
Ameshima, S.1
Golpon, H.2
Cool, C.D.3
Chan, D.4
Vandivier, R.W.5
Gardai, S.J.6
-
98
-
-
33947731898
-
Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation
-
Hansmann G, Wagner RA, Schellong S, Perez VA, Urashima T, Wang L, et al. Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation 2007;115:1275-84.
-
(2007)
Circulation
, vol.115
, pp. 1275-1284
-
-
Hansmann, G.1
Wagner, R.A.2
Schellong, S.3
Perez, V.A.4
Urashima, T.5
Wang, L.6
-
99
-
-
43049092988
-
An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension
-
Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, et al. An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest 2008;118:1846-57.
-
(2008)
J Clin Invest
, vol.118
, pp. 1846-1857
-
-
Hansmann, G.1
De Jesus Perez, V.A.2
Alastalo, T.P.3
Alvira, C.M.4
Guignabert, C.5
Bekker, J.M.6
-
100
-
-
71949120983
-
Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization
-
Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, et al. Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization. Am J Physiol Lung Cell Mol Physiol 2009;297:L1082-L1090.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
, pp. L1082-L1090
-
-
Guignabert, C.1
Alvira, C.M.2
Alastalo, T.P.3
Sawada, H.4
Hansmann, G.5
Zhao, M.6
-
101
-
-
68949149049
-
Adiponectin deficiency: A model of pulmonary hypertension associated with pulmonary vascular disease
-
Summer R, Fiack CA, Ikeda Y, Sato K, Dwyer D, Ouchi N, et al. Adiponectin deficiency: A model of pulmonary hypertension associated with pulmonary vascular disease. Am J Physiol Lung Cell Mol Physiol 2009;297:L432-L438.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
, pp. L432-L438
-
-
Summer, R.1
Fiack, C.A.2
Ikeda, Y.3
Sato, K.4
Dwyer, D.5
Ouchi, N.6
-
102
-
-
79960013903
-
Unrecognized glucose intolerance is common in pulmonary arterial hypertension
-
Pugh ME, Robbins IM, Rice TW, West J, Newman JH, Hemnes AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J Heart Lung Transplant 2011;30:904-11.
-
(2011)
J Heart Lung Transplant
, vol.30
, pp. 904-911
-
-
Pugh, M.E.1
Robbins, I.M.2
Rice, T.W.3
West, J.4
Newman, J.H.5
Hemnes, A.R.6
-
103
-
-
78649258232
-
Metabolic and hormonal derangements in pulmonary hypertension: From mouse to man
-
Pugh ME, Hemnes AR. Metabolic and hormonal derangements in pulmonary hypertension: From mouse to man. Int J Clin Pract Suppl 2010;168:5-13.
-
(2010)
Int J Clin Pract Suppl
, vol.168
, pp. 5
-
-
Pugh, M.E.1
Hemnes, A.R.2
-
104
-
-
77954594805
-
PPARgamma activation: A potential treatment for pulmonary hypertension
-
Hansmann G, Zamanian RT. PPARgamma activation: A potential treatment for pulmonary hypertension. Sci Transl Med 2009;1:12ps4.
-
(2009)
Sci Transl Med
, vol.1
-
-
Hansmann, G.1
Zamanian, R.T.2
-
105
-
-
26444540768
-
Reversal of experimental pulmonary hypertension by PDGF inhibition
-
Schermuly RT, Dony E, Ghofrani HA, Pullamsetti S, Savai R, Roth M, et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 2005;115:2811-21.
-
(2005)
J Clin Invest
, vol.115
, pp. 2811-2821
-
-
Schermuly, R.T.1
Dony, E.2
Ghofrani, H.A.3
Pullamsetti, S.4
Savai, R.5
Roth, M.6
-
106
-
-
33747041655
-
Long term imatinib treatment in pulmonary arterial hypertension
-
Souza R, Sitbon O, Parent F, Simonneau G, Humbert M. Long term imatinib treatment in pulmonary arterial hypertension. Thorax 2006;61:736.
-
(2006)
Thorax
, vol.61
, pp. 736
-
-
Souza, R.1
Sitbon, O.2
Parent, F.3
Simonneau, G.4
Humbert, M.5
-
107
-
-
33746745449
-
Imatinib mesylate in the treatment of refractory idiopathic pulmonary arterial hypertension
-
Patterson KC, Weissmann A, Ahmadi T, Farber HW. Imatinib mesylate in the treatment of refractory idiopathic pulmonary arterial hypertension. Ann Intern Med 2006;145:152-3.
-
(2006)
Ann Intern Med
, vol.145
, pp. 152-153
-
-
Patterson, K.C.1
Weissmann, A.2
Ahmadi, T.3
Farber, H.W.4
-
108
-
-
25444484658
-
Imatinib for the treatment of pulmonary arterial hypertension
-
Ghofrani HA, Seeger W, Grimminger F. Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med 2005;353:1412-3.
-
(2005)
N Engl J Med
, vol.353
, pp. 1412-1413
-
-
Ghofrani, H.A.1
Seeger, W.2
Grimminger, F.3
-
109
-
-
84858809665
-
Imatinib Improves Exercise Capacity and Hemodynamics at 24 Weeks as Add-on Therapy in Symptomatic Pulmonary Arterial Hypertension Patients: The IMPRES Study
-
Hoeper MM, Barst RJ, Bourge R, Feldman J, Frost A, Galie N, et al. Imatinib Improves Exercise Capacity and Hemodynamics at 24 Weeks as Add-on Therapy in Symptomatic Pulmonary Arterial Hypertension Patients: The IMPRES Study. Chest 2011;140:1045A.
-
(2011)
Chest
, vol.140
-
-
Hoeper, M.M.1
Barst, R.J.2
Bourge, R.3
Feldman, J.4
Frost, A.5
Galie, N.6
-
110
-
-
84866612898
-
Imatinib Safety And Efficacy: Interim Analysis Of IMPRES Extension Study In Patients With Pulmonary Arterial Hypertension
-
Hoeper MM, Barst RJ, Chang HJ, Frantz RP, Fukumoto Y, Galié N, et al. Imatinib Safety And Efficacy: Interim Analysis Of IMPRES Extension Study In Patients With Pulmonary Arterial Hypertension. Am J Respir Crit Care Med 2012;185:A2495.
-
(2012)
Am J Respir Crit Care Med
, vol.185
-
-
Hoeper, M.M.1
Barst, R.J.2
Chang, H.J.3
Frantz, R.P.4
Fukumoto, Y.5
Galié, N.6
-
111
-
-
78651024796
-
Influence of sex upon the lethal effects of an hepatotoxic alkaloid, monocrotaline
-
Ratnoff OD, Mirick GS. Influence of sex upon the lethal effects of an hepatotoxic alkaloid, monocrotaline. Bull Johns Hopkins Hosp 1949;84:507-25.
-
(1949)
Bull Johns Hopkins Hosp
, vol.84
, pp. 507-525
-
-
Ratnoff, O.D.1
Mirick, G.S.2
-
112
-
-
0344666398
-
Monocrotaline-induced pulmonary arteritis in rats
-
Lalich JJ, Ehrhart LA. Monocrotaline-induced pulmonary arteritis in rats. J Atheroscler Res 1962;2:482-92.
-
(1962)
J Atheroscler Res
, vol.2
, pp. 482-492
-
-
Lalich, J.J.1
Ehrhart, L.A.2
-
113
-
-
0014477426
-
Monocrotaline-induced pulmonary hypertension and p-chlorophenylalanine (PCPA)
-
Carrillo L, Aviado DM. Monocrotaline-induced pulmonary hypertension and p-chlorophenylalanine (PCPA). Lab Invest 1969;20:243-8.
-
(1969)
Lab Invest
, vol.20
, pp. 243-248
-
-
Carrillo, L.1
Aviado, D.M.2
-
114
-
-
0014779455
-
Electron microscopic observations of hypertrophied myocardium of rat produced by injection of monocrotaline
-
Kajihara H. Electron microscopic observations of hypertrophied myocardium of rat produced by injection of monocrotaline. Acta Pathol Jpn 1970;20:183-206.
-
(1970)
Acta Pathol Jpn
, vol.20
, pp. 183-206
-
-
Kajihara, H.1
-
115
-
-
0019082316
-
Development of Crotalaria pulmonary hypertension: Hemodynamic and structural study
-
Meyrick B, Gamble W, Reid L. Development of Crotalaria pulmonary hypertension: Hemodynamic and structural study. Am J Physiol 1980;239:H692-702.
-
(1980)
Am J Physiol
, vol.239
, pp. H692-H702
-
-
Meyrick, B.1
Gamble, W.2
Reid, L.3
-
116
-
-
0024268337
-
Beneficial effects of trimetazidine on mitochondrial function and superoxide production in the cardiac muscle of monocrotaline-treated rats
-
Guarnieri C, Muscari C. Beneficial effects of trimetazidine on mitochondrial function and superoxide production in the cardiac muscle of monocrotaline-treated rats. Biochem Pharmacol 1988;37:4685-8.
-
(1988)
Biochem Pharmacol
, vol.37
, pp. 4685-4688
-
-
Guarnieri, C.1
Muscari, C.2
-
117
-
-
75749133554
-
The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: Resuscitating the hibernating right ventricle
-
Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, Toth PT, et al. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: Resuscitating the hibernating right ventricle. J Mol Med (Berl) 2010;88:47-60.
-
(2010)
J Mol Med (Berl)
, vol.88
, pp. 47-60
-
-
Piao, L.1
Fang, Y.H.2
Cadete, V.J.3
Wietholt, C.4
Urboniene, D.5
Toth, P.T.6
-
118
-
-
78149415338
-
Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure
-
Piao L, Marsboom G, Archer SL. Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure. J Mol Med (Berl) 2010;88:1011-20.
-
(2010)
J Mol Med (Berl)
, vol.88
, pp. 1011-1020
-
-
Piao, L.1
Marsboom, G.2
Archer, S.L.3
-
120
-
-
77955635790
-
Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension
-
Sutendra G, Bonnet S, Rochefort G, Haromy A, Folmes KD, Lopaschuk GD, et al. Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension. Sci Transl Med 2010;2:44ra58.
-
(2010)
Sci Transl Med
, vol.2
-
-
Sutendra, G.1
Bonnet, S.2
Rochefort, G.3
Haromy, A.4
Folmes, K.D.5
Lopaschuk, G.D.6
-
121
-
-
79960090535
-
Rodent models of pulmonary hypertension: Harmonisation with the world health organisation’s categorisation of human PH
-
Ryan J, Bloch K, Archer SL. Rodent models of pulmonary hypertension: Harmonisation with the world health organisation’s categorisation of human PH. Int J Clin Pract Suppl 2011:15-34.
-
(2011)
Int J Clin Pract Suppl
, pp. 15
-
-
Ryan, J.1
Bloch, K.2
Archer, S.L.3
-
122
-
-
0021955760
-
Monocrotaline
-
Molteni A, Ward W F, Ts’ao C H, Solliday N H, Dunne M. Monocrotaline-induced pulmonary fibrosis in rats: Amelioration by captopril and penicillamine. Proc Soc Exp Biol Med 1985;180:112-20.
-
(1985)
Proc Soc Exp Biol Med
, vol.180
, pp. 112-120
-
-
Molteni, A.1
Ward, W.F.2
Ts’Ao, C.H.3
Solliday, N.H.4
Dunne, M.5
-
123
-
-
0032911940
-
Manipulation of injury and repair of the alveolar epithelium using two pneumotoxicants: 3-methylindole and monocrotaline
-
Woods LW, Wilson DW, Segall HJ. Manipulation of injury and repair of the alveolar epithelium using two pneumotoxicants: 3-methylindole and monocrotaline. Exp Lung Res 1999;25:165-81.
-
(1999)
Exp Lung Res
, vol.25
, pp. 165-181
-
-
Woods, L.W.1
Wilson, D.W.2
Segall, H.J.3
-
124
-
-
0033032746
-
Characterization of a reproducible rat model of hepatic veno-occlusive disease
-
DeLeve LD, McCuskey RS, Wang X, Hu L, McCuskey MK, Epstein RB, et al. Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology 1999;29:1779-91.
-
(1999)
Hepatology
, vol.29
, pp. 1779-1791
-
-
Deleve, L.D.1
McCuskey, R.S.2
Wang, X.3
Hu, L.4
McCuskey, M.K.5
Epstein, R.B.6
-
125
-
-
84861972788
-
The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats
-
Ezzat T, van den Broek MA, Davies N, Dejong CH, Bast A, Malagó M, et al. The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats. J Surg Oncol 2012;106:72-8.
-
(2012)
J Surg Oncol
, vol.106
, pp. 72-78
-
-
Ezzat, T.1
Van Den Broek, M.A.2
Davies, N.3
Dejong, C.H.4
Bast, A.5
Malagó, M.6
-
126
-
-
0025280748
-
Immunotoxicity of the pyrrolizidine alkaloid monocrotaline following subchronic administration to C57Bl/6 mice
-
Deyo JA, Kerkvliet NI. Immunotoxicity of the pyrrolizidine alkaloid monocrotaline following subchronic administration to C57Bl/6 mice. Fundam Appl Toxicol 1990;14:842-9.
-
(1990)
Fundam Appl Toxicol
, vol.14
, pp. 842-849
-
-
Deyo, J.A.1
Kerkvliet, N.I.2
-
127
-
-
0026323916
-
Tier-2 studies on monocrotaline immunotoxicity in C57BL/6 mice
-
Deyo JA, Kerkvliet NI. Tier-2 studies on monocrotaline immunotoxicity in C57BL/6 mice. Toxicology 1991;70:313-25.
-
(1991)
Toxicology
, vol.70
, pp. 313-325
-
-
Deyo, J.A.1
Kerkvliet, N.I.2
-
128
-
-
0027994741
-
Role of metabolism in monocrotaline-induced immunotoxicity in C57BL/6 mice
-
Deyo JA, Reed RL, Buhler DR, Kerkvliet NI. Role of metabolism in monocrotaline-induced immunotoxicity in C57BL/6 mice. Toxicology 1994;94:209-22.
-
(1994)
Toxicology
, vol.94
, pp. 209-222
-
-
Deyo, J.A.1
Reed, R.L.2
Buhler, D.R.3
Kerkvliet, N.I.4
-
129
-
-
0032401919
-
Dehydromonocrotaline generates sequence-selective N-7 guanine alkylation and heat and alkali stable multiple fragment DNA crosslinks
-
Pereira TN, Webb RI, Reilly PE, Seawright AA, Prakash AS. Dehydromonocrotaline generates sequence-selective N-7 guanine alkylation and heat and alkali stable multiple fragment DNA crosslinks. Nucleic Acids Res 1998;26:5441-7.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 5441-5447
-
-
Pereira, T.N.1
Webb, R.I.2
Reilly, P.E.3
Seawright, A.A.4
Prakash, A.S.5
-
130
-
-
0030296590
-
Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA
-
Thomas HC, Lame MW, Wilson DW, Segall HJ. Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA. Toxicol Appl Pharmacol 1996;141:319-29.
-
(1996)
Toxicol Appl Pharmacol
, vol.141
, pp. 319-329
-
-
Thomas, H.C.1
Lame, M.W.2
Wilson, D.W.3
Segall, H.J.4
-
131
-
-
0023746438
-
Crosslinking of DNA by dehydroretronecine, a metabolite of pyrrolizidine alkaloids
-
Reed RL, Ahern KG, Pearson GD, Buhler DR. Crosslinking of DNA by dehydroretronecine, a metabolite of pyrrolizidine alkaloids. Carcinogenesis 1988;9:1355-61.
-
(1988)
Carcinogenesis
, vol.9
, pp. 1355-1361
-
-
Reed, R.L.1
Ahern, K.G.2
Pearson, G.D.3
Buhler, D.R.4
-
132
-
-
84865577315
-
Attenuation of monocrotaline-induced pulmonary arterial hypertension in rats by rosuvastatin
-
Li XL, Guan RJ, Li JJ. Attenuation of monocrotaline-induced pulmonary arterial hypertension in rats by rosuvastatin. J Cardiovasc Pharmacol 2012;60:219-26.
-
(2012)
J Cardiovasc Pharmacol
, vol.60
, pp. 219-226
-
-
Li, X.L.1
Guan, R.J.2
Li, J.J.3
-
133
-
-
84859142970
-
Fluoxetine protects against monocrotaline-induced pulmonary arterial remodeling by inhibition of hypoxia-inducible factor-1alpha and vascular endothelial growth factor
-
Han DD, Wang Y, Zhang XH, Liu JR, Wang HL. Fluoxetine protects against monocrotaline-induced pulmonary arterial remodeling by inhibition of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Can J Physiol Pharmacol 2012;90:445-54.
-
(2012)
Can J Physiol Pharmacol
, vol.90
, pp. 445-454
-
-
Han, D.D.1
Wang, Y.2
Zhang, X.H.3
Liu, J.R.4
Wang, H.L.5
-
134
-
-
0017600164
-
The prevention of monocrotaline-induced right ventricular hypertrophy
-
Huxtable R, Paplanus S, Laugharn J. The prevention of monocrotaline-induced right ventricular hypertrophy. Chest 1977;71:308-10.
-
(1977)
Chest
, vol.71
, pp. 308-310
-
-
Huxtable, R.1
Paplanus, S.2
Laugharn, J.3
-
135
-
-
84857027921
-
The monocrotaline model of pulmonary hypertension in perspective
-
Gomez-Arroyo JG, Farkas L, Alhussaini AA, Farkas D, Kraskauskas D, Voelkel NF, et al. The monocrotaline model of pulmonary hypertension in perspective. Am J Physiol Lung Cell Mol Physiol 2012;302:L363-L369.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.302
, pp. L363-L369
-
-
Gomez-Arroyo, J.G.1
Farkas, L.2
Alhussaini, A.A.3
Farkas, D.4
Kraskauskas, D.5
Voelkel, N.F.6
-
136
-
-
33748455321
-
Carbon monoxide reverses established pulmonary hypertension
-
Zuckerbraun BS, Chin BY, Wegiel B, Billiar TR, Czsimadia E, Rao J, et al. Carbon monoxide reverses established pulmonary hypertension. J Exp Med 2006;203:2109-19.
-
(2006)
J Exp Med
, vol.203
, pp. 2109-2119
-
-
Zuckerbraun, B.S.1
Chin, B.Y.2
Wegiel, B.3
Billiar, T.R.4
Czsimadia, E.5
Rao, J.6
-
137
-
-
84859644104
-
Reactive oxygen and nitrogen species in pulmonary hypertension
-
Tabima DM, Frizzell S, Gladwin MT. Reactive oxygen and nitrogen species in pulmonary hypertension. Free Radic Biol Med 2012;52:1970-86.
-
(2012)
Free Radic Biol Med
, vol.52
, pp. 1970-1986
-
-
Tabima, D.M.1
Frizzell, S.2
Gladwin, M.T.3
-
138
-
-
0032896721
-
The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia
-
Fagan KA, Fouty BW, Tyler RC, Morris KG Jr, Hepler LK, Sato K, et al. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest 1999;103:291-9.
-
(1999)
J Clin Invest
, vol.103
, pp. 291-299
-
-
Fagan, K.A.1
Fouty, B.W.2
Tyler, R.C.3
Morris, K.G.4
Hepler, L.K.5
Sato, K.6
-
139
-
-
0033696120
-
ENOS
-
Quinlan TR, Li D, Laubach VE, Shesely EG, Zhou N, Johns RA. eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 2000;279:L641-L650.
-
(2000)
Am J Physiol Lung Cell Mol Physiol
, vol.279
, pp. L641-L650
-
-
Quinlan, T.R.1
Li, D.2
Laubach, V.E.3
Shesely, E.G.4
Zhou, N.5
Johns, R.A.6
-
140
-
-
0029805172
-
Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
-
Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly. Am J Physiol 1996;271:C1424-C1437.
-
(1996)
Am J Physiol
, vol.271
-
-
Beckman, J.S.1
Koppenol, W.H.2
-
141
-
-
77955607922
-
Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction
-
Francis BN, Wilkins MR, Zhao L. Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction. Eur Respir J 2010;36:323-30.
-
(2010)
Eur Respir J
, vol.36
, pp. 323-330
-
-
Francis, B.N.1
Wilkins, M.R.2
Zhao, L.3
-
142
-
-
68849084669
-
Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration
-
Zhao YY, Zhao YD, Mirza MK, Huang JH, Potula HH, Vogel SM, et al. Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J Clin Invest 2009;119:2009-18.
-
(2009)
J Clin Invest
, vol.119
, pp. 2009-2018
-
-
Zhao, Y.Y.1
Zhao, Y.D.2
Mirza, M.K.3
Huang, J.H.4
Potula, H.H.5
Vogel, S.M.6
-
143
-
-
79952043054
-
Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders
-
Gielis JF, Lin JY, Wingler K, Van Schil PE, Schmidt HH, Moens AL. Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders. Free Radic Biol Med 2011;50:765-76.
-
(2011)
Free Radic Biol Med
, vol.50
, pp. 765-776
-
-
Gielis, J.F.1
Lin, J.Y.2
Wingler, K.3
Van Schil, P.E.4
Schmidt, H.H.5
Moens, A.L.6
-
144
-
-
78649735545
-
Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties
-
Kunuthur SP, Milliken PH, Gibson CL, Suckling CJ, Wadsworth RM. Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties. Eur J Pharmacol 2011;650:371-7.
-
(2011)
Eur J Pharmacol
, vol.650
, pp. 371-377
-
-
Kunuthur, S.P.1
Milliken, P.H.2
Gibson, C.L.3
Suckling, C.J.4
Wadsworth, R.M.5
-
145
-
-
79251493500
-
Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension
-
Robbins IM, Hemnes AR, Gibbs JS, Christman BW, Howard L, Meehan S, et al. Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension. Exp Lung Res 2011;37:26-34.
-
(2011)
Exp Lung Res
, vol.37
, pp. 26-34
-
-
Robbins, I.M.1
Hemnes, A.R.2
Gibbs, J.S.3
Christman, B.W.4
Howard, L.5
Meehan, S.6
-
146
-
-
0035851197
-
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities
-
Razani B, Engelman JA, Wang XB, Schubert W, Zhang XL, Marks CB, et al. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem 2001;276:38121-38.
-
(2001)
J Biol Chem
, vol.276
, pp. 38121-38138
-
-
Razani, B.1
Engelman, J.A.2
Wang, X.B.3
Schubert, W.4
Zhang, X.L.5
Marks, C.B.6
-
147
-
-
0037143769
-
Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice
-
Zhao YY, Liu Y, Stan RV, Fan L, Gu Y, Dalton N, et al. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A 2002;99:11375-80.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 11375-11380
-
-
Zhao, Y.Y.1
Liu, Y.2
Stan, R.V.3
Fan, L.4
Gu, Y.5
Dalton, N.6
-
148
-
-
42749088607
-
The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium
-
Wunderlich C, Schober K, Schmeisser A, Heerwagen C, Tausche AK, Steinbronn N, et al. The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium. J Mol Cell Cardiol 2008;44:938-47.
-
(2008)
J Mol Cell Cardiol
, vol.44
, pp. 938-947
-
-
Wunderlich, C.1
Schober, K.2
Schmeisser, A.3
Heerwagen, C.4
Tausche, A.K.5
Steinbronn, N.6
-
149
-
-
56049085997
-
Nitric oxide synthases are crucially involved in the development of the severe cardiomyopathy of caveolin-1 knockout mice
-
Wunderlich C, Schober K, Kasper M, Heerwagen C, Marquetant R, Ebner B, et al. Nitric oxide synthases are crucially involved in the development of the severe cardiomyopathy of caveolin-1 knockout mice. Biochem Biophys Res Commun 2008;377:769-74.
-
(2008)
Biochem Biophys Res Commun
, vol.377
, pp. 769-774
-
-
Wunderlich, C.1
Schober, K.2
Kasper, M.3
Heerwagen, C.4
Marquetant, R.5
Ebner, B.6
-
150
-
-
43049126174
-
Chronic NOS inhibition prevents adverse lung remodeling and pulmonary arterial hypertension in caveolin-1 knockout mice
-
Wunderlich C, Schmeisser A, Heerwagen C, Ebner B, Schober K, Braun-Dullaeus RC, et al. Chronic NOS inhibition prevents adverse lung remodeling and pulmonary arterial hypertension in caveolin-1 knockout mice. Pulm Pharmacol Ther 2008;21:507-15.
-
(2008)
Pulm Pharmacol Ther
, vol.21
, pp. 507-515
-
-
Wunderlich, C.1
Schmeisser, A.2
Heerwagen, C.3
Ebner, B.4
Schober, K.5
Braun-Dullaeus, R.C.6
-
151
-
-
84859980069
-
Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration
-
Fernández-Rojo MA, Restall C, Ferguson C, Martel N, Martin S, Bosch M, et al. Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration. Hepatology 2012;55:1574-84.
-
(2012)
Hepatology
, vol.55
, pp. 1574-1584
-
-
Fernández-Rojo, M.A.1
Restall, C.2
Ferguson, C.3
Martel, N.4
Martin, S.5
Bosch, M.6
-
152
-
-
77953560003
-
Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation
-
Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, et al. Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation. Cell Cycle 2010;9:2201-19.
-
(2010)
Cell Cycle
, vol.9
, pp. 2201-2219
-
-
Pavlides, S.1
Tsirigos, A.2
Vera, I.3
Flomenberg, N.4
Frank, P.G.5
Casimiro, M.C.6
-
153
-
-
14744270462
-
Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue
-
Cohen AW, Schubert W, Brasaemle DL, Scherer PE, Lisanti MP. Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue. Diabetes 2005;54:679-86.
-
(2005)
Diabetes
, vol.54
, pp. 679-686
-
-
Cohen, A.W.1
Schubert, W.2
Brasaemle, D.L.3
Scherer, P.E.4
Lisanti, M.P.5
-
154
-
-
79955471276
-
Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility
-
Bosch M, Marí M, Herms A, Fernández A, Fajardo A, Kassan A, et al. Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr Biol 2011;21:681-6.
-
(2011)
Curr Biol
, vol.21
, pp. 681-686
-
-
Bosch, M.1
Marí, M.2
Herms, A.3
Fernández, A.4
Fajardo, A.5
Kassan, A.6
-
155
-
-
80053601906
-
Mitochondrial cholesterol: A connection between caveolin, metabolism, and disease
-
Bosch M, Mari M, Gross SP, Fernandez-Checa JC, Pol A. Mitochondrial cholesterol: A connection between caveolin, metabolism, and disease. Traffic 2011;12:1483-9.
-
(2011)
Traffic
, vol.12
, pp. 1483-1489
-
-
Bosch, M.1
Mari, M.2
Gross, S.P.3
Fernandez-Checa, J.C.4
Pol, A.5
-
156
-
-
79951833645
-
Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: A new genetically tractable model for human cancer associated fibroblasts
-
Trimmer C, Sotgia F, Whitaker-Menezes D, Balliet RM, Eaton G, Martinez-Outschoorn UE, et al. Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: A new genetically tractable model for human cancer associated fibroblasts. Cancer Biol Ther 2011;11:383-94.
-
(2011)
Cancer Biol Ther
, vol.11
, pp. 383-394
-
-
Trimmer, C.1
Sotgia, F.2
Whitaker-Menezes, D.3
Balliet, R.M.4
Eaton, G.5
Martinez-Outschoorn, U.E.6
-
157
-
-
39149106144
-
Mitochondrial metabolism, redox signaling, and fusion: A mitochondria
-
Archer SL, Gomberg-Maitland M, Maitland ML, Rich S, Garcia JG, Weir EK. Mitochondrial metabolism, redox signaling, and fusion: A mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol 2008;294:H570-H578.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
, pp. H570-H578
-
-
Archer, S.L.1
Gomberg-Maitland, M.2
Maitland, M.L.3
Rich, S.4
Garcia, J.G.5
Weir, E.K.6
-
158
-
-
84869089160
-
The genetics of pulmonary arterial hypertension in the post-BMPR2 era
-
Fessel JP, Loyd JE, Austin ED. The genetics of pulmonary arterial hypertension in the post-BMPR2 era. Pulm Circ 2011;1:305-19.
-
(2011)
Pulm Circ
, vol.1
, pp. 305-319
-
-
Fessel, J.P.1
Loyd, J.E.2
Austin, E.D.3
-
159
-
-
78651341882
-
BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways
-
Perez VA, Ali Z, Alastalo TP, Ikeno F, Sawada H, Lai YJ, et al. BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. J Cell Biol 2011;192:171-88.
-
(2011)
J Cell Biol
, vol.192
, pp. 171-188
-
-
Perez, V.A.1
Ali, Z.2
Alastalo, T.P.3
Ikeno, F.4
Sawada, H.5
Lai, Y.J.6
-
160
-
-
80052348254
-
Disruption of PPARgamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
-
Alastalo TP, Li M, Perez Vde J, Pham D, Sawada H, Wang JK, et al. Disruption of PPARgamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival. J Clin Invest 2011;121:3735-46.
-
(2011)
J Clin Invest
, vol.121
, pp. 3735-3746
-
-
Alastalo, T.P.1
Li, M.2
Perez Vde, J.3
Pham, D.4
Sawada, H.5
Wang, J.K.6
-
161
-
-
80053020850
-
Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation
-
Gangopahyay A, Oran M, Bauer EM, Wertz JW, Comhair SA, Erzurum SC, et al. Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation. J Biol Chem 2011;286:33134-40.
-
(2011)
J Biol Chem
, vol.286
, pp. 33134-33140
-
-
Gangopahyay, A.1
Oran, M.2
Bauer, E.M.3
Wertz, J.W.4
Comhair, S.A.5
Erzurum, S.C.6
-
162
-
-
84863249942
-
Oxidative injury is a common consequence of BMPR2 mutations
-
Lane KL, Talati M, Austin E, Hemnes AR, Johnson JA, Fessel JP, et al. Oxidative injury is a common consequence of BMPR2 mutations. Pulm Circ 2011;1:72-83.
-
(2011)
Pulm Circ
, vol.1
, pp. 72-83
-
-
Lane, K.L.1
Talati, M.2
Austin, E.3
Hemnes, A.R.4
Johnson, J.A.5
Fessel, J.P.6
-
163
-
-
84863279449
-
Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension
-
Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, et al. Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 2012;302:L474-L484.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.302
, pp. L474-L484
-
-
Johnson, J.A.1
Hemnes, A.R.2
Perrien, D.S.3
Schuster, M.4
Robinson, L.J.5
Gladson, S.6
-
164
-
-
71049130696
-
Gene expression in BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension suggests pathways relevant to disease penetrance
-
West J, Cogan J, Geraci M, Robinson L, Newman J, Phillips JA, et al. Gene expression in BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension suggests pathways relevant to disease penetrance. BMC Med Genomics 2008;1:45.
-
(2008)
BMC Med Genomics
, vol.1
, pp. 45
-
-
West, J.1
Cogan, J.2
Geraci, M.3
Robinson, L.4
Newman, J.5
Phillips, J.A.6
-
165
-
-
79959329487
-
Physiologic and molecular consequences of endothelial Bmpr2 mutation
-
Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, et al. Physiologic and molecular consequences of endothelial Bmpr2 mutation. Respir Res 2011;12:84.
-
(2011)
Respir Res
, vol.12
, pp. 84
-
-
Majka, S.1
Hagen, M.2
Blackwell, T.3
Harral, J.4
Johnson, J.A.5
Gendron, R.6
-
166
-
-
84893582897
-
Universal Expression Of BMPR2 Mutation Is Associated With Impairment Of Right Ventricular Hypertrophy And Steatosis In Mice
-
Hemnes A, Fessel JP, Penner N, Gleaves L, Robinson L, West J. Universal Expression Of BMPR2 Mutation Is Associated With Impairment Of Right Ventricular Hypertrophy And Steatosis In Mice. Am J Respir Crit Care Med 2012;185:A3454.
-
(2012)
Am J Respir Crit Care Med
, vol.185
-
-
Hemnes, A.1
Fessel, J.P.2
Penner, N.3
Gleaves, L.4
Robinson, L.5
West, J.6
-
167
-
-
84869108665
-
Metabolomic Analysis Reveals Widespread Metabolic Derangements In Pulmonary Arterial Hypertension
-
Fessel JP, Hamid R, Austin ED, Tada Y, Wittmann B, Hemnes A, West J, et al. Metabolomic Analysis Reveals Widespread Metabolic Derangements In Pulmonary Arterial Hypertension. Am J Respir Crit Care Med 2012;185:A6512.
-
(2012)
Am J Respir Crit Care Med
, vol.185
-
-
Fessel, J.P.1
Hamid, R.2
Austin, E.D.3
Tada, Y.4
Wittmann, B.5
Hemnes, A.6
West, J.7
-
168
-
-
80053899412
-
Contribution of oxidative stress to pulmonary arterial hypertension
-
Demarco VG, Whaley-Connell AT, Sowers JR, Habibi J, Dellsperger KC. Contribution of oxidative stress to pulmonary arterial hypertension. World J Cardiol 2010;2:316-24.
-
(2010)
World J Cardiol
, vol.2
, pp. 316-324
-
-
Demarco, V.G.1
Whaley-Connell, A.T.2
Sowers, J.R.3
Habibi, J.4
Dellsperger, K.C.5
-
169
-
-
81055125053
-
Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress
-
Jerkic M, Kabir MG, Davies A, Yu LX, McIntyre BA, Husain NW, et al. Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress. Cardiovasc Res 2011;92:375-84.
-
(2011)
Cardiovasc Res
, vol.92
, pp. 375-384
-
-
Jerkic, M.1
Kabir, M.G.2
Davies, A.3
Yu, L.X.4
McIntyre, B.A.5
Husain, N.W.6
-
170
-
-
34547828784
-
Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species
-
Redout EM, Wagner MJ, Zuidwijk MJ, Boer C, Musters RJ, van Hardeveld C, et al. Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species. Cardiovasc Res 2007;75:770-81.
-
(2007)
Cardiovasc Res
, vol.75
, pp. 770
-
-
Redout, E.M.1
Wagner, M.J.2
Zuidwijk, M.J.3
Boer, C.4
Musters, R.J.5
Van Hardeveld, C.6
-
171
-
-
0033749842
-
Enhanced expression and activity of xanthine oxidoreductase in the failing heart
-
de Jong JW, Schoemaker RG, de Jonge R, Bernocchi P, Keijzer E, Harrison R, et al. Enhanced expression and activity of xanthine oxidoreductase in the failing heart. J Mol Cell Cardiol 2000;32:2083-9.
-
(2000)
J Mol Cell Cardiol
, vol.32
, pp. 2083-2089
-
-
De Jong, J.W.1
Schoemaker, R.G.2
De Jonge, R.3
Bernocchi, P.4
Keijzer, E.5
Harrison, R.6
-
172
-
-
70349161964
-
RAGE, vascular tone and vascular disease
-
Farmer DG, Kennedy S. RAGE, vascular tone and vascular disease. Pharmacol Ther 2009;124:185-94.
-
(2009)
Pharmacol Ther
, vol.124
, pp. 185-194
-
-
Farmer, D.G.1
Kennedy, S.2
-
173
-
-
80052572916
-
Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
-
Dorfmüller P, Chaumais MC, Giannakouli M, Durand-Gasselin I, Raymond N, Fadel E, et al. Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension. Respir Res 2011;12:119.
-
(2011)
Respir Res
, vol.12
, pp. 119
-
-
Dorfmüller, P.1
Chaumais, M.C.2
Giannakouli, M.3
Durand-Gasselin, I.4
Raymond, N.5
Fadel, E.6
-
174
-
-
1542511743
-
Oxidative stress in severe pulmonary hypertension
-
Bowers R, Cool C, Murphy RC, Tuder RM, Hopken MW, Flores SC, et al. Oxidative stress in severe pulmonary hypertension. Am J Respir Crit Care Med 2004;169:764-9.
-
(2004)
Am J Respir Crit Care Med
, vol.169
, pp. 764-769
-
-
Bowers, R.1
Cool, C.2
Murphy, R.C.3
Tuder, R.M.4
Hopken, M.W.5
Flores, S.C.6
-
175
-
-
2942715210
-
Extracellular superoxide enhances 5-HT-induced murine pulmonary artery vasoconstriction
-
Liu JQ, Folz RJ. Extracellular superoxide enhances 5-HT-induced murine pulmonary artery vasoconstriction. Am J Physiol Lung Cell Mol Physiol 2004;287:L111-L118.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.287
, pp. L111-L118
-
-
Liu, J.Q.1
Folz, R.J.2
-
176
-
-
0031912674
-
Effect of monocrotaline metabolites on glutathione levels in human and bovine pulmonary artery endothelial cells
-
Reid MJ, Dunston SK, Lame MW, Wilson DW, Morin D, Segall HJ. Effect of monocrotaline metabolites on glutathione levels in human and bovine pulmonary artery endothelial cells. Res Commun Mol Pathol Pharmacol 1998;99:53-68.
-
(1998)
Res Commun Mol Pathol Pharmacol
, vol.99
, pp. 53-68
-
-
Reid, M.J.1
Dunston, S.K.2
Lame, M.W.3
Wilson, D.W.4
Morin, D.5
Segall, H.J.6
-
177
-
-
80051473132
-
Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase
-
Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, et al. Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. Hypertension 2011;58:303-9.
-
(2011)
Hypertension
, vol.58
, pp. 303-309
-
-
Xu, D.1
Guo, H.2
Xu, X.3
Lu, Z.4
Fassett, J.5
Hu, X.6
-
178
-
-
77954083190
-
Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: A basis for excessive cell proliferation and a new therapeutic target
-
Archer SL, Marsboom G, Kim GH, Zhang HJ, Toth PT, Svensson EC, et al. Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: A basis for excessive cell proliferation and a new therapeutic target. Circulation 2010;121:2661-71.
-
(2010)
Circulation
, vol.121
, pp. 2661-2671
-
-
Archer, S.L.1
Marsboom, G.2
Kim, G.H.3
Zhang, H.J.4
Toth, P.T.5
Svensson, E.C.6
-
179
-
-
38349041914
-
Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats
-
Kamezaki F, Tasaki H, Yamashita K, Tsutsui M, Koide S, Nakata S, et al. Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med 2008;177:219-26.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 219-226
-
-
Kamezaki, F.1
Tasaki, H.2
Yamashita, K.3
Tsutsui, M.4
Koide, S.5
Nakata, S.6
-
180
-
-
79952199606
-
Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model
-
Wang Y, Jing L, Zhao XM, Han JJ, Xia ZL, Qin SC, et al. Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respir Res 2011;12:26.
-
(2011)
Respir Res
, vol.12
, pp. 26
-
-
Wang, Y.1
Jing, L.2
Zhao, X.M.3
Han, J.J.4
Xia, Z.L.5
Qin, S.C.6
-
181
-
-
77749291756
-
Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure
-
Redout EM, van der Toorn A, Zuidwijk MJ, van de Kolk CW, van Echteld CJ, Musters RJ, et al. Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure. Am J Physiol Heart Circ Physiol 2010;298:H1038-H1047.
-
(2010)
Am J Physiol Heart Circ Physiol
, vol.298
, pp. H1038-H1047
-
-
Redout, E.M.1
Van Der Toorn, A.2
Zuidwijk, M.J.3
Van De Kolk, C.W.4
Van Echteld, C.J.5
Musters, R.J.6
-
182
-
-
0033710451
-
A possible role of the oxidant tissue injury in the development of hypoxic pulmonary hypertension
-
Herget J, Wilhelm J, Novotná J, Eckhardt A, Vytásek R, Mrázková L, et al. A possible role of the oxidant tissue injury in the development of hypoxic pulmonary hypertension. Physiol Res 2000;49:493-501.
-
(2000)
Physiol Res
, vol.49
, pp. 493-501
-
-
Herget, J.1
Wilhelm, J.2
Novotná, J.3
Eckhardt, A.4
Vytásek, R.5
Mrázková, L.6
-
183
-
-
33947602453
-
Role of reactive oxygen species in Kv channel inhibition and vasoconstriction induced by TP receptor activation in rat pulmonary arteries
-
Cogolludo A, Frazziano G, Cobeño L, Moreno L, Lodi F, Villamor E, et al. Role of reactive oxygen species in Kv channel inhibition and vasoconstriction induced by TP receptor activation in rat pulmonary arteries. Ann N Y Acad Sci 2006;1091:41-51.
-
(2006)
Ann N Y Acad Sci
, vol.1091
, pp. 41-51
-
-
Cogolludo, A.1
Frazziano, G.2
Cobeño, L.3
Moreno, L.4
Lodi, F.5
Villamor, E.6
-
184
-
-
80955133245
-
A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins
-
Navarro-Sastre A, Tort F, Stehling O, Uzarska MA, Arranz JA, Del Toro M, et al. A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins. Am J Hum Genet 2011;89:656-67.
-
(2011)
Am J Hum Genet
, vol.89
, pp. 656-667
-
-
Navarro-Sastre, A.1
Tort, F.2
Stehling, O.3
Uzarska, M.A.4
Arranz, J.A.5
Del Toro, M.6
-
185
-
-
46749104461
-
Murine pulmonary response to chronic hypoxia is strain specific
-
Tada Y, Laudi S, Harral J, Carr M, Ivester C, Tanabe N, et al. Murine pulmonary response to chronic hypoxia is strain specific. Exp Lung Res 2008;34:313-23.
-
(2008)
Exp Lung Res
, vol.34
, pp. 313-323
-
-
Tada, Y.1
Laudi, S.2
Harral, J.3
Carr, M.4
Ivester, C.5
Tanabe, N.6
-
186
-
-
40749102181
-
Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature
-
Frank DB, Lowery J, Anderson L, Brink M, Reese J, de Caestecker M. Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol 2008;294:L98-L109.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.294
, pp. LL98-L109
-
-
Frank, D.B.1
Lowery, J.2
Erson, L.3
Brink, M.4
Reese, J.5
De Caestecker, M.6
-
187
-
-
33749345684
-
Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms
-
Stenmark KR, Fagan KA, Frid MG. Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms. Circ Res 2006;99:675-91.
-
(2006)
Circ Res
, vol.99
, pp. 675-691
-
-
Stenmark, K.R.1
Fagan, K.A.2
Frid, M.G.3
-
188
-
-
62549141438
-
Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia
-
Dempsey EC, Wick MJ, Karoor V, Barr EJ, Tallman DW, Wehling CA, et al. Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. Am J Pathol 2009;174:782-96.
-
(2009)
Am J Pathol
, vol.174
, pp. 782-796
-
-
Dempsey, E.C.1
Wick, M.J.2
Karoor, V.3
Barr, E.J.4
Tallman, D.W.5
Wehling, C.A.6
-
189
-
-
34248187453
-
Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice
-
Paddenberg R, Stieger P, von Lilien AL, Faulhammer P, Goldenberg A, Tillmanns HH, et al. Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice. Respir Res 2007;8:15.
-
(2007)
Respir Res
, vol.8
, pp. 15
-
-
Paddenberg, R.1
Stieger, P.2
Von Lilien, A.L.3
Faulhammer, P.4
Goldenberg, A.5
Tillmanns, H.H.6
-
190
-
-
68549132471
-
Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia
-
Estrada KD, Chesler NC. Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia. Biomech Model Mechanobiol 2009;8:263-72.
-
(2009)
Biomech Model Mechanobiol
, vol.8
, pp. 263-272
-
-
Estrada, K.D.1
Chesler, N.C.2
-
191
-
-
33847675337
-
Pulmonary vascular remodeling in isolated mouse lungs: Effects on pulsatile pressure-flow relationships
-
Tuchscherer HA, Vanderpool RR, Chesler NC. Pulmonary vascular remodeling in isolated mouse lungs: Effects on pulsatile pressure-flow relationships. J Biomech 2007;40:993-1001.
-
(2007)
J Biomech
, vol.40
, pp. 993-1001
-
-
Tuchscherer, H.A.1
Vanderpool, R.R.2
Chesler, N.C.3
-
192
-
-
2342486700
-
Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
-
West J, Fagan K, Steudel W, Fouty B, Lane K, Harral J, et al. Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res 2004;94:1109-14.
-
(2004)
Circ Res
, vol.94
, pp. 1109-1114
-
-
West, J.1
Fagan, K.2
Steudel, W.3
Fouty, B.4
Lane, K.5
Harral, J.6
-
193
-
-
8644256840
-
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
-
Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, et al. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol 2004;287:L1241-L1247.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.287
, pp. L1241-L1247
-
-
Beppu, H.1
Ichinose, F.2
Kawai, N.3
Jones, R.C.4
Yu, P.B.5
Zapol, W.M.6
-
194
-
-
33645751955
-
Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice
-
Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, et al. Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res 2006;98:818-27.
-
(2006)
Circ Res
, vol.98
, pp. 818-827
-
-
Long, L.1
Maclean, M.R.2
Jeffery, T.K.3
Morecroft, I.4
Yang, X.5
Rudarakanchana, N.6
-
195
-
-
23044504042
-
Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice
-
Song Y, Jones JE, Beppu H, Keaney JF Jr, Loscalzo J, Zhang YY. Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation 2005;112:553-62.
-
(2005)
Circulation
, vol.112
, pp. 553-562
-
-
Song, Y.1
Jones, J.E.2
Beppu, H.3
Keaney, J.F.4
Loscalzo, J.5
Zhang, Y.Y.6
-
196
-
-
34548853386
-
Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity
-
Liu D, Wang J, Kinzel B, Müeller M, Mao X, Valdez R, et al. Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity. Blood 2007;110:1502-10.
-
(2007)
Blood
, vol.110
, pp. 1502-1510
-
-
Liu, D.1
Wang, J.2
Kinzel, B.3
Müeller, M.4
Mao, X.5
Valdez, R.6
-
197
-
-
79959329487
-
Physiologic and Molecular Consequences of Endothelial Bmpr2 Mutation
-
Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, et al. Physiologic and Molecular Consequences of Endothelial Bmpr2 Mutation. Respir Res 2011;12:84.
-
(2011)
Respir Res
, vol.12
, pp. 84
-
-
Majka, S.1
Hagen, M.2
Blackwell, T.3
Harral, J.4
Johnson, J.A.5
Gendron, R.6
-
198
-
-
57049159708
-
Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions
-
West J, Harral J, Lane K, Deng Y, Ickes B, Crona D, et al. Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am J Physiol Lung Cell Mol Physiol 2008;295:L744-L755.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.295
, pp. L744-L755
-
-
West, J.1
Harral, J.2
Lane, K.3
Deng, Y.4
Ickes, B.5
Crona, D.6
-
199
-
-
50349096148
-
Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension
-
Hong KH, Lee YJ, Lee E, Park SO, Han C, Beppu H, et al. Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation 2008;118:722-30.
-
(2008)
Circulation
, vol.118
, pp. 722-730
-
-
Hong, K.H.1
Lee, Y.J.2
Lee, E.3
Park, S.O.4
Han, C.5
Beppu, H.6
-
200
-
-
80055117501
-
Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene
-
Yasuda T, Tada Y, Tanabe N, Tatsumi K, West J. Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene. Am J Physiol Lung Cell Mol Physiol 2011;301:L667-74.
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.301
, pp. L667-L674
-
-
Yasuda, T.1
Tada, Y.2
Tanabe, N.3
Tatsumi, K.4
West, J.5
-
201
-
-
0034096980
-
Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene
-
Eddahibi S, Hanoun N, Lanfumey L, Lesch KP, Raffestin B, Hamon M, et al. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest 2000;105:1555-62.
-
(2000)
J Clin Invest
, vol.105
, pp. 1555-1562
-
-
Eddahibi, S.1
Hanoun, N.2
Lanfumey, L.3
Lesch, K.P.4
Raffestin, B.5
Hamon, M.6
-
202
-
-
33744970745
-
Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension
-
Guignabert C, Izikki M, Tu LI, Li Z, Zadigue P, Barlier-Mur AM, et al. Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension. Circ Res 2006;98:1323-30.
-
(2006)
Circ Res
, vol.98
, pp. 1323-1330
-
-
Guignabert, C.1
Izikki, M.2
Tu, L.I.3
Li, Z.4
Zadigue, P.5
Barlier-Mur, A.M.6
-
203
-
-
33947721196
-
Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene
-
Said SI, Hamidi SA, Dickman KG, Szema AM, Lyubsky S, Lin RZ, et al. Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene. Circulation 2007;115:1260-8.
-
(2007)
Circulation
, vol.115
, pp. 1260-1268
-
-
Said, S.I.1
Hamidi, S.A.2
Dickman, K.G.3
Szema, A.M.4
Lyubsky, S.5
Lin, R.Z.6
-
204
-
-
0027080477
-
Analysis of systemic and pulmonary vascular responses to PACAP and VIP: Role of adrenal catecholamines
-
Minkes RK, McMahon TJ, Higuera TR, Murphy WA, Coy DH, Kadowitz PJ. Analysis of systemic and pulmonary vascular responses to PACAP and VIP: Role of adrenal catecholamines. Am J Physiol 1992;263:H1659-H1669.
-
(1992)
Am J Physiol
, vol.263
, pp. H1659-H1669
-
-
Minkes, R.K.1
McMahon, T.J.2
Higuera, T.R.3
Murphy, W.A.4
Coy, D.H.5
Kadowitz, P.J.6
-
205
-
-
8744285611
-
Pulmonary hypertension and right heart failure in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice
-
Otto C, Hein L, Brede M, Jahns R, Engelhardt S, Gröne HJ, et al. Pulmonary hypertension and right heart failure in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice. Circulation 2004;110:3245-51.
-
(2004)
Circulation
, vol.110
, pp. 3245-3251
-
-
Otto, C.1
Hein, L.2
Brede, M.3
Jahns, R.4
Engelhardt, S.5
Gröne, H.J.6
-
206
-
-
0033856110
-
PTEN, a unique tumor suppressor gene
-
Dahia PL. PTEN, a unique tumor suppressor gene. Endocr Relat Cancer 2000;7:115-29.
-
(2000)
Endocr Relat Cancer
, vol.7
, pp. 115-129
-
-
Dahia, P.L.1
-
207
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998;273:13375-8.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
208
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 1998;280:1614-7.
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
Aota, S.4
Parsons, R.5
Yamada, K.M.6
-
209
-
-
43449083502
-
Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha
-
Nemenoff RA, Simpson PA, Furgeson SB, Kaplan-Albuquerque N, Crossno J, Garl PJ, et al. Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha. Circ Res 2008;102:1036-45.
-
(2008)
Circ Res
, vol.102
, pp. 1036-1045
-
-
Nemenoff, R.A.1
Simpson, P.A.2
Furgeson, S.B.3
Kaplan-Albuquerque, N.4
Crossno, J.5
Garl, P.J.6
-
210
-
-
77951798101
-
Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia
-
Jin Y, Calvert TJ, Chen B, Chicoine LG, Joshi M, Bauer JA, et al. Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia. Am J Physiol Heart Circ Physiol 2010;298:H1518-H1528.
-
(2010)
Am J Physiol Heart Circ Physiol
, vol.298
, pp. H1518-H1528
-
-
Jin, Y.1
Calvert, T.J.2
Chen, B.3
Chicoine, L.G.4
Joshi, M.5
Bauer, J.A.6
-
211
-
-
79251523863
-
Mitogen-activated protein kinase phosphatase-1 is a key regulator of hypoxia-induced vascular endothelial growth factor expression and vessel density in lung
-
Shields KM, Panzhinskiy E, Burns N, Zawada WM, Das M. Mitogen-activated protein kinase phosphatase-1 is a key regulator of hypoxia-induced vascular endothelial growth factor expression and vessel density in lung. Am J Pathol 2011;178:98-109.
-
(2011)
Am J Pathol
, vol.178
, pp. 98-109
-
-
Shields, K.M.1
Panzhinskiy, E.2
Burns, N.3
Zawada, W.M.4
Das, M.5
-
212
-
-
84863812038
-
Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis
-
Maurer B, Reich N, Juengel A, Kriegsmann J, Gay RE, Schett G, et al. Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis. Ann Rheum Dis 2012;71:1382-7.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 1382-1387
-
-
Maurer, B.1
Reich, N.2
Juengel, A.3
Kriegsmann, J.4
Gay, R.E.5
Schett, G.6
-
213
-
-
48749092428
-
Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1
-
Eferl R, Hasselblatt P, Rath M, Popper H, Zenz R, Komnenovic V, et al. Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. Proc Natl Acad Sci U S A 2008;105:10525-10530.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 10525-10530
-
-
Eferl, R.1
Hasselblatt, P.2
Rath, M.3
Popper, H.4
Zenz, R.5
Komnenovic, V.6
-
214
-
-
73449115656
-
Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis
-
Maurer B, Busch N, Jüngel A, Pileckyte M, Gay RE, Michel BA, et al. Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis. Circulation 2009;120:2367-76.
-
(2009)
Circulation
, vol.120
, pp. 2367-2376
-
-
Maurer, B.1
Busch, N.2
Jüngel, A.3
Pileckyte, M.4
Gay, R.E.5
Michel, B.A.6
-
215
-
-
30144434322
-
Cellular and molecular pathobiology of pulmonary hypertension conference summary
-
Rabinovitch M. Cellular and molecular pathobiology of pulmonary hypertension conference summary. Chest 2005;128:642S-646S.
-
(2005)
Chest
, vol.128
, pp. 642S-646S
-
-
Rabinovitch, M.1
-
216
-
-
25444527720
-
Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension
-
Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, et al. Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circ Res 2005;97:596-604.
-
(2005)
Circ Res
, vol.97
, pp. 596-604
-
-
Merklinger, S.L.1
Wagner, R.A.2
Spiekerkoetter, E.3
Hinek, A.4
Knutsen, R.H.5
Kabir, M.G.6
-
217
-
-
39549087002
-
Pulmonary arterial remodeling induced by a Th2 immune response
-
Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J, Kurup VP, et al. Pulmonary arterial remodeling induced by a Th2 immune response. J Exp Med 2008;205:361-72.
-
(2008)
J Exp Med
, vol.205
, pp. 361-372
-
-
Daley, E.1
Emson, C.2
Guignabert, C.3
De Waal Malefyt, R.4
Louten, J.5
Kurup, V.P.6
-
218
-
-
0022864244
-
Pulmonary arterial changes in patients with ventricular septal defects and severe pulmonary hypertension
-
Fried R, Falkovsky G, Newburger J, Gorchakova AI, Rabinovitch M, Gordonova MI, et al. Pulmonary arterial changes in patients with ventricular septal defects and severe pulmonary hypertension. Pediatr Cardiol 1986;7:147-54.
-
(1986)
Pediatr Cardiol
, vol.7
, pp. 147-154
-
-
Fried, R.1
Falkovsky, G.2
Newburger, J.3
Gorchakova, A.I.4
Rabinovitch, M.5
Gordonova, M.I.6
-
219
-
-
0021416477
-
Vascular structure in lung tissue obtained at biopsy correlated with pulmonary hemodynamic findings after repair of congenital heart defects
-
Rabinovitch M, Keane JF, Norwood WI, Castaneda AR, Reid L. Vascular structure in lung tissue obtained at biopsy correlated with pulmonary hemodynamic findings after repair of congenital heart defects. Circulation 1984;69:655-67.
-
(1984)
Circulation
, vol.69
, pp. 655-667
-
-
Rabinovitch, M.1
Keane, J.F.2
Norwood, W.I.3
Castaneda, A.R.4
Reid, L.5
-
220
-
-
0028282859
-
Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension
-
Tuder RM, Groves B, Badesch DB, Voelkel NF. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 1994;144:275-85.
-
(1994)
Am J Pathol
, vol.144
, pp. 275-285
-
-
Tuder, R.M.1
Groves, B.2
Badesch, D.B.3
Voelkel, N.F.4
-
221
-
-
0029062419
-
Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension
-
Humbert M, Monti G, Brenot F, Sitbon O, Portier A, Grangeot-Keros L, et al. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med 1995;151:1628-31.
-
(1995)
Am J Respir Crit Care Med
, vol.151
, pp. 1628-1631
-
-
Humbert, M.1
Monti, G.2
Brenot, F.3
Sitbon, O.4
Portier, A.5
Grangeot-Keros, L.6
-
222
-
-
4444374427
-
Decreased numbers of T-lymphocytes and predominance of recently recruited macrophages in the walls of peripheral pulmonary arteries from 26 patients with pulmonary hypertension secondary to congenital cardiac shunts
-
Pinto RF, Higuchi Mde L, Aiello VD. Decreased numbers of T-lymphocytes and predominance of recently recruited macrophages in the walls of peripheral pulmonary arteries from 26 patients with pulmonary hypertension secondary to congenital cardiac shunts. Cardiovasc Pathol 2004;13:268-75.
-
(2004)
Cardiovasc Pathol
, vol.13
, pp. 268-275
-
-
Pinto, R.F.1
Higuchi Mde, L.2
Aiello, V.D.3
-
223
-
-
33644824392
-
Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension
-
Itoh T, Nagaya N, Ishibashi-Ueda H, Kyotani S, Oya H, Sakamaki F, et al. Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension. Respirology 2006;11:158-63.
-
(2006)
Respirology
, vol.11
, pp. 158-163
-
-
Itoh, T.1
Nagaya, N.2
Ishibashi-Ueda, H.3
Kyotani, S.4
Oya, H.5
Sakamaki, F.6
-
224
-
-
36248952716
-
Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension
-
Sanchez O, Marcos E, Perros F, Fadel E, Tu L, Humbert M, et al. Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 2007;176:1041-7.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 1041-1047
-
-
Sanchez, O.1
Marcos, E.2
Perros, F.3
Fadel, E.4
Tu, L.5
Humbert, M.6
-
225
-
-
11144229675
-
Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels
-
Tormanen KR, Uller L, Persson CG, Erjefalt JS. Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels. Am J Respir Crit Care Med 2005;171:19-25.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 19-25
-
-
Tormanen, K.R.1
Uller, L.2
Persson, C.G.3
Erjefalt, J.S.4
-
226
-
-
41149092973
-
Remodeling of extra-bronchial lung vasculature following allergic airway inflammation
-
Rydell-Tormanen K, Uller L, Erjefalt JS. Remodeling of extra-bronchial lung vasculature following allergic airway inflammation. Respir Res 2008;9:18.
-
(2008)
Respir Res
, vol.9
, pp. 18
-
-
Rydell-Tormanen, K.1
Uller, L.2
Erjefalt, J.S.3
-
227
-
-
45849114330
-
Induction of vascular remodeling in the lung by chronic house dust mite exposure
-
Rydell-Tormanen K, Johnson JR, Fattouh R, Jordana M, Erjefalt JS. Induction of vascular remodeling in the lung by chronic house dust mite exposure. Am J Respir Cell Mol Biol 2008;39:61-7.
-
(2008)
Am J Respir Cell Mol Biol
, vol.39
, pp. 61-67
-
-
Rydell-Tormanen, K.1
Johnson, J.R.2
Fattouh, R.3
Jordana, M.4
Erjefalt, J.S.5
-
228
-
-
59849118025
-
Interleukin-6 overexpression induces pulmonary hypertension
-
Steiner MK, Syrkina OL, Kolliputi N, Mark EJ, Hales CA, Waxman AB. Interleukin-6 overexpression induces pulmonary hypertension. Circ Res 2009;104:236-44.
-
(2009)
Circ Res
, vol.104
, pp. 236-244
-
-
Steiner, M.K.1
Syrkina, O.L.2
Kolliputi, N.3
Mark, E.J.4
Hales, C.A.5
Waxman, A.B.6
-
229
-
-
0035902447
-
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
-
Minamino T, Christou H, Hsieh CM, Liu Y, Dhawan V, Abraham NG, et al. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A 2001;98:8798-803.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 8798-8803
-
-
Minamino, T.1
Christou, H.2
Hsieh, C.M.3
Liu, Y.4
Dhawan, V.5
Abraham, N.G.6
-
230
-
-
33144471139
-
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage
-
Frid MG, Brunetti JA, Burke DL, Carpenter TC, Davie NJ, Reeves JT, et al. Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Am J Pathol 2006;168:659-69.
-
(2006)
Am J Pathol
, vol.168
, pp. 659-669
-
-
Frid, M.G.1
Brunetti, J.A.2
Burke, D.L.3
Carpenter, T.C.4
Davie, N.J.5
Reeves, J.T.6
-
231
-
-
19844374754
-
Bone marrow-derived cells contribute to pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension
-
Hayashida K, Fujita J, Miyake Y, Kawada H, Ando K, Ogawa S, et al. Bone marrow-derived cells contribute to pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension. Chest 2005;127:1793-8.
-
(2005)
Chest
, vol.127
, pp. 1793-1798
-
-
Hayashida, K.1
Fujita, J.2
Miyake, Y.3
Kawada, H.4
Ando, K.5
Ogawa, S.6
-
232
-
-
34249074463
-
Chemokines in vascular remodeling
-
Schober A, Zernecke A. Chemokines in vascular remodeling. Thromb Haemost 2007;97:730-7.
-
(2007)
Thromb Haemost
, vol.97
, pp. 730-737
-
-
Schober, A.1
Zernecke, A.2
-
233
-
-
0031945938
-
Pulmonary hypertension in POEMS syndrome: A new feature mediated by cytokines
-
Lesprit P, Godeau B, Authier FJ, Soubrier M, Zuber M, Larroche C, et al. Pulmonary hypertension in POEMS syndrome: A new feature mediated by cytokines. Am J Respir Crit Care Med 1998;157:907-11.
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 907-911
-
-
Lesprit, P.1
Godeau, B.2
Authier, F.J.3
Soubrier, M.4
Zuber, M.5
Larroche, C.6
-
234
-
-
9644258488
-
Cytokine and chemokine levels in systemic sclerosis: Relationship with cutaneous and internal organ involvement
-
Scala E, Pallotta S, Frezzolini A, Abeni D, Barbieri C, Sampogna F, et al. Cytokine and chemokine levels in systemic sclerosis: Relationship with cutaneous and internal organ involvement. Clin Exp Immunol 2004;138:540-6.
-
(2004)
Clin Exp Immunol
, vol.138
, pp. 540-546
-
-
Scala, E.1
Pallotta, S.2
Frezzolini, A.3
Abeni, D.4
Barbieri, C.5
Sampogna, F.6
-
235
-
-
17444438249
-
Association of interleukin 6 release from endothelial cells and pulmonary hypertension in SLE
-
Yoshio T, Masuyama JI, Kohda N, Hirata D, Sato H, Iwamoto M, et al. Association of interleukin 6 release from endothelial cells and pulmonary hypertension in SLE. J Rheumatol 1997;24:489-95.
-
(1997)
J Rheumatol
, vol.24
, pp. 489-495
-
-
Yoshio, T.1
Masuyama, J.I.2
Kohda, N.3
Hirata, D.4
Sato, H.5
Iwamoto, M.6
-
236
-
-
61549104663
-
Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
-
Savale L, Tu L, Rideau D, Izziki M, Maitre B, Adnot S, et al. Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice. Respir Res 2009;10:6.
-
(2009)
Respir Res
, vol.10
, pp. 6
-
-
Savale, L.1
Tu, L.2
Rideau, D.3
Izziki, M.4
Maitre, B.5
Adnot, S.6
-
237
-
-
70349160768
-
Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling
-
Medoff BD, Okamoto Y, Leyton P, Weng M, Sandall BP, Raher MJ, et al. Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol 2009;41:397-406.
-
(2009)
Am J Respir Cell Mol Biol
, vol.41
, pp. 397-406
-
-
Medoff, B.D.1
Okamoto, Y.2
Leyton, P.3
Weng, M.4
Sandall, B.P.5
Raher, M.J.6
-
238
-
-
82855167219
-
Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension
-
Weng M, Baron DM, Bloch KD, Luster AD, Lee JJ, Medoff BD. Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2011;301:L927-L936.
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.301
, pp. L927-L936
-
-
Weng, M.1
Baron, D.M.2
Bloch, K.D.3
Luster, A.D.4
Lee, J.J.5
Medoff, B.D.6
-
239
-
-
1542784420
-
S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy
-
Greenway S, van Suylen RJ, Du Marchie Sarvaas G, Kwan E, Ambartsumian N, Lukanidin E, et al. S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy. Am J Pathol 2004;164:253-62.
-
(2004)
Am J Pathol
, vol.164
, pp. 253-262
-
-
Greenway, S.1
Van Suylen, R.J.2
Du Marchie Sarvaas, G.3
Kwan, E.4
Ambartsumian, N.5
Lukanidin, E.6
-
240
-
-
77957035915
-
Dysregulation of the IL-13 receptor system: A novel pathomechanism in pulmonary arterial hypertension
-
Hecker M, Zaslona Z, Kwapiszewska G, Niess G, Zakrzewicz A, Hergenreider E, et al. Dysregulation of the IL-13 receptor system: A novel pathomechanism in pulmonary arterial hypertension. Am J Respir Crit Care Med 2010;182:805-18.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 805-818
-
-
Hecker, M.1
Zaslona, Z.2
Kwapiszewska, G.3
Niess, G.4
Zakrzewicz, A.5
Hergenreider, E.6
-
241
-
-
77952729147
-
Pulmonary hypertension is ameliorated in mice deficient in thrombin-activatable fibrinolysis inhibitor
-
Qin L, D’Alessandro-Gabazza CN, Aoki S, Gil-Bernabe P, Yano Y, Takagi T, et al. Pulmonary hypertension is ameliorated in mice deficient in thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost 2010;8:808-16.
-
(2010)
J Thromb Haemost
, vol.8
, pp. 808-816
-
-
Qin, L.1
D’alessandro-Gabazza, C.N.2
Aoki, S.3
Gil-Bernabe, P.4
Yano, Y.5
Takagi, T.6
-
242
-
-
56649122070
-
The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation
-
Said SI. The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation. Ann N Y Acad Sci 2008;1144:148-53.
-
(2008)
Ann N Y Acad Sci
, vol.1144
, pp. 148-153
-
-
Said, S.I.1
-
243
-
-
84857987240
-
Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice
-
Mushaben EM, Hershey GK, Pauciulo MW, Nichols WC, Le Cras TD. Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice. PLoS One 2012;7:e32468.
-
(2012)
Plos One
, vol.7
-
-
Mushaben, E.M.1
Hershey, G.K.2
Pauciulo, M.W.3
Nichols, W.C.4
Le Cras, T.D.5
-
244
-
-
79959991944
-
Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice
-
Hara Y, Sassi Y, Guibert C, Gambaryan N, Dorfmüller P, Eddahibi S, et al. Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. J Clin Invest 2011;121:2888-97.
-
(2011)
J Clin Invest
, vol.121
, pp. 2888-2897
-
-
Hara, Y.1
Sassi, Y.2
Guibert, C.3
Gambaryan, N.4
Dorfmüller, P.5
Eddahibi, S.6
-
245
-
-
0043132421
-
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
-
Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, et al. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A 2003;100:9244-9.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 9244-9249
-
-
Reid, G.1
Wielinga, P.2
Zelcer, N.3
Van Der Heijden, I.4
Kuil, A.5
De Haas, M.6
-
246
-
-
64249164802
-
Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs
-
Oevermann L, Scheitz J, Starke K, Köck K, Kiefer T, Dölken G, et al. Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs. Int J Cancer 2009;124:2303-11.
-
(2009)
Int J Cancer
, vol.124
, pp. 2303-2311
-
-
Oevermann, L.1
Scheitz, J.2
Starke, K.3
Köck, K.4
Kiefer, T.5
Dölken, G.6
-
247
-
-
0028676054
-
Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline
-
Voelkel NF, Tuder RM, Bridges J, Arend WP. Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Am J Respir Cell Mol Biol 1994;11:664-75.
-
(1994)
Am J Respir Cell Mol Biol
, vol.11
, pp. 664-675
-
-
Voelkel, N.F.1
Tuder, R.M.2
Bridges, J.3
Arend, W.P.4
-
248
-
-
0033157383
-
Monocrotaline induces interleukin-6 mRNA expression in rat lungs
-
Bhargava A, Kumar A, Yuan N, Gewitz MH, Mathew R. Monocrotaline induces interleukin-6 mRNA expression in rat lungs. Heart Dis 1999;1:126-32.
-
(1999)
Heart Dis
, vol.1
, pp. 126-132
-
-
Bhargava, A.1
Kumar, A.2
Yuan, N.3
Gewitz, M.H.4
Mathew, R.5
-
249
-
-
0022002405
-
Effect of methyl prednisoloneon monocrotaline-induced pulmonary vascular disease and right ventricular hypertrophy
-
Langleben D, Reid LM. Effect of methyl prednisoloneon monocrotaline-induced pulmonary vascular disease and right ventricular hypertrophy. Lab Invest 1985;52:298-303.
-
(1985)
Lab Invest
, vol.52
, pp. 298-303
-
-
Langleben, D.1
Reid, L.M.2
-
250
-
-
34547456414
-
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
-
Bonnet S, Rochefort G, Sutendra G, Archer SL, Haromy A, Webster L, et al. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A 2007;104:11418-23.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 11418-11423
-
-
Bonnet, S.1
Rochefort, G.2
Sutendra, G.3
Archer, S.L.4
Haromy, A.5
Webster, L.6
-
251
-
-
0036839051
-
Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats
-
Ikeda Y, Yonemitsu Y, Kataoka C, Kitamoto S, Yamaoka T, Nishida K, et al. Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats. Am J Physiol Heart Circ Physiol 2002;283:H2021-H2028.
-
(2002)
Am J Physiol Heart Circ Physiol
, vol.283
, pp. H2021-H2028
-
-
Ikeda, Y.1
Yonemitsu, Y.2
Kataoka, C.3
Kitamoto, S.4
Yamaoka, T.5
Nishida, K.6
-
252
-
-
33748439778
-
Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats
-
Suzuki C, Takahashi M, Morimoto H, Izawa A, Ise H, Hongo M, et al. Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats. Biochem Biophys Res Commun 2006;349:781-8.
-
(2006)
Biochem Biophys Res Commun
, vol.349
, pp. 781-788
-
-
Suzuki, C.1
Takahashi, M.2
Morimoto, H.3
Izawa, A.4
Ise, H.5
Hongo, M.6
-
253
-
-
0024336827
-
Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension
-
Kato T, Kitamura H, Kanisawa M. Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension. Exp Mol Pathol 1989;50:303-15.
-
(1989)
Exp Mol Pathol
, vol.50
, pp. 303-315
-
-
Kato, T.1
Kitamura, H.2
Kanisawa, M.3
-
254
-
-
79953690566
-
Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats
-
Price LC, Montani D, Tcherakian C, Dorfmüller P, Souza R, Gambaryan N, et al. Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats. Eur Respir J 2011;37:813-22.
-
(2011)
Eur Respir J
, vol.37
, pp. 813-822
-
-
Price, L.C.1
Montani, D.2
Tcherakian, C.3
Dorfmüller, P.4
Souza, R.5
Gambaryan, N.6
|