Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 5, 2010, Pages

  Jin, Yi ^a   Calvert, Thomas J ^a   Chen, Bernadette ^a   Chicoine, Louis G ^a   Joshi, Mandar ^a   Bauer, John Anthony ^a   Liu, Yusen ^a   Nelin, Leif D ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Arginase; Nitric oxide synthase; Pulmonary vascular remodeling

Indexed keywords

ARGINASE; ARGINASE 1; ARGINASE II; CYCLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE; PHOSPHATASE; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GENOTYPE; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE PRESSURE; HEART VENTRICLE SEPTUM; HYPOXIA; LUNG PROTEIN LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; ANOXIA; ARGINASE; BLOTTING, WESTERN; BODY WEIGHT; CHRONIC DISEASE; DUAL SPECIFICITY PHOSPHATASE 1; HYPERTENSION, PULMONARY; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; NITRATES; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEINS; VENTRICULAR FUNCTION, RIGHT;

EID: 77951798101     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00813.2009     Document Type: Article

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