Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

Journal of Clinical Investigation

Volumn 115, Issue 6, 2005, Pages 1479-1491

  McMurtry, M Sean ^a   Archer, Stephen L ^a   Altieri, Dario C ^b   Bonnet, Sebastien ^a   Haromy, Alois ^a   Harry, Gwyneth ^a   Bonnet, Sandra ^a   Puttagunta, Lakshmi ^a   Michelakis, Evangelos D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; APOPTOSIS INDUCING FACTOR; CYTOCHROME C; MONOCROTALINE; POTASSIUM CHANNEL; SURVIVIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENE THERAPY; HEART RIGHT VENTRICLE HYPERTROPHY; HYPERTROPHY; ION CURRENT; LUNG BLOOD VESSEL; LUNG VASCULAR RESISTANCE; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME;

ADENOVIRIDAE; ADULT; ANIMALS; APOPTOSIS; CYTOCHROMES C; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GENE THERAPY; GENES, DOMINANT; HUMANS; HYPERTENSION, PULMONARY; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MITOCHONDRIA; MUSCLE, SMOOTH, VASCULAR; MUTATION; NEOPLASM PROTEINS; POTASSIUM CHANNELS, VOLTAGE-GATED; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR RESISTANCE;

EID: 20444483234     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI23203     Document Type: Article

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