The pulmonary hypertensive fawn-hooded rat has a normal serotonin transporter coding sequence

American Journal of Respiratory Cell and Molecular Biology

Volumn 19, Issue 2, 1998, Pages 245-249

  Gonzalez, Ana Maria ^a   Smith, Adrian P L ^a   Emery, Celia J ^a   Higenbottam, Timothy W ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RATTUS NORVEGICUS;

CARRIER PROTEIN; COMPLEMENTARY DNA; MEMBRANE PROTEIN; NERVE PROTEIN; PRIMER DNA; SEROTONIN; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN; SLC6A4 PROTEIN, RAT;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; GENETICS; HUMAN; MALE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PULMONARY HYPERTENSION; RAT; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; THROMBOCYTE; THROMBOCYTE DISORDER; WISTAR RAT;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOOD PLATELETS; CARRIER PROTEINS; DNA PRIMERS; DNA, COMPLEMENTARY; HUMANS; HYPERTENSION, PULMONARY; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PLATELET STORAGE POOL DEFICIENCY; RATS; RATS, WISTAR; SEQUENCE HOMOLOGY, AMINO ACID; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPECIES SPECIFICITY;

EID: 0032132874     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.19.2.3073     Document Type: Article

References (36)

1. Dinh Xuan, A. T., T. W. Higenbottam, J. P. Scott, and J. Wallwork. 1990. Primary pulmonary hypertension: diagnosis, medical and surgical treatment. Respir. Med. 84:189-197.
2. Nichols, W. C., D. L. Koller, B. Slovis, T. Foroud, V. H. Terry, N. D. Arnold, D. R. Siemieniak, L. Wheeler, J. A. Phillips, III. J. H. Newman, P. M. Conneally, D. Ginsburg, and J. E. Loyd. 1997. Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32. Nat. Genet. 15:277-280.
3. Herve, P., L. Drouet, C. Dosquet, J. M. Launay, B. Rain, G. Simonneau, J. Caen, and P. Duroux. 1990. Primary pulmonary hypertension in a patient with a familial platelet storage pool disease: role of serotonin. Am. J. Med. 89:117-120.
4. Herve, P., J. M. Launay, M. L. Scrobohaci, F. Brenot, G. Simonneau, P. Petitpretz, P. Poubeau, J. Cerrina, P. Duroux, and L. Drouet. 1995. Increased plasma serotonin in primary pulmonary hypertension. Am. J. Med. 99:249-254.
5. Brenot, F., P. Herve, P. Petitpretz, F. Parent, P. Duroux, and G. Simonneau. 1993. Primary pulmonary hypertension and fenfluramine use. Br. Heart J. 70:537-541.
6. Abenhaim, L., Y. Moride, F. Brenot, S. Rich, J. Benichou, X. Kurz, T. Higenbottam, C. Oakley, E. Wouters, M. Aubier, G. Simonneau, and B. Begaud. 1996. Appetite-suppressant drugs and the risk of primary pulmonary hypertension: International Primary Pulmonary Hypertension Study Group. N. Engl. J. Med. 335:609-616.
7. Rattray, M., G. Wotherspoon, D. Savery, S. Baldessari, C. Marden, J. V. Priestley, and C. Bendotti. 1994. Chronic D-fenfluramine decreases serotonin transporter messenger RNA expression in dorsal raphe nucleus. Eur. J. Pharmacol. 268:439-442.
8. Brown, D. M., A. P. Provoost, M. J. Daly, E. S. Lander, and H. J. Jacob. 1996. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat. Genet. 12:44-51.
9. Kuijpers, M. H., A. P. Provoost, and W. de Jong. 1986. Development of hypertension and proteinuria with age in fawn-hooded rats. Clin. Exp. Pharmacol. Physiol. 13:201-209.
10. Aulakh, C. S., T. Tolliver, K. M. Wozniak, J. L. Hill, and D. L. Murphy. 1994. Functional and biochemical evidence for altered serotonergic function in the fawn-hooded rat strain. Pharmacol. Biochem. Behav. 49:615-620.
11. Tschopp, T. B., and M. B. Zucker. 1972. Hereditary defect in platelet function in rats. Blood 40:217-226.
12. Sato, K., S. Webb, A. Tucker, M. Rabinovitch, R. F. O'Brien, I. F. McMurtry, and T. J. Stelzner. 1992. Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat. Am. Rev. Respir. Dis. 145:793-797.
13. Lesch, K. P., U. Balling, J. Gross, K. Strauss, B. L. Wolozin, D. L. Murphy, and P. Riederer. 1994. Organization of the human serotonin transporter gene. J. Neural Transm. Gen. Sect. 95:157-162.
14. Gregor, P., A. Patel, S. Shimada, C. L. Lin, J. M. Rochelle, S. Kitayama, M. F. Seldin, and G. R. Uhl. 1993. Murine serotonin transporter: sequence and localization to chromosome 11. Mamm. Genome 4:283-284.
15. 3H]5-hydroxytryptamine induced by d-fenfluramine in rat hippocampal synaptosomes. Eur. J. Pharmacol. 238:9-17.
16. Weir, E. K., H. L. Reeve, J. M. Huang, E. Michelakis, D. P. Nelson, V. Hampl, and S. L. Archer. 1996. Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. Circulation 94:2216-2220.
17. Miyamoto, J. K., E. Uezu, T. Yusa, and S. Terashima. 1990. Efflux of 5-HIAA from 5-HT neurons: a membrane potential-dependent process. Physiol. Behav. 47:767-772.
18. Pei, Q., R. A. Leslie, D. G. Grahame Smith, and T. S. Zetterstrom. 1995. 5-HT efflux from rat hippocampus in vivo produced by 4-aminopyridine is increased by chronic lithium administration. Neuroreport 6:716-720.
19. Semple Rowland, S. L., A. Mahatme, and N. E. Rowland. 1996. Effects of dexfenfluramine or 5.7-dihydroxytryptamine on tryptophan hydroxylase and serotonin transporter mRNAS in rat dorsal raphe. Mol. Brain Res. 41:121-127.
20. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Press. Cold Spring Harbor, NY.
21. Steinberg, H., and D. K. Das. 1980. Competition between platelets and lung for 5-hydroxytryptamine uptake. Exp. Lung Res. 1:121-130.
22. Lesch, K. P., C. S. Aulakh, B. L. Wolozin, T. J. Tolliver, J. L. Hill, and D. L. Murphy. 1993. Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. Mol. Brain Res. 17:31-35.
23. Blakely, R. D., H. E. Berson, R. T. Fremeau, Jr., M. G. Caron, M. M. Peek, H. K. Prince, and C. C. Bradley. 1991. Cloning and expression of a functional serotonin transporter from rat brain. Nature 354:66-70.
24. Hoffman, B. J., E. Mezey, and M. J. Brownstein. 1991. Cloning of a serotonin transporter affected by antidepressants. Science 254:579-580.
25. Gelernter, J., A. J. Pakstis, and K. K. Kidd. 1995. Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17. Hum. Genet. 95:677-680.
26. Hranilovic, D., K. P. Lesch, D. Ugarkovic, L. Cicin Sain, and B. Jernej. 1996. Identification of serotonin transporter mRNA in rat platelets. J. Neural Transm. 103:957-965.
27. Ramamoorthy, S., A. L. Bauman, K. R. Moore, H. Han, T. Yang Feng, A. S. Chang, V. Ganapathy, and R. D. Blakely. 1993. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc. Natl. Acad. Sci. USA 90:2542-2546.
28. Wade, P. R., J. Chen, B. Jaffe, I. S. Kassem, R. D. Blakely, and M. D. Gershon. 1996. Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J. Neurosci. 16:2352-2364.
29. McMillen, B. A., and H. L. Williams. 1995. Volitional consumption of ethanol by fawn-hooded rats: effects of alternative solutions and drug treatments. Alcohol 12:345-350.
30. Overstreet, D. H., and A. H. Rezvani. 1996. Behavioral differences between two inbred strains of Fawn-hooded rat: a model of serotonin dysfunction. Psychopharmacology (Berl.) 128:328-330.
31. Ogilvie, A. D., S. Battersby, V. J. Bubb, G. Fink, A. J. Harmar, G. M. Goodwim, and C. A. Smith. 1996. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347:731-733.
32. Sogni, P., A. P. L. Smith, A. Gadano, D. Lebrec, and T. W. Higenbottam. 1997. Induction of nitric oxide synthase II does not account for excess vascular nitric oxide production in experimental cirrhosis. J. Hepatol. 26:1120-1127.
33. Prieur, D. J., and K. M. Meyers. 1984. Genetics of the fawn-hooded rat strain: the coat color dilution and platelet storage pool deficiency are pleiotropic effects of the autosomal recessive red-eyed dilution gene. J. Hered. 75:349-352.
34. Kentera, D., D. Susic, V. Veljkovic, G. Tucakovic, and V. Koko. 1988. Pulmonary artery pressure in rats with hereditary platelet function defect. Respiration 54:110-114.
35. Stelzner, T. J., R. F. O'Brien, M. Yanagisawa, T. Sakurai, K. Sato, S. Webb, M. Zamora, I. F. McMurtry, and J. H. Fisher. 1992. Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension. Am. J. Physiol 262:L614-L620.
36. Kirchmaier, C. M., M. Meyer, P. Spangenberg, R. Heller, D. Haroske, H. K. Breddin, and U. Till. 1990. Platelet membrane defects in fawn hooded bleeder rats. Thromb. Res. 57:353-360.