Bringing down the ROS: A new therapeutic approach for PPHN

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 295, Issue 6, 2008, Pages

  Firth, Amy L ^a   Yuan, Jason X J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

FETUS LUNG; HUMAN; LUNG CIRCULATION; LUNG GAS EXCHANGE; NEWBORN DISEASE; OXYGEN THERAPY; PERSISTENT PULMONARY HYPERTENSION; PRIORITY JOURNAL; REVIEW;

BIOPTERIN; EXTRACORPOREAL MEMBRANE OXYGENATION; HUMANS; INFANT, NEWBORN; LUNG; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXYGEN; PERSISTENT FETAL CIRCULATION SYNDROME; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; VASODILATION;

EID: 57149113351     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90515.2008     Document Type: Review

References (15)

1. Cornfield DN, Resnik ER, Herron JM, Abman SH. Chronic intrauterine pulmonary hypertension decreases calcium-sensitive potassium channel mRNA expression. Am J Physiol Lung Cell Mol Physiol 279: L857-L862, 2000.
2. Deruelle P, Grover TR, Abman SH. Pulmonary vascular effects of nitric oxide-cGMP augmentation in a model of chronic pulmonary hypertension in fetal and neonatal sheep. Am J Physiol Lung Cell Mol Physiol 289:L798-L806, 2005.
3. Farrow KN, Lakshminrusimha S, Reda WJ, Wedgwood S, Czech L, Gugino SF, Davis JM, Russell JA, Steinhorn RH. Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (September 12, 2008).
4. Grover TR, Parker TA, Markham NE, Abman SH. rhVEGF treatment preserves pulmonary vascular reactivity and structure in an experimental model of pulmonary hypertension in fetal sheep. Am J Physiol Lung Cell Mol Physiol 289: L315-L321, 2005.
5. Hanson KA, Ziegler JW, Rybalkin SD, Miller JW, Abman SH, Clarke WR. Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity. Am J Physiol Lung Cell Mol Physiol 275: L931-L941, 1998.
6. Kinsella JP, Neish SR, Shaffer E, Abman SH. Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 340: 819-820, 1992.
7. Konduri GG, Bakhutashvili I, Eis A, Pritchard K Jr. Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension. Am J Physiol Heart Circ Physiol 292: H1812-H1820, 2007.
8. Mukherjee A, Dombi T, Wittke B, Lalonde R. Population pharmacokinetics of sildenafil in term neonates: evidence of rapid maturation of metabolic clearance in the early postnatal period. Clin Pharmacol Ther. In press.
9. 2 sensitivity is decreased in an ovine PPHN model. Am J Physiol Lung Cell Mol Physiol 283: L1103-L1109, 2002.
10. Roberts JD, Polaner DM, Lang P, Zapol WM. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 340: 818-819, 1992.
11. Shah PS, Ohlsson A. Sildenafil for pulmonary hypertension in neonates. Cochrane Database Syst Rev: CD005494, 2007.
12. Steinhorn RH, Albert G, Swartz DD, Russell JA, Levine CR, Davis JM. Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension. Am J Respir Crit Care Med 164: 834-839, 2001.
13. Tourneux P, Chester MA, Grover TR, Abman S. Fasudil inhibits the myogenic response in the fetal pulmonary circulation. Am J Physiol Heart Circ Physiol 295: H1505-H1513, 2008.
14. Wedgwood S, Black SM. Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide. Am J Physiol Lung Cell Mol Physiol 288: L480-L487, 2005.
15. Wedgwood S, Steinhorn RH, Bunderson M, Wilham J, Lakshminrusimha S, Brennan LA, Black SM. Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol 289: L660-L666, 2005.