The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: Resuscitating the hibernating right ventricle

Journal of Molecular Medicine

Volumn 88, Issue 1, 2010, Pages 47-60

  Piao, Lin ^a   Fang, Yong Hu ^a   Cadete, Virgilio J J ^b   Wietholt, Christian ^a   Urboniene, Dalia ^a   Toth, Peter T ^a   Marsboom, Glenn ^a   Zhang, Hannah J ^a   Haber, Idith ^a   Rehman, Jalees ^a   Lopaschuk, Gary D ^b   Archer, Stephen L ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Mitochondrial metabolism; Pulmonary artery banding; Pulmonic stenosis; Voltage gated potassium channels (Kv); Warburg hypothesis

Indexed keywords

DICHLOROACETIC ACID; FLUORODEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER 1; MONOCROTALINE; OXYGEN; PYRUVATE DEHYDROGENASE; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GLUCOSE OXIDATION; GLYCOLYSIS; HEART DISEASE; HEART REPOLARIZATION; HEART RIGHT VENTRICLE HYPERTROPHY; LUNG ARTERY BANDING; MALE; MUSCLE CELL; NONHUMAN; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; QT INTERVAL; RAT;

ANIMALS; HEART VENTRICLES; HEMODYNAMICS; HUMANS; HYPERTROPHY, RIGHT VENTRICULAR; MALE; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 75749133554     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0524-6     Document Type: Article

References (37)

1. S Bonnet ED Michelakis CJ Porter MA Andrade-Navarro B Thebaud A Haromy G Harry R Moudgil MS McMurtry EK Weir SL Archer 2006 An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension Circulation 113 2630 2641 10.1161/CIRCULATIONAHA.105.609008 1:CAS:528:DC%2BD28XltFWgtbk%3D 16735674 (Pubitemid 43948012)
2. SA van Wolferen JT Marcus A Boonstra KM Marques JG Bronzwaer MD Spreeuwenberg PE Postmus A Vonk-Noordegraaf 2007 Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension Eur Heart J 28 1250 1257 10.1093/eurheartj/ehl477 17242010 (Pubitemid 47343830)
3. MH Hessel P Steendijk B den Adel CI Schutte A van der Laarse 2006 Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat Am J Physiol Heart Circ Physiol 291 H2424 H2430 10.1152/ajpheart.00369.2006 1:CAS:528:DC%2BD28Xht1Gnsb%2FJ 16731643 (Pubitemid 44776673)
4. RR Lamberts E Caldenhoven M Lansink G Witte RJ Vaessen JA St Cyr GJ Stienen 2007 Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats Am J Physiol Heart Circ Physiol 293 H1869 H1876 10.1152/ajpheart.00294.2007 1:CAS:528:DC%2BD2sXhtVOqtrjE 17604325 (Pubitemid 47367237)
5. JK Lee I Kodama H Honjo T Anno K Kamiya J Toyama 1997 Stage-dependent changes in membrane currents in rats with monocrotaline-induced right ventricular hypertrophy Am J Physiol 272 H2833 H2842 1:CAS:528: DyaK2sXksVSkurg%3D 9227563
6. JK Lee A Nishiyama F Kambe H Seo S Takeuchi K Kamiya I Kodama J Toyama 1999 Downregulation of voltage-gated K(+) channels in rat heart with right ventricular hypertrophy Am J Physiol 277 H1725 H1731 1:CAS:528: DyaK1MXns1yrs7o%3D 10564125
7. TT Zhang B Cui DZ Dai 2004 Downregulation of Kv4.2 and Kv4.3 channel gene expression in right ventricular hypertrophy induced by monocrotaline in rat Acta Pharmacol Sin 25 226 230 1:CAS:528:DC%2BD2cXhsVSqsbk%3D 14769214
8. T Hlaing D Guo X Zhao T DiMino L Greenspon PR Kowey GX Yan 2005 The QT and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension J Electrocardiol 38 154 158 10.1016/j.jelectrocard.2005.06.028 16226092 (Pubitemid 41436505)
9. L De Ambroggi P Francia G De Ambroggi 2007 Repolarization abnormalities and arrhythmogenesis in hypertrophic myocardium Anadolu Kardiyol Derg 7 Suppl 1 71 72 17584686
10. R Kaprielian AD Wickenden Z Kassiri TG Parker PP Liu PH Backx 1999 Relationship between K+channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction J Physiol 517 Pt 1 229 245 10.1111/j.1469-7793.1999.0229z.x 1:CAS:528:DyaK1MXjvVelsrs%3D 10226162 (Pubitemid 29243484)
11. EH Wood 2000 Action potential control of cardiac contractility Ann Biomed Eng 28 860 870 10.1114/1.1313772 1:STN:280:DC%2BD3M7hsFansg%3D%3D 11144669 (Pubitemid 32085370)
12. DM Harris GD Mills X Chen H Kubo RM Berretta VS Votaw LF Santana SR Houser 2005 Alterations in early action potential repolarization causes localized failure of sarcoplasmic reticulum Ca2+ release Circ Res 96 543 550 10.1161/01.RES.0000158966.58380.37 1:CAS:528:DC%2BD2MXitFCgsb8%3D 15705962 (Pubitemid 40463463)
13. M Oikawa Y Kagaya H Otani M Sakuma J Demachi J Suzuki T Takahashi J Nawata T Ido J Watanabe K Shirato 2005 Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol J Am Coll Cardiol 45 1849 1855 10.1016/j.jacc.2005.02.065 1:CAS:528:DC%2BD2MXpsVCqt7g%3D 15936618 (Pubitemid 40779867)
14. S Basu S Alzeair G Li S Dadparvar A Alavi 2007 Etiopathologies associated with intercostal muscle hypermetabolism and prominent right ventricle visualization on 2-deoxy-2[F-18]fluoro-D-glucose-positron emission tomography: significance of an incidental finding and in the setting of a known pulmonary disease Mol Imaging Biol 9 333 339 10.1007/s11307-007-0102-7 17610018
15. NS Hill P Jederlinic J Gagnon 1989 Supplemental oxygen reduces right ventricular hypertrophy in monocrotaline-injected rats J Appl Physiol 66 1642 1648 1:CAS:528:DyaL1MXktVGitbk%3D 2525121
16. W Xu T Koeck AR Lara D Neumann FP DiFilippo M Koo AJ Janocha FA Masri AC Arroliga C Jennings RA Dweik RM Tuder DJ Stuehr SC Erzurum 2007 Alterations of cellular bioenergetics in pulmonary artery endothelial cells Proc Natl Acad Sci U S A 104 1342 1347 10.1073/pnas.0605080104 1:CAS:528:DC%2BD2sXht12hs7o%3D 17227868 (Pubitemid 46184006)
17. TR Knoechel AD Tucker CM Robinson C Phillips W Taylor PJ Bungay SA Kasten TE Roche DG Brown 2006 Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands Biochemistry 45 402 415 10.1021/bi051402s 1:CAS:528:DC%2BD2MXhtlajtr7L 16401071 (Pubitemid 43100407)
18. ED Michelakis MS McMurtry XC Wu JR Dyck R Moudgil TA Hopkins GD Lopaschuk L Puttagunta R Waite SL Archer 2002 Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels Circulation 105 244 250 10.1161/hc0202.101974 1:CAS:528:DC%2BD38XhsFeksL0%3D 11790708 (Pubitemid 34084326)
19. S Bonnet SL Archer J Allalunis-Turner A Haromy C Beaulieu R Thompson CT Lee GD Lopaschuk L Puttagunta G Harry K Hashimoto CJ Porter MA Andrade B Thebaud ED Michelakis 2007 A mitochondria-K+channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth Cancer Cell 11 37 51 10.1016/j.ccr.2006.10.020 1:CAS:528:DC%2BD2sXhtFClsLg%3D 17222789 (Pubitemid 46054520)
20. MF Allard BO Schonekess SL Henning DR English GD Lopaschuk 1994 Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts Am J Physiol 267 H742 H750 1:CAS:528:DyaK2cXlslKmsLk%3D 8067430
21. RB Wambolt GD Lopaschuk RW Brownsey MF Allard 2000 Dichloroacetate improves postischemic function of hypertrophied rat hearts J Am Coll Cardiol 36 1378 1385 10.1016/S0735-1097(00)00856-1 1:CAS:528:DC%2BD3cXnvV2hu7o%3D 11028498 (Pubitemid 30760609)
22. GJ Rozanski Z Xu K Zhang KP Patel 1998 Altered K+current of ventricular myocytes in rats with chronic myocardial infarction Am J Physiol 274 H259 H265 1:CAS:528:DyaK1cXnsFOiug%3D%3D 9458875
23. BC Knollmann AN Katchman MR Franz 2001 Monophasic action potential recordings from intact mouse heart: validation, regional heterogeneity, and relation to refractoriness J Cardiovasc Electrophysiol 12 1286 1294 10.1046/j.1540-8167.2001.01286.x 1:STN:280:DC%2BD38%2FjtlKhuw%3D%3D 11761418
24. B Liu AS Clanachan R Schulz GD Lopaschuk 1996 Cardiac efficiency is improved after ischemia by altering both the source and fate of protons Circ Res 79 940 948 1:CAS:528:DyaK28XmsFGlsL4%3D 8888686
25. RL Barr GD Lopaschuk 2000 Methodology for measuring in vitro/ex vivo cardiac energy metabolism J Pharmacol Toxicol Methods 43 141 152 10.1016/S1056-8719(00)00096-4 1:CAS:528:DC%2BD3MXitlOqtw%3D%3D 11150742 (Pubitemid 32057036)
26. ED Abel 2004 Glucose transport in the heart Front Biosci 9 201 215 10.2741/1216 1:CAS:528:DC%2BD2cXhtFCkurs%3D 14766360
27. S Sharma H Taegtmeyer J Adrogue P Razeghi S Sen K Ngumbela MF Essop 2004 Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy Am J Physiol Heart Circ Physiol 286 H1185 H1192 10.1152/ajpheart. 00916.2003 1:CAS:528:DC%2BD2cXitlShtrk%3D 14630626
28. RB Kleiman SR Houser 1989 Outward currents in normal and hypertrophied feline ventricular myocytes Am J Physiol 256 H1450 H1461 1:STN:280: DyaL1M3ksFSgsg%3D%3D 2524172
29. J Nagendran V Gurtu DZ Fu JR Dyck A Haromy DB Ross IM Rebeyka ED Michelakis 2008 A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted J Thorac Cardiovasc Surg 136 168 178 10.1016/j.jtcvs.2008.01.040 18603070 178 e161-163
30. MC Sugden ML Langdown RA Harris MJ Holness 2000 Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply Biochem J 352 Pt 3 731 738 10.1042/0264-6021:3520731 1:CAS:528:DC%2BD3MXkvVSltQ%3D%3D 11104680 (Pubitemid 32015029)
31. B Clarke KM Wyatt JG McCormack 1996 Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: evidence for an indirect mechanism J Mol Cell Cardiol 28 341 350 10.1006/jmcc.1996.0032 1:CAS:528:DyaK28Xht1emsLk%3D 8729066 (Pubitemid 26110478)
32. P Schott SS Singer H Kogler D Neddermeier K Leineweber OE Brodde V Regitz-Zagrosek B Schmidt H Dihazi G Hasenfuss 2005 Pressure overload and neurohumoral activation differentially affect the myocardial proteome Proteomics 5 1372 1381 10.1002/pmic.200401005 1:CAS:528:DC%2BD2MXjtlSjurw%3D 15732135
33. CP Lydell A Chan RB Wambolt N Sambandam H Parsons GP Bondy B Rodrigues KM Popov RA Harris RW Brownsey MF Allard 2002 Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts Cardiovasc Res 53 841 851 10.1016/S0008-6363(01)00560-0 1:CAS:528:DC%2BD38Xitlaqtbo%3D 11922894 (Pubitemid 34261022)
34. B Swynghedauw C Baillard P Milliez 2003 The long QT interval is not only inherited but is also linked to cardiac hypertrophy J Mol Med 81 336 345 12750820
35. D Saito T Shiraki K Inoue A Kajiyama S Takemoto S Hori T Takamura H Kono 1996 Reduced vasodilator response of the right coronary artery to myocardial ischemia in the hypertrophied right ventricle Jpn Circ J 60 247 253 10.1253/jcj.60.247 1:STN:280:DyaK28zksVWmsA%3D%3D 8726173 (Pubitemid 26185449)
36. PW Stacpoole DS Kerr C Barnes ST Bunch PR Carney EM Fennell NM Felitsyn RL Gilmore M Greer GN Henderson AD Hutson RE Neiberger RG O'Brien LA Perkins RG Quisling AL Shroads JJ Shuster JH Silverstein DW Theriaque E Valenstein 2006 Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children Pediatrics 117 1519 1531 10.1542/peds.2005-1226 16651305 (Pubitemid 46071378)
37. PR Bakerman KR Stenmark JH Fisher 1990 Alpha-skeletal actin messenger RNA increases in acute right ventricular hypertrophy Am J Physiol 258 L173 L178 1:CAS:528:DyaK3cXitlehurk%3D 2139762