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Volumn 88, Issue 10, 2010, Pages 1011-1020

Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure

Author keywords

Action potential duration; Dichloroacetate; Fatty acid oxidation inhibitors; Myc; Pyruvate dehydrogenase kinase

Indexed keywords

DICHLOROACETIC ACID; MONOCROTALINE;

EID: 78149415338     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-010-0679-1     Document Type: Review
Times cited : (127)

References (53)
  • 1
    • 77953520985 scopus 로고    scopus 로고
    • Prognostic factors of acute heart failure in patients with pulmonary arterial hypertension
    • 1:STN:280:DC%2BC3czntlOjtQ%3D%3D 10.1183/09031936.00070209 19897557
    • B Sztrymf R Souza L Bertoletti X Jais O Sitbon LC Price G Simonneau M Humbert 2010 Prognostic factors of acute heart failure in patients with pulmonary arterial hypertension Eur Respir J 35 1286 1293 1:STN:280: DC%2BC3czntlOjtQ%3D%3D 10.1183/09031936.00070209 19897557
    • (2010) Eur Respir J , vol.35 , pp. 1286-1293
    • Sztrymf, B.1    Souza, R.2    Bertoletti, L.3    Jais, X.4    Sitbon, O.5    Price, L.C.6    Simonneau, G.7    Humbert, M.8
  • 2
    • 0030809361 scopus 로고    scopus 로고
    • Value of right ventricular ejection fraction in predicting short-term prognosis of patients with severe chronic heart failure
    • 1:STN:280:DyaK2svgtFCmtg%3D%3D 9257260
    • A Gavazzi C Berzuini C Campana C Inserra M Ponzetta R Sebastiani S Ghio F Recusani 1997 Value of right ventricular ejection fraction in predicting short-term prognosis of patients with severe chronic heart failure J Heart Lung Transplant 16 774 785 1:STN:280:DyaK2svgtFCmtg%3D%3D 9257260
    • (1997) J Heart Lung Transplant , vol.16 , pp. 774-785
    • Gavazzi, A.1    Berzuini, C.2    Campana, C.3    Inserra, C.4    Ponzetta, M.5    Sebastiani, R.6    Ghio, S.7    Recusani, F.8
  • 6
    • 33750879543 scopus 로고    scopus 로고
    • Right coronary autoregulation in conscious, chronically instrumented dogs
    • 1:CAS:528:DyaK1cXkvFaru70%3D 9688910
    • X Bian AG Williams Jr PA Gwirtz HF Downey 1998 Right coronary autoregulation in conscious, chronically instrumented dogs Am J Physiol 275 H169 H175 1:CAS:528:DyaK1cXkvFaru70%3D 9688910
    • (1998) Am J Physiol , vol.275
    • Bian, X.1    Williams, Jr.A.G.2    Gwirtz, P.A.3    Downey, H.F.4
  • 9
    • 75749133554 scopus 로고    scopus 로고
    • The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: Resuscitating the hibernating right ventricle
    • 1:CAS:528:DC%2BC3cXlvFChtQ%3D%3D 10.1007/s00109-009-0524-6 19949938
    • L Piao YH Fang VJ Cadete C Wietholt D Urboniene PT Toth G Marsboom HJ Zhang I Haber J Rehman GD Lopaschuk SL Archer 2010 The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle J Mol Med 88 47 60 1:CAS:528:DC%2BC3cXlvFChtQ%3D%3D 10.1007/s00109-009-0524-6 19949938
    • (2010) J Mol Med , vol.88 , pp. 47-60
    • Piao, L.1    Fang, Y.H.2    Cadete, V.J.3    Wietholt, C.4    Urboniene, D.5    Toth, P.T.6    Marsboom, G.7    Zhang, H.J.8    Haber, I.9    Rehman, J.10    Lopaschuk, G.D.11    Archer, S.L.12
  • 10
    • 37349012830 scopus 로고    scopus 로고
    • Quantitative FDG-uptake by positron emission tomography in progressive hypertrophy of rat hearts in vivo
    • DOI 10.1007/s12149-007-0067-2
    • N Handa Y Magata T Mukai T Nishina J Konishi M Komeda 2007 Quantitative FDG-uptake by positron emission tomography in progressive hypertrophy of rat hearts in vivo Ann Nucl Med 21 569 576 10.1007/s12149-007-0067-2 18092133 (Pubitemid 350293598)
    • (2007) Annals of Nuclear Medicine , vol.21 , Issue.10 , pp. 569-576
    • Handa, N.1    Magata, Y.2    Mukai, T.3    Nishina, T.4    Konishi, J.5    Komeda, M.6
  • 11
    • 35848955451 scopus 로고    scopus 로고
    • Return to the fetal gene program protects the stressed heart: A strong hypothesis
    • DOI 10.1007/s10741-007-9034-1, Special Issue on Cardioprotection; Guest Editors: Dennis V. Cokkinos and Gerd Heusch
    • M Rajabi C Kassiotis P Razeghi H Taegtmeyer 2007 Return to the fetal gene program protects the stressed heart: a strong hypothesis Heart Fail Rev 12 331 343 1:CAS:528:DC%2BD2sXnvFKnt7o%3D 10.1007/s10741-007-9034-1 17516164 (Pubitemid 350176706)
    • (2007) Heart Failure Reviews , vol.12 , Issue.3-4 , pp. 331-343
    • Rajabi, M.1    Kassiotis, C.2    Razeghi, P.3    Taegtmeyer, H.4
  • 12
    • 1842389677 scopus 로고
    • Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle
    • 1:CAS:528:DyaE2cXkt1egsbg%3D 10.1146/annurev.ph.36.030174.002213 19400669
    • JR Neely HE Morgan 1974 Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle Annu Rev Physiol 36 413 459 1:CAS:528:DyaE2cXkt1egsbg%3D 10.1146/annurev.ph.36.030174.002213 19400669
    • (1974) Annu Rev Physiol , vol.36 , pp. 413-459
    • Neely, J.R.1    Morgan, H.E.2
  • 13
    • 0031036553 scopus 로고    scopus 로고
    • Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions
    • DOI 10.1016/S0008-6363(96)00245-3, PII S0008636396002453
    • WC Stanley GD Lopaschuk JL Hall JG McCormack 1997 Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions Cardiovasc Res 33 243 257 1:CAS:528:DyaK2sXhvVSmsL0%3D 10.1016/S0008-6363(96)00245-3 9074687 (Pubitemid 27072627)
    • (1997) Cardiovascular Research , vol.33 , Issue.2 , pp. 243-257
    • Stanley, W.C.1    Lopaschuk, G.D.2    Hall, J.L.3    McCormack, J.G.4
  • 14
    • 0038433338 scopus 로고    scopus 로고
    • Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemia
    • DOI 10.1016/S0008-6363(03)00327-4
    • MP Chandler PN Chavez TA McElfresh H Huang CS Harmon WC Stanley 2003 Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemia Cardiovasc Res 59 143 151 1:CAS:528:DC%2BD3sXkvVKisbs%3D 10.1016/S0008-6363(03)00327-4 12829185 (Pubitemid 36776380)
    • (2003) Cardiovascular Research , vol.59 , Issue.1 , pp. 143-151
    • Chandler, M.P.1    Chavez, P.N.2    McElfresh, T.A.3    Huang, H.4    Harmon, C.S.5    Stanley, W.C.6
  • 15
    • 33747872227 scopus 로고    scopus 로고
    • Modification of myocardial substrate use as a therapy for heart failure
    • DOI 10.1038/ncpcardio0583, PII NCPCARDIO0583
    • K Abozguia K Clarke L Lee M Frenneaux 2006 Modification of myocardial substrate use as a therapy for heart failure Nat Clin Pract Cardiovasc Med 3 490 498 1:CAS:528:DC%2BD28XpvFegsbs%3D 10.1038/ncpcardio0583 16932766 (Pubitemid 44288462)
    • (2006) Nature Clinical Practice Cardiovascular Medicine , vol.3 , Issue.9 , pp. 490-498
    • Abozguia, K.1    Clarke, K.2    Lee, L.3    Frenneaux, M.4
  • 16
    • 85047678759 scopus 로고
    • Oxygen metabolism of the hypertrophic right ventricle in open chest dogs
    • 1:STN:280:DyaK387ptFaguw%3D%3D 10.1093/cvr/25.9.731 1839241
    • D Saito H Tani S Kusachi S Uchida N Ohbayashi M Marutani K Maekawa T Tsuji S Haraoka 1991 Oxygen metabolism of the hypertrophic right ventricle in open chest dogs Cardiovasc Res 25 731 739 1:STN:280:DyaK387ptFaguw%3D%3D 10.1093/cvr/25.9.731 1839241
    • (1991) Cardiovasc Res , vol.25 , pp. 731-739
    • Saito, D.1    Tani, H.2    Kusachi, S.3    Uchida, S.4    Ohbayashi, N.5    Marutani, M.6    Maekawa, K.7    Tsuji, T.8    Haraoka, S.9
  • 17
    • 0014702860 scopus 로고
    • Increased glycolytic metabolism in cardiac hypertrophy and congestive failure
    • 1:CAS:528:DyaE3cXltlSiug%3D%3D 4243400
    • SP Bishop RA Altschuld 1970 Increased glycolytic metabolism in cardiac hypertrophy and congestive failure Am J Physiol 218 153 159 1:CAS:528: DyaE3cXltlSiug%3D%3D 4243400
    • (1970) Am J Physiol , vol.218 , pp. 153-159
    • Bishop, S.P.1    Altschuld, R.A.2
  • 18
    • 46049096732 scopus 로고    scopus 로고
    • A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted
    • 10.1016/j.jtcvs.2008.01.040 18603070 178 e161-163
    • J Nagendran V Gurtu DZ Fu JR Dyck A Haromy DB Ross IM Rebeyka ED Michelakis 2008 A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted J Thorac Cardiovasc Surg 136 168 178 10.1016/j.jtcvs.2008.01.040 18603070 178 e161-163
    • (2008) J Thorac Cardiovasc Surg , vol.136 , pp. 168-178
    • Nagendran, J.1    Gurtu, V.2    Fu, D.Z.3    Dyck, J.R.4    Haromy, A.5    Ross, D.B.6    Rebeyka, I.M.7    Michelakis, E.D.8
  • 19
    • 1342325500 scopus 로고    scopus 로고
    • Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy
    • 1:CAS:528:DC%2BD2cXitlShtrk%3D 10.1152/ajpheart.00916.2003 14630626
    • S Sharma H Taegtmeyer J Adrogue P Razeghi S Sen K Ngumbela MF Essop 2004 Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy Am J Physiol Heart Circ Physiol 286 H1185 H1192 1:CAS:528: DC%2BD2cXitlShtrk%3D 10.1152/ajpheart.00916.2003 14630626
    • (2004) Am J Physiol Heart Circ Physiol , vol.286
    • Sharma, S.1    Taegtmeyer, H.2    Adrogue, J.3    Razeghi, P.4    Sen, S.5    Ngumbela, K.6    Essop, M.F.7
  • 20
    • 0030866627 scopus 로고    scopus 로고
    • Detection of impaired fatty acid metabolism in right ventricular hypertrophy: Assessment by I-123 beta-methyl iodophenyl pentadecanoic acid (BMIPP) myocardial single-photon emission computed tomography
    • 1:CAS:528:DyaK2sXntVCltb0%3D 10.1007/BF03164765 9310169
    • Y Kim H Goto K Kobayashi Y Sawada Y Miyake G Fujiwara H Chiba T Okada T Nishimura 1997 Detection of impaired fatty acid metabolism in right ventricular hypertrophy: assessment by I-123 beta-methyl iodophenyl pentadecanoic acid (BMIPP) myocardial single-photon emission computed tomography Ann Nucl Med 11 207 212 1:CAS:528:DyaK2sXntVCltb0%3D 10.1007/BF03164765 9310169
    • (1997) Ann Nucl Med , vol.11 , pp. 207-212
    • Kim, Y.1    Goto, H.2    Kobayashi, K.3    Sawada, Y.4    Miyake, Y.5    Fujiwara, G.6    Chiba, H.7    Okada, T.8    Nishimura, T.9
  • 23
    • 70349481328 scopus 로고    scopus 로고
    • Possible involvement of mitochondrial energy-producing ability in the development of right ventricular failure in monocrotaline-induced pulmonary hypertensive rats
    • 1:CAS:528:DC%2BD1MXht1ert7vL 10.1254/jphs.08322FP 19763046
    • T Daicho T Yagi Y Abe M Ohara T Marunouchi S Takeo K Tanonaka 2009 Possible involvement of mitochondrial energy-producing ability in the development of right ventricular failure in monocrotaline-induced pulmonary hypertensive rats J Pharmacol Sci 111 33 43 1:CAS:528:DC%2BD1MXht1ert7vL 10.1254/jphs.08322FP 19763046
    • (2009) J Pharmacol Sci , vol.111 , pp. 33-43
    • Daicho, T.1    Yagi, T.2    Abe, Y.3    Ohara, M.4    Marunouchi, T.5    Takeo, S.6    Tanonaka, K.7
  • 24
    • 38849162370 scopus 로고    scopus 로고
    • Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes
    • 10.1093/europace/eum166 17766323
    • C Antzelevitch 2007 Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes Europace 9 Suppl 4 iv4 iv15 10.1093/europace/eum166 17766323
    • (2007) Europace , vol.9 , Issue.SUPPL. 4
    • Antzelevitch, C.1
  • 25
    • 0030755921 scopus 로고    scopus 로고
    • Stage-dependent changes in membrane currents in rats with monocrotaline-induced right ventricular hypertrophy
    • 1:CAS:528:DyaK2sXksVSkurg%3D 9227563
    • JK Lee I Kodama H Honjo T Anno K Kamiya J Toyama 1997 Stage-dependent changes in membrane currents in rats with monocrotaline-induced right ventricular hypertrophy Am J Physiol 272 H2833 H2842 1:CAS:528: DyaK2sXksVSkurg%3D 9227563
    • (1997) Am J Physiol , vol.272
    • Lee, J.K.1    Kodama, I.2    Honjo, H.3    Anno, T.4    Kamiya, K.5    Toyama, J.6
  • 26
    • 26444620100 scopus 로고    scopus 로고
    • p-e intervals in left and right chest leads: Comparison between patients with systemic and pulmonary hypertension
    • DOI 10.1016/j.jelectrocard.2005.06.028, PII S0022073605001391
    • T Hlaing D Guo X Zhao T DiMino L Greenspon PR Kowey GX Yan 2005 The QT and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension J Electrocardiol 38 154 158 10.1016/j.jelectrocard.2005.06.028 16226092 (Pubitemid 41436505)
    • (2005) Journal of Electrocardiology , vol.38 , Issue.4 SUPPL. , pp. 154-158
    • Hlaing, T.1    Guo, D.2    Zhao, X.3    DiMino, T.4    Greenspon, L.5    Kowey, P.R.6    Yan, G.-X.7
  • 27
    • 0032714640 scopus 로고    scopus 로고
    • Downregulation of voltage-gated K(+) channels in rat heart with right ventricular hypertrophy
    • 1:CAS:528:DyaK1MXns1yrs7o%3D 10564125
    • JK Lee A Nishiyama F Kambe H Seo S Takeuchi K Kamiya I Kodama J Toyama 1999 Downregulation of voltage-gated K(+) channels in rat heart with right ventricular hypertrophy Am J Physiol 277 H1725 H1731 1:CAS:528: DyaK1MXns1yrs7o%3D 10564125
    • (1999) Am J Physiol , vol.277
    • Lee, J.K.1    Nishiyama, A.2    Kambe, F.3    Seo, H.4    Takeuchi, S.5    Kamiya, K.6    Kodama, I.7    Toyama, J.8
  • 28
    • 0442309441 scopus 로고    scopus 로고
    • Downregulation of Kv4.2 and Kv4.3 channel gene expression in right ventricular hypertrophy induced by monocrotaline in rat
    • 1:CAS:528:DC%2BD2cXhsVSqsbk%3D 14769214
    • TT Zhang B Cui DZ Dai 2004 Downregulation of Kv4.2 and Kv4.3 channel gene expression in right ventricular hypertrophy induced by monocrotaline in rat Acta Pharmacol Sin 25 226 230 1:CAS:528:DC%2BD2cXhsVSqsbk%3D 14769214
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 226-230
    • Zhang, T.T.1    Cui, B.2    Dai, D.Z.3
  • 29
    • 0019351279 scopus 로고
    • The pathophysiology of failure in acute right ventricular hypertension: Hemodynamic and biochemical correlations
    • 1:STN:280:DyaL3M%2FmsFWmsQ%3D%3D 7438411
    • GJ Vlahakes K Turley JI Hoffman 1981 The pathophysiology of failure in acute right ventricular hypertension: hemodynamic and biochemical correlations Circulation 63 87 95 1:STN:280:DyaL3M%2FmsFWmsQ%3D%3D 7438411
    • (1981) Circulation , vol.63 , pp. 87-95
    • Vlahakes, G.J.1    Turley, K.2    Hoffman, J.I.3
  • 31
    • 0032429293 scopus 로고    scopus 로고
    • Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension
    • 1:CAS:528:DyaK1MXht1Ogug%3D%3D 9843792
    • C Partovian S Adnot S Eddahibi E Teiger M Levame P Dreyfus B Raffestin C Frelin 1998 Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension Am J Physiol 275 H1948 H1956 1:CAS:528:DyaK1MXht1Ogug%3D%3D 9843792
    • (1998) Am J Physiol , vol.275
    • Partovian, C.1    Adnot, S.2    Eddahibi, S.3    Teiger, E.4    Levame, M.5    Dreyfus, P.6    Raffestin, B.7    Frelin, C.8
  • 33
    • 37549032776 scopus 로고    scopus 로고
    • The interplay between MYC and HIF in cancer
    • 1:CAS:528:DC%2BD2sXhsVKku73K 10.1038/nrc2274 18046334
    • CV Dang JW Kim P Gao J Yustein 2008 The interplay between MYC and HIF in cancer Nat Rev Cancer 8 51 56 1:CAS:528:DC%2BD2sXhsVKku73K 10.1038/nrc2274 18046334
    • (2008) Nat Rev Cancer , vol.8 , pp. 51-56
    • Dang, C.V.1    Kim, J.W.2    Gao, P.3    Yustein, J.4
  • 34
    • 34547828784 scopus 로고    scopus 로고
    • Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species
    • DOI 10.1016/j.cardiores.2007.05.012, PII S0008636307002416
    • EM Redout MJ Wagner MJ Zuidwijk C Boer RJ Musters C van Hardeveld WJ Paulus WS Simonides 2007 Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species Cardiovasc Res 75 770 781 1:CAS:528:DC%2BD2sXpt1Srsr8%3D 10.1016/j.cardiores. 2007.05.012 17582388 (Pubitemid 47243719)
    • (2007) Cardiovascular Research , vol.75 , Issue.4 , pp. 770-781
    • Redout, E.M.1    Wagner, M.J.2    Zuidwijk, M.J.3    Boer, C.4    Musters, R.J.P.5    Van Hardeveld, C.6    Paulus, W.J.7    Simonides, W.S.8
  • 35
    • 0028269128 scopus 로고
    • C-myc gene expression is localized to the myocyte following hemodynamic overload in vivo
    • 10.1002/jcb.240540109 1:CAS:528:DyaK2cXhtlWitbY%3D 10.1002/jcb.240540109 8126088
    • PS Pollack SR Houser R Budjak B Goldman 1994 c-myc gene expression is localized to the myocyte following hemodynamic overload in vivo J Cell Biochem 54 78 84 10.1002/jcb.240540109 1:CAS:528:DyaK2cXhtlWitbY%3D 10.1002/jcb. 240540109 8126088
    • (1994) J Cell Biochem , vol.54 , pp. 78-84
    • Pollack, P.S.1    Houser, S.R.2    Budjak, R.3    Goldman, B.4
  • 36
    • 33748062350 scopus 로고    scopus 로고
    • Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathway
    • DOI 10.1038/sj.emboj.7601252, PII 7601252
    • W Zhong S Mao S Tobis E Angelis MC Jordan KP Roos MC Fishbein IM de Alboran WR MacLellan 2006 Hypertrophic growth in cardiac myocytes is mediated by Myc through a cyclin D2-dependent pathway EMBO J 25 3869 3879 1:CAS:528:DC%2BD28XovVSqurY%3D 10.1038/sj.emboj.7601252 16902412 (Pubitemid 44300272)
    • (2006) EMBO Journal , vol.25 , Issue.16 , pp. 3869-3879
    • Zhong, W.1    Mao, S.2    Tobis, S.3    Angelis, E.4    Jordan, M.C.5    Roos, K.P.6    Fishbein, M.C.7    De Alboran, I.M.8    MacLellan, W.R.9
  • 37
    • 34547872783 scopus 로고    scopus 로고
    • Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization
    • DOI 10.1152/ajpheart.00455.2007
    • JS Jaswal M Gandhi BA Finegan JR Dyck AS Clanachan 2007 Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization Am J Physiol Heart Circ Physiol 293 H1107 H1114 1:CAS:528:DC%2BD2sXptlyku7k%3D 10.1152/ajpheart.00455. 2007 17496214 (Pubitemid 47254211)
    • (2007) American Journal of Physiology - Heart and Circulatory Physiology , vol.293 , Issue.2
    • Jaswal, J.S.1    Gandhi, M.2    Finegan, B.A.3    Dyck, J.R.B.4    Clanachan, A.S.5
  • 38
    • 0034672346 scopus 로고    scopus 로고
    • Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: Role of thyroid hormone status and lipid supply
    • DOI 10.1042/0264-6021:3520731
    • MC Sugden ML Langdown RA Harris MJ Holness 2000 Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply Biochem J 352 Pt 3 731 738 1:CAS:528:DC%2BD3MXkvVSltQ%3D%3D 10.1042/0264-6021:3520731 11104680 (Pubitemid 32015029)
    • (2000) Biochemical Journal , vol.352 , Issue.3 , pp. 731-738
    • Sugden, M.C.1    Langdown, M.L.2    Harris, R.A.3    Holness, M.J.4
  • 39
    • 0037080541 scopus 로고    scopus 로고
    • Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: Role of increased expression and activity of voltage-gated potassium channels
    • DOI 10.1161/hc0202.101974
    • ED Michelakis MS McMurtry XC Wu JR Dyck R Moudgil TA Hopkins GD Lopaschuk L Puttagunta R Waite SL Archer 2002 Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels Circulation 105 244 250 1:CAS:528:DC%2BD38XhsFeksL0%3D 10.1161/hc0202.101974 11790708 (Pubitemid 34084326)
    • (2002) Circulation , vol.105 , Issue.2 , pp. 244-250
    • Michelakis, E.D.1    McMurtry, M.S.2    Wu, X.-C.3    Dyck, J.R.B.4    Moudgil, R.5    Hopkins, T.A.6    Lopaschuk, G.D.7    Puttagunta, L.8    Waite, R.9    Archer, S.L.10
  • 41
    • 68249139968 scopus 로고    scopus 로고
    • Improved left and right ventricular functions with trimetazidine in patients with heart failure: A tissue Doppler study
    • 10.1007/s00380-008-1118-x 19626400
    • Y Gunes U Guntekin M Tuncer M Sahin 2009 Improved left and right ventricular functions with trimetazidine in patients with heart failure: a tissue Doppler study Heart Vessels 24 277 282 10.1007/s00380-008-1118-x 19626400
    • (2009) Heart Vessels , vol.24 , pp. 277-282
    • Gunes, Y.1    Guntekin, U.2    Tuncer, M.3    Sahin, M.4
  • 42
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • 1:CAS:528:DC%2BD3cXitFWgsrk%3D 10720420
    • PF Kantor A Lucien R Kozak GD Lopaschuk 2000 The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase Circ Res 86 580 588 1:CAS:528:DC%2BD3cXitFWgsrk%3D 10720420
    • (2000) Circ Res , vol.86 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3    Lopaschuk, G.D.4
  • 43
    • 2942512039 scopus 로고    scopus 로고
    • Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: A double-blind placebo-controlled study
    • DOI 10.1186/1475-2840-2-16
    • GM Rosano C Vitale B Sposato G Mercuro M Fini 2003 Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study Cardiovasc Diabetol 2 16 10.1186/1475-2840-2-16 14641923 (Pubitemid 38751097)
    • (2003) Cardiovascular Diabetology , vol.2 , pp. 16
    • Rosano, G.M.C.1    Vitale, C.2    Sposato, B.3    Mercuro, G.4    Fini, M.5
  • 45
    • 34948849728 scopus 로고    scopus 로고
    • Modulation of fatty acids oxidation in heart failure by selective pharmacological inhibition of 3-ketoacyl coenzyme-A thiolase
    • DOI 10.2174/157488407781668776
    • G Fragasso R Spoladore A Cuko A Palloshi 2007 Modulation of fatty acids oxidation in heart failure by selective pharmacological inhibition of 3-ketoacyl coenzyme-A thiolase Curr Clin Pharmacol 2 190 196 1:CAS:528:DC%2BD2sXhtVWgurrI 10.2174/157488407781668776 18690865 (Pubitemid 47520957)
    • (2007) Current Clinical Pharmacology , vol.2 , Issue.3 , pp. 190-196
    • Fragasso, G.1    Spoladore, R.2    Cuko, A.3    Palloshi, A.4
  • 46
    • 0035999736 scopus 로고    scopus 로고
    • Partial fatty acid oxidation inhibitors for stable angina
    • DOI 10.1517/13543784.11.5.615
    • WC Stanley 2002 Partial fatty acid oxidation inhibitors for stable angina Expert Opin Investig Drugs 11 615 629 1:CAS:528:DC%2BD38XjvVGgsbw%3D 10.1517/13543784.11.5.615 11996644 (Pubitemid 34520613)
    • (2002) Expert Opinion on Investigational Drugs , vol.11 , Issue.5 , pp. 615-629
    • Stanley, W.C.1
  • 47
    • 33947431938 scopus 로고    scopus 로고
    • A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion
    • DOI 10.1124/jpet.106.115519
    • P Wang H Fraser SG Lloyd JJ McVeigh L Belardinelli JC Chatham 2007 A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion J Pharmacol Exp Ther 321 213 220 1:CAS:528:DC%2BD2sXktVSksbg%3D 10.1124/jpet.106.115519 17202401 (Pubitemid 46456960)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.321 , Issue.1 , pp. 213-220
    • Wang, P.1    Fraser, H.2    Lloyd, S.G.3    McVeigh, J.J.4    Belardinelli, L.5    Chatham, J.C.6
  • 48
    • 0029996458 scopus 로고    scopus 로고
    • Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: Evidence for an indirect mechanism
    • DOI 10.1006/jmcc.1996.0032
    • B Clarke KM Wyatt JG McCormack 1996 Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: evidence for an indirect mechanism J Mol Cell Cardiol 28 341 350 1:CAS:528:DyaK28Xht1emsLk%3D 10.1006/jmcc.1996.0032 8729066 (Pubitemid 26110478)
    • (1996) Journal of Molecular and Cellular Cardiology , vol.28 , Issue.2 , pp. 341-350
    • Clarke, B.1    Wyatt, K.M.2    McCormack, J.G.3
  • 49
    • 0030032681 scopus 로고    scopus 로고
    • Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts
    • 1:CAS:528:DyaK28XhtVyhsrs%3D 8616920
    • JG McCormack RL Barr AA Wolff GD Lopaschuk 1996 Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts Circulation 93 135 142 1:CAS:528:DyaK28XhtVyhsrs%3D 8616920
    • (1996) Circulation , vol.93 , pp. 135-142
    • McCormack, J.G.1    Barr, R.L.2    Wolff, A.A.3    Lopaschuk, G.D.4
  • 51
    • 33646007982 scopus 로고    scopus 로고
    • Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current
    • 10.1111/j.1540-8167.2006.00401.x 16686675
    • AI Undrovinas L Belardinelli NA Undrovinas HN Sabbah 2006 Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current J Cardiovasc Electrophysiol 17 Suppl 1 S169 S177 10.1111/j.1540-8167.2006.00401.x 16686675
    • (2006) J Cardiovasc Electrophysiol , vol.17 , Issue.SUPPL. 1
    • Undrovinas, A.I.1    Belardinelli, L.2    Undrovinas, N.A.3    Sabbah, H.N.4
  • 52
    • 0029796954 scopus 로고    scopus 로고
    • Effects of ranolazine on the exercise capacity of rats with chronic heart failure induced by myocardial infarction
    • DOI 10.1097/00005344-199609000-00002
    • A Aaker JG McCormack T Hirai TI Musch 1996 Effects of ranolazine on the exercise capacity of rats with chronic heart failure induced by myocardial infarction J Cardiovasc Pharmacol 28 353 362 1:CAS:528:DyaK28XlsFegu7w%3D 10.1097/00005344-199609000-00002 8877580 (Pubitemid 26317432)
    • (1996) Journal of Cardiovascular Pharmacology , vol.28 , Issue.3 , pp. 353-362
    • Aaker, A.1    McCormack, J.G.2    Hirai, T.3    Musch, T.I.4


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