메뉴 건너뛰기




Volumn 65, Issue SUPPL. 172, 2011, Pages 15-34

Rodent models of pulmonary hypertension: Harmonisation with the world health organisation's categorisation of human PH

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CALVASCULIN; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MONOCROTALINE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POTASSIUM CHANNEL KV1.5; SEMAXANIB; SEROTONIN TRANSPORTER; SHORT HAIRPIN RNA; SILDENAFIL; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NFAT; ANTIHYPERTENSIVE AGENT;

EID: 79960090535     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2011.02710.x     Document Type: Review
Times cited : (76)

References (108)
  • 1
    • 67649579669 scopus 로고    scopus 로고
    • Updated clinical classification of pulmonary hypertension
    • Simonneau G, Robbins IM, Beghetti M, et al., Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 2009; 54 (Suppl. 1): S43-54.
    • (2009) J Am Coll Cardiol , vol.54 , Issue.SUPPL. 1
    • Simonneau, G.1    Robbins, I.M.2    Beghetti, M.3
  • 2
    • 77952234421 scopus 로고    scopus 로고
    • Basic science of pulmonary arterial hypertension for clinicians: New concepts and experimental therapies
    • Archer SL, Weir EK, Wilkins MR,. Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation 2010; 121: 2045-66.
    • (2010) Circulation , vol.121 , pp. 2045-2066
    • Archer, S.L.1    Weir, E.K.2    Wilkins, M.R.3
  • 4
    • 10644252927 scopus 로고    scopus 로고
    • The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilatory efficiency, and oxygen uptake kinetics in chronic heart failure
    • DOI 10.1016/j.jacc.2004.09.041, PII S0735109704018625
    • Guazzi M, Tumminello G, Di Marco F, Fiorentini C, Guazzi MD,. The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilatory efficiency, and oxygen uptake kinetics in chronic heart failure. J Am Coll Cardiol 2004; 44: 2339-48. (Pubitemid 39647608)
    • (2004) Journal of the American College of Cardiology , vol.44 , Issue.12 , pp. 2339-2348
    • Guazzi, M.1    Tumminello, G.2    Di Marco, F.3    Fiorentini, C.4    Guazzi, M.D.5
  • 6
    • 0015589301 scopus 로고
    • Animal model: Pulmonary hypertension, cor pulmonale and endocardial fibroelastosis in monocrotaline-intoxicated nonhuman primates
    • Chesney CF, Allen JR,. Animal model: pulmonary hypertension, cor pulmonale and endocardial fibroelastosis in monocrotaline-intoxicated nonhuman primates. Am J Pathol 1973; 70: 489-92.
    • (1973) Am J Pathol , vol.70 , pp. 489-492
    • Chesney, C.F.1    Allen, J.R.2
  • 7
    • 0022550968 scopus 로고
    • Serotonin uptake by bovine pulmonary artery endothelial cells in culture I. Characterization
    • Lee SL, Fanburg BL,. Serotonin uptake by bovine pulmonary artery endothelial cells in culture I. Characterization. Am J Physiol 1986; 250: C761-5.
    • (1986) Am J Physiol , vol.250
    • Lee, S.L.1    Fanburg, B.L.2
  • 8
    • 0030979142 scopus 로고    scopus 로고
    • Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus
    • Villamor E, Le Cras TD, Horan MP, Halbower AC, Tuder RM, Abman SH,. Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus. Am J Physiol 1997; 272: L1013-20.
    • (1997) Am J Physiol , vol.272
    • Villamor, E.1    Le Cras, T.D.2    Horan, M.P.3    Halbower, A.C.4    Tuder, R.M.5    Abman, S.H.6
  • 9
    • 0018663870 scopus 로고
    • 2)
    • DOI 10.1016/0161-4630(79)90078-8
    • Starling MB, Neutze JM, Elliott RL,. Control of elevated pulmonary vascular resistance in neonatal swine with prostacyclin (PGI2). Prostaglandins Med 1979; 3: 105-17. (Pubitemid 10225535)
    • (1979) Prostaglandins and Medicine , vol.3 , Issue.2 , pp. 105-117
    • Starling, M.B.1    Neutze, J.M.2    Elliott, R.L.3
  • 10
    • 0023203985 scopus 로고
    • Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m
    • Stenmark KR, Fasules J, Hyde DM, et al., Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m. J Appl Physiol 1987; 62: 821-30. (Pubitemid 17066650)
    • (1987) Journal of Applied Physiology , vol.62 , Issue.2 , pp. 821-830
    • Stenmark, K.R.1    Fasules, J.2    Hyde, D.M.3
  • 12
    • 0034727717 scopus 로고    scopus 로고
    • Primary pulmonary hypertension: A vascular biology and translational research "work in progress"
    • Archer S, Rich S,. Primary pulmonary hypertension: a vascular biology and translational research "Work in progress". Circulation 2000; 102: 2781-91.
    • (2000) Circulation , vol.102 , pp. 2781-2791
    • Archer, S.1    Rich, S.2
  • 13
    • 77951961897 scopus 로고    scopus 로고
    • Survival in pulmonary arterial hypertension: A reappraisal of the NIH risk stratification equation
    • Thenappan T, Shah SJ, Rich S, Tian L, Archer SL, Gomberg-Maitland M,. Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation. Eur Respir J 2010; 35: 1079-87.
    • (2010) Eur Respir J , vol.35 , pp. 1079-1087
    • Thenappan, T.1    Shah, S.J.2    Rich, S.3    Tian, L.4    Archer, S.L.5    Gomberg-Maitland, M.6
  • 14
    • 33646269035 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in France: Results from a national registry
    • Humbert M, Sitbon O, Chaouat A, et al., Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 2006; 173: 1023-30.
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 1023-1030
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 16
    • 17644406055 scopus 로고    scopus 로고
    • Pulmonary hypertension and right heart failure in chronic obstructive pulmonary disease
    • DOI 10.1513/pats.200407-037MS
    • Naeije R,. Pulmonary hypertension and right heart failure in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005; 2: 20-2. (Pubitemid 40562958)
    • (2005) Proceedings of the American Thoracic Society , vol.2 , Issue.1 , pp. 20-22
    • Naeije, R.1
  • 17
    • 2442643903 scopus 로고    scopus 로고
    • Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism
    • Pengo V, Lensing AW, Prins MH, et al., Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med 2004; 350: 2257-64.
    • (2004) N Engl J Med , vol.350 , pp. 2257-2264
    • Pengo, V.1    Lensing, A.W.2    Prins, M.H.3
  • 18
    • 77249095292 scopus 로고    scopus 로고
    • Diagnosis and management of pulmonary hypertension in systemic sclerosis
    • Sweiss NJ, Hushaw L, Thenappan T, et al., Diagnosis and management of pulmonary hypertension in systemic sclerosis. Curr Rheumatol Rep 2010; 12: 8-18.
    • (2010) Curr Rheumatol Rep , vol.12 , pp. 8-18
    • Sweiss, N.J.1    Hushaw, L.2    Thenappan, T.3
  • 19
    • 0029033224 scopus 로고
    • Increased plasma serotonin in primary pulmonary hypertension
    • Herve P, Launay JM, Scrobohaci ML, et al., Increased plasma serotonin in primary pulmonary hypertension. Am J Med 1995; 99: 249-54.
    • (1995) Am J Med , vol.99 , pp. 249-254
    • Herve, P.1    Launay, J.M.2    Scrobohaci, M.L.3
  • 20
    • 0026628265 scopus 로고
    • An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • Christman BW, McPherson CD, Newman JH, et al., An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med 1992; 327: 70-5.
    • (1992) N Engl J Med , vol.327 , pp. 70-75
    • Christman, B.W.1    McPherson, C.D.2    Newman, J.H.3
  • 22
    • 0026034713 scopus 로고
    • Increased plasma endothelin-1 in pulmonary hypertension: Marker or mediator of disease?
    • Stewart DJ, Levy RD, Cernacek P, Langleben D,. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann Intern Med 1991; 114: 464-9.
    • (1991) Ann Intern Med , vol.114 , pp. 464-469
    • Stewart, D.J.1    Levy, R.D.2    Cernacek, P.3    Langleben, D.4
  • 25
    • 22544484537 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension
    • DOI 10.1161/CIRCULATIONAHA.105.540542
    • Merklinger SL, Jones PL, Martinez EC, Rabinovitch M,. Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension. Circulation 2005; 112: 423-31. (Pubitemid 41022085)
    • (2005) Circulation , vol.112 , Issue.3 , pp. 423-431
    • Merklinger, S.L.1    Jones, P.L.2    Martinez, E.C.3    Rabinovitch, M.4
  • 31
    • 77954083190 scopus 로고    scopus 로고
    • Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: A basis for excessive cell proliferation and a new therapeutic target
    • Archer SL, Marsboom G, Kim GH, et al., Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Circulation 2010; 121: 2661-71.
    • (2010) Circulation , vol.121 , pp. 2661-2671
    • Archer, S.L.1    Marsboom, G.2    Kim, G.H.3
  • 36
    • 6344257102 scopus 로고    scopus 로고
    • Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    • DOI 10.1161/01.RES.0000145360.16770.9f
    • McMurtry MS, Bonnet S, Wu X, et al., Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 2004; 95: 830-40. (Pubitemid 39390586)
    • (2004) Circulation Research , vol.95 , Issue.8 , pp. 830-840
    • McMurtry, M.S.1    Bonnet, S.2    Wu, X.3    Dyck, J.R.B.4    Haromy, A.5    Hashimoto, K.6    Michelakis, E.D.7
  • 37
    • 0037080541 scopus 로고    scopus 로고
    • Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: Role of increased expression and activity of voltage-gated potassium channels
    • DOI 10.1161/hc0202.101974
    • Michelakis ED, McMurtry MS, Wu XC, et al., Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation 2002; 105: 244-50. (Pubitemid 34084326)
    • (2002) Circulation , vol.105 , Issue.2 , pp. 244-250
    • Michelakis, E.D.1    McMurtry, M.S.2    Wu, X.-C.3    Dyck, J.R.B.4    Moudgil, R.5    Hopkins, T.A.6    Lopaschuk, G.D.7    Puttagunta, L.8    Waite, R.9    Archer, S.L.10
  • 38
    • 33745155785 scopus 로고    scopus 로고
    • An Abnormal mitochondrial-hypoxia inducible factor-1-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
    • DOI 10.1161/CIRCULATIONAHA.105.609008, PII 0000301720060606000012
    • Bonnet S, Michelakis ED, Porter CJ, et al., An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 2006; 113: 2630-41. (Pubitemid 43948012)
    • (2006) Circulation , vol.113 , Issue.22 , pp. 2630-2641
    • Bonnet, S.1    Michelakis, E.D.2    Porter, C.J.3    Andrade-Navarro, M.A.4    Thebaud, B.5    Bonnet, S.6    Haromy, A.7    Harry, G.8    Moudgil, R.9    McMurtry, M.S.10    Weir, E.K.11    Archer, S.L.12
  • 41
    • 72749086606 scopus 로고    scopus 로고
    • Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter
    • Guignabert C, Tu L, Izikki M, et al., Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter. FASEB J 2009; 23: 4135-47.
    • (2009) FASEB J , vol.23 , pp. 4135-4147
    • Guignabert, C.1    Tu, L.2    Izikki, M.3
  • 42
    • 77956713444 scopus 로고    scopus 로고
    • Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension
    • Urboniene D, Haber I, Fang YH, Thenappan T, Archer SL,. Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2010; 299: L401-12.
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299
    • Urboniene, D.1    Haber, I.2    Fang, Y.H.3    Thenappan, T.4    Archer, S.L.5
  • 43
    • 77951908850 scopus 로고    scopus 로고
    • Noninvasive assessment of murine pulmonary arterial pressure: Validation and application to models of pulmonary hypertension
    • Thibault HB, Kurtz B, Raher MJ, et al., Noninvasive assessment of murine pulmonary arterial pressure: validation and application to models of pulmonary hypertension. Circ Cardiovasc Imaging 2010; 3: 157-63.
    • (2010) Circ Cardiovasc Imaging , vol.3 , pp. 157-163
    • Thibault, H.B.1    Kurtz, B.2    Raher, M.J.3
  • 45
    • 78651040838 scopus 로고
    • Veno-occlusive disease of liver with nonportal type of cirrhosis, occurring in Jamaica
    • Bras G, Jelliffe DB, Stuart KL,. Veno-occlusive disease of liver with nonportal type of cirrhosis, occurring in Jamaica. AMA Arch Pathol 1954; 57: 285-300.
    • (1954) AMA Arch Pathol , vol.57 , pp. 285-300
    • Bras, G.1    Jelliffe, D.B.2    Stuart, K.L.3
  • 46
    • 84916362625 scopus 로고
    • Pulmonary arteritis produced in rat by feeding Crotalaria spectabilis
    • Lalich JJ, Merkow L,. Pulmonary arteritis produced in rat by feeding Crotalaria spectabilis. Lab Invest 1961; 10: 744-50.
    • (1961) Lab Invest , vol.10 , pp. 744-750
    • Lalich, J.J.1    Merkow, L.2
  • 47
    • 0014056244 scopus 로고
    • Renal and pulmonary alterations induced in rats by a single injection of monocrotaline
    • Hayashi Y, Lalich JJ,. Renal and pulmonary alterations induced in rats by a single injection of monocrotaline. Proc Soc Exp Biol Med 1967; 124: 392-6.
    • (1967) Proc Soc Exp Biol Med , vol.124 , pp. 392-396
    • Hayashi, Y.1    Lalich, J.J.2
  • 48
    • 0014061764 scopus 로고
    • Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds
    • Kay JM, Harris P, Heath D,. Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds. Thorax 1967; 22: 176-9.
    • (1967) Thorax , vol.22 , pp. 176-179
    • Kay, J.M.1    Harris, P.2    Heath, D.3
  • 50
    • 0024245337 scopus 로고
    • Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension
    • Rosenberg HC, Rabinovitch M,. Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension. Am J Physiol 1988; 255: H1484-91.
    • (1988) Am J Physiol , vol.255
    • Rosenberg, H.C.1    Rabinovitch, M.2
  • 51
    • 0009394524 scopus 로고
    • Exacerbation of monocrotaline pulmonary hypertension by a high fat diet: Association with increased production lung levels of activated oxygen species
    • Archer S, Gebhard R, Levine A, Prigge W, Weir E,. Exacerbation of monocrotaline pulmonary hypertension by a high fat diet: association with increased production lung levels of activated oxygen species. J Vasc Med Biol 1990; 2: 125-35.
    • (1990) J Vasc Med Biol , vol.2 , pp. 125-135
    • Archer, S.1    Gebhard, R.2    Levine, A.3    Prigge, W.4    Weir, E.5
  • 52
    • 0030828893 scopus 로고    scopus 로고
    • Pulmonary hemodynamics modify the rat pulmonary artery response to injury: A neointimal model of pulmonary hypertension
    • Okada K, Tanaka Y, Bernstein M, Zhang W, Patterson GA, Botney MD,. Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension. Am J Pathol 1997; 151: 1019-25. (Pubitemid 27424311)
    • (1997) American Journal of Pathology , vol.151 , Issue.4 , pp. 1019-1025
    • Okada, K.1    Tanaka, Y.2    Bernstein, M.3    Zhang, W.4    Patterson, G.A.5    Botney, M.D.6
  • 54
    • 0016305953 scopus 로고
    • Decreased ATP, ADP and serotonin in young platelets of fawn-hooded rats with storage pool disease
    • Tschopp B, Weiss HJ,. Decreased ATP, ADP and serotonin in young platelets of fawn-hooded rats with storage pool disease. Thromb Diath Haemorrh 1974; 32: 670-7.
    • (1974) Thromb Diath Haemorrh , vol.32 , pp. 670-677
    • Tschopp, B.1    Weiss, H.J.2
  • 55
    • 0021358413 scopus 로고
    • 1- fawn-hooded rats derived from crosses with their putative ancestors (Rattus norvegicus)
    • Tobach E, DeSantis JL, Zucker MB,. Platelet storage pool disease in hybrid rats. F1 fawn-hooded rats derived from crosses with their putative ancestors (Rattus norvegicus). J Hered 1984; 75: 15-8. (Pubitemid 14196997)
    • (1984) Journal of Heredity , vol.75 , Issue.1 , pp. 15-18
    • Tobah, E.1    DeSantis, J.L.2    Zucker, M.B.3
  • 56
    • 0023774918 scopus 로고
    • Pulmonary artery pressure in rats with hereditary platelet function defect
    • Kentera D, Susic D, Veljkovic V, Tucakovic G, Koko V,. Pulmonary artery pressure in rats with hereditary platelet function defect. Respiration 1988; 54: 110-4.
    • (1988) Respiration , vol.54 , pp. 110-114
    • Kentera, D.1    Susic, D.2    Veljkovic, V.3    Tucakovic, G.4    Koko, V.5
  • 59
    • 0033839977 scopus 로고    scopus 로고
    • Early abnormalities of pulmonary vascular development in the Fawn-Hooded rat raised at Denver's altitude
    • Le Cras TD, Kim DH, Markham NE, Abman AS,. Early abnormalities of pulmonary vascular development in the Fawn-Hooded rat raised at Denver's altitude. Am J Physiol Lung Cell Mol Physiol 2000; 279: L283-91.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279
    • Le Cras, T.D.1    Kim, D.H.2    Markham, N.E.3    Abman, A.S.4
  • 60
    • 0026524283 scopus 로고
    • Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat
    • Sato K, Webb S, Tucker A, et al., Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat. Am Rev Respir Dis 1992; 145: 793-7.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 793-797
    • Sato, K.1    Webb, S.2    Tucker, A.3
  • 61
    • 0034943184 scopus 로고    scopus 로고
    • Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats
    • DOI 10.1016/S0034-5687(01)00217-1, PII S0034568701002171
    • Nagaoka T, Muramatsu M, Sato K, McMurtry I, Oka M, Fukuchi Y,. Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats. Respir Physiol 2001; 127: 53-60. (Pubitemid 32622147)
    • (2001) Respiration Physiology , vol.127 , Issue.1 , pp. 53-60
    • Nagaoka, T.1    Muramatsu, M.2    Sato, K.3    McMurtry, I.4    Oka, M.5    Fukuchi, Y.6
  • 62
    • 0025859748 scopus 로고
    • Paradoxical constriction to platelets by arteries from rats with pulmonary hypertension
    • Ashmore RC, Rodman DM, Sato K, et al., Paradoxical constriction to platelets by arteries from rats with pulmonary hypertension. Am J Physiol 1991; 260: H1929-34.
    • (1991) Am J Physiol , vol.260
    • Ashmore, R.C.1    Rodman, D.M.2    Sato, K.3
  • 65
    • 0035130107 scopus 로고    scopus 로고
    • Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
    • DOI 10.1096/fj.00-0343com
    • Taraseviciene-Stewart L, Kasahara Y, Alger L, et al., Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J 2001; 15: 427-38. (Pubitemid 32141434)
    • (2001) FASEB Journal , vol.15 , Issue.2 , pp. 427-438
    • Taraseviciene-Stewart, L.1    Kasahara, Y.2    Alger, L.3    Hirth, P.4    Mc Mahon, G.5    Waltenberger, J.6    Voelkel, N.F.7    Tuder, R.M.8
  • 67
    • 77954243018 scopus 로고    scopus 로고
    • Formation of plexiform lesions in experimental severe pulmonary arterial hypertension
    • Abe K, Toba M, Alzoubi A, et al., Formation of plexiform lesions in experimental severe pulmonary arterial hypertension. Circulation 2010; 121: 2747-54.
    • (2010) Circulation , vol.121 , pp. 2747-2754
    • Abe, K.1    Toba, M.2    Alzoubi, A.3
  • 69
    • 30144435869 scopus 로고    scopus 로고
    • Role of angiopoietin-1 in experimental and human pulmonary arterial hypertension
    • DOI 10.1378/chest.128.6-suppl.633S
    • Kugathasan L, Dutly AE, Zhao YD, et al., Role of angiopoietin-1 in experimental and human pulmonary arterial hypertension. Chest 2005; 128: 633S-42S. (Pubitemid 43054177)
    • (2005) Chest , vol.128 , Issue.SUPPL. 6
    • Kugathasan, L.1    Dutly, A.E.2    Zhao, Y.D.3    Deng, Y.4    Robb, M.J.5    Keshavjee, S.6    Stewart, D.J.7
  • 73
    • 0033817459 scopus 로고    scopus 로고
    • Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
    • Lane KB, Machado RD, Pauciulo MW, et al., Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat Genet 2000; 26: 81-4.
    • (2000) Nat Genet , vol.26 , pp. 81-84
    • Lane, K.B.1    MacHado, R.D.2    Pauciulo, M.W.3
  • 75
    • 34548853386 scopus 로고    scopus 로고
    • Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity
    • DOI 10.1182/blood-2006-11-058594
    • Liu D, Wang J, Kinzel B, et al., Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity. Blood 2007; 110: 1502-10. (Pubitemid 47443965)
    • (2007) Blood , vol.110 , Issue.5 , pp. 1502-1510
    • Liu, D.1    Wang, J.2    Kinzel, B.3    Mueller, M.4    Mao, X.5    Valdez, R.6    Liu, Y.7    Li, E.8
  • 77
    • 50349096148 scopus 로고    scopus 로고
    • Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension
    • Hong KH, Lee YJ, Lee E, et al., Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation 2008; 118: 722-30.
    • (2008) Circulation , vol.118 , pp. 722-730
    • Hong, K.H.1    Lee, Y.J.2    Lee, E.3
  • 79
    • 57049159708 scopus 로고    scopus 로고
    • Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions
    • West J, Harral J, Lane K, et al., Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am J Physiol Lung Cell Mol Physiol 2008; 295: L744-55.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • West, J.1    Harral, J.2    Lane, K.3
  • 81
    • 23044504042 scopus 로고    scopus 로고
    • Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice
    • DOI 10.1161/CIRCULATIONAHA.104.492488
    • Song Y, Jones JE, Beppu H, Keaney JF Jr, Loscalzo J, Zhang YY,. Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation 2005; 112: 553-62. (Pubitemid 41060796)
    • (2005) Circulation , vol.112 , Issue.4 , pp. 553-562
    • Song, Y.1    Jones, J.E.2    Beppu, H.3    Keaney Jr., J.F.4    Loscalzo, J.5    Zhang, Y.-Y.6
  • 82
    • 33645751955 scopus 로고    scopus 로고
    • Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice
    • Long L, MacLean MR, Jeffery TK, et al., Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res 2006; 98: 818-27.
    • (2006) Circ Res , vol.98 , pp. 818-827
    • Long, L.1    MacLean, M.R.2    Jeffery, T.K.3
  • 83
    • 17044369273 scopus 로고    scopus 로고
    • Generation of a floxed allele of the mouse BMP type II receptor gene
    • Beppu H, Lei H, Bloch KD, Li E,. Generation of a floxed allele of the mouse BMP type II receptor gene. Genesis 2005; 41: 133-7.
    • (2005) Genesis , vol.41 , pp. 133-137
    • Beppu, H.1    Lei, H.2    Bloch, K.D.3    Li, E.4
  • 84
    • 67549128823 scopus 로고    scopus 로고
    • BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis
    • Beppu H, Malhotra R, Beppu Y, Lepore JJ, Parmacek MS, Bloch KD,. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 2009; 331: 167-75.
    • (2009) Dev Biol , vol.331 , pp. 167-175
    • Beppu, H.1    Malhotra, R.2    Beppu, Y.3    Lepore, J.J.4    Parmacek, M.S.5    Bloch, K.D.6
  • 85
    • 67650786508 scopus 로고    scopus 로고
    • Association of the metabolic syndrome with pulmonary venous hypertension
    • Robbins IM, Newman JH, Johnson RF, et al., Association of the metabolic syndrome with pulmonary venous hypertension. Chest 2009; 136: 31-6.
    • (2009) Chest , vol.136 , pp. 31-36
    • Robbins, I.M.1    Newman, J.H.2    Johnson, R.F.3
  • 86
    • 66349121082 scopus 로고    scopus 로고
    • Apolipoprotein e knock-out and knock-in mice: Atherosclerosis, metabolic syndrome, and beyond
    • Pendse AA, Arbones-Mainar JM, Johnson LA, Altenburg MK, Maeda N,. Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond. J Lipid Res 2009; 50 (Suppl): S178-82.
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Pendse, A.A.1    Arbones-Mainar, J.M.2    Johnson, L.A.3    Altenburg, M.K.4    Maeda, N.5
  • 89
    • 76749098219 scopus 로고    scopus 로고
    • Pulmonary vascular remodeling correlates with lung eggs and cytokines in murine schistosomiasis
    • Crosby A, Jones FM, Southwood M, et al., Pulmonary vascular remodeling correlates with lung eggs and cytokines in murine schistosomiasis. Am J Respir Crit Care Med 2010; 181: 279-88.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 279-288
    • Crosby, A.1    Jones, F.M.2    Southwood, M.3
  • 91
    • 0025222599 scopus 로고
    • Changes in heart function and cardiac cell size in rats with chronic myocardial infarction
    • Zimmer HG, Gerdes AM, Lortet S, Mall G,. Changes in heart function and cardiac cell size in rats with chronic myocardial infarction. J Mol Cell Cardiol 1990; 22: 1231-43.
    • (1990) J Mol Cell Cardiol , vol.22 , pp. 1231-1243
    • Zimmer, H.G.1    Gerdes, A.M.2    Lortet, S.3    Mall, G.4
  • 92
    • 1542343885 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase and endothelin-1 in pulmonary hypertension secondary to heart failure in aorta-banded rats
    • Dai ZK, Tan MS, Chai CY, et al., Upregulation of endothelial nitric oxide synthase and endothelin-1 in pulmonary hypertension secondary to heart failure in aorta-banded rats. Pediatr Pulmonol 2004; 37: 249-56.
    • (2004) Pediatr Pulmonol , vol.37 , pp. 249-256
    • Dai, Z.K.1    Tan, M.S.2    Chai, C.Y.3
  • 93
    • 33744914582 scopus 로고    scopus 로고
    • Effects of sildenafil on pulmonary hypertension and levels of ET-1, eNOS, and cGMP in aorta-banded rats
    • Dai ZK, Tan MS, Chai CY, et al., Effects of sildenafil on pulmonary hypertension and levels of ET-1, eNOS, and cGMP in aorta-banded rats. Exp Biol Med (Maywood) 2006; 231: 942-7.
    • (2006) Exp Biol Med (Maywood) , vol.231 , pp. 942-947
    • Dai, Z.K.1    Tan, M.S.2    Chai, C.Y.3
  • 94
    • 0018411822 scopus 로고
    • Thallium-201: Quantitation of right ventricular hypertrophy in chronically hypoxic rats
    • Rabinovitch M, Fisher K, Gamble W, Reid L, Treves S,. Thallium-201: quantitation of right ventricular hypertrophy in chronically hypoxic rats. Radiology 1979; 130: 223-5. (Pubitemid 9087339)
    • (1979) Radiology , vol.130 , Issue.1 , pp. 223-225
    • Rabinovitch, M.1    Fisher, K.2    Gamble, W.3
  • 96
    • 0036933431 scopus 로고    scopus 로고
    • Hypoxic activation of adventitial fibroblasts: Role in vascular remodeling
    • Stenmark KR, Gerasimovskaya E, Nemenoff RA, Das M,. Hypoxic activation of adventitial fibroblasts: role in vascular remodeling. Chest 2002; 122: 326S-34S. (Pubitemid 36043023)
    • (2002) Chest , vol.122 , Issue.SUPPL. 6
    • Stenmark, K.R.1    Gerasimovskaya, E.2    Nemenoff, R.A.3    Das, M.4
  • 97
    • 33749345684 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms
    • DOI 10.1161/01.RES.0000243584.45145.3f, PII 0000301220060929000005
    • Stenmark KR, Fagan KA, Frid MG,. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 2006; 99: 675-91. (Pubitemid 44498302)
    • (2006) Circulation Research , vol.99 , Issue.7 , pp. 675-691
    • Stenmark, K.R.1    Fagan, K.A.2    Frid, M.G.3
  • 98
    • 0024452034 scopus 로고
    • The control of cellular proliferation in the pulmonary circulation
    • Reid LM,. The third grover conference on the pulmonary circulation. The control of cellular proliferation in the pulmonary circulation. Am Rev Respir Dis 1989; 140: 1490-3. (Pubitemid 19276249)
    • (1989) American Review of Respiratory Disease , vol.140 , Issue.5 , pp. 1490-1493
    • Reid, L.M.1
  • 99
    • 0027451371 scopus 로고
    • Chronic EDRF inhibition and hypoxia: Effects on pulmonary circulation and systemic blood pressure
    • Hampl V, Archer SL, Nelson DP, Weir EK,. Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure. J Appl Physiol 1993; 75: 1748-57. (Pubitemid 23318227)
    • (1993) Journal of Applied Physiology , vol.75 , Issue.4 , pp. 1748-1757
    • Hampl, V.1    Archer, S.L.2    Nelson, D.P.3    Weir, E.K.4
  • 102
  • 103
    • 0028042120 scopus 로고
    • Increased endothelin receptor gene expression in hypoxic rat lung
    • Li H, Elton TS, Chen YF, Oparil S,. Increased endothelin receptor gene expression in hypoxic rat lung. Am J Physiol 1994; 266: L553-60.
    • (1994) Am J Physiol , vol.266
    • Li, H.1    Elton, T.S.2    Chen, Y.F.3    Oparil, S.4
  • 105
    • 20444434392 scopus 로고    scopus 로고
    • Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: A new model of severe pulmonary arterial hypertension
    • DOI 10.1161/CIRCULATIONAHA.104.491456
    • Ivy DD, McMurtry IF, Colvin K, et al., Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension. Circulation 2005; 111: 2988-96. (Pubitemid 40814193)
    • (2005) Circulation , vol.111 , Issue.22 , pp. 2988-2996
    • Ivy, D.D.1    McMurtry, I.F.2    Colvin, K.3    Imamura, M.4    Oka, M.5    Lee, D.-S.6    Gebb, S.7    Jones, P.L.8
  • 106
    • 77954641196 scopus 로고    scopus 로고
    • Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters
    • Wang T, Han SX, Zhang SF, et al., Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters. Respir Res 2010; 11: 36.
    • (2010) Respir Res , vol.11 , pp. 36
    • Wang, T.1    Han, S.X.2    Zhang, S.F.3
  • 107
    • 0025847326 scopus 로고
    • Chronic pulmonary thromboembolism in dogs treated with tranexamic acid
    • Moser KM, Cantor JP, Olman M, et al., Chronic pulmonary thromboembolism in dogs treated with tranexamic acid. Circulation 1991; 83: 1371-9.
    • (1991) Circulation , vol.83 , pp. 1371-1379
    • Moser, K.M.1    Cantor, J.P.2    Olman, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.