Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA

Toxicology and Applied Pharmacology

Volumn 141, Issue 1, 1996, Pages 319-329

  Thomas, H C ^a   Lame M W ^a   Wilson, D W ^a   Segall, H J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCROTALINE PYRROLE;

ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; CATTLE; CELL CYCLE; CONTROLLED STUDY; DNA BINDING; DOSE RESPONSE; ENDOTHELIUM CELL; IN VITRO STUDY; LUNG ARTERY; MODEL; NONHUMAN;

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0030296590     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0289     Document Type: Article

References (35)

1. Bruner, L. H., Carpenter, L. J., Hamlow, P., and Roth, R. A. (1986). Effect of a mixed function oxidase inducer and inhibitor on monocrotaline pyrrole pneumotoxicity. Toxicol. Appl. Pharmacol. 85(3), 416-427.
2. Bull, L. B., Culvenor, C. C. J., and Dick, A. T. (1968). The pyrrolizidine alkaloids: Their chemistry, pathogenecity and other biological properties. In Frontiers of Biology (A. Neuberger and E. L. Tatum, Ed.), pp. 168-176. North Holland Publishing Company, Amsterdam.
3. Culvenor, C. C. J., Downing, D. T., Edgar, J. A., and Jago, M. V. (1969). Pyrrolizidine alkaloids as alkylating and antimitotic agents. Ann. N.Y. Acad. Sci. 163, 837-847.
4. 14C-monocrotaline kinetics and metabolism in the rat. Drug Metab. Dispos. 19(1), 135-139.
5. Hartley, J. A., Berardini, M. D., and Souhami, R. L. (1991). An agarose gel method for the determination of DNA interstrand crosslinking applicable to the measurement of the rate of total and "second-arm" crosslink reactions. Anal. Biochem. 193(1), 131-134.
6. Hincks, J. R., Kim, H.-Y., Segall, H. J., Molyneux, R. J., Stermitz, F. R., and Coulombe, R. A. (1991). DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: Structure activity relationships. Toxicol. Appl. Pharmacol. 111, 90-98.
7. Hoorn, C. M., and Roth, R. A. (1992). Monocrotaline pyrrole alters DNA, RNA and protein synthesis in pulmonary artery endothelial cells. Am. J. Physiol., L740-L747.
8. Hsu, I.-C., Chesney, C. F., and Alien, J. R. (1973). Chronic effects of monocrotaline pyrrole on hepatic mitosis and DNA synthesis. Proc. Soc. Exp. Biol. Med. 142, 1133-1136.
9. Lalich, J. J., and Merkow, L. (1961). Pulmonary arteritis produced in rats by feeding Crotolaria spectabilis. Lab. Invest. 10, 744-750.
10. 14C-monocrotaline by isolated perfused rat liver. Drug Metab. Dispos. 19(2), 516-524.
11. Maity, A., McKenna, W. G., and Muschel, R. J. (1994). The molecular basis for cell cycle delays following ionizing radiation: A review. Radiother. Oncol. 31(1), 1-13.
12. Mattocks, A. R. (1968). Toxicity of pyrrolizidine alkaloids. Nature 217(130), 723-728.
13. Mattocks, A. R. (1986). Chemistry and Toxicology of Pyrrolizidine Alkaloids. Academic Press, Orlando, FL.
14. Mattocks, A. R., Jukes, R., and Brown, J. (1989). Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids. Toxicon 27(561), 561-567.
15. 3H-thymidine by the cells of the pulmonary circulation and alveolar walls. Am. J. Pathol. 106(1), 84-94.
16. Muschel, R. J., Zhang, H. B., Iliakis, G., and McKenna, W. G. (1991). Cyclin B expression in HeLa cells during the G2 block induced by ionizing radiation. Cancer Res. 51(19), 5113-5117.
17. O'Connor, P. M., Ferris, D. K., Pagano, M., Draetta, G., Pines, J., Hunter, T., Longo, D. L., and Kohn, K. W. (1993). G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J. Biol Chem. 268(11), 8298-8308.
18. O'Connor, P. M., Ferris, D. K., White, G. A., Pines, J., Hunter, T., Longo, D. L., and Kohn, K. W. (1992). Relationships between cdc2 kinase, DNA cross-linking, and cell cycle perturbations induced by nitrogen mustard. Cell Growth Differ. 3(1), 43-52.
19. Pan, L. C., Lamé, M. W., Morin, D., Wilson, D. W., and Segall, H. J. (1991). Red blood cells augment transport of reactive metabolites of monocrotaline from liver to lung in isolated and tandem liver and lung preparations. Toxicol. Appl. Pharmacol. 110(2), 336-346.
20. Paulovich, A. G., and Hartwell, L. H. (1995). A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 82(5), 841-847.
21. Pines, J. (1995). Cyclins and cyclin-dependent kinases: theme and variations. Adv. Cancer Res. 66(181), 181-212.
22. Reed, R. L., Ahern, K. G., Pearson, G. D., and Buhler, D. R. (1988). Cross-linking of DNA by dehydroretronecine, a metabolite of pyrrolizidine alkaloids. Carcinogenesis 9(8), 1355-1361.
23. Reindel, J. F., Chang, C. C., Madhukar, B. V., and Roth, R. A. (1988). Monocrotaline pyrrole induces antiproliferative and delayed cytotoxic responses in cultured cells. FASEB J. A1181, 5142.
24. Reindel, J. F., Ganey, P. E., Wagner, J. G., Slocombe, R. F., and Roth, R. A. (1990). Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrrole. Toxicol. Appl. Pharmacol. 106(2), 179-200.
25. Reindel, J. F., Hoorn, C. M., Wagner, J. G., and Roth, R. A. (1991). Comparison of response of bovine and porcine pulmonary arterial endothelial cells to monocrotaline pyrrole. Am. J. Physiol., L406-L414.
26. Reindel, J. F., and Roth, R. A. (1991). The effects of monocrotaline pyrrole on cultured bovine pulmonary artery endothelial and smooth muscle cells. Am. J. Pathol. 138(3), 707-719.
27. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989). Analysis and cloning of eukaryotic genomic DNA. In Molecular Cloning: A Laboratory Manual (C. Nolan, Ed.), Cold Spring Harbor Laboratory Press, New York.
28. Samuel, A., and Jago, M. V. (1975). Localization in the cell cycle of the antimitotic action of the pyrrolizidine alkaloid, lasiocarpine and of its metabolite, dehydroheliotridine. Chem. Biol. Interact. 10(3), 185-197.
29. Segall, H. J., Wilson, D. W., Lamé, M. W., Morin, D., and Winter, C. K. (1991). Metabolism of pyrrolizidine alkaloids. In Toxicology of Plant and Fungal Compounds. Handbook of Natural Toxins (R. F. Keeler and A. T. Tu, Eds.), Vol. 6, pp. 3-26. Dekker, New York.
30. Tobey, R. A. (1975). Different drugs arrest cells at a number of distinct stages in G2. Nature 254, 245-247.
31. Towner, P. (1991). Purification of DNA. In Essential Molecular Biology: A Practical Approach (T. A. Brown, Ed.), pp. 48. Oxford University Press, New York.
32. Wagner, J. G., Petry, T. W., and Roth, R. A. (1993). Characterization of monocrotaline pyrrole-induced DNA cross-linking in pulmonary artery endothelium. Am. J. Physiol. 264, L517-522.
33. Wilson, D. W., and Segall, H. J. (1990). Changes in type II cell populations in monocrotaline pneumotoxicity. Am. J. Pathol. 136, 1293-1299.
34. Wilson, D. W., Segall, H. J., Pan, L. C., and Dunston, S. K. (1989). Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline treated rats. Microvasc. Res. 38(57), 57-80.
35. Wilson, D. W., Segall, H. J., Pan, L. C., Lamé, M. W., Estep, J. E., and Morin, D. (1992). Mechanisms and pathology of monocrotaline pulmonary toxicity. Crit. Rev. Toxicol. 22((5/6), 307-325.