In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats

Circulation

Volumn 107, Issue 15, 2003, Pages 2037-2044

  Pozeg, Zlatko I ^b   Michelakis, Evangelos D ^b   McMurtry, Sean ^b   Thébaud, Bernard ^b   Wu, Xi Chen ^b   Dyck, Jason R B ^b   Hashimoto, Kyoko ^b   Wang, Shaohua ^b   Moudgil, Rohit ^b   Harry, Gwyneth ^b   Sultanian, Richard ^b   Koshal, Arvind ^b   Archer, Stephen L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NONE

Author keywords

Cardiac output; Catheterization; Gene therapy; Hypoxia; Oxygen

Indexed keywords

ADENOVIRUS VECTOR; GENE PRODUCT; GREEN FLUORESCENT PROTEIN; MEMBRANE PROTEIN; MEMBRANE PROTEIN KV1.5; OXYGEN; POTASSIUM CHANNEL; POTASSIUM ION; UNCLASSIFIED DRUG; KCNA5 PROTEIN, RAT; POTASSIUM CHANNEL KV1.5; VOLTAGE GATED POTASSIUM CHANNEL;

ADENOVIRUS 5; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CHRONIC DISEASE; CONTROLLED STUDY; DRUG TARGETING; GENE THERAPY; GENE TRANSFER; HEART OUTPUT; HEART RIGHT VENTRICLE HYPERTROPHY; HEMODYNAMICS; HYPOXIA; HYPOXIC LUNG VASOCONSTRICTION; LUNG VASCULAR RESISTANCE; MALE; MORBIDITY; MORTALITY; NONHUMAN; OXYGEN SENSITIVE POTASSIUM CHANNEL; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THERMODILUTION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; ADENOVIRUS; ANIMAL; ANOXIA; DRUG EFFECT; GENE VECTOR; GENETICS; IN VITRO STUDY; INHALATIONAL DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; PATCH CLAMP; PATHOPHYSIOLOGY; PULMONARY ARTERY; SPRAGUE DAWLEY RAT; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

ADENOVIRIDAE; ADMINISTRATION, INHALATION; ANIMALS; ANOXIA; CARDIAC OUTPUT; CHRONIC DISEASE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; HEMODYNAMIC PROCESSES; HYPERTENSION, PULMONARY; KV1.5 POTASSIUM CHANNEL; MALE; MUSCLE, SMOOTH, VASCULAR; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 0037461359     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000062688.76508.B3     Document Type: Article

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