Mitochondrial metabolism, redox signaling, and fusion: A mitochondria-ROS-HIF-1α-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 2, 2008, Pages

  Archer, Stephen L ^a   Gomberg Maitland, Mardi ^a   Maitland, Michael L ^a   Rich, Stuart ^a   Garcia, Joe G N ^a   Weir, E Kenneth ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Fawn hooded rats; Hypoxia inducible factor 1 ; Lung cancer; Mitochondrial electron transport chain; Mitochondrial fusion; Nuclear factor activating T cells; Pyruvate dehydrogenase kinase; Reactive oxygen species; Voltage gated potassium channels

Indexed keywords

DICHLOROACETIC ACID; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POTASSIUM CHANNEL KV1.5; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SEROTONIN TRANSPORTER; SUPEROXIDE DISMUTASE; SURVIVIN; TRANSCRIPTION FACTOR NFAT;

APOPTOSIS; BLOOD VESSEL OCCLUSION; BLOOD VESSEL TONE; DISEASE MODEL; ENZYME ACTIVATION; ENZYME ACTIVITY; GLYCOLYSIS; HUMAN; HYPOXIA; MITOCHONDRIAL RESPIRATION; NEOPLASM; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN SENSING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ARTERY; PULMONARY HYPERTENSION; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANIMALS; HUMANS; HYPERTENSION, PULMONARY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KV1.5 POTASSIUM CHANNEL; LUNG NEOPLASMS; MITOCHONDRIA; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 39149106144     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01324.2007     Document Type: Review

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