Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model

Respiratory Research

Volumn 12, Issue , 2011, Pages

  Wang, Yun ^a   Jing, Lei ^a   Zhao, Xiao Min ^a   Han, Ji Ju ^a   Xia, Zuo Li ^a   Qin, Shu Cun ^a   Wu, Ya Ping ^a,b   Sun, Xue Jun ^c  

^a TAISHAN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGUANOSINE; HYDROGEN; HYDROGEN RICH SALINE; INTERLEUKIN 6; MALONALDEHYDE; MONOCROTALINE; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 8 HYDROXYDEOXYGUANOSINE; 8-HYDROXY-2'-DEOXYGUANOSINE; ANTIHYPERTENSIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; AUTACOID; BIOLOGICAL MARKER; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEMODYNAMICS; HISTOLOGY; MALE; NONHUMAN; PULMONARY HYPERTENSION; RAT; ANIMAL; BLOOD; BLOOD PRESSURE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART RIGHT VENTRICLE HYPERTROPHY; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; BIOLOGICAL MARKERS; BLOOD PRESSURE; DEOXYGUANOSINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MALE; MALONDIALDEHYDE; MONOCROTALINE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79952199606     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-12-26     Document Type: Article

References (22)

1. McLaughlin VV, McGoon MD. Pulmonary arterial hypertension. Circulation 2006, 114:1417-1431. 10.1161/CIRCULATIONAHA.104.503540, 17000921.
2. Crosswhite P, Sun Z. Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension. J Hypertens 2010, 28:201-212. 10.1097/HJH.0b013e328332bcdb, 2809140, 20051913.
3. Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol 2006, 290:L1069-L1077. 10.1152/ajplung.00408.2005, 16684951.
4. Kamezaki F, Tasaki H, Yamashita K, Tsutsui M, Koide S, Nakata S, Tanimoto A, Okazaki M, Sasaguri Y, Adachi T, Otsuji Y. Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med 2008, 177:219-226. 10.1164/rccm.200702-264OC, 17962640.
5. Redout EM, van der Toorn A, Zuidwijk MJ, van de Kolk CW, van Echteld CJ, Musters RJ, van Hardeveld C, Paulus WJ, Simonides WS. Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure. Am J Physiol Heart Circ Physiol 2010, 298:H1038-H1047. 10.1152/ajpheart.00097.2009, 20061549.
6. Fontanari P, Badier M, Guillot C, Tomei C, Burnet H, Gardette B, Jammes Y. Changes in maximal performance of inspiratory and skeletal muscles during and after the 7.1-MPa Hydra 10 record human dive. Eur J Appl Physiol 2000, 81:325-328. 10.1007/s004210050050, 10664092.
7. Shirahata S, Kabayama S, Nakano M, Miura T, Kusumoto K, Gotoh M, Hayashi H, Otsubo K, Morisawa S, Katakura Y. Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage. Biochem Biophys Res Commun 1997, 234:269-274. 10.1006/bbrc.1997.6622, 9169001.
8. Ohta S. Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept. Nippon Ronen Igakkai Zasshi 2008, 45:355-362.
9. Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, Ohta S, Sun X, Xu W, Tao H, Li R. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett 2008, 441:167-172. 10.1016/j.neulet.2008.05.077, 18603371.
10. Mao YF, Zheng XF, Cai JM, You XM, Deng XM, Zhang JH, Jiang L, Sun XJ. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun 2009, 381:602-605. 10.1016/j.bbrc.2009.02.105, 19249288.
11. Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda K. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 2008, 373:30-35. 10.1016/j.bbrc.2008.05.165, 18541148.
12. Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun 2007, 361:670-674. 10.1016/j.bbrc.2007.07.088, 17673169.
13. Chen H, Sun YP, Li Y, Liu WW, Xiang HG, Fan LY, Sun Q, Xu XY, Cai JM, Ruan CP, Su N, Yan RL, Sun XJ, Wang Q. Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun 2010, 393:308-313. 10.1016/j.bbrc.2010.02.005, 20138831.
14. Cai J, Kang Z, Liu K, Liu W, Li R, Zhang JH, Luo X, Sun X. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res 2009, 23:129-137.
15. Pichardo J, Palace V, Farahmand F, Singal PK. Myocardial oxidative stress changes during compensated right heart failure in rats. Mol Cell Biochem 1999, 196:51-57. 10.1023/A:1006914111957, 10448902.
16. Sun B, Liu WL. The method to measure pulmonary artery pressure in pulmonary hypertension model. Acta Academiae Medicinae Sinicae 1984, 6:465.
17. Abe K, Shimokawa H, Morikawa K, watoku TU, Oi K, Matsumoto Y, Hattori T, Nakashima Y, Kaibuchi K, Sueishi K, Takeshit A. Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 2004, 94:385-393. 10.1161/01.RES.0000111804.34509.94, 14670839.
18. Handoko ML, Schalij I, Kramer K, Sebkhi A, Postmus PE, Van Der Laarse WJ, Paulus WJ, Vonk-Noordegraaf A. A refined radio-telemetry technique to monitor right ventricle or pulmonary artery pressures in rats: a useful tool in pulmonary hypertension research. Pflügers Arch 2008, 455:951-959.
19. Rosenberg HC, Rabinovitch M. Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension. Am J Physiol 1988, 255:H1484-H1491.
20. Voelkel NF, Cool C, Lee SD, Wright L, Geraci MW, Tuder RM. Primary pulmonary hypertension between inflammation and cancer. Chest 1998, 114(Suppl 3):225-230.
21. Bowers R, Cool C, Murphy RC, Tuder RM, Hopken MW, Flores SC, Voelkel NF. Oxidative stress in severe pulmonary hypertension. Am J Respir Crit Care Med 2004, 169:764-769. 10.1164/rccm.200301-147OC, 14701708.
22. Au WW, Oberheitmann B, Harms C. Assessing DNA damage and health risk using biomarkers. Mut Res 2002, 509:153-163.