Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility In Vivo

Gastroenterology

Volumn 137, Issue 4, 2009, Pages 1415-1424

  Tsvilovskyy, Volodymyr V ^a   Zholos, Alexander V ^b   Aberle, Thomas ^a   Philipp, Stephan E ^a   Dietrich, Alexander ^c   Zhu, Michael X ^d   Birnbaumer, Lutz ^e   Freichel, Marc ^a   Flockerzi, Veit ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d Center for Molecular Neurobiology   (United States)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ATROPINE; CARBACHOL; CATION CHANNEL; MUSCARINIC RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; CALCIUM CHANNEL L TYPE; CHOLINERGIC RECEPTOR STIMULATING AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC4 ION CHANNEL; TRPC6 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; GASTROINTESTINAL TRANSIT; GENE DELETION; GENE EXPRESSION; ILEUM; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MOTILITY; ION CURRENT; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MOTONEURON; MOUSE; MUSCLE CELL; MUSCLE FUNCTION; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; CELL MEMBRANE POTENTIAL; CHANNEL GATING; DRUG EFFECT; ELECTROSTIMULATION; GASTROINTESTINAL MOTILITY; GENETICS; INNERVATION; INTESTINE INNERVATION; METABOLISM; MOUSE MUTANT; MUSCLE CONTRACTION; SMOOTH MUSCLE;

ACETYLCHOLINE; ANIMALS; ATROPINE; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CARBACHOL; CHOLINERGIC AGONISTS; ELECTRIC STIMULATION; ENTERIC NERVOUS SYSTEM; GASTROINTESTINAL MOTILITY; ILEUM; ION CHANNEL GATING; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; RECEPTORS, MUSCARINIC; TRPC CATION CHANNELS;

EID: 70349432267     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.06.046     Document Type: Article

References (50)

1. Kuriyama H., Kitamura K., Itoh T., et al. Physiological features of visceral smooth muscle cells, with special reference to receptors and ion channels. Physiol Rev 78 (1998) 811-920
2. Bolton T.B., Prestwich S.A., Zholos A.V., et al. Excitation-contraction coupling in gastrointestinal and other smooth muscles. Annu Rev Physiol 61 (1999) 85-115
3. Sanders K.M. Invited review: mechanisms of calcium handling in smooth muscles. J Appl Physiol 91 (2001) 1438-1449
4. Bolton T.B. The depolarizing action of acetylcholine or carbachol in intestinal smooth muscle. J Physiol 220 (1972) 647-671
5. Klevets M.Y., and Shuba M.F. Mechanisms of adrenaline, noradrenaline and acetylcholine effects on the electrophysiological properties of smooth muscle cells. 92-107. Transactions of the 2nd Symposium on General Physiology: Synaptic Processes. [in Russian] (1968), Naukova Dumka, Kiev
6. Inoue R., and Isenberg G. Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein. Am J Physiol 258 (1990) C1173-C1178
7. Wang Y.X., Fleischmann B.K., and Kotlikoff M.I. M2 receptor activation of nonselective cation channels in smooth muscle cells: calcium and Gi/G(o) requirements. Am J Physiol 273 (1997) C500-C508
8. Unno T., Kwon S.C., Okamoto H., et al. Receptor signaling mechanisms underlying muscarinic agonist-evoked contraction in guinea-pig ileal longitudinal smooth muscle. Br J Pharmacol 139 (2003) 337-350
9. So I., and Kim K.W. Nonselective cation channels activated by the stimulation of muscarinic receptors in mammalian gastric smooth muscle. J Smooth Muscle Res 39 (2003) 231-247
10. Ramsey I.S., Delling M., and Clapham D.E. An introduction to TRP channels. Annu Rev Physiol 68 (2006) 619-647
11. Venkatachalam K., and Montell C. TRP channels. Annu Rev Biochem 76 (2007) 387-417
12. Beech D.J., Muraki K., and Flemming R. Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol 559 (2004) 685-706
13. Inoue R., Okada T., Onoue H., et al. The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res 88 (2001) 325-332
14. Freichel M., Suh S.H., Pfeifer A., et al. Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol 3 (2001) 121-127
15. Dietrich A., Mederos Y.S., Gollasch M., et al. Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol 25 (2005) 6980-6989
16. Hamill O.P., Marty A., Neher E., et al. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391 (1981) 85-100
17. Chang F.Y., Doong M.L., Chen T.S., et al. Vasoactive intestinal polypeptide appears to be one of the mediators in misoprostol-enhanced small intestinal transit in rats. J Gastroenterol Hepatol 15 (2000) 1120-1124
18. Torjman M.C., Joseph J.I., Munsick C., et al. Effects of isoflurane on gastrointestinal motility after brief exposure in rats. Int J Pharm 294 (2005) 65-71
19. Zholos A.V., and Bolton T.B. Muscarinic receptor subtypes controlling the cationic current in guinea-pig ileal smooth muscle. Br J Pharmacol 122 (1997) 885-893
20. Rhee J.C., Rhee P.L., Park M.K., et al. Muscarinic receptors controlling the carbachol-activated nonselective cationic current in guinea pig gastric smooth muscle cells. Jpn J Pharmacol 82 (2000) 331-337
21. Okamoto H., Prestwich S.A., Asai S., et al. Muscarinic agonist potencies at three different effector systems linked to the M(2) or M(3) receptor in longitudinal smooth muscle of guinea-pig small intestine. Br J Pharmacol 135 (2002) 1765-1775
22. Unno T., Matsuyama H., and Komori S. Interaction between the M2- and M3-receptor subtypes in muscarinic electrical and mechanical responses of intestinal smooth muscles. Neurophysiology 35 (2003) 290-301 [3/4]
23. Sakamoto T., Unno T., Kitazawa T., et al. Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells. J Physiol 582 (2007) 41-61
24. Otsuguro K., Tang J., Tang Y., et al. Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem 283 (2008) 10026-10036
25. Zholos A.V., Tsytsyura Y.D., Gordienko D.V., et al. Phospholipase C, but not InsP3 or DAG, -dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells. Br J Pharmacol 141 (2004) 23-36
26. Okamoto H., Unno T., Arima D., et al. Phospholipase C involvement in activation of the muscarinic receptor-operated cationic current in Guinea pig ileal smooth muscle cells. J Pharmacol Sci 95 (2004) 203-213
27. Plant T.D., and Schaefer M. TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels. Cell Calcium 33 (2003) 441-450
28. Strubing C., Krapivinsky G., Krapivinsky L., et al. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29 (2001) 645-655
29. Bigay J., Deterre P., Pfister C., et al. Fluoroaluminates activate transducin-GDP by mimicking the gamma-phosphate of GTP in its binding site. FEBS Lett 191 (1985) 181-185
30. Inoue R., and Isenberg G. Intracellular calcium ions modulate acetylcholine-induced inward current in guinea-pig ileum. J Physiol 424 (1990) 73-92
31. Zholos A.V., Zholos A.A., and Bolton T.B. G-protein-gated TRP-like cationic channel activated by muscarinic receptors: effect of potential on single-channel gating. J Gen Physiol 123 (2004) 581-598
32. Dresviannikov A.V., Bolton T.B., and Zholos A.V. Muscarinic receptor-activated cationic channels in murine ileal myocytes. Br J Pharmacol 149 (2006) 179-187
33. Walker R.L., Hume J.R., and Horowitz B. Differential expression and alternative splicing of TRP channel genes in smooth muscles. Am J Physiol Cell Physiol 280 (2001) C1184-C1192
34. Dietrich A., Schnitzler M., Emmel J., et al. N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity. J Biol Chem 278 (2003) 47842-47852
35. Hofmann T., Obukhov A.G., Schaefer M., et al. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397 (1999) 259-263
36. Bolton T.B. Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 59 (1979) 606-718
37. Wegener J.W., Schulla V., Koller A., et al. Control of intestinal motility by the Cav1.2 L-type calcium channel in mice. FASEB J (2006)
38. Weissmann N., Dietrich A., Fuchs B., et al. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc Natl Acad Sci U S A 103 (2006) 19093-19098
39. Dietrich A., Kalwa H., Storch U., et al. Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch 20 (2007) 1260-1262
40. Varga-Szabo D., Authi K.S., Braun A., et al. Store-operated Ca(2+) entry in platelets occurs independently of transient receptor potential (TRP) C1. Pflugers Arch 455 (2008) 465-477
41. Tiruppathi C., Freichel M., Vogel S.M., et al. Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ Res 91 (2002) 70-76
42. Munsch T., Freichel M., Flockerzi V., et al. Contribution of transient receptor potential channels to the control of GABA release from dendrites. Proc Natl Acad Sci U S A 100 (2003) 16065-16070
43. Lee K.P., Jun J.Y., Chang I.Y., et al. TRPC4 is an essential component of the nonselective cation channel activated by muscarinic stimulation in mouse visceral smooth muscle cells. Mol Cell 20 (2005) 435-441
44. Flockerzi V., Jung C., Aberle T., et al. Specific detection and semi-quantitative analysis of TRPC4 protein expression by antibodies. Pflugers Arch 451 (2005) 81-86
45. Komori S., Kawai M., Takewaki T., et al. GTP-binding protein involvement in membrane currents evoked by carbachol and histamine in guinea-pig ileal muscle. J Physiol 450 (1992) 105-126
46. Yan H.D., Okamoto H., Unno T., et al. Effects of G-protein-specific antibodies and G beta gamma subunits on the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells. Br J Pharmacol 139 (2003) 605-615
47. Schaefer M., Plant T.D., Obukhov A.G., et al. Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem 275 (2000) 17517-17526
48. Unno T., Inaba T., Ohashi H., et al. Role of Ca2+ mobilization in muscarinic receptor-mediated membrane depolarization in guinea pig ileal smooth muscle cells. Jpn J Pharmacol 84 (2000) 431-437
49. i in guinea-pig ileal smooth muscle cells. J Physiol 511 (1998) 559-571
50. Sakamoto T., Unno T., Matsuyama H., et al. Characterization of muscarinic receptor-mediated cationic currents in longitudinal smooth muscle cells of mouse small intestine. J Pharmacol Sci 100 (2006) 215-226