eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 279, Issue 4 23-4, 2000, Pages

  Quinlan, Timothy R ^a   Dechun, Li ^a   Laubach, Victor E ^b   Shesely, Edward G ^c   Zhou, Nan ^a   Johns, Roger A ^a,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c HENRY FORD HOSPITAL   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelial nitric oxide synthase; Hypertension; Lung; Muscularization

Indexed keywords

NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LUNG BLOOD VESSEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; VASCULAR SMOOTH MUSCLE;

EID: 0033696120     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2000.279.4.l641     Document Type: Article

References (46)

1. Nitric oxide and chronic hypoxic pulmonary hypertension
2. Endothelium-derived nitric oxide and vascular physiology and pathology
3. Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype
4. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
5. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP
6. Promotion of proliferation of murine BALB/CT3 fibroblasts mediated by nitric oxide at lower concentrations
7. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia
8. Assays for nitric oxide induced apoptosis
9. Isoforms of nitric oxide synthase: Function in the cardiovascular system
10. Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair
11. Endothelium-derived relaxing and contracting factors
12. Chronic EDRF inhibition and hypoxia: Effects on pulmonary circulation and systemic blood pressure
13. Hypoxia potentiates nitric oxide synthase and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells
14. Nitric oxide selectively amplifies FGF-2-induced mitogenesis in primary rat aortic smooth muscle cells
15. Vasculature remodeling in clinical and experimental pulmonary hypertensions
16. Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells
17. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
18. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung
19. Impaired wound healing and angiogenesis in eNOS-deficient mice
20. Effects of endogenous nitric oxide on pulmonary vascular tone in intact dogs
21. Soluble guanylate cyclase gene expression and localization in the rat lung after exposure to hypoxia
22. Pleiotropic regulation of vascular smooth muscle tone by cyclic GMP-dependent protein kinase
23. Role of nitric oxide in autocrine control of growth and apoptosis of endothelial cells
24. Flow-induced vascular remodeling in the rat carotid artery diminishes with age
25. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice
26. The nitric oxide-cyclic GMP signal transduction pathway in vascular smooth muscle preparations and other tissues
27. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
28. Nitric oxide as a secretory product of mammalian cells
29. Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR
30. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
31. Pathology of atheromatous lesions in inbred and genetically engineered mice: Genetic determination of arterial calcification
32. Alterations in nitric oxide synthase isoform expression in NOS knockout mice exposed to normoxia or hypoxia
33. Role of endothelium-derived nitric oxide in the regulation of blood pressure
34. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling
35. Dual cell cycle-specific mechanisms mediate the antimitogenic effects of nitric oxide in vascular smooth muscle cells
36. Genetic control of blood pressure in mice
37. Elevated blood pressure in mice lacking endothelial nitric oxide synthase
38. Mouse models of atherosclerosis
39. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS3) gene
40. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3
41. Mechanisms of transcriptional regulation of gene expression in smooth muscle cells
42. Angiogenesis in mice with chronic airway inflammation: Strain-dependent differences
43. Role of NO in flow-induced remodeling of the rabbit common carotid artery
44. Nitric oxide donors, sodium nitroprusside and S-nitroso-N-acetylpenicillamine, stimulate myoblast proliferation in vitro
45. Upregulation of nitric oxide synthase correlates temporally with onset of pulmonary vascular remodeling in the hypoxic rat
46. Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF