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Volumn 28, Issue , 2016, Pages 65-81

Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics

Author keywords

Anticancer drugs; Biomarkers; Cancer; Chemotherapeutics; Cisplatin; Doxorubicin (adriamycin); Drug resistance

Indexed keywords

ALKYLATING AGENT; ANTIMETABOLITE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOPHOSPHAMIDE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; GYRASE INHIBITOR; IFOSFAMIDE; METHOTREXATE; MICROTUBULE ASSOCIATED PROTEIN; NAVELBINE; PACLITAXEL; PEMETREXED; TOPOTECAN; TUMOR MARKER; TUMOR PROTEIN;

EID: 84980367693     PISSN: 13687646     EISSN: 15322084     Source Type: Journal    
DOI: 10.1016/j.drup.2016.07.001     Document Type: Article
Times cited : (154)

References (219)
  • 2
    • 33846531356 scopus 로고    scopus 로고
    • The tumour microenvironment as a target for chemoprevention
    • Albini, A., Sporn, M.B., The tumour microenvironment as a target for chemoprevention. Nat. Rev. Cancer 7 (2007), 139–147.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 139-147
    • Albini, A.1    Sporn, M.B.2
  • 4
    • 0036897325 scopus 로고    scopus 로고
    • Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer
    • Alli, E., Bash-Babula, J., Yang, J.M., Hait, W.N., Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer. Cancer Res. 62:23 (2002), 6864–6869.
    • (2002) Cancer Res. , vol.62 , Issue.23 , pp. 6864-6869
    • Alli, E.1    Bash-Babula, J.2    Yang, J.M.3    Hait, W.N.4
  • 5
    • 0037586498 scopus 로고    scopus 로고
    • AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    • Anand, S., Penrhyn-Lowe, S., Venkitaraman, A.R., AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3:1 (2003), 51–62.
    • (2003) Cancer Cell , vol.3 , Issue.1 , pp. 51-62
    • Anand, S.1    Penrhyn-Lowe, S.2    Venkitaraman, A.R.3
  • 6
    • 33947375647 scopus 로고    scopus 로고
    • Molecular basis of antifolate resistance
    • Assaraf, Y.G., Molecular basis of antifolate resistance. Cancer Metast. Rev. 26 (2007), 153–181.
    • (2007) Cancer Metast. Rev. , vol.26 , pp. 153-181
    • Assaraf, Y.G.1
  • 7
    • 33750975065 scopus 로고    scopus 로고
    • The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis
    • Assaraf, Y.G., The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist. Updates: Rev. Comment. Antimicrob. Anticancer Chemother. 9 (2006), 227–246.
    • (2006) Drug Resist. Updates: Rev. Comment. Antimicrob. Anticancer Chemother. , vol.9 , pp. 227-246
    • Assaraf, Y.G.1
  • 8
    • 0030839959 scopus 로고    scopus 로고
    • Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells
    • Assaraf, Y.G., Goldman, I.D., Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells. J. Biol. Chem. 272 (1997), 17460–17466.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17460-17466
    • Assaraf, Y.G.1    Goldman, I.D.2
  • 9
    • 85013226765 scopus 로고    scopus 로고
    • Correlations between expression levels of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, and efficacy of 5-fluorouracil-based chemotherapy for advanced colorectal cancer
    • Bai, W., Wu, Y., Zhang, P., Xi, Y., Correlations between expression levels of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, and efficacy of 5-fluorouracil-based chemotherapy for advanced colorectal cancer. Int. J. Clin. Exp. Pathol. 8 (2015), 12333–12345.
    • (2015) Int. J. Clin. Exp. Pathol. , vol.8 , pp. 12333-12345
    • Bai, W.1    Wu, Y.2    Zhang, P.3    Xi, Y.4
  • 10
    • 79952081873 scopus 로고    scopus 로고
    • Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell lines
    • Bandyopadhyay, K., Gjerset, R.A., Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell lines. Biochemistry 50:5 (2011), 704–714.
    • (2011) Biochemistry , vol.50 , Issue.5 , pp. 704-714
    • Bandyopadhyay, K.1    Gjerset, R.A.2
  • 11
    • 84869803372 scopus 로고    scopus 로고
    • CK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA binding, and increases cellular camptothecin sensitivity
    • Bandyopadhyay, K., Li, P., Gjerset, R.A., CK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA binding, and increases cellular camptothecin sensitivity. PLoS One, 7(11), 2012, e50427.
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e50427
    • Bandyopadhyay, K.1    Li, P.2    Gjerset, R.A.3
  • 12
    • 0030045003 scopus 로고    scopus 로고
    • Structure and mechanism of DNA topoisomerase II
    • Berger, J.M., Gamblin, S.J., Harrison, S.C., Wang, J.C., Structure and mechanism of DNA topoisomerase II. Nature 379:6562 (1996), 225–232.
    • (1996) Nature , vol.379 , Issue.6562 , pp. 225-232
    • Berger, J.M.1    Gamblin, S.J.2    Harrison, S.C.3    Wang, J.C.4
  • 14
    • 84942814286 scopus 로고    scopus 로고
    • Predictive and prognostic value of the tauprotein in breast cancer
    • Bonneau, C., Gurard-Levin, Z.A., Andre, F., Pusztai, L., Rouzier, R., Predictive and prognostic value of the tauprotein in breast cancer. Anticancer Res. 35:10 (2015), 5179–5184.
    • (2015) Anticancer Res. , vol.35 , Issue.10 , pp. 5179-5184
    • Bonneau, C.1    Gurard-Levin, Z.A.2    Andre, F.3    Pusztai, L.4    Rouzier, R.5
  • 15
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: the multidrug resistance-associated proteins
    • Borst, P., Evers, R., Kool, M., Wijnholds, J., A family of drug transporters: the multidrug resistance-associated proteins. J. Natl. Cancer Inst. 92:16 (2000), 1295–1302.
    • (2000) J. Natl. Cancer Inst. , vol.92 , Issue.16 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 17
    • 84896122888 scopus 로고    scopus 로고
    • Nucleotide excision repair: why is it not used to predict response to platinum-based chemotherapy?
    • Bowden, N.A., Nucleotide excision repair: why is it not used to predict response to platinum-based chemotherapy?. Cancer Lett. 346 (2014), 163–171.
    • (2014) Cancer Lett. , vol.346 , pp. 163-171
    • Bowden, N.A.1
  • 18
    • 84863162537 scopus 로고    scopus 로고
    • Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair
    • Bulgar, A.D., Weeks, L.D., Miao, Y., Yang, S., Xu, Y., Guo, C., Markowitz, S., Oleinick, N., Gerson, S.L., Liu, L., Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair. Cell Death Dis., 3, 2012, pe252.
    • (2012) Cell Death Dis. , vol.3 , pp. pe252
    • Bulgar, A.D.1    Weeks, L.D.2    Miao, Y.3    Yang, S.4    Xu, Y.5    Guo, C.6    Markowitz, S.7    Oleinick, N.8    Gerson, S.L.9    Liu, L.10
  • 20
    • 84896131650 scopus 로고    scopus 로고
    • Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?
    • Callaghan, R., Luk, F., Bebawy, M., Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?. Drug Metab. Dispos.: Biol. Fate Chem. 42 (2014), 623–631.
    • (2014) Drug Metab. Dispos.: Biol. Fate Chem. , vol.42 , pp. 623-631
    • Callaghan, R.1    Luk, F.2    Bebawy, M.3
  • 21
    • 84859973897 scopus 로고    scopus 로고
    • Improved chemotherapy for hepatocellular carcinoma
    • Cao, H., Phan, H., Yang, L.X., Improved chemotherapy for hepatocellular carcinoma. Anticancer Res. 32 (2012), 1379–1386.
    • (2012) Anticancer Res. , vol.32 , pp. 1379-1386
    • Cao, H.1    Phan, H.2    Yang, L.X.3
  • 22
    • 84870192369 scopus 로고    scopus 로고
    • The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
    • Carmena, M., Wheelock, M., Funabiki, H., Earnshaw, W.C., The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol 13:12 (2012), 789–803.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.12 , pp. 789-803
    • Carmena, M.1    Wheelock, M.2    Funabiki, H.3    Earnshaw, W.C.4
  • 25
    • 84865364870 scopus 로고    scopus 로고
    • Playing the end game: DNA double-strand break repair pathway choice
    • Chapman, J.R., Taylor, M.R., Boulton, S.J., Playing the end game: DNA double-strand break repair pathway choice. Mol. Cell 47 (2012), 497–510.
    • (2012) Mol. Cell , vol.47 , pp. 497-510
    • Chapman, J.R.1    Taylor, M.R.2    Boulton, S.J.3
  • 26
    • 34548207202 scopus 로고    scopus 로고
    • Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability
    • Chattopadhyay, S., Tamari, R., Min, S.H., Zhao, R., Tsai, E., Goldman, I.D., Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability. Oncologist 12 (2007), 808–815.
    • (2007) Oncologist , vol.12 , pp. 808-815
    • Chattopadhyay, S.1    Tamari, R.2    Min, S.H.3    Zhao, R.4    Tsai, E.5    Goldman, I.D.6
  • 27
    • 84980414227 scopus 로고    scopus 로고
    • Adjuvant Gemcitabine Versus 5-FU/Leucovorin Based on hENT1 Immunostaining
    • ClinicalTrials.gov [Internet], NCT02486497
    • ClinicalTrial, S.N.U.H., Adjuvant Gemcitabine Versus 5-FU/Leucovorin Based on hENT1 Immunostaining. 2015 ClinicalTrials.gov [Internet], NCT02486497.
    • (2015)
    • ClinicalTrial, S.N.U.H.1
  • 28
    • 0036554731 scopus 로고    scopus 로고
    • Amplification and overexpression of topoisomerase IIα predict response to anthracycline-based therapy in locally advanced breast cancer
    • Coon, J.S., Marcus, E., Gupta-Burt, S., Seelig, S., Jacobson, K., Chen, S., Renta, V., Fronda, G., Preisler, H.D., Amplification and overexpression of topoisomerase IIα predict response to anthracycline-based therapy in locally advanced breast cancer. Clin. Cancer Res. 8 (2002), 1061–1067.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1061-1067
    • Coon, J.S.1    Marcus, E.2    Gupta-Burt, S.3    Seelig, S.4    Jacobson, K.5    Chen, S.6    Renta, V.7    Fronda, G.8    Preisler, H.D.9
  • 30
    • 84890909335 scopus 로고    scopus 로고
    • Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
    • Czabotar, P.E., Lessene, G., Strasser, A., Adams, J.M., Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat. Rev. Mol. Cell Biol. 15 (2014), 49–63.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 49-63
    • Czabotar, P.E.1    Lessene, G.2    Strasser, A.3    Adams, J.M.4
  • 34
    • 0013057087 scopus 로고    scopus 로고
    • Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
    • Ditchfield, C., Johnson, V.L., Tighe, A., Ellston, R., Haworth, C., Johnson, T., …, Taylor, S.S., Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161:2 (2003), 267–280.
    • (2003) J. Cell Biol. , vol.161 , Issue.2 , pp. 267-280
    • Ditchfield, C.1    Johnson, V.L.2    Tighe, A.3    Ellston, R.4    Haworth, C.5    Johnson, T.6    Taylor, S.S.7
  • 35
    • 0034613382 scopus 로고    scopus 로고
    • Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake
    • Drori, S., Jansen, G., Mauritz, R., Peters, G.J., Assaraf, Y.G., Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake. J. Biol. Chem. 275 (2000), 30855–30863.
    • (2000) J. Biol. Chem. , vol.275 , pp. 30855-30863
    • Drori, S.1    Jansen, G.2    Mauritz, R.3    Peters, G.J.4    Assaraf, Y.G.5
  • 36
    • 77957374075 scopus 로고    scopus 로고
    • Microtubule-binding agents: a dynamic field of cancer therapeutics
    • Dumontet, C., Jordan, M.A., Microtubule-binding agents: a dynamic field of cancer therapeutics. Nat. Rev. Drug Discov. 9:10 (2010), 790–803.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , Issue.10 , pp. 790-803
    • Dumontet, C.1    Jordan, M.A.2
  • 38
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: a review of programmed cell death
    • Elmore, S., Apoptosis: a review of programmed cell death. Toxicol. Pathol. 35 (2007), 495–516.
    • (2007) Toxicol. Pathol. , vol.35 , pp. 495-516
    • Elmore, S.1
  • 39
    • 70350786392 scopus 로고    scopus 로고
    • Cyclophosphamide and cancer: golden anniversary
    • Emadi, A., Jones, R.J., Brodsky, R.A., Cyclophosphamide and cancer: golden anniversary. Nat. Rev. Clin. Oncol. 6 (2009), 638–647.
    • (2009) Nat. Rev. Clin. Oncol. , vol.6 , pp. 638-647
    • Emadi, A.1    Jones, R.J.2    Brodsky, R.A.3
  • 44
    • 8744256424 scopus 로고    scopus 로고
    • Thymidylate synthase expression and prognosis of patients with gastrointestinal cancers receiving adjuvant chemotherapy: a review
    • Formentini, A., Henne-Bruns, D., Kornmann, M., Thymidylate synthase expression and prognosis of patients with gastrointestinal cancers receiving adjuvant chemotherapy: a review. Langenbeck's Arch. Surg./Deutsche Gesellschaft Chirurgie 389 (2004), 405–413.
    • (2004) Langenbeck's Arch. Surg./Deutsche Gesellschaft Chirurgie , vol.389 , pp. 405-413
    • Formentini, A.1    Henne-Bruns, D.2    Kornmann, M.3
  • 46
    • 84857996830 scopus 로고    scopus 로고
    • Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer
    • Furlong, F., Fitzpatrick, P., O'Toole, S., Phelan, S., McGrogan, B., Maguire, A., …, McCann, A., Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer. J. Pathol. 226:5 (2012), 746–755.
    • (2012) J. Pathol. , vol.226 , Issue.5 , pp. 746-755
    • Furlong, F.1    Fitzpatrick, P.2    O'Toole, S.3    Phelan, S.4    McGrogan, B.5    Maguire, A.6    McCann, A.7
  • 49
    • 79958725353 scopus 로고    scopus 로고
    • Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel
    • Ganguly, A., Yang, H., Cabral, F., Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel. Mol. Cancer Ther. 10:6 (2011), 929–937.
    • (2011) Mol. Cancer Ther. , vol.10 , Issue.6 , pp. 929-937
    • Ganguly, A.1    Yang, H.2    Cabral, F.3
  • 50
    • 70350316226 scopus 로고    scopus 로고
    • Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells
    • Gao, J., Zheng, Z., Rawal, B., Schell, M.J., Bepler, G., Haura, E.B., Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. Cancer Biol. Ther. 8 (2009), 1671–1679.
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 1671-1679
    • Gao, J.1    Zheng, Z.2    Rawal, B.3    Schell, M.J.4    Bepler, G.5    Haura, E.B.6
  • 51
    • 84875740314 scopus 로고    scopus 로고
    • Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
    • Gao, J., Aksoy, B.A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S.O., …, Schultz, N., Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal, 6(269), 2013, pl1.
    • (2013) Sci Signal , vol.6 , Issue.269 , pp. pl1
    • Gao, J.1    Aksoy, B.A.2    Dogrusoz, U.3    Dresdner, G.4    Gross, B.5    Sumer, S.O.6    Schultz, N.7
  • 53
    • 0030758777 scopus 로고    scopus 로고
    • Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization
    • Giannakakou, P., Sackett, D.L., Kang, Y.K., Zhan, Z., Buters, J.T., Fojo, T., Poruchynsky, M.S., Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization. J. Biol. Chem. 272:27 (1997), 17118–17125.
    • (1997) J. Biol. Chem. , vol.272 , Issue.27 , pp. 17118-17125
    • Giannakakou, P.1    Sackett, D.L.2    Kang, Y.K.3    Zhan, Z.4    Buters, J.T.5    Fojo, T.6    Poruchynsky, M.S.7
  • 57
    • 0030948473 scopus 로고    scopus 로고
    • Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression
    • Gorlick, R., Goker, E., Trippett, T., Steinherz, P., Elisseyeff, Y., Mazumdar, M., Flintoff, W.F., Bertino, J.R., Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. Blood 89 (1997), 1013–1018.
    • (1997) Blood , vol.89 , pp. 1013-1018
    • Gorlick, R.1    Goker, E.2    Trippett, T.3    Steinherz, P.4    Elisseyeff, Y.5    Mazumdar, M.6    Flintoff, W.F.7    Bertino, J.R.8
  • 58
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • Gottesman, M.M., Fojo, T., Bates, S.E., Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer 2 (2002), 48–58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 61
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 62
    • 0032190407 scopus 로고    scopus 로고
    • Clinical applications of anticancer drugs targeted to topoisomerase II
    • Hande, K.R., Clinical applications of anticancer drugs targeted to topoisomerase II. Biochim. Biophys. Acta (BBA) – Gene Struct. Expr. 1400 (1998), 173–184.
    • (1998) Biochim. Biophys. Acta (BBA) – Gene Struct. Expr. , vol.1400 , pp. 173-184
    • Hande, K.R.1
  • 63
    • 33644977169 scopus 로고    scopus 로고
    • Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules
    • Hari, M., Loganzo, F., Annable, T., Tan, X., Musto, S., Morilla, D.B., …, Greenberger, L.M., Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules. Mol. Cancer Ther. 5:2 (2006), 270–278.
    • (2006) Mol. Cancer Ther. , vol.5 , Issue.2 , pp. 270-278
    • Hari, M.1    Loganzo, F.2    Annable, T.3    Tan, X.4    Musto, S.5    Morilla, D.B.6    Greenberger, L.M.7
  • 66
    • 34250711394 scopus 로고    scopus 로고
    • Depletion of major vault protein increases doxorubicin sensitivity and nuclear accumulation and disrupts its sequestration in lysosomes
    • Herlevsen, M., Oxford, G., Owens, C.R., Conaway, M., Theodorescu, D., Depletion of major vault protein increases doxorubicin sensitivity and nuclear accumulation and disrupts its sequestration in lysosomes. Mol. Cancer Therapeut. 6 (2007), 1804–1813.
    • (2007) Mol. Cancer Therapeut. , vol.6 , pp. 1804-1813
    • Herlevsen, M.1    Oxford, G.2    Owens, C.R.3    Conaway, M.4    Theodorescu, D.5
  • 68
    • 0024388737 scopus 로고
    • Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells
    • Holm, C., Covey, J.M., Kerrigan, D., Pommier, Y., Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells. Cancer Res. 49:22 (1989), 6365–6368.
    • (1989) Cancer Res. , vol.49 , Issue.22 , pp. 6365-6368
    • Holm, C.1    Covey, J.M.2    Kerrigan, D.3    Pommier, Y.4
  • 70
    • 67249152349 scopus 로고    scopus 로고
    • Topoisomerase I expression correlates to response to neoadjuvant irinotecan-based chemoradiation in rectal cancer
    • Horisberger, K., Erben, P., Muessle, B., Woernle, C., Stroebel, P., Kaehler, G., …, Hofheinz, R.D., Topoisomerase I expression correlates to response to neoadjuvant irinotecan-based chemoradiation in rectal cancer. Anticancer Drugs 20:6 (2009), 519–524.
    • (2009) Anticancer Drugs , vol.20 , Issue.6 , pp. 519-524
    • Horisberger, K.1    Erben, P.2    Muessle, B.3    Woernle, C.4    Stroebel, P.5    Kaehler, G.6    Hofheinz, R.D.7
  • 71
    • 0015692519 scopus 로고
    • Effects of camptothecin on the breakage and repair of DNA during the cell cycle
    • Horwitz, S.B., Horwitz, M.S., Effects of camptothecin on the breakage and repair of DNA during the cell cycle. Cancer Res. 33:11 (1973), 2834–2836.
    • (1973) Cancer Res. , vol.33 , Issue.11 , pp. 2834-2836
    • Horwitz, S.B.1    Horwitz, M.S.2
  • 72
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Hsiang, Y.H., Hertzberg, R., Hecht, S., Liu, L.F., Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 260:27 (1985), 14873–14878.
    • (1985) J. Biol. Chem. , vol.260 , Issue.27 , pp. 14873-14878
    • Hsiang, Y.H.1    Hertzberg, R.2    Hecht, S.3    Liu, L.F.4
  • 73
    • 0024420685 scopus 로고
    • Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
    • Hsiang, Y.H., Lihou, M.G., Liu, L.F., Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res. 49:18 (1989), 5077–5082.
    • (1989) Cancer Res. , vol.49 , Issue.18 , pp. 5077-5082
    • Hsiang, Y.H.1    Lihou, M.G.2    Liu, L.F.3
  • 74
    • 84919393748 scopus 로고    scopus 로고
    • Nucleotide excision repair gene polymorphisms and prognosis of non-small cell lung cancer patients receiving platinum-based chemotherapy: a meta-analysis based on 44 studies
    • Huang, D., Zhou, Y., Nucleotide excision repair gene polymorphisms and prognosis of non-small cell lung cancer patients receiving platinum-based chemotherapy: a meta-analysis based on 44 studies. Biomed. Rep. 2 (2014), 452–462.
    • (2014) Biomed. Rep. , vol.2 , pp. 452-462
    • Huang, D.1    Zhou, Y.2
  • 76
    • 84878373665 scopus 로고    scopus 로고
    • Expression of survivin and patients survival in non-small cell lung cancer: a meta-analysis of the published studies
    • Huang, L.N., Wang, D.S., Chen, Y.Q., Zhao, C.L., Gong, B.L., Jiang, A.B., …, Hu, F.D., Expression of survivin and patients survival in non-small cell lung cancer: a meta-analysis of the published studies. Mol. Biol. Rep. 40:2 (2013), 917–924.
    • (2013) Mol. Biol. Rep. , vol.40 , Issue.2 , pp. 917-924
    • Huang, L.N.1    Wang, D.S.2    Chen, Y.Q.3    Zhao, C.L.4    Gong, B.L.5    Jiang, A.B.6    Hu, F.D.7
  • 77
    • 84924272625 scopus 로고    scopus 로고
    • p22phox confers resistance to cisplatin, by blocking its entry into the nucleus
    • Hung, C.C., Chien, C.Y., Chiang, W.F., Lin, C.S., Hour, T.C., Chen, H.R., …, Chen, J.Y., p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. Oncotarget 6:6 (2015), 4110–4125.
    • (2015) Oncotarget , vol.6 , Issue.6 , pp. 4110-4125
    • Hung, C.C.1    Chien, C.Y.2    Chiang, W.F.3    Lin, C.S.4    Hour, T.C.5    Chen, H.R.6    Chen, J.Y.7
  • 78
    • 0036547417 scopus 로고    scopus 로고
    • Death and anti-death: tumour resistance to apoptosis
    • Igney, F.H., Krammer, P.H., Death and anti-death: tumour resistance to apoptosis. Nat. Rev. Cancer 2 (2002), 277–288.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 277-288
    • Igney, F.H.1    Krammer, P.H.2
  • 80
    • 80052413958 scopus 로고    scopus 로고
    • Topoisomerase I expression in tumors as a biological marker for CPT-11 chemosensitivity in patients with colorectal cancer
    • Ikeguchi, M., Arai, Y., Maeta, Y., Ashida, K., Katano, K., Wakatsuki, T., Topoisomerase I expression in tumors as a biological marker for CPT-11 chemosensitivity in patients with colorectal cancer. Surg. Today 41:9 (2011), 1196–1199.
    • (2011) Surg. Today , vol.41 , Issue.9 , pp. 1196-1199
    • Ikeguchi, M.1    Arai, Y.2    Maeta, Y.3    Ashida, K.4    Katano, K.5    Wakatsuki, T.6
  • 81
    • 84877815745 scopus 로고    scopus 로고
    • A re-evaluation of the role of hCTR1, the human high-affinity copper transporter, in platinum-drug entry into human cells
    • Ivy, K.D., Kaplan, J.H., A re-evaluation of the role of hCTR1, the human high-affinity copper transporter, in platinum-drug entry into human cells. Mol. Pharmacol. 83:6 (2013), 1237–1246.
    • (2013) Mol. Pharmacol. , vol.83 , Issue.6 , pp. 1237-1246
    • Ivy, K.D.1    Kaplan, J.H.2
  • 82
    • 84942191470 scopus 로고    scopus 로고
    • Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate
    • Jabeen, S., Holmboe, L., Alnaes, G.I., Andersen, A.M., Hall, K.S., Kristensen, V.N., Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate. Pharmacogenom. J. 15 (2015), 385–390.
    • (2015) Pharmacogenom. J. , vol.15 , pp. 385-390
    • Jabeen, S.1    Holmboe, L.2    Alnaes, G.I.3    Andersen, A.M.4    Hall, K.S.5    Kristensen, V.N.6
  • 85
    • 0029665095 scopus 로고    scopus 로고
    • Expression of topoisomerase IIalpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer
    • Järvinen, T.A., Kononen, J., Pelto-Huikko, M., Isola, J., Expression of topoisomerase IIalpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer. Am. J. Pathol. 148 (1996), 2073–2082.
    • (1996) Am. J. Pathol. , vol.148 , pp. 2073-2082
    • Järvinen, T.A.1    Kononen, J.2    Pelto-Huikko, M.3    Isola, J.4
  • 86
    • 84939417508 scopus 로고    scopus 로고
    • p57Kip2 is an unrecognized DNA damage response effector molecule that functions in tumor suppression and chemoresistance
    • Jia, H., Cong, Q., Chua, J.F., Liu, H., Xia, X., Zhang, X., Lin, J., Habib, S.L., Ao, J., Zuo, Q., Fu, C., Li, B., p57Kip2 is an unrecognized DNA damage response effector molecule that functions in tumor suppression and chemoresistance. Oncogene 34 (2015), 3568–3581.
    • (2015) Oncogene , vol.34 , pp. 3568-3581
    • Jia, H.1    Cong, Q.2    Chua, J.F.3    Liu, H.4    Xia, X.5    Zhang, X.6    Lin, J.7    Habib, S.L.8    Ao, J.9    Zuo, Q.10    Fu, C.11    Li, B.12
  • 87
  • 91
    • 84880164180 scopus 로고    scopus 로고
    • Cytoskeletal alterations that confer resistance to anti-tubulin chemotherapeutics
    • Kanakkanthara, A., Teesdale-Spittle, P.H., Miller, J.H., Cytoskeletal alterations that confer resistance to anti-tubulin chemotherapeutics. Anticancer Agents Med. Chem. 13:1 (2013), 147–158.
    • (2013) Anticancer Agents Med. Chem. , vol.13 , Issue.1 , pp. 147-158
    • Kanakkanthara, A.1    Teesdale-Spittle, P.H.2    Miller, J.H.3
  • 92
    • 84885440374 scopus 로고    scopus 로고
    • Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer
    • Kang, Y., Hu, W., Ivan, C., Dalton, H.J., Miyake, T., Pecot, C.V., …, Sood, A.K., Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J. Natl. Cancer Inst. 105:19 (2013), 1485–1495.
    • (2013) J. Natl. Cancer Inst. , vol.105 , Issue.19 , pp. 1485-1495
    • Kang, Y.1    Hu, W.2    Ivan, C.3    Dalton, H.J.4    Miyake, T.5    Pecot, C.V.6    Sood, A.K.7
  • 93
    • 0037413708 scopus 로고    scopus 로고
    • Repeat motifs of tau bind to the insides of microtubules in the absence of taxol
    • Kar, S., Fan, J., Smith, M.J., Goedert, M., Amos, L.A., Repeat motifs of tau bind to the insides of microtubules in the absence of taxol. Embo. J. 22:1 (2003), 70–77.
    • (2003) Embo. J. , vol.22 , Issue.1 , pp. 70-77
    • Kar, S.1    Fan, J.2    Smith, M.J.3    Goedert, M.4    Amos, L.A.5
  • 96
    • 77649191871 scopus 로고    scopus 로고
    • Microtubules and resistance to tubulin-binding agents
    • Kavallaris, M., Microtubules and resistance to tubulin-binding agents. Nat. Rev. Cancer 10:3 (2010), 194–204.
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.3 , pp. 194-204
    • Kavallaris, M.1
  • 97
    • 65849391100 scopus 로고    scopus 로고
    • Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer
    • Kawahara, A., Akagi, Y., Hattori, S., Mizobe, T., Shirouzu, K., Ono, M., Yanagawa, T., Kuwano, M., Kage, M., Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer. J. Clin. Pathol. 62 (2009), 364–369.
    • (2009) J. Clin. Pathol. , vol.62 , pp. 364-369
    • Kawahara, A.1    Akagi, Y.2    Hattori, S.3    Mizobe, T.4    Shirouzu, K.5    Ono, M.6    Yanagawa, T.7    Kuwano, M.8    Kage, M.9
  • 98
    • 33645727988 scopus 로고    scopus 로고
    • TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer
    • Kelly, M.G., Alvero, A.B., Chen, R., Silasi, D.A., Abrahams, V.M., Chan, S., …, Mor, G., TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer. Cancer Res. 66:7 (2006), 3859–3868.
    • (2006) Cancer Res. , vol.66 , Issue.7 , pp. 3859-3868
    • Kelly, M.G.1    Alvero, A.B.2    Chen, R.3    Silasi, D.A.4    Abrahams, V.M.5    Chan, S.6    Mor, G.7
  • 99
    • 79951986443 scopus 로고    scopus 로고
    • A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients
    • Kim, H.K., Choi, I.J., Kim, C.G., Kim, H.S., Oshima, A., Michalowski, A., Green, J.E., A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. PLoS ONE, 6, 2011, pe16694.
    • (2011) PLoS ONE , vol.6 , pp. pe16694
    • Kim, H.K.1    Choi, I.J.2    Kim, C.G.3    Kim, H.S.4    Oshima, A.5    Michalowski, A.6    Green, J.E.7
  • 100
    • 84957555628 scopus 로고    scopus 로고
    • Targeting EZH2 in cancer
    • Kim, K.H., Roberts, C.W., Targeting EZH2 in cancer. Nat. Med. 22 (2016), 128–134.
    • (2016) Nat. Med. , vol.22 , pp. 128-134
    • Kim, K.H.1    Roberts, C.W.2
  • 101
    • 0037945211 scopus 로고    scopus 로고
    • HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells
    • Knuefermann, C., Lu, Y., Liu, B., Jin, W., Liang, K., Wu, L., …, Fan, Z., HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. Oncogene. 22:21 (2003), 3205–3212.
    • (2003) Oncogene. , vol.22 , Issue.21 , pp. 3205-3212
    • Knuefermann, C.1    Lu, Y.2    Liu, B.3    Jin, W.4    Liang, K.5    Wu, L.6    Fan, Z.7
  • 102
    • 4944241573 scopus 로고    scopus 로고
    • Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition
    • Koehler, S.E., Ladner, R.D., Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. Mol. Pharmacol. 66 (2004), 620–626.
    • (2004) Mol. Pharmacol. , vol.66 , pp. 620-626
    • Koehler, S.E.1    Ladner, R.D.2
  • 105
    • 84941206785 scopus 로고    scopus 로고
    • Stathmin and phospho-stathmin protein signature is associated with survival outcomes of breast cancer patients
    • Kuang, X.Y., Chen, L., Zhang, Z.J., Liu, Y.R., Zheng, Y.Z., Ling, H., …, Shao, Z.M., Stathmin and phospho-stathmin protein signature is associated with survival outcomes of breast cancer patients. Oncotarget 6:26 (2015), 22227–22238.
    • (2015) Oncotarget , vol.6 , Issue.26 , pp. 22227-22238
    • Kuang, X.Y.1    Chen, L.2    Zhang, Z.J.3    Liu, Y.R.4    Zheng, Y.Z.5    Ling, H.6    Shao, Z.M.7
  • 106
    • 79953310106 scopus 로고    scopus 로고
    • Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF
    • Lai, D., Ho, K.C., Hao, Y., Yang, X., Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res. 71:7 (2011), 2728–2738.
    • (2011) Cancer Res. , vol.71 , Issue.7 , pp. 2728-2738
    • Lai, D.1    Ho, K.C.2    Hao, Y.3    Yang, X.4
  • 108
    • 34248166978 scopus 로고    scopus 로고
    • The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers
    • Leong, C.O., Vidnovic, N., DeYoung, M.P., Sgroi, D., Ellisen, L.W., The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers. J. Clin. investig. 117 (2007), 1370–1380.
    • (2007) J. Clin. investig. , vol.117 , pp. 1370-1380
    • Leong, C.O.1    Vidnovic, N.2    DeYoung, M.P.3    Sgroi, D.4    Ellisen, L.W.5
  • 109
    • 84908137596 scopus 로고    scopus 로고
    • Prognostic significance of survivin in breast cancer: meta-analysis
    • Li, Y., Ma, X., Wu, X., Liu, X., Liu, L., Prognostic significance of survivin in breast cancer: meta-analysis. Breast J. 20:5 (2014), 514–524.
    • (2014) Breast J. , vol.20 , Issue.5 , pp. 514-524
    • Li, Y.1    Ma, X.2    Wu, X.3    Liu, X.4    Liu, L.5
  • 110
    • 84900529274 scopus 로고    scopus 로고
    • FOXM1 mediates resistance to docetaxel in gastric cancer via up-regulating Stathmin
    • Li, X., Yao, R., Yue, L., Qiu, W., Qi, W., Liu, S., …, Liang, J., FOXM1 mediates resistance to docetaxel in gastric cancer via up-regulating Stathmin. J. Cell Mol. Med. 18:5 (2014), 811–823.
    • (2014) J. Cell Mol. Med. , vol.18 , Issue.5 , pp. 811-823
    • Li, X.1    Yao, R.2    Yue, L.3    Qiu, W.4    Qi, W.5    Liu, S.6    Liang, J.7
  • 111
    • 77649341172 scopus 로고    scopus 로고
    • Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy
    • Li, F., Sethi, G., Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. Biochim. Biophys. Acta 1805 (2010), 167–180.
    • (2010) Biochim. Biophys. Acta , vol.1805 , pp. 167-180
    • Li, F.1    Sethi, G.2
  • 113
    • 84888205791 scopus 로고    scopus 로고
    • Rationally designed nanovehicles to overcome cancer chemoresistance
    • Livney, Y.D., Assaraf, Y.G., Rationally designed nanovehicles to overcome cancer chemoresistance. Adv. Drug Deliv. Rev. 65 (2013), 1716–1730.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 1716-1730
    • Livney, Y.D.1    Assaraf, Y.G.2
  • 115
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • Mackey, J.R., Mani, R.S., Selner, M., Mowles, D., Young, J.D., Belt, J.A., Crawford, C.R., Cass, C.E., Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res. 58 (1998), 4349–4357.
    • (1998) Cancer Res. , vol.58 , pp. 4349-4357
    • Mackey, J.R.1    Mani, R.S.2    Selner, M.3    Mowles, D.4    Young, J.D.5    Belt, J.A.6    Crawford, C.R.7    Cass, C.E.8
  • 118
    • 39749197508 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and clinical aspects
    • Mazzanti, R., Gramantieri, L., Bolondi, L., Hepatocellular carcinoma: epidemiology and clinical aspects. Mol. Aspects Med. 29 (2008), 130–143.
    • (2008) Mol. Aspects Med. , vol.29 , pp. 130-143
    • Mazzanti, R.1    Gramantieri, L.2    Bolondi, L.3
  • 119
    • 77953750777 scopus 로고    scopus 로고
    • betaIII-tubulin is a multifunctional protein involved in drug sensitivity and tumorigenesis in non-small cell lung cancer
    • McCarroll, J.A., Gan, P.P., Liu, M., Kavallaris, M., betaIII-tubulin is a multifunctional protein involved in drug sensitivity and tumorigenesis in non-small cell lung cancer. Cancer Res. 70 (2010), 4995–5003.
    • (2010) Cancer Res. , vol.70 , pp. 4995-5003
    • McCarroll, J.A.1    Gan, P.P.2    Liu, M.3    Kavallaris, M.4
  • 121
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    • Minotti, G., Menna, P., Salvatorelli, E., Cairo, G., Gianni, L., Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol. Rev. 56 (2004), 185–229.
    • (2004) Pharmacol. Rev. , vol.56 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3    Cairo, G.4    Gianni, L.5
  • 122
    • 0026781986 scopus 로고
    • bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs
    • Miyashita, T., Reed, J.C., bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res. 52 (1992), 5407–5411.
    • (1992) Cancer Res. , vol.52 , pp. 5407-5411
    • Miyashita, T.1    Reed, J.C.2
  • 127
    • 84901951940 scopus 로고    scopus 로고
    • Single-agent versus combination chemotherapy as first-line treatment for patients with advanced non-small cell lung cancer and performance status 2: a literature-based meta-analysis of randomized studies
    • Morth, C., Valachis, A., Single-agent versus combination chemotherapy as first-line treatment for patients with advanced non-small cell lung cancer and performance status 2: a literature-based meta-analysis of randomized studies. Lung Cancer (Amst. Neth.) 84 (2014), 209–214.
    • (2014) Lung Cancer (Amst. Neth.) , vol.84 , pp. 209-214
    • Morth, C.1    Valachis, A.2
  • 128
    • 84980321843 scopus 로고    scopus 로고
    • SLFN11 Inhibits Checkpoint Maintenance and Homologous Recombination Repair
    • EMBO reports
    • Mu, Y., Lou, J., Srivastava, M., Zhao, B., Feng, X.H., Liu, T., Chen, J., Huang, J., SLFN11 Inhibits Checkpoint Maintenance and Homologous Recombination Repair. 2015, EMBO reports.
    • (2015)
    • Mu, Y.1    Lou, J.2    Srivastava, M.3    Zhao, B.4    Feng, X.H.5    Liu, T.6    Chen, J.7    Huang, J.8
  • 130
    • 64649090292 scopus 로고    scopus 로고
    • Targeting DNA topoisomerase II in cancer chemotherapy
    • Nitiss, J.L., Targeting DNA topoisomerase II in cancer chemotherapy. Nat. Rev. Cancer 9 (2009), 338–350.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 338-350
    • Nitiss, J.L.1
  • 132
    • 84904395417 scopus 로고    scopus 로고
    • hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: a systematic review
    • Nordh, S., Ansari, D., Andersson, R., hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: a systematic review. World J. Gastroenterol. 20 (2014), 8482–8490.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 8482-8490
    • Nordh, S.1    Ansari, D.2    Andersson, R.3
  • 136
    • 84931578409 scopus 로고    scopus 로고
    • Chemical profiling of the genome with anti-cancer drugs defines target specificities
    • Pang, B., de Jong, J., Qiao, X., Wessels, L.F., Neefjes, J., Chemical profiling of the genome with anti-cancer drugs defines target specificities. Nat. Chem. Biol. 11 (2015), 472–480.
    • (2015) Nat. Chem. Biol. , vol.11 , pp. 472-480
    • Pang, B.1    de Jong, J.2    Qiao, X.3    Wessels, L.F.4    Neefjes, J.5
  • 138
    • 0037081269 scopus 로고    scopus 로고
    • X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance
    • Park, S.Y., Lam, W., Cheng, Y.C., X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance. Cancer Res. 62 (2002), 459–465.
    • (2002) Cancer Res. , vol.62 , pp. 459-465
    • Park, S.Y.1    Lam, W.2    Cheng, Y.C.3
  • 139
    • 84926452313 scopus 로고    scopus 로고
    • Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets
    • Pastor-Anglada, M., Perez-Torras, S., Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets. Front. Pharmacol., 6, 2015, p13.
    • (2015) Front. Pharmacol. , vol.6 , pp. p13
    • Pastor-Anglada, M.1    Perez-Torras, S.2
  • 140
    • 84874058291 scopus 로고    scopus 로고
    • Topotecan and doxorubicin combination to treat recurrent ovarian cancer: the influence of drug exposure time and delivery systems to achieve optimum therapeutic activity
    • Patankar, N.A., Pritchard, J., van Grinsven, M., Osooly, M., Bally, M.B., Topotecan and doxorubicin combination to treat recurrent ovarian cancer: the influence of drug exposure time and delivery systems to achieve optimum therapeutic activity. Clin. Cancer Res.: Off. J. Am. Assoc. Cancer Res. 19 (2013), 865–877.
    • (2013) Clin. Cancer Res.: Off. J. Am. Assoc. Cancer Res. , vol.19 , pp. 865-877
    • Patankar, N.A.1    Pritchard, J.2    van Grinsven, M.3    Osooly, M.4    Bally, M.B.5
  • 144
    • 84872547120 scopus 로고    scopus 로고
    • Drugging topoisomerases: lessons and challenges
    • Pommier, Y., Drugging topoisomerases: lessons and challenges. ACS Chem. Biol. 8:1 (2013), 82–95.
    • (2013) ACS Chem. Biol. , vol.8 , Issue.1 , pp. 82-95
    • Pommier, Y.1
  • 145
    • 0033208192 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors: selectivity and cellular resistance
    • Pommier, Y., Pourquier, P., Urasaki, Y., Wu, J., Laco, G.S., Topoisomerase I inhibitors: selectivity and cellular resistance. Drug Resist Updat 2:5 (1999), 307–318.
    • (1999) Drug Resist Updat , vol.2 , Issue.5 , pp. 307-318
    • Pommier, Y.1    Pourquier, P.2    Urasaki, Y.3    Wu, J.4    Laco, G.S.5
  • 148
    • 84910029508 scopus 로고    scopus 로고
    • Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia
    • Raz, S., Stark, M., Assaraf, Y.G., Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia. Oncotarget 5 (2014), 9183–9198.
    • (2014) Oncotarget , vol.5 , pp. 9183-9198
    • Raz, S.1    Stark, M.2    Assaraf, Y.G.3
  • 149
    • 84978492560 scopus 로고    scopus 로고
    • Folylpoly-γ-glutamate synthetase: a key determinant of folate homeostasis and antifolate resistance in cancer
    • Raz, S., Stark, M., Assaraf, Y.G., Folylpoly-γ-glutamate synthetase: a key determinant of folate homeostasis and antifolate resistance in cancer. Drug Resist. Updates, 2016.
    • (2016) Drug Resist. Updates
    • Raz, S.1    Stark, M.2    Assaraf, Y.G.3
  • 150
    • 84875722622 scopus 로고    scopus 로고
    • Molecular aspects of cancer cell resistance to chemotherapy
    • Rebucci, M., Michiels, C., Molecular aspects of cancer cell resistance to chemotherapy. Biochem. Pharmacol. 85 (2013), 1219–1226.
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 1219-1226
    • Rebucci, M.1    Michiels, C.2
  • 151
    • 0030701599 scopus 로고    scopus 로고
    • Flip-flop of doxorubicin across erythrocyte and lipid membranes
    • Regev, R., Eytan, G.D., Flip-flop of doxorubicin across erythrocyte and lipid membranes. Biochem. Pharmacol. 54 (1997), 1151–1158.
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 1151-1158
    • Regev, R.1    Eytan, G.D.2
  • 152
    • 20444389423 scopus 로고    scopus 로고
    • Transport of anthracyclines and mitoxantrone across membranes by a flip-flop mechanism
    • Regev, R., Yeheskely-Hayon, D., Katzir, H., Eytan, G.D., Transport of anthracyclines and mitoxantrone across membranes by a flip-flop mechanism. Biochem. Pharmacol. 70 (2005), 161–169.
    • (2005) Biochem. Pharmacol. , vol.70 , pp. 161-169
    • Regev, R.1    Yeheskely-Hayon, D.2    Katzir, H.3    Eytan, G.D.4
  • 153
    • 0036844903 scopus 로고    scopus 로고
    • Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines
    • Rothem, L., Ifergan, I., Kaufman, Y., Priest, D.G., Jansen, G., Assaraf, Y.G., Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines. Biochem. J. 367 (2002), 741–750.
    • (2002) Biochem. J. , vol.367 , pp. 741-750
    • Rothem, L.1    Ifergan, I.2    Kaufman, Y.3    Priest, D.G.4    Jansen, G.5    Assaraf, Y.G.6
  • 154
    • 0033104709 scopus 로고    scopus 로고
    • Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia
    • Rots, M.G., Pieters, R., Peters, G.J., Noordhuis, P., van Zantwijk, C.H., Kaspers, G.J., Hahlen, K., Creutzig, U., Veerman, A.J., Jansen, G., Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia. Blood 93 (1999), 1677–1683.
    • (1999) Blood , vol.93 , pp. 1677-1683
    • Rots, M.G.1    Pieters, R.2    Peters, G.J.3    Noordhuis, P.4    van Zantwijk, C.H.5    Kaspers, G.J.6    Hahlen, K.7    Creutzig, U.8    Veerman, A.J.9    Jansen, G.10
  • 155
    • 20444388706 scopus 로고    scopus 로고
    • Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer
    • Rouzier, R., Rajan, R., Wagner, P., Hess, K.R., Gold, D.L., Stec, J., …, Pusztai, L., Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer. Proc Natl Acad Sci U S A 102:23 (2005), 8315–8320.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.23 , pp. 8315-8320
    • Rouzier, R.1    Rajan, R.2    Wagner, P.3    Hess, K.R.4    Gold, D.L.5    Stec, J.6    Pusztai, L.7
  • 158
    • 84945138331 scopus 로고    scopus 로고
    • Role of mismatch repair proteins in the processing of cisplatin interstrand cross-links
    • Sawant, A., Kothandapani, A., Zhitkovich, A., Sobol, R.W., Patrick, S.M., Role of mismatch repair proteins in the processing of cisplatin interstrand cross-links. DNA Rep. 35 (2015), 126–136.
    • (2015) DNA Rep. , vol.35 , pp. 126-136
    • Sawant, A.1    Kothandapani, A.2    Zhitkovich, A.3    Sobol, R.W.4    Patrick, S.M.5
  • 162
    • 84928897022 scopus 로고    scopus 로고
    • Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs
    • Serdjebi, C., Milano, G., Ciccolini, J., Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs. Expert Opin. Drug Metab. Toxicol. 11 (2015), 665–672.
    • (2015) Expert Opin. Drug Metab. Toxicol. , vol.11 , pp. 665-672
    • Serdjebi, C.1    Milano, G.2    Ciccolini, J.3
  • 165
    • 0345256652 scopus 로고    scopus 로고
    • Cisplatin: mode of cytotoxic action and molecular basis of resistance
    • Siddik, Z.H., Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22 (2003), 7265–7279.
    • (2003) Oncogene , vol.22 , pp. 7265-7279
    • Siddik, Z.H.1
  • 167
    • 0036202207 scopus 로고    scopus 로고
    • Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens
    • Sladek, N.E., Kollander, R., Sreerama, L., Kiang, D.T., Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens. Cancer Chemother. Pharmacol. 49 (2002), 309–321.
    • (2002) Cancer Chemother. Pharmacol. , vol.49 , pp. 309-321
    • Sladek, N.E.1    Kollander, R.2    Sreerama, L.3    Kiang, D.T.4
  • 170
    • 84876786400 scopus 로고    scopus 로고
    • Tau protein as a potential predictive marker in epithelial ovarian cancer patients treated with paclitaxel/platinum first-line chemotherapy
    • Smoter, M., Bodnar, L., Grala, B., Stec, R., Zieniuk, K., Kozlowski, W., Szczylik, C., Tau protein as a potential predictive marker in epithelial ovarian cancer patients treated with paclitaxel/platinum first-line chemotherapy. J. Exp. Clin. Cancer Res., 32, 2013, 25.
    • (2013) J. Exp. Clin. Cancer Res. , vol.32 , pp. 25
    • Smoter, M.1    Bodnar, L.2    Grala, B.3    Stec, R.4    Zieniuk, K.5    Kozlowski, W.6    Szczylik, C.7
  • 173
    • 0041842584 scopus 로고    scopus 로고
    • Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate
    • Stark, M., Rothem, L., Jansen, G., Scheffer, G.L., Goldman, I.D., Assaraf, Y.G., Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate. Mol. Pharmacol. 64 (2003), 220–227.
    • (2003) Mol. Pharmacol. , vol.64 , pp. 220-227
    • Stark, M.1    Rothem, L.2    Jansen, G.3    Scheffer, G.L.4    Goldman, I.D.5    Assaraf, Y.G.6
  • 174
    • 0032489675 scopus 로고    scopus 로고
    • A model for the mechanism of human topoisomerase I
    • Stewart, L., Redinbo, M.R., Qiu, X., Hol, W.G., Champoux, J.J., A model for the mechanism of human topoisomerase I. Science 279:5356 (1998), 1534–1541.
    • (1998) Science , vol.279 , Issue.5356 , pp. 1534-1541
    • Stewart, L.1    Redinbo, M.R.2    Qiu, X.3    Hol, W.G.4    Champoux, J.J.5
  • 175
    • 1942474378 scopus 로고    scopus 로고
    • Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint
    • Sudo, T., Nitta, M., Saya, H., Ueno, N.T., Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint. Cancer Res. 64:7 (2004), 2502–2508.
    • (2004) Cancer Res. , vol.64 , Issue.7 , pp. 2502-2508
    • Sudo, T.1    Nitta, M.2    Saya, H.3    Ueno, N.T.4
  • 179
    • 84880081204 scopus 로고    scopus 로고
    • Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models
    • Tiwari, A.K., Zhang, R., Gallo, J.M., Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models. Mol. Cancer Ther. 12:7 (2013), 1343–1355.
    • (2013) Mol. Cancer Ther. , vol.12 , Issue.7 , pp. 1343-1355
    • Tiwari, A.K.1    Zhang, R.2    Gallo, J.M.3
  • 180
  • 187
    • 84944166647 scopus 로고    scopus 로고
    • Targeting BCL2-proteins for the treatment of solid tumours
    • Vogler, M., Targeting BCL2-proteins for the treatment of solid tumours. Adv. Med., 2014, 2014, p943648.
    • (2014) Adv. Med. , vol.2014 , pp. p943648
    • Vogler, M.1
  • 188
    • 0036085460 scopus 로고    scopus 로고
    • Cellular roles of DNA topoisomerases: a molecular perspective
    • Wang, J.C., Cellular roles of DNA topoisomerases: a molecular perspective. Nat. Rev. Mol. Cell Biol. 3:6 (2002), 430–440.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , Issue.6 , pp. 430-440
    • Wang, J.C.1
  • 189
    • 80755167837 scopus 로고    scopus 로고
    • DNA repair capacity in peripheral lymphocytes predicts survival of patients with non-small-cell lung cancer treated with first-line platinum-based chemotherapy
    • Wang, L.E., Yin, M., Dong, Q., Stewart, D.J., Merriman, K.W., Amos, C.I., Spitz, M.R., Wei, Q., DNA repair capacity in peripheral lymphocytes predicts survival of patients with non-small-cell lung cancer treated with first-line platinum-based chemotherapy. J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol. 29 (2011), 4121–4128.
    • (2011) J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol. , vol.29 , pp. 4121-4128
    • Wang, L.E.1    Yin, M.2    Dong, Q.3    Stewart, D.J.4    Merriman, K.W.5    Amos, C.I.6    Spitz, M.R.7    Wei, Q.8
  • 190
    • 79952228118 scopus 로고    scopus 로고
    • Genetic polymorphisms of ERCC1 and their effects on the efficacy of cisplatin-based chemotherapy in advanced esophageal carcinoma
    • Wang, Y., Chen, J., Li, X., He, Y., Hu, B., Ji, C., Xu, J., Genetic polymorphisms of ERCC1 and their effects on the efficacy of cisplatin-based chemotherapy in advanced esophageal carcinoma. Oncol. Rep. 25 (2011), 1047–1052.
    • (2011) Oncol. Rep. , vol.25 , pp. 1047-1052
    • Wang, Y.1    Chen, J.2    Li, X.3    He, Y.4    Hu, B.5    Ji, C.6    Xu, J.7
  • 192
    • 84946056925 scopus 로고    scopus 로고
    • IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
    • Wee, Z.N., Yatim, S.M., Kohlbauer, V.K., Feng, M., Goh, J.Y., Yi, B., …, Yu, Q., IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel. Nat. Commun., 6, 2015, 8746.
    • (2015) Nat. Commun. , vol.6 , pp. 8746
    • Wee, Z.N.1    Yatim, S.M.2    Kohlbauer, V.K.3    Feng, M.4    Goh, J.Y.5    Yi, B.6    Yu, Q.7
  • 193
    • 84885576391 scopus 로고    scopus 로고
    • Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed
    • Weeks, L.D., Fu, P., Gerson, S.L., Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed. Mol. Cancer Therapeut. 12 (2013), 2248–2260.
    • (2013) Mol. Cancer Therapeut. , vol.12 , pp. 2248-2260
    • Weeks, L.D.1    Fu, P.2    Gerson, S.L.3
  • 194
    • 84887275064 scopus 로고    scopus 로고
    • A meta-analysis of gemcitabine biomarkers in patients with pancreaticobiliary cancers
    • Wei, C.H., Gorgan, T.R., Elashoff, D.A., Hines, O.J., Farrell, J.J., Donahue, T.R., A meta-analysis of gemcitabine biomarkers in patients with pancreaticobiliary cancers. Pancreas 42 (2013), 1303–1310.
    • (2013) Pancreas , vol.42 , pp. 1303-1310
    • Wei, C.H.1    Gorgan, T.R.2    Elashoff, D.A.3    Hines, O.J.4    Farrell, J.J.5    Donahue, T.R.6
  • 195
    • 81055149849 scopus 로고    scopus 로고
    • A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome
    • Wei, G., Ni, W., Chiao, J.W., Cai, Z., Huang, H., Liu, D., A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome. J. Hematol. Oncol., 4, 2011, 46.
    • (2011) J. Hematol. Oncol. , vol.4 , pp. 46
    • Wei, G.1    Ni, W.2    Chiao, J.W.3    Cai, Z.4    Huang, H.5    Liu, D.6
  • 196
    • 0026714331 scopus 로고
    • The anthracyclines: will we ever find a better doxorubicin?
    • Weiss, R.B., The anthracyclines: will we ever find a better doxorubicin?. Semin. Oncol. 19 (1992), 670–686.
    • (1992) Semin. Oncol. , vol.19 , pp. 670-686
    • Weiss, R.B.1
  • 197
    • 84897866380 scopus 로고    scopus 로고
    • Stathmin protein level, a potential predictive marker for taxane treatment response in endometrial cancer
    • Werner, H.M., Trovik, J., Halle, M.K., Wik, E., Akslen, L.A., Birkeland, E., …, Salvesen, H.B., Stathmin protein level, a potential predictive marker for taxane treatment response in endometrial cancer. PLoS One, 9(2), 2014, e90141.
    • (2014) PLoS One , vol.9 , Issue.2 , pp. e90141
    • Werner, H.M.1    Trovik, J.2    Halle, M.K.3    Wik, E.4    Akslen, L.A.5    Birkeland, E.6    Salvesen, H.B.7
  • 198
    • 0025302665 scopus 로고
    • Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis
    • Whitehead, V.M., Rosenblatt, D.S., Vuchich, M.J., Shuster, J.J., Witte, A., Beaulieu, D., Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis. Blood 76 (1990), 44–49.
    • (1990) Blood , vol.76 , pp. 44-49
    • Whitehead, V.M.1    Rosenblatt, D.S.2    Vuchich, M.J.3    Shuster, J.J.4    Witte, A.5    Beaulieu, D.6
  • 201
    • 84859378612 scopus 로고    scopus 로고
    • Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer
    • Wilson, P.M., LaBonte, M.J., Lenz, H.J., Mack, P.C., Ladner, R.D., Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer. Mol. Cancer Therapeut. 11 (2012), 616–628.
    • (2012) Mol. Cancer Therapeut. , vol.11 , pp. 616-628
    • Wilson, P.M.1    LaBonte, M.J.2    Lenz, H.J.3    Mack, P.C.4    Ladner, R.D.5
  • 203
    • 84955620795 scopus 로고    scopus 로고
    • Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance
    • Wojtuszkiewicz, A., Raz, S., Stark, M., Assaraf, Y.G., Jansen, G., Peters, G.J., Sonneveld, E., Kaspers, G.J., Cloos, J., Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance. Int. J. Cancer. J. Int. Cancer 138 (2016), 1645–1656.
    • (2016) Int. J. Cancer. J. Int. Cancer , vol.138 , pp. 1645-1656
    • Wojtuszkiewicz, A.1    Raz, S.2    Stark, M.3    Assaraf, Y.G.4    Jansen, G.5    Peters, G.J.6    Sonneveld, E.7    Kaspers, G.J.8    Cloos, J.9
  • 204
    • 84938089515 scopus 로고    scopus 로고
    • FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-kappaB/Slug-mediated PUMA reduction
    • Wu, D.W., Lee, M.C., Hsu, N.Y., Wu, T.C., Wu, J.Y., Wang, Y.C., Cheng, Y.W., Chen, C.Y., Lee, H., FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-kappaB/Slug-mediated PUMA reduction. Oncogene 34 (2015), 2505–2515.
    • (2015) Oncogene , vol.34 , pp. 2505-2515
    • Wu, D.W.1    Lee, M.C.2    Hsu, N.Y.3    Wu, T.C.4    Wu, J.Y.5    Wang, Y.C.6    Cheng, Y.W.7    Chen, C.Y.8    Lee, H.9
  • 205
    • 84930586812 scopus 로고    scopus 로고
    • Proteomic profiling of paclitaxel treated cells identifies a novel mechanism of drug resistance mediated by PDCD4
    • Xu, H., Dephoure, N., Sun, H., Zhang, H., Fan, F., Liu, J., …, Zhou, C., Proteomic profiling of paclitaxel treated cells identifies a novel mechanism of drug resistance mediated by PDCD4. J. Proteome. Res. 14:6 (2015), 2480–2491.
    • (2015) J. Proteome. Res. , vol.14 , Issue.6 , pp. 2480-2491
    • Xu, H.1    Dephoure, N.2    Sun, H.3    Zhang, H.4    Fan, F.5    Liu, J.6    Zhou, C.7
  • 206
    • 85012095450 scopus 로고    scopus 로고
    • Inhibition of topoisomerase (DNA) I (TOP1): DNA damage repair and anticancer therapy
    • Xu, Y., Her, C., Inhibition of topoisomerase (DNA) I (TOP1): DNA damage repair and anticancer therapy. Biomolecules 5 (2015), 1652–1670.
    • (2015) Biomolecules , vol.5 , pp. 1652-1670
    • Xu, Y.1    Her, C.2
  • 207
    • 84890992190 scopus 로고    scopus 로고
    • Bcl-2 expression predicts sensitivity to chemotherapy in breast cancer: a systematic review and meta-analysis
    • Yang, D., Chen, M.B., Wang, L.Q., Yang, L., Liu, C.Y., Lu, P.H., Bcl-2 expression predicts sensitivity to chemotherapy in breast cancer: a systematic review and meta-analysis. J. Exp. Clin. Cancer Res.: CR, 32, 2013, 105.
    • (2013) J. Exp. Clin. Cancer Res.: CR , vol.32 , pp. 105
    • Yang, D.1    Chen, M.B.2    Wang, L.Q.3    Yang, L.4    Liu, C.Y.5    Lu, P.H.6
  • 208
    • 84877585708 scopus 로고    scopus 로고
    • Doxorubicin enhances nucleosome turnover around promoters
    • Yang, F., Kemp, C.J., Henikoff, S., Doxorubicin enhances nucleosome turnover around promoters. Curr. Biol.: CB 23 (2013), 782–787.
    • (2013) Curr. Biol.: CB , vol.23 , pp. 782-787
    • Yang, F.1    Kemp, C.J.2    Henikoff, S.3
  • 210
    • 76649138611 scopus 로고    scopus 로고
    • Human mutations that confer paclitaxel resistance
    • Yin, S., Bhattacharya, R., Cabral, F., Human mutations that confer paclitaxel resistance. Mol. Cancer Ther. 9:2 (2010), 327–335.
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.2 , pp. 327-335
    • Yin, S.1    Bhattacharya, R.2    Cabral, F.3
  • 211
    • 84937441218 scopus 로고    scopus 로고
    • Inhibition of spleen tyrosine kinase potentiates paclitaxel-induced cytotoxicity in ovarian cancer cells by stabilizing microtubules
    • Yu, Y., Gaillard, S., Phillip, J.M., Huang, T.C., Pinto, S.M., Tessarollo, N.G., …, Shih Ie, M., Inhibition of spleen tyrosine kinase potentiates paclitaxel-induced cytotoxicity in ovarian cancer cells by stabilizing microtubules. Cancer Cell 28:1 (2015), 82–96.
    • (2015) Cancer Cell , vol.28 , Issue.1 , pp. 82-96
    • Yu, Y.1    Gaillard, S.2    Phillip, J.M.3    Huang, T.C.4    Pinto, S.M.5    Tessarollo, N.G.6    Shih Ie, M.7
  • 212
    • 0036693488 scopus 로고    scopus 로고
    • Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer
    • Zaffaroni, N., Pennati, M., Colella, G., Perego, P., Supino, R., Gatti, L., …, Daidone, M.G., Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer. Cell Mol. Life Sci. 59:8 (2002), 1406–1412.
    • (2002) Cell Mol. Life Sci. , vol.59 , Issue.8 , pp. 1406-1412
    • Zaffaroni, N.1    Pennati, M.2    Colella, G.3    Perego, P.4    Supino, R.5    Gatti, L.6    Daidone, M.G.7
  • 215
    • 84912051474 scopus 로고    scopus 로고
    • Overexpression of forkhead box protein M1 (FOXM1) in ovarian cancer correlates with poor patient survival and contributes to paclitaxel resistance
    • Zhao, F., Siu, M.K., Jiang, L., Tam, K.F., Ngan, H.Y., Le, X.F., …, Cheung, A.N., Overexpression of forkhead box protein M1 (FOXM1) in ovarian cancer correlates with poor patient survival and contributes to paclitaxel resistance. PLoS One, 9(11), 2014, e113478.
    • (2014) PLoS One , vol.9 , Issue.11 , pp. e113478
    • Zhao, F.1    Siu, M.K.2    Jiang, L.3    Tam, K.F.4    Ngan, H.Y.5    Le, X.F.6    Cheung, A.N.7
  • 216
    • 84948407218 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
    • Zheng, X., Carstens, J.L., Kim, J., Scheible, M., Kaye, J., Sugimoto, H., Wu, C.C., LeBleu, V.S., Kalluri, R., Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature 527 (2015), 525–530.
    • (2015) Nature , vol.527 , pp. 525-530
    • Zheng, X.1    Carstens, J.L.2    Kim, J.3    Scheible, M.4    Kaye, J.5    Sugimoto, H.6    Wu, C.C.7    LeBleu, V.S.8    Kalluri, R.9
  • 217
    • 84921799144 scopus 로고    scopus 로고
    • Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance
    • Zhitomirsky, B., Assaraf, Y.G., Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance. Oncotarget 6 (2015), 1143–1156.
    • (2015) Oncotarget , vol.6 , pp. 1143-1156
    • Zhitomirsky, B.1    Assaraf, Y.G.2


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