Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines

Biochemical Journal

Volumn 367, Issue 3, 2002, Pages 741-750

  Rothem, Lilah ^a   Ifergan, Ilan ^a   Kaufman, Yotam ^a   Priest, David G ^a   Jansen, Gerrit ^a   Assaraf, Yehuda G ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Drug resistance; Mutation; Transporter

Indexed keywords

AMINO ACIDS; DRUG PRODUCTS; ENZYMES; GENES; RNA;

MUTATIONS;

BIOCHEMISTRY;

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; AG 2037; AG 377; EDATREXATE; FOLIC ACID; FOLIC ACID ANTAGONIST; GENE PRODUCT; N [[5 [2 (2 AMINO 4,6,7,8 TETRAHYDRO 4 OXO 1H PYRIMIDO[5,4 B][1,4]THIAZIN 6 YL)ETHYL] 2 THIENYL]CARBONYL]GLUTAMIC ACID; NALPHA (4 AMINO 4 DEOXYPTEROYL) NDELTA HEMIPHTHALOYLORNITHINE; PEMETREXED; PLEVITREXED; RALTITREXED; REDUCED FOLATE CARRIER; TRIMETREXATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CROSS RESISTANCE; DRUG RESISTANCE; DRUG TRANSPORT; FRAMESHIFT MUTATION; GENE MUTATION; HUMAN; HUMAN CELL; HYDROPHILICITY; LEUKEMIA; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SINGLE STRAND CONFORMATION POLYMORPHISM; TRANSLATION REGULATION; TUMOR CELL LINE;

BASE SEQUENCE; BLOTTING, WESTERN; CARRIER PROTEINS; DNA PRIMERS; DRUG RESISTANCE, NEOPLASM; FOLIC ACID ANTAGONISTS; HUMANS; LEUKEMIA; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

EID: 0036844903     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020801     Document Type: Article

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