Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs

EMBO Journal

Volumn 34, Issue 24, 2015, Pages 2993-3008

  Planells Cases, Rosa ^a   Lutter, Darius ^a   Guyader, Charlotte ^b   Gerhards, Nora M ^c   Ullrich, Florian ^a   Elger, Deborah A ^a   Kucukosmanoglu, Asli ^b   Xu, Guotai ^b   Voss, Felizia K ^a   Reincke, S Momsen ^a   Stauber, Tobias ^a,e   Blomen, Vincent A ^b   Vis, Daniel J ^b   Wessels, Lodewyk F ^b   Brummelkamp, Thijn R ^b   Borst, Piet ^b   Rottenberg, Sven ^b,c   Jentsch, Thomas J ^a,d  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c UNIVERSITY OF BERN   (Switzerland)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

chloride channel; haploid cell screen; swelling activated; VSOAC; VSOR

Indexed keywords

ANION CHANNEL; CARBOPLATIN; CISPLATIN; OXALIPLATIN; STAUROSPORINE; TAURINE; UNCLASSIFIED DRUG; VOLUME REGULATED ANION CHANNEL; ANTINEOPLASTIC AGENT; LRRC8A PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN SUBUNIT;

APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL SWELLING; CELL VOLUME; CONTROLLED STUDY; DRUG PENETRATION; DRUG RESPONSE; DRUG UPTAKE; ENZYME SPECIFICITY; FEMALE; GENOME ANALYSIS; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; REGULATORY MECHANISM; CELL SIZE; DRUG RESISTANCE; GENETICS; HCT 116 CELL LINE; HEK293 CELL LINE; METABOLISM; PROTEIN SUBUNIT;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBOPLATIN; CELL SIZE; CISPLATIN; DRUG RESISTANCE, NEOPLASM; HCT116 CELLS; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; PROTEIN SUBUNITS;

EID: 84955178178     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201592409     Document Type: Article

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