The role of DNA mismatch repair in platinum drug resistance

Cancer Research

Volumn 56, Issue 21, 1996, Pages 4881-4886

  Fink, Daniel ^a,b   Nebel, Sibylle ^a   Aebi, Stefan ^a   Zheng, Hua ^a   Cenni, Bruno ^a   Nehmé, Alissar ^a   Christen, Randolph D ^a   Howell, Stephen B ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; DNA FRAGMENT; OXALIPLATIN; PLATINUM DERIVATIVE; SATRAPLATIN; TETRAPLATIN; TRANS AMMINEDICHLORO(CYCLOHEXYLAMINE)DIHYDROXOPLATINUM; TRANSPLATIN;

ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CLONOGENIC ASSAY; COLON CANCER; CONCENTRATION RESPONSE; CYTOTOXICITY; DNA PROTEIN COMPLEX; DNA REPAIR; DRUG STRUCTURE; ENDOMETRIUM CARCINOMA; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; OVARY ADENOCARCINOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CARBOPLATIN; CARRIER PROTEINS; CISPLATIN; DNA ADDUCTS; DNA REPAIR; DNA-BINDING PROTEINS; DRUG RESISTANCE; FEMALE; HUMANS; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; ORGANOPLATINUM COMPOUNDS; PROTO-ONCOGENE PROTEINS; TUMOR CELLS, CULTURED;

EID: 0029904811     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Kavanagh, J., Tresukosol, D., Eduards, C., Freedman, R., Gonzalez de Leon, C., Fishman, A., Mante, R., Hord, M., and Kudelka, A. Carboplatin reinduction after taxane in patients with platinum-refractory epithelial ovarian cancer. J. Clin. Oncol., 13: 1584-1588, 1995.
2. Andrews, P. A., Jones, J A., Varki, N. M, and Howell, S. B Rapid emergence of acquired cis-dichlorodiammineplatinum(II) resistance in an in vivo model of human ovarian carcinoma. Cancer Commun., 2: 93-100, 1990.
3. Gately, D. P., and Howell, S. B Cellular accumulation of the anticancer agent cisplatin a review. Br. J. Cancer, 67: 1171-1176, 1993
4. Aebi, S, Kurdi-Haidar, B, Gordon, R, Cenni, B., Zheng, H., Fink, D., Christen, R. D., Boland, C. R., Koi, M, Fishel, R, and Howell, S. B. Loss of DNA mismatch repair in acquired resistance to cisplatin Cancer Res., 56: 3087-3090, 1996
5. Fishel, R., and Kolodner, R D Identification of mismatch repair genes and their role in the development of cancer. Curr Opin. Genet. Dev., 5: 382-395, 1995.
6. Kat, A., Thilly, W G., Fang, W H, Longley, M J., Li, G M., and Modrich, P. An alkylation-tolerant mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl. Acad. Sci. USA, 90: 6426-6428, 1993.
7. Griffin, S., Branch, P, Xu, Y. Z., and Karran, P. DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: implications for tolerance to DNA methylation damage Biochemistry, 33: 4787-4793, 1994.
8. 4-methylthymine, or the cisplatin-d(GpG) adduct. Proc. Natl Acad. Sci. USA, 93: 6443-6447, 1996.
9. Levi, F., Perpoint, B, Garufi, C., Focan, C., Chollet, P., Depres-Brummer, P., Zidani, R, Brienza, S., Itzhaki, M., Iacobelli, S., Kunstlinger, F., Gastiaburu, J., and Misset, J-L Oxaliplatin activity against metastatic colorectal cancer a Phase II study of 5-day continuous venous infusion at circadian rhythm-modulated rate. Eur. J. Cancer, 29: 1280-1284, 1993.
10. Raynaud, F. I, Mistry, P., Donaghue, A., Poon, G. K, Kelland, L. R., Barnard, C. F., Murrer, B A., and Harrap, K. R. Biotransformation of the platinum drug JM216 following oral administration to cancer patients. Cancer Chemother. Pharmacol., 38: 155-162, 1996.
11. DiSaia, P. J., Sinkovics, J G, Rutledge, F. N, and Smith, J. P. Cell-mediated immunity to human malignant cells. Am J. Obstet. Gynecol., 114: 979-989, 1972
12. Koi, M., Umar, A., Chauhan, D. P, Chenan, S. P, Carethers, J. M., Kunkel, T. A, and Boland, C R. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLHI mutation. Cancer Res., 54: 4308-4312, 1994
13. Boyer, J. C, Umar, A., Risinger, J I., Lipford, J R., Kane, M, Yin, S., Barrett, J C, Kolodner, R. D., and Kunkel, T A. Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res., 55: 6063-6070, 1995.
14. Rathmell, W. K., and Chu, G. A DNA end-binding factor involved in double-strand break repair and V(D)J recombination. Mol. Cell. Biol., 14: 4741-4748, 1994.
15. Andrews, P. A, and Jones, J. A. Characterization of binding proteins from ovarian carcinoma and kidney tubule cells that are specific for cisplatin-modified DNA. Cancer Commun., 3: 93-102, 1991
16. Fishel, R., Ewel, A . and Lescoe, M. K. Purified human MSH2 protein binds to DNA containing mismatched nucleotides Cancer Res., 54: 5539-5542, 1994.
17. Palombo, F., Gallinari, P., Iaccarino, I. Lettieri, T., Hughes, M., D'Arrigo, A., Truong, O., Hsuan, J J., and Jiricny, J. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science (Washington DC), 268: 1912-1914, 1995.
18. Drummond, J T., Li, G-M., Longley, M. J., and Modrich, P. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science (Washington DC), 268: 1909-1912, 1995.
19. Szymkowski, D E, Yarema, K., Essigmann, J M, and Lippard, S. J An intrastrand d(GpG) platinum cross-link in duplex M13 DNA is refractory to repair by human cell extracts. Proc. Natl. Acad. Sci. USA, 89: 10772-10776, 1992.
20. Huang, J-C., Zamble, D B., Reardon, J. T., Lippard, S. J, and Sancar, A. HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. Proc. Natl. Acad Sci. USA, 91: 10394-10398, 1994
21. Fraval, H. N., Rawlings, C. J., and Roberts, J J. Increased sensitivity of UV-repair-deficient human cells to DNA-bound platinum products which unlike thymine dimers are not recognized by an endonuclease extracted from Micrococcus luteus Mutat. Res, 51: 121-132, 1978.
22. Dijt, F. J., Fichtinger-Schepman, A M. J, Berends, F, and Reedijk, J. Formation and repair of cisplatin-induced adducts to DNA in cultured normal and repair-deficient human fibroblasts Cancer Res., 48: 6058-6062, 1988
23. Li, G-M., and Modrich, P. Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs Proc. Natl. Acad. Sci. USA, 92: 1950-1954, 1995.
24. Baker, S. M, Plug, A. W., Prolla, T. A, Bronner, C. E., Harris, A. C., Yao, X., Christie, D-M., Monell, C., Arnheim, N, Bradley, A., Ashley, T., and Liskay, M. Involvement of mouse MLHI in DNA mismatch repair and meiotic crossing over. Nat. Genet., 13: 336-342, 1996.
25. Turchi, J J., Li, M., and Henkels, K. M. Cisplatin-DNA binding specificity of calf high-mobility group 1 protein. Biochemistry, 35: 2992-3000, 1996
26. Baxevanis, A D., and Landsman, D. The HMG-1 box protein family classification and functional relationships. Nucleic Acids Res., 23 1604-1613, 1995
27. Brown, S. J., Kellett, P. J, and Lippard, S. J. Ixr1, a yeast protein that binds to platinated DNA and confers sensitivity to cisplatin. Science (Washington DC), 261: 603-605, 1993.
28. McA'Nulty, M. M., and Lippard, S. J. The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast Mutat Res., 362: 75-86, 1996.