A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance

Journal of Biological Chemistry

Volumn 273, Issue 46, 1998, Pages 30189-30198

  Jansen, Gerrit ^a   Mauritz, Robert ^a   Drori, Stavit ^b   Sprecher, Hannah ^b   Kathmann, Ietje ^a   Bunni, Marlene ^c   Priest, David G ^c   Noordhuis, Paul ^a   Schornagel, Jan H ^d   Pinedo, Herbert M ^a   Peters, Godefridus J ^a   Assaraf, Yehuda G ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; CARRIER PROTEIN; CHLORIDE ION; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLINIC ACID; METHOTREXATE;

AMINO ACID SUBSTITUTION; ARTICLE; DRUG RESISTANCE; DRUG TRANSPORT; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MICHAELIS CONSTANT; PRIORITY JOURNAL;

AFFINITY LABELS; BIOLOGICAL TRANSPORT; BLOTTING, NORTHERN; CARRIER PROTEINS; DRUG RESISTANCE, NEOPLASM; FOLIC ACID; FOLIC ACID ANTAGONISTS; GLUTAMATES; HUMANS; KINETICS; LEUKEMIA; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; PYRIMETHAMINE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATES; TRIMETREXATE; TUMOR CELLS, CULTURED;

EID: 15144346421     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.46.30189     Document Type: Article

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