-
1
-
-
0025978216
-
A phase I clinical, plasma, and cellular pharmacology study of gemcitabine
-
J.L. Abbruzzese, R. Grunewald, E.A. Weeks, D. Gravel, T. Adams, B. Nowak, S. Mineishi, P. Tarassoff, W. Satterlee, M.N. Raber, and et al. A phase I clinical, plasma, and cellular pharmacology study of gemcitabine J. Clin. Oncol. 9 3 1991 491 498
-
(1991)
J. Clin. Oncol.
, vol.9
, Issue.3
, pp. 491-498
-
-
Abbruzzese, J.L.1
Grunewald, R.2
Weeks, E.A.3
Gravel, D.4
Adams, T.5
Nowak, B.6
Mineishi, S.7
Tarassoff, P.8
Satterlee, W.9
Raber, M.N.10
-
2
-
-
5044225419
-
Determinants of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer
-
H. Achiwa, and et al. Determinants of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer Cancer Sci. 95 2004 753 757
-
(2004)
Cancer Sci.
, vol.95
, pp. 753-757
-
-
Achiwa, H.1
-
3
-
-
17144390205
-
Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer
-
M. Akada, T. Crnogorac-Jurcevic, S. Lattimore, P. Mahon, R. Lopes, M. Sunamura, S. Matsuno, and N.R. Lemoine Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer Clin. Cancer Res. 11 8 2005 3094 3101 10.1158/1078-0432.CCR-04-1785
-
(2005)
Clin. Cancer Res.
, vol.11
, Issue.8
, pp. 3094-3101
-
-
Akada, M.1
Crnogorac-Jurcevic, T.2
Lattimore, S.3
Mahon, P.4
Lopes, R.5
Sunamura, M.6
Matsuno, S.7
Lemoine, N.R.8
-
4
-
-
68949154477
-
Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma
-
H. Akita, and et al. Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma Oncogene 28 2009 2903 2909
-
(2009)
Oncogene
, vol.28
, pp. 2903-2909
-
-
Akita, H.1
-
5
-
-
77951745289
-
Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF
-
S. Ali, and et al. Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF Cancer Res. 70 2010 3606 3617
-
(2010)
Cancer Res.
, vol.70
, pp. 3606-3617
-
-
Ali, S.1
-
6
-
-
0038621384
-
Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
-
A. Arlt, and et al. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death Oncogene 22 2003 3243 3251
-
(2003)
Oncogene
, vol.22
, pp. 3243-3251
-
-
Arlt, A.1
-
7
-
-
33846327942
-
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer
-
N.B. Arnold, N. Arkus, J. Gunn, and M. Korc The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer Clin. Cancer Res. 13 2007 18 26
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 18-26
-
-
Arnold, N.B.1
Arkus, N.2
Gunn, J.3
Korc, M.4
-
8
-
-
84880555876
-
An undesired effect of chemotherapy: Gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor κb- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4
-
S. Arora, and et al. An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor κB- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4 J. Biol. Chem. 288 2013 21197 21207
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 21197-21207
-
-
Arora, S.1
-
9
-
-
70349653064
-
Pancreatic cancer cells resistance to gemcitabine: The role of MUC4 mucin
-
S. Bafna, S. Kaur, N. Momi, and S.K. Batra Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin Br. J. Cancer 101 2009 1155 1161
-
(2009)
Br. J. Cancer
, vol.101
, pp. 1155-1161
-
-
Bafna, S.1
Kaur, S.2
Momi, N.3
Batra, S.K.4
-
10
-
-
84857917917
-
Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas
-
M. Bahra, and et al. Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas Pancreas 41 2012
-
(2012)
Pancreas
, vol.41
-
-
Bahra, M.1
-
11
-
-
33750579074
-
RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer
-
G. Bepler, and et al. RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer J. Clin. Oncol. 24 2006 4731 4737
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 4731-4737
-
-
Bepler, G.1
-
12
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
H.A. Burris, and et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J. Clin. Oncol. 15 1997 2403 2413
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 2403-2413
-
-
Burris, H.A.1
-
13
-
-
84938629534
-
Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells
-
S. Calabretta, and et al. Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells Oncogene 2015 10.1038/onc.2015.270
-
(2015)
Oncogene
-
-
Calabretta, S.1
-
14
-
-
84947437504
-
-
Vincent T., Jr.; Hellman, Samuel; Rosenberg, Steven A.: Lippincott-Raven, Philadelphia, PA, U.S.A. 9780397515738 Hardcover, Fifth Edition - Tin Can Mailman, Arcata. (n.d.). Retrieved November 29
-
Cancer: Principles and Practice of Oncology, 5th Edition by DeVita, Vincent T., Jr.; Hellman, Samuel; Rosenberg, Steven A.: Lippincott-Raven, Philadelphia, PA, U.S.A. 9780397515738 Hardcover, Fifth Edition - Tin Can Mailman, Arcata. (n.d.). Retrieved November 29, 2014, from http://www.abebooks.com/Cancer-Principles-Practice-Oncology-5th-Edition/126561158/bd
-
(2014)
Cancer: Principles and Practice of Oncology, 5th Edition by DeVita
-
-
-
15
-
-
33845361135
-
ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine
-
P. Ceppi, and et al. ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine Ann. Oncol. 17 2006 1818 1825
-
(2006)
Ann. Oncol.
, vol.17
, pp. 1818-1825
-
-
Ceppi, P.1
-
16
-
-
80054042816
-
Proteomic analysis of gemcitabine-induced drug resistance in pancreatic cancer cells
-
Y.-W. Chen, and et al. Proteomic analysis of gemcitabine-induced drug resistance in pancreatic cancer cells Mol. Biosyst. 7 2011 3065 3074
-
(2011)
Mol. Biosyst.
, vol.7
, pp. 3065-3074
-
-
Chen, Y.-W.1
-
18
-
-
76249090605
-
Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer
-
S.G. Chun, W. Zhou, and N.S. Yee Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer Cancer Biol. Ther. 8 2009 1328 1339
-
(2009)
Cancer Biol. Ther.
, vol.8
, pp. 1328-1339
-
-
Chun, S.G.1
Zhou, W.2
Yee, N.S.3
-
19
-
-
79959984687
-
Integrating pharmacogenetics into gemcitabine dosing - Time for a change?
-
J. Ciccolini, C. Mercier, L. Dahan, and N. André Integrating pharmacogenetics into gemcitabine dosing - time for a change? Nat. Rev. Clin. Oncol. 8 2011 439 444
-
(2011)
Nat. Rev. Clin. Oncol.
, vol.8
, pp. 439-444
-
-
Ciccolini, J.1
Mercier, C.2
Dahan, L.3
André, N.4
-
20
-
-
79551509386
-
Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
-
S. Dangi-Garimella, and et al. Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2 Cancer Res. 71 2011 1019 1028
-
(2011)
Cancer Res.
, vol.71
, pp. 1019-1028
-
-
Dangi-Garimella, S.1
-
21
-
-
33645298447
-
Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients
-
R. de las Peñas, and et al. Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients Ann. Oncol. 17 2006 668 675
-
(2006)
Ann. Oncol.
, vol.17
, pp. 668-675
-
-
De Las Peñas, R.1
-
22
-
-
84947424807
-
Abstract 5028: CXCL10 within the tumor microenvironment induces gemcitabine resistance in pancreatic cancer cells
-
D. Delitto, and et al. Abstract 5028: CXCL10 within the tumor microenvironment induces gemcitabine resistance in pancreatic cancer cells Cancer Res. 75 2015 5028
-
(2015)
Cancer Res.
, vol.75
, pp. 5028
-
-
Delitto, D.1
-
23
-
-
4644316230
-
Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis
-
(discussion 1207-14)
-
C.E. Denlinger, B.K. Rundall, M.D. Keller, and D.R. Jones Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis Ann. Thorac. Surg. 78 2004 1207 1214 (discussion 1207-14)
-
(2004)
Ann. Thorac. Surg.
, vol.78
, pp. 1207-1214
-
-
Denlinger, C.E.1
Rundall, B.K.2
Keller, M.D.3
Jones, D.R.4
-
24
-
-
34250200750
-
Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine
-
M. Donadelli, and et al. Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine Biochim. Biophys. Acta 1773 2007 1095 1106
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 1095-1106
-
-
Donadelli, M.1
-
25
-
-
84886392013
-
MicroRNA-gene signaling pathways in pancreatic cancer
-
A. Drakaki, and D. Iliopoulos MicroRNA-gene signaling pathways in pancreatic cancer Biomed. J. 36 2013 200 208
-
(2013)
Biomed. J.
, vol.36
, pp. 200-208
-
-
Drakaki, A.1
Iliopoulos, D.2
-
26
-
-
0013040873
-
Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562
-
C. Dumontet, and et al. Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562 Br. J. Haematol. 106 1999 78 85
-
(1999)
Br. J. Haematol.
, vol.106
, pp. 78-85
-
-
Dumontet, C.1
-
27
-
-
1642551021
-
Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells
-
M.S. Duxbury, H. Ito, M.J. Zinner, S.W. Ashley, and E.E. Whang Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells Clin. Cancer Res. 10 7 2004 2307 2318
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.7
, pp. 2307-2318
-
-
Duxbury, M.S.1
Ito, H.2
Zinner, M.J.3
Ashley, S.W.4
Whang, E.E.5
-
29
-
-
0036466841
-
Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine
-
C.M. Galmarini, and et al. Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine Int. J. Cancer 97 2002 439 445
-
(2002)
Int. J. Cancer
, vol.97
, pp. 439-445
-
-
Galmarini, C.M.1
-
30
-
-
2642535305
-
Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene
-
C.M. Galmarini, M.L. Clarke, L. Jordheim, C.L. Santos, E. Cros, J.R. Mackey, and C. Dumontet Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene BMC Pharmacol. 4 1 2004 8 10.1186/1471-2210-4-8
-
(2004)
BMC Pharmacol.
, vol.4
, Issue.1
, pp. 8
-
-
Galmarini, C.M.1
Clarke, M.L.2
Jordheim, L.3
Santos, C.L.4
Cros, E.5
Mackey, J.R.6
Dumontet, C.7
-
31
-
-
0029782426
-
Excision of 2′,2′-difluorodeoxycytidine (gemcitabine) monophosphate residues from DNA
-
V. Gandhi, J. Legha, F. Chen, L.W. Hertel, and W. Plunkett Excision of 2′,2′-difluorodeoxycytidine (gemcitabine) monophosphate residues from DNA Cancer Res. 56 1996 4453 4459
-
(1996)
Cancer Res.
, vol.56
, pp. 4453-4459
-
-
Gandhi, V.1
Legha, J.2
Chen, F.3
Hertel, L.W.4
Plunkett, W.5
-
32
-
-
84863652136
-
Circumventing cancer drug resistance in the era of personalized medicine
-
L.a. Garraway, and P.a. Jänne Circumventing cancer drug resistance in the era of personalized medicine Cancer Discovery 2 2012 214 226
-
(2012)
Cancer Discovery
, vol.2
, pp. 214-226
-
-
Garraway, L.A.1
Jänne, P.A.2
-
33
-
-
80052470635
-
Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer
-
I. Garrido-Laguna, and et al. Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer Clin. Cancer Res. 17 2011 5793 5800
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5793-5800
-
-
Garrido-Laguna, I.1
-
34
-
-
1642475113
-
The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines
-
Y. Ge, T.L. Jensen, M.L. Stout, R.M. Flatley, P.J. Grohar, Y. Ravindranath, L.H. Matherly, and J.W. Taub The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines Cancer Res. 64 2 2004 728 735
-
(2004)
Cancer Res.
, vol.64
, Issue.2
, pp. 728-735
-
-
Ge, Y.1
Jensen, T.L.2
Stout, M.L.3
Flatley, R.M.4
Grohar, P.J.5
Ravindranath, Y.6
Matherly, L.H.7
Taub, J.W.8
-
35
-
-
33645731188
-
Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
-
E. Giovannetti, and et al. Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine Cancer Res. 66 2006 3928 3935
-
(2006)
Cancer Res.
, vol.66
, pp. 3928-3935
-
-
Giovannetti, E.1
-
36
-
-
77953169001
-
MicroRNA-21 in pancreatic cancer: Correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity
-
E. Giovannetti, and et al. MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity Cancer Res. 70 2010 4528 4538
-
(2010)
Cancer Res.
, vol.70
, pp. 4528-4538
-
-
Giovannetti, E.1
-
37
-
-
33750114423
-
Probing the human kinome for kinases involved in pancreatic cancer cell survival and gemcitabine resistance
-
V. Giroux, J. Iovanna, and J.-C. Dagorn Probing the human kinome for kinases involved in pancreatic cancer cell survival and gemcitabine resistance FASEB J. 20 2006 1982 1991
-
(2006)
FASEB J.
, vol.20
, pp. 1982-1991
-
-
Giroux, V.1
Iovanna, J.2
Dagorn, J.-C.3
-
38
-
-
0033198464
-
Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line
-
Y.G. Goan, B. Zhou, E. Hu, S. Mi, and Y. Yen Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line Cancer Res. 59 17 1999 4204 4207
-
(1999)
Cancer Res.
, vol.59
, Issue.17
, pp. 4204-4207
-
-
Goan, Y.G.1
Zhou, B.2
Hu, E.3
Mi, S.4
Yen, Y.5
-
39
-
-
66449134500
-
Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug
-
J. Guillermet-Guibert, and et al. Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug Mol. Cancer Ther. 8 2009 809 820
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 809-820
-
-
Guillermet-Guibert, J.1
-
40
-
-
77249117637
-
Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines
-
X. Guo, and et al. Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines Cancer Lett. 290 2010 104 113
-
(2010)
Cancer Lett.
, vol.290
, pp. 104-113
-
-
Guo, X.1
-
41
-
-
1542285510
-
Involvement of p38 mitogen-activated protein kinase in gemcitabine-induced apoptosis in human pancreatic cancer cells
-
A. Habiro, and et al. Involvement of p38 mitogen-activated protein kinase in gemcitabine-induced apoptosis in human pancreatic cancer cells Biochem. Biophys. Res. Commun. 316 2004 71 77
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.316
, pp. 71-77
-
-
Habiro, A.1
-
42
-
-
84888426235
-
MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX
-
S. Hamada, A. Masamune, S. Miura, K. Satoh, and T. Shimosegawa MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX Cell Signal. 26 2013 179 185
-
(2013)
Cell Signal.
, vol.26
, pp. 179-185
-
-
Hamada, S.1
Masamune, A.2
Miura, S.3
Satoh, K.4
Shimosegawa, T.5
-
44
-
-
0023783698
-
Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-beta-d-arabinofuranosylcytosine
-
V. Heinemann, L.W. Hertel, G.B. Grindey, and W. Plunkett Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-beta-d-arabinofuranosylcytosine Cancer Res. 48 1988 4024 4031
-
(1988)
Cancer Res.
, vol.48
, pp. 4024-4031
-
-
Heinemann, V.1
Hertel, L.W.2
Grindey, G.B.3
Plunkett, W.4
-
45
-
-
0026571795
-
Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: A mechanism of self-potentiation
-
V. Heinemann, and et al. Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: a mechanism of self-potentiation Cancer Res. 52 1992 533 539
-
(1992)
Cancer Res.
, vol.52
, pp. 533-539
-
-
Heinemann, V.1
-
46
-
-
33947406840
-
Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance
-
H. Hernández-Vargas, and et al. Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance Breast Cancer Res. Treat. 102 2007 157 172
-
(2007)
Breast Cancer Res. Treat.
, vol.102
, pp. 157-172
-
-
Hernández-Vargas, H.1
-
47
-
-
33646577163
-
Genetics and biology of pancreatic ductal adenocarcinoma
-
A.F. Hezel, A.C. Kimmelman, B.Z. Stanger, N. Bardeesy, and R.a. Depinho Genetics and biology of pancreatic ductal adenocarcinoma Genes Dev. 20 2006 1218 1249
-
(2006)
Genes Dev.
, vol.20
, pp. 1218-1249
-
-
Hezel, A.F.1
Kimmelman, A.C.2
Stanger, B.Z.3
Bardeesy, N.4
Depinho, R.A.5
-
48
-
-
77951755278
-
Pancreatic cancer
-
M. Hidalgo Pancreatic cancer N. Engl. J. Med. 362 2010 1605 1617
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 1605-1617
-
-
Hidalgo, M.1
-
49
-
-
37549016730
-
Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy
-
C.-C. Ho, and et al. Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy Lung Cancer 59 2008 105 110
-
(2008)
Lung Cancer
, vol.59
, pp. 105-110
-
-
Ho, C.-C.1
-
50
-
-
84947472365
-
Abstract 5473: Human cancer cells acquire chemoresistance to gemcitabine mainly through loss-of-function mutations in the DCK gene
-
A. Horii, Y. Saiki, T. Nakano, C. Kudo, and M. Sunamura Abstract 5473: human cancer cells acquire chemoresistance to gemcitabine mainly through loss-of-function mutations in the DCK gene Cancer Res. 75 2015 5473
-
(2015)
Cancer Res.
, vol.75
, pp. 5473
-
-
Horii, A.1
Saiki, Y.2
Nakano, T.3
Kudo, C.4
Sunamura, M.5
-
51
-
-
34248335374
-
Pancreatic adenocarcinoma: Update on the surgical pathology of carcinomas of ductal origin and PanINs
-
R.H. Hruban, and N. Fukushima Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs Mod. Pathol. 20 Suppl. 1 2007 S61 S70
-
(2007)
Mod. Pathol.
, vol.201 SUPPL.
, pp. S61-S70
-
-
Hruban, R.H.1
Fukushima, N.2
-
52
-
-
84947429080
-
Defective hCNT1 transport contributes to gemcitabine defects using a nanoparticle approach
-
S.W. Hung, and et al. Defective hCNT1 transport contributes to gemcitabine defects using a nanoparticle approach Cancer Lett. 359 2015 1 8
-
(2015)
Cancer Lett.
, vol.359
, pp. 1-8
-
-
Hung, S.W.1
-
53
-
-
80053405625
-
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
-
H. Ijichi, A. Chytil, A.E. Gorska, M.E. Aakre, B. Bierie, M. Tada, D. Mohri, K. Miyabayashi, Y. Asaoka, S. Maeda, T. Ikenoue, K. Tateishi, C.V. Wright, K. Koike, M. Omata, and H.L. Moses Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma J. Clin. Invest. 121 10 2011 4106 4117 10.1172/JCI42754
-
(2011)
J. Clin. Invest.
, vol.121
, Issue.10
, pp. 4106-4117
-
-
Ijichi, H.1
Chytil, A.2
Gorska, A.E.3
Aakre, M.E.4
Bierie, B.5
Tada, M.6
Mohri, D.7
Miyabayashi, K.8
Asaoka, Y.9
Maeda, S.10
Ikenoue, T.11
Tateishi, K.12
Wright, C.V.13
Koike, K.14
Omata, M.15
Moses, H.L.16
-
56
-
-
76649120217
-
A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer
-
A. Jimeno, and et al. A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer Mol. Cancer Ther. 9 2010 311 318
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 311-318
-
-
Jimeno, A.1
-
57
-
-
1942438135
-
Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: Increased expression of matrix metalloproteinase-7 predicts poor survival
-
L.E. Jones, M.J. Humphreys, F. Campbell, J.P. Neoptolemos, and M.T. Boyd Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix metalloproteinase-7 predicts poor survival Clin. Cancer Res. 10 2004 2832 2845
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 2832-2845
-
-
Jones, L.E.1
Humphreys, M.J.2
Campbell, F.3
Neoptolemos, J.P.4
Boyd, M.T.5
-
58
-
-
4143111313
-
Characterization of a gemcitabine-resistant murine leukemic cell line: Reversion of in vitro resistance by a mononucleotide prodrug
-
L.P. Jordheim, E. Cros, M.H. Gouy, C.M. Galmarini, S. Peyrottes, J. Mackey, C. Perigaud, and C. Dumontet Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug Clin. Cancer Res. 10 16 2004 5614 5621 10.1158/1078-0432.CCR-04-0506
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.16
, pp. 5614-5621
-
-
Jordheim, L.P.1
Cros, E.2
Gouy, M.H.3
Galmarini, C.M.4
Peyrottes, S.5
Mackey, J.6
Perigaud, C.7
Dumontet, C.8
-
59
-
-
23844466231
-
Increased expression of the large subunit of ribonucleotide reductase is involved in resistance to gemcitabine in human mammary adenocarcinoma cells
-
L.P. Jordheim, O. Guittet, M. Lepoivre, C.M. Galmarini, and C. Dumontet Increased expression of the large subunit of ribonucleotide reductase is involved in resistance to gemcitabine in human mammary adenocarcinoma cells Mol. Cancer Ther. 4 2005 1268 1276
-
(2005)
Mol. Cancer Ther.
, vol.4
, pp. 1268-1276
-
-
Jordheim, L.P.1
Guittet, O.2
Lepoivre, M.3
Galmarini, C.M.4
Dumontet, C.5
-
60
-
-
33745712217
-
Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells
-
L.P. Jordheim, C.M. Galmarini, and C. Dumontet Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells Cancer Chemother. Pharmacol. 58 2006 547 554
-
(2006)
Cancer Chemother. Pharmacol.
, vol.58
, pp. 547-554
-
-
Jordheim, L.P.1
Galmarini, C.M.2
Dumontet, C.3
-
61
-
-
84936947905
-
Mechanisms of overcoming intrinsic resistance to gemcitabine in pancreatic ductal adenocarcinoma through the redox modulation
-
H.-Q. Ju, and et al. Mechanisms of overcoming intrinsic resistance to gemcitabine in pancreatic ductal adenocarcinoma through the redox modulation Mol. Cancer Ther. 14 2015 788 798
-
(2015)
Mol. Cancer Ther.
, vol.14
, pp. 788-798
-
-
Ju, H.-Q.1
-
62
-
-
0034887130
-
Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit
-
C.P. Jung, M.V. Motwani, and G.K. Schwartz Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit Clin. Cancer Res. 7 8 2001 2527 2536
-
(2001)
Clin. Cancer Res.
, vol.7
, Issue.8
, pp. 2527-2536
-
-
Jung, C.P.1
Motwani, M.V.2
Schwartz, G.K.3
-
63
-
-
21244502175
-
Possible antitumor activity of 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd, TAS-106) against an established gemcitabine (dFdCyd)-resistant human pancreatic cancer cell line
-
H. Kazuno, K. Sakamoto, A. Fujioka, M. Fukushima, A. Matsuda, and T. Sasaki Possible antitumor activity of 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd, TAS-106) against an established gemcitabine (dFdCyd)-resistant human pancreatic cancer cell line Cancer Sci. 96 5 2005 295 302 10.1111/j.1349-7006.2005.00046.x
-
(2005)
Cancer Sci.
, vol.96
, Issue.5
, pp. 295-302
-
-
Kazuno, H.1
Sakamoto, K.2
Fujioka, A.3
Fukushima, M.4
Matsuda, A.5
Sasaki, T.6
-
64
-
-
84861162319
-
KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer
-
J.A. Kelber, T. Reno, S. Kaushal, C. Metildi, T. Wright, K. Stoletov, J.M. Weems, F.D. Park, E. Mose, Y. Wang, R.M. Hoffman, A.M. Lowy, M. Bouvet, and R.L. Klemke KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer Cancer Res. 72 10 2012 2554 2564 10.1158/0008-5472.CAN-11-3552
-
(2012)
Cancer Res.
, vol.72
, Issue.10
, pp. 2554-2564
-
-
Kelber, J.A.1
Reno, T.2
Kaushal, S.3
Metildi, C.4
Wright, T.5
Stoletov, K.6
Weems, J.M.7
Park, F.D.8
Mose, E.9
Wang, Y.10
Hoffman, R.M.11
Lowy, A.M.12
Bouvet, M.13
Klemke, R.L.14
-
65
-
-
40949143108
-
Gemcitabine resistance in pancreatic cancer: Picking the key players
-
M.P. Kim, and G.E. Gallick Gemcitabine resistance in pancreatic cancer: picking the key players Clin. Cancer Res. 14 2008 1284 1285
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 1284-1285
-
-
Kim, M.P.1
Gallick, G.E.2
-
66
-
-
84887494006
-
MicroRNA profile to predict gemcitabine resistance in bladder carcinoma cell lines
-
S.I. Kozinn, and et al. MicroRNA profile to predict gemcitabine resistance in bladder carcinoma cell lines Genes Cancer 4 2013 61 69
-
(2013)
Genes Cancer
, vol.4
, pp. 61-69
-
-
Kozinn, S.I.1
-
67
-
-
0033778922
-
Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines
-
J.R. Kroep, and et al. Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines Br. J. Cancer 83 2000 1069 1076
-
(2000)
Br. J. Cancer
, vol.83
, pp. 1069-1076
-
-
Kroep, J.R.1
-
69
-
-
77958581453
-
Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry
-
Y. Kuramitsu, K. Taba, S. Ryozawa, K. Yoshida, X. Zhang, T. Tanaka, S. Maehara, Y. Maehara, I. Sakaida, and K. Nakamura Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry Anticancer Res. 30 9 2010 3367 3372
-
(2010)
Anticancer Res.
, vol.30
, Issue.9
, pp. 3367-3372
-
-
Kuramitsu, Y.1
Taba, K.2
Ryozawa, S.3
Yoshida, K.4
Zhang, X.5
Tanaka, T.6
Maehara, S.7
Maehara, Y.8
Sakaida, I.9
Nakamura, K.10
-
70
-
-
84895919029
-
Methods of biological network inference for reverse engineering cancer chemoresistance mechanisms
-
P. Lecca Methods of biological network inference for reverse engineering cancer chemoresistance mechanisms Drug Discovery Today 00 2013
-
(2013)
Drug Discovery Today
-
-
Lecca, P.1
-
71
-
-
84904994417
-
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
-
J.J. Lee, and et al. Stromal response to Hedgehog signaling restrains pancreatic cancer progression Proc. Natl. Acad. Sci. U.S.A. 111 2014 E3091 E3100
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. E3091-E3100
-
-
Lee, J.J.1
-
72
-
-
84874733206
-
Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2
-
H. Li, and B.B. Yang Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2 Oncotarget 3 2012 1653 1668
-
(2012)
Oncotarget
, vol.3
, pp. 1653-1668
-
-
Li, H.1
Yang, B.B.2
-
73
-
-
84881409958
-
Friend or foe: The role of microRNA in chemotherapy resistance
-
H. Li, and B.B. Yang Friend or foe: the role of microRNA in chemotherapy resistance Acta Pharmacol. Sin. 34 2013 870 879
-
(2013)
Acta Pharmacol. Sin.
, vol.34
, pp. 870-879
-
-
Li, H.1
Yang, B.B.2
-
74
-
-
69249096109
-
Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
-
Y. Li, and et al. Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells Cancer Res. 69 2009 6704 6712
-
(2009)
Cancer Res.
, vol.69
, pp. 6704-6712
-
-
Li, Y.1
-
75
-
-
33747610198
-
Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine
-
K. Liang, Y. Lu, X. Li, X. Zeng, R.I. Glazer, G.B. Mills, and Z. Fan Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine Mol. Pharmacol. 70 3 2006 1045 1052 10.1124/mol.106.023333
-
(2006)
Mol. Pharmacol.
, vol.70
, Issue.3
, pp. 1045-1052
-
-
Liang, K.1
Lu, Y.2
Li, X.3
Zeng, X.4
Glazer, R.I.5
Mills, G.B.6
Fan, Z.7
-
76
-
-
0032803291
-
Effect of loss of DNA mismatch repair on development of topotecan-, gemcitabine-, and paclitaxel-resistant variants after exposure to cisplatin
-
X. Lin, and S.B. Howell Effect of loss of DNA mismatch repair on development of topotecan-, gemcitabine-, and paclitaxel-resistant variants after exposure to cisplatin Mol. Pharmacol. 56 2 1999 390 395
-
(1999)
Mol. Pharmacol.
, vol.56
, Issue.2
, pp. 390-395
-
-
Lin, X.1
Howell, S.B.2
-
77
-
-
84931083174
-
MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine
-
C. Liang, X.-J. Yu, X.-Z. Guo, M.-H. Sun, Z. Wang, Y. Song, Q.-X. Ni, H.-Y. Li, N. Mukaida, and Y.-Y. Li MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine Oncotarget 6 16 2015 14440 14455
-
(2015)
Oncotarget
, vol.6
, Issue.16
, pp. 14440-14455
-
-
Liang, C.1
Yu, X.-J.2
Guo, X.-Z.3
Sun, M.-H.4
Wang, Z.5
Song, Y.6
Ni, Q.-X.7
Li, H.-Y.8
Mukaida, N.9
Li, Y.-Y.10
-
78
-
-
0035988959
-
Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer
-
R.V. Lord, J. Brabender, D. Gandara, V. Alberola, C. Camps, M. Domine, F. Cardenal, J.M. Sánchez, P.H. Gumerlock, M. Tarón, J.J. Sánchez, K.D. Danenberg, P.V. Danenberg, and R. Rosell Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer Clin. Cancer Res. 8 7 2002 2286 2291
-
(2002)
Clin. Cancer Res.
, vol.8
, Issue.7
, pp. 2286-2291
-
-
Lord, R.V.1
Brabender, J.2
Gandara, D.3
Alberola, V.4
Camps, C.5
Domine, M.6
Cardenal, F.7
Sánchez, J.M.8
Gumerlock, P.H.9
Tarón, M.10
Sánchez, J.J.11
Danenberg, K.D.12
Danenberg, P.V.13
Rosell, R.14
-
79
-
-
0033910993
-
Differential expression of matrix metalloproteinase (MMP)-2 MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: Implications for tumor progression and clinical prognosis
-
M. Määttä, Y. Soini, A. Liakka, and H. Autio-Harmainen Differential expression of matrix metalloproteinase (MMP)-2 MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis Clin. Cancer Res. 6 7 2000 2726 2734
-
(2000)
Clin. Cancer Res.
, vol.6
, Issue.7
, pp. 2726-2734
-
-
Määttä, M.1
Soini, Y.2
Liakka, A.3
Autio-Harmainen, H.4
-
80
-
-
0032188825
-
Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
-
J.R. Mackey, R.S. Mani, M. Selner, D. Mowles, J.D. Young, J.A. Belt, C.R. Crawford, and C.E. Cass Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines Cancer Res. 58 19 1998 4349 4357
-
(1998)
Cancer Res.
, vol.58
, Issue.19
, pp. 4349-4357
-
-
Mackey, J.R.1
Mani, R.S.2
Selner, M.3
Mowles, D.4
Young, J.D.5
Belt, J.A.6
Crawford, C.R.7
Cass, C.E.8
-
82
-
-
4544267592
-
Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells
-
S.-I. Maehara, and et al. Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells Int. J. Cancer 112 2004 184 189
-
(2004)
Int. J. Cancer
, vol.112
, pp. 184-189
-
-
Maehara, S.-I.1
-
83
-
-
84947447072
-
Post-translational modifications of ribonucleotide reductase can explain acquired gemcitabine resistance in pancreatic cancer
-
K. Mann, and et al. Post-translational modifications of ribonucleotide reductase can explain acquired gemcitabine resistance in pancreatic cancer Pancreatology 15 2015 S20
-
(2015)
Pancreatology
, vol.15
, pp. S20
-
-
Mann, K.1
-
84
-
-
65349163336
-
Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma
-
R. Maréchal, and et al. Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma Clin. Cancer Res. 15 2009 2913 2919
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 2913-2919
-
-
Maréchal, R.1
-
85
-
-
84875174768
-
The role of tumour-stromal interactions in modifying drug response: Challenges and opportunities
-
D.W. McMillin, J.M. Negri, and C.S. Mitsiades The role of tumour-stromal interactions in modifying drug response: challenges and opportunities Nat. Rev. Drug Discovery 12 2013 217 228
-
(2013)
Nat. Rev. Drug Discovery
, vol.12
, pp. 217-228
-
-
McMillin, D.W.1
Negri, J.M.2
Mitsiades, C.S.3
-
86
-
-
33745686698
-
Cellular pharmacology of gemcitabine
-
E. Mini, S. Nobili, B. Caciagli, I. Landini, and T. Mazzei Cellular pharmacology of gemcitabine Ann. Oncol. 17 Suppl. 5 2006 v7 v12
-
(2006)
Ann. Oncol.
, vol.17
, pp. v7-v12
-
-
Mini, E.1
Nobili, S.2
Caciagli, B.3
Landini, I.4
Mazzei, T.5
-
87
-
-
0032958512
-
Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines
-
C.J. van Moorsel, H.M. Pinedo, G. Veerman, A.M. Bergman, C.M. Kuiper, J.B. Vermorken, W.J. van der Vijgh, and G.J. Peters Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines Br. J. Cancer 80 7 1999 981 990 10.1038/sj.bjc.6690452
-
(1999)
Br. J. Cancer
, vol.80
, Issue.7
, pp. 981-990
-
-
Van Moorsel, C.J.1
Pinedo, H.M.2
Veerman, G.3
Bergman, A.M.4
Kuiper, C.M.5
Vermorken, J.B.6
Van Der Vijgh, W.J.7
Peters, G.J.8
-
88
-
-
69249144061
-
A proteomic profiling of gemcitabine resistance in pancreatic cancer cell lines
-
S. Mori-Iwamoto, Y. Kuramitsu, S. Ryozawa, K. Taba, M. Fujimoto, K. Okita, K. Nakamura, and I. Sakaida A proteomic profiling of gemcitabine resistance in pancreatic cancer cell lines Mol. Med. Rep. 1 3 2008 429 434
-
(2008)
Mol. Med. Rep.
, vol.1
, Issue.3
, pp. 429-434
-
-
Mori-Iwamoto, S.1
Kuramitsu, Y.2
Ryozawa, S.3
Taba, K.4
Fujimoto, M.5
Okita, K.6
Nakamura, K.7
Sakaida, I.8
-
89
-
-
84934292263
-
Thymoquinone pretreatment overcomes the insensitivity and potentiates the antitumor effect of gemcitabine through abrogation of Notch1, PI3K/Akt/mTOR regulated signaling pathways in pancreatic cancer
-
G. Mu, L. Zhang, H. Li, Y. Liao, and H. Yu Thymoquinone pretreatment overcomes the insensitivity and potentiates the antitumor effect of gemcitabine through abrogation of Notch1, PI3K/Akt/mTOR regulated signaling pathways in pancreatic cancer Dig. Dis. Sci. 60 2015 1067 1080
-
(2015)
Dig. Dis. Sci.
, vol.60
, pp. 1067-1080
-
-
Mu, G.1
Zhang, L.2
Li, H.3
Liao, Y.4
Yu, H.5
-
90
-
-
33846958737
-
Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer
-
S. Nakahira, and et al. Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer Int. J. Cancer 120 2007 1355 1363
-
(2007)
Int. J. Cancer
, vol.120
, pp. 1355-1363
-
-
Nakahira, S.1
-
91
-
-
33846816556
-
Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
-
Y. Nakano, and et al. Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells Br. J. Cancer 96 2007 457 463
-
(2007)
Br. J. Cancer
, vol.96
, pp. 457-463
-
-
Nakano, Y.1
-
92
-
-
84989344362
-
Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway
-
T. Namba, R. Kodama, S. Moritomo, T. Hoshino, and T. Mizushima Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway Cell Death Dis. 6 2015 e1795
-
(2015)
Cell Death Dis.
, vol.6
, pp. e1795
-
-
Namba, T.1
Kodama, R.2
Moritomo, S.3
Hoshino, T.4
Mizushima, T.5
-
93
-
-
79955828776
-
Stromal biology and therapy in pancreatic cancer
-
A. Neesse, and et al. Stromal biology and therapy in pancreatic cancer Gut 60 2011 861 868
-
(2011)
Gut
, vol.60
, pp. 861-868
-
-
Neesse, A.1
-
94
-
-
84947427466
-
Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells inhibition of phosphatidylinositide 3-Kinase enhances gemcitabine-induced apoptosis in human pancreatic
-
S.S.W. Ng, M. Tsao, and S. Chow Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells inhibition of phosphatidylinositide 3-Kinase enhances gemcitabine-induced apoptosis in human pancreatic Cancer Cells 1. 2000 5451 5455
-
(2000)
Cancer Cells
, vol.1
, pp. 5451-5455
-
-
Ng, S.S.W.1
Tsao, M.2
Chow, S.3
-
95
-
-
67149143399
-
Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
K.P. Olive, and et al. Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer Science 324 2009 1457 1461
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
-
96
-
-
84902469661
-
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
-
B.C. Özdemir, and et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival Cancer Cell 25 2014 719 734
-
(2014)
Cancer Cell
, vol.25
, pp. 719-734
-
-
Özdemir, B.C.1
-
97
-
-
70349904531
-
Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma
-
J.-K. Park, E.J. Lee, C. Esau, and T.D. Schmittgen Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma Pancreas 38 2009 e190 e199
-
(2009)
Pancreas
, vol.38
, pp. e190-e199
-
-
Park, J.-K.1
Lee, E.J.2
Esau, C.3
Schmittgen, T.D.4
-
98
-
-
84921752050
-
Self-assembled nanoscale coordination polymers carrying oxaliplatin and gemcitabine for synergistic combination therapy of pancreatic cancer
-
C. Poon, C. He, D. Liu, K. Lu, and W. Lin Self-assembled nanoscale coordination polymers carrying oxaliplatin and gemcitabine for synergistic combination therapy of pancreatic cancer J. Control Release 201 2015 90 99
-
(2015)
J. Control Release
, vol.201
, pp. 90-99
-
-
Poon, C.1
He, C.2
Liu, D.3
Lu, K.4
Lin, W.5
-
99
-
-
0036023405
-
Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I
-
P. Pourquier, C. Gioffre, G. Kohlhagen, Y. Urasaki, F. Goldwasser, L.W. Hertel, S. Yu, R.T. Pon, W.H. Gmeiner, and Y. Pommier Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I Clin. Cancer Res. 8 8 2002 2499 2504
-
(2002)
Clin. Cancer Res.
, vol.8
, Issue.8
, pp. 2499-2504
-
-
Pourquier, P.1
Gioffre, C.2
Kohlhagen, G.3
Urasaki, Y.4
Goldwasser, F.5
Hertel, L.W.6
Yu, S.7
Pon, R.T.8
Gmeiner, W.H.9
Pommier, Y.10
-
100
-
-
84870368833
-
Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma
-
A. Purushothaman, S.K. Babitz, and R.D. Sanderson Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma J. Biol. Chem. 287 2012 41288 41296
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 41288-41296
-
-
Purushothaman, A.1
Babitz, S.K.2
Sanderson, R.D.3
-
102
-
-
0027451344
-
Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts
-
V.W. Ruiz van Haperen, and et al. Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts Eur. J. Cancer 29A 1993 2132 2137
-
(1993)
Eur. J. Cancer
, vol.29 A
, pp. 2132-2137
-
-
Ruiz Van Haperen, V.W.1
-
103
-
-
33845981502
-
Impact of interferon-alpha in combined chemoradioimmunotherapy for pancreatic adenocarcinoma (CapRI): First data from the immunomonitoring
-
J. Schmidt, D. Ja, K. Hoffmann, and M.W. Bu Impact of interferon-alpha in combined chemoradioimmunotherapy for pancreatic adenocarcinoma (CapRI): first data from the immunomonitoring J. Immunother. (Hagerstown, Md.: 1997) 30 2007 108 115 10.1097/01.cji.0000211317.15278.27
-
(2007)
J. Immunother. (Hagerstown, Md.: 1997)
, vol.30
, pp. 108-115
-
-
Schmidt, J.1
Ja, D.2
Hoffmann, K.3
Bu, M.W.4
-
104
-
-
84871080983
-
From sentinel cells to inflammatory culprits: Cancer-associated fibroblasts in tumour-related inflammation
-
C. Servais, and N. Erez From sentinel cells to inflammatory culprits: cancer-associated fibroblasts in tumour-related inflammation J. Pathol. 229 2013 198 207
-
(2013)
J. Pathol.
, vol.229
, pp. 198-207
-
-
Servais, C.1
Erez, N.2
-
105
-
-
84861220123
-
Downregulation of BCL2 by miRNAs augments drug-induced apoptosis - A combined computational and experimental approach
-
R. Singh, and N. Saini Downregulation of BCL2 by miRNAs augments drug-induced apoptosis - a combined computational and experimental approach J. Cell Sci. 125 2012 1568 1578
-
(2012)
J. Cell Sci.
, vol.125
, pp. 1568-1578
-
-
Singh, R.1
Saini, N.2
-
106
-
-
78650194206
-
CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: A novel target for therapy
-
S. Singh, S.K. Srivastava, a Bhardwaj, L.B. Owen, and a P. Singh CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy Br. J. Cancer 103 2010 1671 1679
-
(2010)
Br. J. Cancer
, vol.103
, pp. 1671-1679
-
-
Singh, S.1
Srivastava, S.K.2
Bhardwaj, A.3
Owen, L.B.4
Singh, A.P.5
-
107
-
-
0030016274
-
Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: Implication of quercetin as sensitiser in chemotherapy
-
G. Sliutz, J. Karlseder, C. Tempfer, L. Orel, G. Holzer, and M.M. Simon Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy Br. J. Cancer 74 2 1996 172 177
-
(1996)
Br. J. Cancer
, vol.74
, Issue.2
, pp. 172-177
-
-
Sliutz, G.1
Karlseder, J.2
Tempfer, C.3
Orel, L.4
Holzer, G.5
Simon, M.M.6
-
108
-
-
77949264996
-
Advanced pancreatic carcinoma: Current treatment and future challenges
-
A. Stathis, and M.J. Moore advanced pancreatic carcinoma: current treatment and future challenges Nat. Rev. Clin. Oncol. 7 2010 163 172
-
(2010)
Nat. Rev. Clin. Oncol.
, vol.7
, pp. 163-172
-
-
Stathis, A.1
Moore, M.J.2
-
109
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
S.P. Thayer, and et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Nature 425 2003 851 856
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
-
110
-
-
84943662289
-
Potent effect of adenoviral vector expressing short hairpin RNA targeting ribonucleotide reductase large subunit M1 on cell viability and chemotherapeutic sensitivity to gemcitabine in non-small cell lung cancer cells
-
Y. Tokunaga, and et al. Potent effect of adenoviral vector expressing short hairpin RNA targeting ribonucleotide reductase large subunit M1 on cell viability and chemotherapeutic sensitivity to gemcitabine in non-small cell lung cancer cells Eur. J. Cancer 2015 1 10 10.1016/j.ejca.2015.05.013
-
(2015)
Eur. J. Cancer
, pp. 1-10
-
-
Tokunaga, Y.1
-
111
-
-
0029990087
-
Regulation of phosphorylation of deoxycytidine and 2′,2′-difluorodeoxycytidine (gemcitabine); Effects of cytidine 5′-triphosphate and uridine 5′-triphosphate in relation to chemosensitivity for 2′,2′-difluorodeoxycytidine
-
V.W. van Haperen, G. Veerman, J.B. Vermorken, H.M. Pinedo, and G. Peters Regulation of phosphorylation of deoxycytidine and 2′,2′-difluorodeoxycytidine (gemcitabine); effects of cytidine 5′-triphosphate and uridine 5′-triphosphate in relation to chemosensitivity for 2′,2′-difluorodeoxycytidine Biochem. Pharmacol. 51 1996 911 918
-
(1996)
Biochem. Pharmacol.
, vol.51
, pp. 911-918
-
-
Van Haperen, V.W.1
Veerman, G.2
Vermorken, J.B.3
Pinedo, H.M.4
Peters, G.5
-
112
-
-
84855590868
-
The desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma
-
Article ID 212810, 12 pages
-
Vegard Tjomsland, Lina Niklasson, Per Sandström, Kurt Borch, Henrik Druid, Charlotte Bratthäll, Davorka Messmer, Marie Larsson, and Anna Spångeus The desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma Clin. Dev. Immunol. 2011 2011 10.1155/2011/212810 Article ID 212810, 12 pages
-
(2011)
Clin. Dev. Immunol.
, vol.2011
-
-
Tjomsland, V.1
Niklasson, L.2
Sandström, P.3
Borch, K.4
Druid, H.5
Bratthäll, C.6
Messmer, D.7
Larsson, M.8
Spångeus, A.9
-
113
-
-
0034904048
-
Heparan sulfate proteoglycans molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
-
I. Vlodavsky, and Y. Friedmann Heparan sulfate proteoglycans molecular properties and involvement of heparanase in cancer metastasis and angiogenesis J. Clin. Invest. 108 3 2001 341 347 10.1172/JCI13662
-
(2001)
J. Clin. Invest.
, vol.108
, Issue.3
, pp. 341-347
-
-
Vlodavsky, I.1
Friedmann, Y.2
-
114
-
-
65549141305
-
Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
-
Z. Wang, and et al. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway Cancer Res. 69 2009 2400 2407
-
(2009)
Cancer Res.
, vol.69
, pp. 2400-2407
-
-
Wang, Z.1
-
115
-
-
84904661611
-
Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase
-
N. Weizman, and et al. Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase Oncogene 2013 1 8 10.1038/onc.2013.357
-
(2013)
Oncogene
, pp. 1-8
-
-
Weizman, N.1
-
117
-
-
79952136207
-
Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers
-
Y. Youyun, L. Hailan, L. Zhaomin, Z. Zijin, Y.-S. Michelle, C. Qipeng Fan, E. Max Schmidt, C. Gabriela, X. Jingwu, C. Liang, C. Jey-Hsin, and Z. Jian-Ting Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers Int. J. Biochem. Mol. Biol. 2 2011 89 98
-
(2011)
Int. J. Biochem. Mol. Biol.
, vol.2
, pp. 89-98
-
-
Youyun, Y.1
Hailan, L.2
Zhaomin, L.3
Zijin, Z.4
Michelle, Y.-S.5
Qipeng Fan, C.6
Max Schmidt, E.7
Gabriela, C.8
Jingwu, X.9
Liang, C.10
Jey-Hsin, C.11
Jian-Ting, Z.12
-
118
-
-
79951558829
-
Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2
-
H. Yoon, J.-K. Min, J.W. Lee, D.-G. Kim, and H.J. Hong Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2 Biochem. Biophys. Res. Commun. 405 2011 333 337
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.405
, pp. 333-337
-
-
Yoon, H.1
Min, J.-K.2
Lee, J.W.3
Kim, D.-G.4
Hong, H.J.5
-
119
-
-
84949097148
-
Antisense inhibition of microRNA-21 and microRNA-221 in tumor-initiating stem-like cells modulates tumorigenesis, metastasis, and chemotherapy resistance in pancreatic cancer
-
Y. Zhao, and et al. Antisense inhibition of microRNA-21 and microRNA-221 in tumor-initiating stem-like cells modulates tumorigenesis, metastasis, and chemotherapy resistance in pancreatic cancer Target Oncol. 2015 10.1007/s11523-015-0360-2
-
(2015)
Target Oncol.
-
-
Zhao, Y.1
|