HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells

Oncogene

Volumn 22, Issue 21, 2003, Pages 3205-3212

  Knuefermann, Christiane ^a   Lu, Yang ^a   Liu, Bolin ^a   Jin, Weidong ^a   Liang, Ke ^a   Wu, Ling ^a   Schmidt, Mathias ^a,b   Mills, Gordon B ^a   Mendelsohn, John ^a   Fan, Zhen ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b ALTANA Phanna AG   (Germany)

Author keywords

Akt; Breast cancer; Chemotherapy; HER2; PI 3K

Indexed keywords

CAMPTOTHECIN; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ETOPOSIDE; FLUOROURACIL; GENE PRODUCT; HER 3 PROTEIN; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPID; PROTEIN KINASE B; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; BREAST CARCINOGENESIS; CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG TARGETING; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; TUMOR CELL LINE; ADENOCARCINOMA; BREAST TUMOR; DOSE RESPONSE; DRUG RESISTANCE; ENZYMOLOGY; FEMALE; GENETICS; METABOLISM; MUTATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FEMALE; HUMANS; MUTATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0037945211     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206394     Document Type: Article

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