Imidazoacridinone-dependent lysosomal photodestruction: A pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

Cell Death and Disease

Volumn 3, Issue 4, 2012, Pages

  Adar, Y ^a   Stark, M ^a   Bram, E E ^a,f   Nowak Sliwinska, P ^b,c   Van Den Bergh, H ^b   Szewczyk, G ^d   Sarna, T ^d   Skladanowski, A ^e   Griffioen, A W ^c   Assaraf, Y G ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b EPFL   (Switzerland)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d JAGIELLONIAN UNIVERSITY   (Poland)

^e GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

^f Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Cancer chemotherapy; Hydrophobic weak base drugs; Lysosomal sequestration; Multidrug resistance; Photodynamic therapy; Reactive oxygen species

Indexed keywords

ABCC1 PROTEIN; ACRIDINE DERIVATIVE; BREAST CANCER RESISTANCE PROTEIN; FLUOROCHROME; IMIDAZOACRIDINONE; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCB1 PROTEIN, HUMAN; ABCG2 PROTEIN, HUMAN; ACRIDONE DERIVATIVE; CHLOROQUINE; GLYCOPROTEIN P; IMIDAZOLE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; PHOTOSENSITIZING AGENT; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CANCER CELL; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; FEMALE; GENE OVEREXPRESSION; HUMAN; HYDROPHOBICITY; IC 50; LYSOSOME; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANT CANCER; NEOPLASM; NONHUMAN; OVARY TUMOR; PHOTOACTIVATION; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TUMOR CELL; TUMOR XENOGRAFT; ANIMAL; ANIMAL EMBRYO; CHEMISTRY; CHICKEN; DRUG EFFECT; DRUG RESISTANCE; LASER; METABOLISM; PHOTOLYSIS; RADIATION EXPOSURE; TUMOR CELL LINE; XENOGRAFT;

EQUIDAE;

ACRIDONES; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; CHICKENS; CHLOROQUINE; DRUG RESISTANCE, NEOPLASM; EMBRYO, NONMAMMALIAN; FEMALE; HUMANS; IMIDAZOLES; LASERS; LYSOSOMES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; P-GLYCOPROTEIN; PHOTOLYSIS; PHOTOSENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; TRANSPLANTATION, HETEROLOGOUS;

EID: 84862082975     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.30     Document Type: Article

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