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Volumn 24, Issue , 2016, Pages 23-33

Lysosomes as mediators of drug resistance in cancer

Author keywords

cancer; Chemotherapeutics; Drug sequestration; Drug transport; Lysosomes; Multidrug resistance

Indexed keywords

ANTHRACYCLINE; BAFILOMYCIN A1; BREAST CANCER RESISTANCE PROTEIN; CAMPTOTHECIN; CARBOPLATIN; CHLOROQUINE; CISPLATIN; COPPER; COPPER EXPORTING ADENOSINE TRIPHOSPHATASE; DAUNORUBICIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ELLIPTICINE; ERLOTINIB; GEFITINIB; IMATINIB; LAPATINIB; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOME ENZYME; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOXANTRONE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; OXALIPLATIN; PAZOPANIB; PROTEIN 14 3 3; SUNITINIB; VINCRISTINE; ANTINEOPLASTIC AGENT;

EID: 84950157673     PISSN: 13687646     EISSN: 15322084     Source Type: Journal    
DOI: 10.1016/j.drup.2015.11.004     Document Type: Article
Times cited : (350)

References (95)
  • 1
    • 84922380040 scopus 로고    scopus 로고
    • The role of P-glycoprotein in drug resistance in multiple myeloma
    • J. Abraham, N.N. Salama, and A.K. Azab The role of P-glycoprotein in drug resistance in multiple myeloma Leuk. Lymphoma 56 2015 26 33
    • (2015) Leuk. Lymphoma , vol.56 , pp. 26-33
    • Abraham, J.1    Salama, N.N.2    Azab, A.K.3
  • 3
    • 84878643872 scopus 로고    scopus 로고
    • Lysosomal cell death at a glance
    • S. Aits, and M. Jaattela Lysosomal cell death at a glance J. Cell Sci. 126 2013 1905 1912
    • (2013) J. Cell Sci. , vol.126 , pp. 1905-1912
    • Aits, S.1    Jaattela, M.2
  • 5
    • 0032543207 scopus 로고    scopus 로고
    • Defective acidification in human breast tumor cells and implications for chemotherapy
    • N. Altan, Y. Chen, M. Schindler, and S.M. Simon Defective acidification in human breast tumor cells and implications for chemotherapy J. Exp. Med. 187 1998 1583 1598
    • (1998) J. Exp. Med. , vol.187 , pp. 1583-1598
    • Altan, N.1    Chen, Y.2    Schindler, M.3    Simon, S.M.4
  • 6
    • 0034256042 scopus 로고    scopus 로고
    • Regulated secretion of conventional lysosomes
    • N.W. Andrews Regulated secretion of conventional lysosomes Trends Cell Biol. 10 2000 316 321
    • (2000) Trends Cell Biol. , vol.10 , pp. 316-321
    • Andrews, N.W.1
  • 8
    • 84921803830 scopus 로고    scopus 로고
    • Lysosomal storage disease: Gene therapy on both sides of the blood-brain barrier
    • E.L. Aronovich, and P.B. Hackett Lysosomal storage disease: gene therapy on both sides of the blood-brain barrier Mol. Genet. Metab. 114 2015 83 93
    • (2015) Mol. Genet. Metab. , vol.114 , pp. 83-93
    • Aronovich, E.L.1    Hackett, P.B.2
  • 9
    • 33947375647 scopus 로고    scopus 로고
    • Molecular basis of antifolate resistance
    • Y.G. Assaraf Molecular basis of antifolate resistance Cancer Metastasis Rev. 26 2007 153 181
    • (2007) Cancer Metastasis Rev. , vol.26 , pp. 153-181
    • Assaraf, Y.G.1
  • 10
    • 33750975065 scopus 로고    scopus 로고
    • The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis
    • Y.G. Assaraf The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis Drug Resist. Updat. 9 2006 227 246
    • (2006) Drug Resist. Updat. , vol.9 , pp. 227-246
    • Assaraf, Y.G.1
  • 11
    • 38949145276 scopus 로고    scopus 로고
    • Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells
    • J. Bertinato, E. Swist, L.J. Plouffe, S.P. Brooks, and R.M. L'Abbe Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells Biochem. J. 409 2008 731 740
    • (2008) Biochem. J. , vol.409 , pp. 731-740
    • Bertinato, J.1    Swist, E.2    Plouffe, L.J.3    Brooks, S.P.4    L'Abbe, R.M.5
  • 12
    • 78650972288 scopus 로고    scopus 로고
    • Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo
    • B.G. Blair, C.A. Larson, P.L. Adams, P.B. Abada, C.E. Pesce, R. Safaei, and S.B. Howell Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo Mol. Pharmacol. 79 2011 157 166
    • (2011) Mol. Pharmacol. , vol.79 , pp. 157-166
    • Blair, B.G.1    Larson, C.A.2    Adams, P.L.3    Abada, P.B.4    Pesce, C.E.5    Safaei, R.6    Howell, S.B.7
  • 13
    • 67650359894 scopus 로고    scopus 로고
    • Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin
    • B.G. Blair, C.A. Larson, R. Safaei, and S.B. Howell Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin Clin. Cancer Res. 15 2009 4312 4321
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4312-4321
    • Blair, B.G.1    Larson, C.A.2    Safaei, R.3    Howell, S.B.4
  • 14
    • 84896131650 scopus 로고    scopus 로고
    • Inhibition of the multidrug resistance P-glycoprotein: Time for a change of strategy?
    • R. Callaghan, F. Luk, and M. Bebawy Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy? Drug Metab. Dispos. 42 2014 623 631
    • (2014) Drug Metab. Dispos. , vol.42 , pp. 623-631
    • Callaghan, R.1    Luk, F.2    Bebawy, M.3
  • 16
    • 70449359660 scopus 로고    scopus 로고
    • ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug
    • B. Chapuy, M. Panse, U. Radunski, R. Koch, D. Wenzel, N. Inagaki, D. Haase, L. Truemper, and G.G. Wulf ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug Haematologica 94 2009 1528 1536
    • (2009) Haematologica , vol.94 , pp. 1528-1536
    • Chapuy, B.1    Panse, M.2    Radunski, U.3    Koch, R.4    Wenzel, D.5    Inagaki, N.6    Haase, D.7    Truemper, L.8    Wulf, G.G.9
  • 18
    • 84855418559 scopus 로고    scopus 로고
    • Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy
    • H.H. Chen, J.J. Yan, W.C. Chen, M.T. Kuo, Y.H. Lai, W.W. Lai, H.S. Liu, and W.C. Su Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy Lung Cancer 75 2012 228 234
    • (2012) Lung Cancer , vol.75 , pp. 228-234
    • Chen, H.H.1    Yan, J.J.2    Chen, W.C.3    Kuo, M.T.4    Lai, Y.H.5    Lai, W.W.6    Liu, H.S.7    Su, W.C.8
  • 19
    • 84906544769 scopus 로고    scopus 로고
    • Cisplatin in cancer therapy: Molecular mechanisms of action
    • S. Dasari, and P.B. Tchounwou Cisplatin in cancer therapy: molecular mechanisms of action Eur. J. Pharmacol. 740 2014 364 378
    • (2014) Eur. J. Pharmacol. , vol.740 , pp. 364-378
    • Dasari, S.1    Tchounwou, P.B.2
  • 21
    • 28544443286 scopus 로고    scopus 로고
    • A chemical strategy to manipulate the intracellular localization of drugs in resistant cancer cells
    • M. Duvvuri, S. Konkar, R.S. Funk, J.M. Krise, and J.P. Krise A chemical strategy to manipulate the intracellular localization of drugs in resistant cancer cells Biochemistry 44 2005 15743 15749
    • (2005) Biochemistry , vol.44 , pp. 15743-15749
    • Duvvuri, M.1    Konkar, S.2    Funk, R.S.3    Krise, J.M.4    Krise, J.P.5
  • 22
    • 17244366637 scopus 로고    scopus 로고
    • Intracellular drug sequestration events associated with the emergence of multidrug resistance: A mechanistic review
    • M. Duvvuri, and J.P. Krise Intracellular drug sequestration events associated with the emergence of multidrug resistance: a mechanistic review Front. Biosci. 10 2005 1499 1509
    • (2005) Front. Biosci. , vol.10 , pp. 1499-1509
    • Duvvuri, M.1    Krise, J.P.2
  • 24
    • 0035066434 scopus 로고    scopus 로고
    • Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia
    • P. Ferrao, P. Sincock, S. Cole, and L. Ashman Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia Leuk. Res. 25 2001 395 405
    • (2001) Leuk. Res. , vol.25 , pp. 395-405
    • Ferrao, P.1    Sincock, P.2    Cole, S.3    Ashman, L.4
  • 25
    • 79953799375 scopus 로고    scopus 로고
    • Advances in the molecular detection of ABC transporters involved in multidrug resistance in cancer
    • J.P. Gillet, and M.M. Gottesman Advances in the molecular detection of ABC transporters involved in multidrug resistance in cancer Curr. Pharm. Biotechnol. 12 2011 686 692
    • (2011) Curr. Pharm. Biotechnol. , vol.12 , pp. 686-692
    • Gillet, J.P.1    Gottesman, M.M.2
  • 26
    • 79952996037 scopus 로고    scopus 로고
    • Mechanisms of amine accumulation in, and egress from, lysosomes
    • S.D. Goldman, R.S. Funk, R.A. Rajewski, and J.P. Krise Mechanisms of amine accumulation in, and egress from, lysosomes Bioanalysis 1 2009 1445 1459
    • (2009) Bioanalysis , vol.1 , pp. 1445-1459
    • Goldman, S.D.1    Funk, R.S.2    Rajewski, R.A.3    Krise, J.P.4
  • 27
    • 84865992002 scopus 로고    scopus 로고
    • Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance
    • N. Gonen, and Y.G. Assaraf Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance Drug Resist. Updat. 15 2012 183 210
    • (2012) Drug Resist. Updat. , vol.15 , pp. 183-210
    • Gonen, N.1    Assaraf, Y.G.2
  • 28
    • 29244474340 scopus 로고    scopus 로고
    • Niemann-Pick C1 protein facilitates the efflux of the anticancer drug daunorubicin from cells according to a novel vesicle-mediated pathway
    • Y. Gong, M. Duvvuri, M.B. Duncan, J. Liu, and J.P. Krise Niemann-Pick C1 protein facilitates the efflux of the anticancer drug daunorubicin from cells according to a novel vesicle-mediated pathway J. Pharmacol. Exp. Ther. 316 2006 242 247
    • (2006) J. Pharmacol. Exp. Ther. , vol.316 , pp. 242-247
    • Gong, Y.1    Duvvuri, M.2    Duncan, M.B.3    Liu, J.4    Krise, J.P.5
  • 29
    • 0347379902 scopus 로고    scopus 로고
    • Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multidrug-resistant human leukemic cell line HL-60
    • Y. Gong, M. Duvvuri, and J.P. Krise Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multidrug-resistant human leukemic cell line HL-60 J. Biol. Chem. 278 2003 50234 50239
    • (2003) J. Biol. Chem. , vol.278 , pp. 50234-50239
    • Gong, Y.1    Duvvuri, M.2    Krise, J.P.3
  • 33
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • M.M. Gottesman Mechanisms of cancer drug resistance Annu. Rev. Med. 53 2002 615 627
    • (2002) Annu. Rev. Med. , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 34
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • M.M. Gottesman, T. Fojo, and S.E. Bates Multidrug resistance in cancer: role of ATP-dependent transporters Nat. Rev. Cancer 2 2002 48 58
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 35
    • 31844444140 scopus 로고    scopus 로고
    • The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research
    • M.M. Gottesman, and V. Ling The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research FEBS Lett. 580 2006 998 1009
    • (2006) FEBS Lett. , vol.580 , pp. 998-1009
    • Gottesman, M.M.1    Ling, V.2
  • 37
    • 84876087934 scopus 로고    scopus 로고
    • Combating apoptosis and multidrug resistant cancers by targeting lysosomes
    • L. Groth-Pedersen, and M. Jaattela Combating apoptosis and multidrug resistant cancers by targeting lysosomes Cancer Lett. 332 2013 265 274
    • (2013) Cancer Lett. , vol.332 , pp. 265-274
    • Groth-Pedersen, L.1    Jaattela, M.2
  • 38
    • 33947235679 scopus 로고    scopus 로고
    • Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine
    • L. Groth-Pedersen, M.S. Ostenfeld, M. Hoyer-Hansen, J. Nylandsted, and M. Jaattela Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine Cancer Res. 67 2007 2217 2225
    • (2007) Cancer Res. , vol.67 , pp. 2217-2225
    • Groth-Pedersen, L.1    Ostenfeld, M.S.2    Hoyer-Hansen, M.3    Nylandsted, J.4    Jaattela, M.5
  • 39
    • 84899963339 scopus 로고    scopus 로고
    • Lysosome: The cell's 'suicidal bag' as a promising cancer target
    • M.T. Gyparaki, and A.G. Papavassiliou Lysosome: the cell's 'suicidal bag' as a promising cancer target Trends Mol. Med. 20 2014 239 241
    • (2014) Trends Mol. Med. , vol.20 , pp. 239-241
    • Gyparaki, M.T.1    Papavassiliou, A.G.2
  • 40
    • 84930622243 scopus 로고    scopus 로고
    • Role of transporters in the distribution of platinum-based drugs
    • S. Harrach, and G. Ciarimboli Role of transporters in the distribution of platinum-based drugs Front. Pharmacol. 6 2015 85
    • (2015) Front. Pharmacol. , vol.6 , pp. 85
    • Harrach, S.1    Ciarimboli, G.2
  • 41
    • 34250711394 scopus 로고    scopus 로고
    • Depletion of major vault protein increases doxorubicin sensitivity and nuclear accumulation and disrupts its sequestration in lysosomes
    • M. Herlevsen, G. Oxford, C.R. Owens, M. Conaway, and D. Theodorescu Depletion of major vault protein increases doxorubicin sensitivity and nuclear accumulation and disrupts its sequestration in lysosomes Mol. Cancer Ther. 6 2007 1804 1813
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1804-1813
    • Herlevsen, M.1    Oxford, G.2    Owens, C.R.3    Conaway, M.4    Theodorescu, D.5
  • 43
    • 4844228226 scopus 로고    scopus 로고
    • The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells
    • A.K. Holzer, G. Samimi, K. Katano, W. Naerdemann, X. Lin, R. Safaei, and S.B. Howell The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells Mol. Pharmacol. 66 2004 817 823
    • (2004) Mol. Pharmacol. , vol.66 , pp. 817-823
    • Holzer, A.K.1    Samimi, G.2    Katano, K.3    Naerdemann, W.4    Lin, X.5    Safaei, R.6    Howell, S.B.7
  • 45
    • 84896818937 scopus 로고    scopus 로고
    • Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin
    • C.P. Huang, M. Fofana, J. Chan, C.J. Chang, and S.B. Howell Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin Metallomics 6 2014 654 661
    • (2014) Metallomics , vol.6 , pp. 654-661
    • Huang, C.P.1    Fofana, M.2    Chan, J.3    Chang, C.J.4    Howell, S.B.5
  • 46
    • 0030962278 scopus 로고    scopus 로고
    • Vesicular anthracycline accumulation in doxorubicin-selected U-937 cells: Participation of lysosomes
    • S.J. Hurwitz, M. Terashima, N. Mizunuma, and C.A. Slapak Vesicular anthracycline accumulation in doxorubicin-selected U-937 cells: participation of lysosomes Blood 89 1997 3745 3754
    • (1997) Blood , vol.89 , pp. 3745-3754
    • Hurwitz, S.J.1    Terashima, M.2    Mizunuma, N.3    Slapak, C.A.4
  • 47
    • 0037195066 scopus 로고    scopus 로고
    • Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals
    • S. Ishida, J. Lee, D.J. Thiele, and I. Herskowitz Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals Proc. Natl. Acad. Sci. U.S.A. 99 2002 14298 14302
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 14298-14302
    • Ishida, S.1    Lee, J.2    Thiele, D.J.3    Herskowitz, I.4
  • 48
    • 0032916531 scopus 로고    scopus 로고
    • Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: Role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration
    • G. Jansen, H. Barr, I. Kathmann, M.A. Bunni, D.G. Priest, P. Noordhuis, G.J. Peters, and Y.G. Assaraf Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration Mol. Pharmacol. 55 1999 761 769
    • (1999) Mol. Pharmacol. , vol.55 , pp. 761-769
    • Jansen, G.1    Barr, H.2    Kathmann, I.3    Bunni, M.A.4    Priest, D.G.5    Noordhuis, P.6    Peters, G.J.7    Assaraf, Y.G.8
  • 49
    • 47349131319 scopus 로고    scopus 로고
    • Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells
    • G.V. Kalayda, C.H. Wagner, I. Buss, J. Reedijk, and U. Jaehde Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells BMC Cancer 8 2008 p175
    • (2008) BMC Cancer , vol.8 , pp. p175
    • Kalayda, G.V.1    Wagner, C.H.2    Buss, I.3    Reedijk, J.4    Jaehde, U.5
  • 50
    • 84876664386 scopus 로고    scopus 로고
    • Cancer-associated lysosomal changes: Friends or foes?
    • T. Kallunki, O.D. Olsen, and M. Jaattela Cancer-associated lysosomal changes: friends or foes? Oncogene 32 2013 1995 2004
    • (2013) Oncogene , vol.32 , pp. 1995-2004
    • Kallunki, T.1    Olsen, O.D.2    Jaattela, M.3
  • 51
    • 34247490248 scopus 로고    scopus 로고
    • Lysosomal sequestration of amine-containing drugs: Analysis and therapeutic implications
    • A.M. Kaufmann, and J.P. Krise Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications J. Pharm. Sci. 96 2007 729 746
    • (2007) J. Pharm. Sci. , vol.96 , pp. 729-746
    • Kaufmann, A.M.1    Krise, J.P.2
  • 52
    • 84875851903 scopus 로고    scopus 로고
    • Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells)
    • F. Kazmi, T. Hensley, C. Pope, R.S. Funk, G.J. Loewen, D.B. Buckley, and A. Parkinson Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells) Drug Metab. Dispos. 41 2013 897 905
    • (2013) Drug Metab. Dispos. , vol.41 , pp. 897-905
    • Kazmi, F.1    Hensley, T.2    Pope, C.3    Funk, R.S.4    Loewen, G.J.5    Buckley, D.B.6    Parkinson, A.7
  • 56
    • 0034104453 scopus 로고    scopus 로고
    • Resistance mechanisms associated with altered intracellular distribution of anticancer agents
    • A.K. Larsen, A.E. Escargueil, and A. Skladanowski Resistance mechanisms associated with altered intracellular distribution of anticancer agents Pharmacol. Ther. 85 2000 217 229
    • (2000) Pharmacol. Ther. , vol.85 , pp. 217-229
    • Larsen, A.K.1    Escargueil, A.E.2    Skladanowski, A.3
  • 58
    • 0036840625 scopus 로고    scopus 로고
    • The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae
    • X. Lin, T. Okuda, A. Holzer, and S.B. Howell The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae Mol. Pharmacol. 62 2002 1154 1159
    • (2002) Mol. Pharmacol. , vol.62 , pp. 1154-1159
    • Lin, X.1    Okuda, T.2    Holzer, A.3    Howell, S.B.4
  • 59
    • 84863997137 scopus 로고    scopus 로고
    • LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis
    • B. Liu, H. Du, R. Rutkowski, A. Gartner, and X. Wang LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis Science 337 2012 351 354
    • (2012) Science , vol.337 , pp. 351-354
    • Liu, B.1    Du, H.2    Rutkowski, R.3    Gartner, A.4    Wang, X.5
  • 60
    • 84888205791 scopus 로고    scopus 로고
    • Rationally designed nanovehicles to overcome cancer chemoresistance
    • Y.D. Livney, and Y.G. Assaraf Rationally designed nanovehicles to overcome cancer chemoresistance Adv. Drug Deliv. Rev. 65 2013 1716 1730
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 1716-1730
    • Livney, Y.D.1    Assaraf, Y.G.2
  • 61
    • 84864031724 scopus 로고    scopus 로고
    • Drug-drug interactions involving lysosomes: Mechanisms and potential clinical implications
    • R. Logan, R.S. Funk, E. Axcell, and J.P. Krise Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications Expert Opin. Drug Metabol. Toxicol. 8 2012 943 958
    • (2012) Expert Opin. Drug Metabol. Toxicol. , vol.8 , pp. 943-958
    • Logan, R.1    Funk, R.S.2    Axcell, E.3    Krise, J.P.4
  • 62
    • 35248897299 scopus 로고    scopus 로고
    • Cathepsin cysteine proteases in cardiovascular disease
    • S.P. Lutgens, K.B. Cleutjens, M.J. Daemen, and S. Heeneman Cathepsin cysteine proteases in cardiovascular disease FASEB J. 21 2007 3029 3041
    • (2007) FASEB J. , vol.21 , pp. 3029-3041
    • Lutgens, S.P.1    Cleutjens, K.B.2    Daemen, M.J.3    Heeneman, S.4
  • 63
    • 0023792145 scopus 로고
    • The potential role of lysosomes in tissue distribution of weak bases
    • A.C. MacIntyre, and D.J. Cutler The potential role of lysosomes in tissue distribution of weak bases Biopharm. Drug Dispos. 9 1988 513 526
    • (1988) Biopharm. Drug Dispos. , vol.9 , pp. 513-526
    • MacIntyre, A.C.1    Cutler, D.J.2
  • 64
    • 84864874958 scopus 로고    scopus 로고
    • MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
    • J.A. Martina, Y. Chen, M. Gucek, and R. Puertollano MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB Autophagy 8 2012 903 914
    • (2012) Autophagy , vol.8 , pp. 903-914
    • Martina, J.A.1    Chen, Y.2    Gucek, M.3    Puertollano, R.4
  • 68
    • 84887468101 scopus 로고    scopus 로고
    • Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain
    • H. Ohrvik, Y. Nose, L.K. Wood, B.E. Kim, S.C. Gleber, M. Ralle, and D.J. Thiele Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain Proc. Natl. Acad. Sci. U.S.A. 110 2013 E4279 E4288
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. E4279-E4288
    • Ohrvik, H.1    Nose, Y.2    Wood, L.K.3    Kim, B.E.4    Gleber, S.C.5    Ralle, M.6    Thiele, D.J.7
  • 70
    • 80052716148 scopus 로고    scopus 로고
    • Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
    • M. Palmieri, S. Impey, H. Kang, A. di Ronza, C. Pelz, M. Sardiello, and A. Ballabio Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways Hum. Mol. Genet. 20 2011 3852 3866
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 3852-3866
    • Palmieri, M.1    Impey, S.2    Kang, H.3    Di Ronza, A.4    Pelz, C.5    Sardiello, M.6    Ballabio, A.7
  • 71
    • 84930380295 scopus 로고    scopus 로고
    • Brief exposure to copper activates lysosomal exocytosis
    • K. Pena, J. Coblenz, and K. Kiselyov Brief exposure to copper activates lysosomal exocytosis Cell Calcium 57 2015 257 262
    • (2015) Cell Calcium , vol.57 , pp. 257-262
    • Pena, K.1    Coblenz, J.2    Kiselyov, K.3
  • 73
    • 0041968944 scopus 로고    scopus 로고
    • Subcellular localization and activity of multidrug resistance proteins
    • A. Rajagopal, and S.M. Simon Subcellular localization and activity of multidrug resistance proteins Mol. Biol. Cell 14 2003 3389 3399
    • (2003) Mol. Biol. Cell , vol.14 , pp. 3389-3399
    • Rajagopal, A.1    Simon, S.M.2
  • 74
    • 84858981234 scopus 로고    scopus 로고
    • The CXXC motifs in the metal binding domains are required for ATP7B to mediate resistance to cisplatin
    • R. Safaei, P.L. Adams, M.H. Maktabi, R.A. Mathews, and S.B. Howell The CXXC motifs in the metal binding domains are required for ATP7B to mediate resistance to cisplatin J. Inorg. Biochem. 110 2012 8 17
    • (2012) J. Inorg. Biochem. , vol.110 , pp. 8-17
    • Safaei, R.1    Adams, P.L.2    Maktabi, M.H.3    Mathews, R.A.4    Howell, S.B.5
  • 75
    • 27644524811 scopus 로고    scopus 로고
    • Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells
    • R. Safaei, B.J. Larson, T.C. Cheng, M.A. Gibson, S. Otani, W. Naerdemann, and S.B. Howell Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells Mol. Cancer Ther. 4 2005 1595 1604
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1595-1604
    • Safaei, R.1    Larson, B.J.2    Cheng, T.C.3    Gibson, M.A.4    Otani, S.5    Naerdemann, W.6    Howell, S.B.7
  • 76
  • 77
    • 84885851739 scopus 로고    scopus 로고
    • Cancer: Killing from the inside
    • P. Saftig, and K. Sandhoff Cancer: killing from the inside Nature 502 2013 312 313
    • (2013) Nature , vol.502 , pp. 312-313
    • Saftig, P.1    Sandhoff, K.2
  • 79
    • 0029939371 scopus 로고    scopus 로고
    • Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr)
    • M. Schindler, S. Grabski, E. Hoff, and S.M. Simon Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr) Biochemistry 35 1996 2811 2817
    • (1996) Biochemistry , vol.35 , pp. 2811-2817
    • Schindler, M.1    Grabski, S.2    Hoff, E.3    Simon, S.M.4
  • 80
    • 84876812269 scopus 로고    scopus 로고
    • Signals from the lysosome: A control centre for cellular clearance and energy metabolism
    • C. Settembre, A. Fraldi, D.L. Medina, and A. Ballabio Signals from the lysosome: a control centre for cellular clearance and energy metabolism Nat. Rev. Mol. Cell Biol. 14 2013 283 296
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 283-296
    • Settembre, C.1    Fraldi, A.2    Medina, D.L.3    Ballabio, A.4
  • 82
    • 0026777870 scopus 로고
    • Subcellular distribution of the anticancer drug mitoxantrone in human and drug-resistant murine cells analyzed by flow cytometry and confocal microscopy and its relationship to the induction of DNA damage
    • P.J. Smith, H.R. Sykes, M.E. Fox, and I.J. Furlong Subcellular distribution of the anticancer drug mitoxantrone in human and drug-resistant murine cells analyzed by flow cytometry and confocal microscopy and its relationship to the induction of DNA damage Cancer Res. 52 1992 4000 4008
    • (1992) Cancer Res. , vol.52 , pp. 4000-4008
    • Smith, P.J.1    Sykes, H.R.2    Fox, M.E.3    Furlong, I.J.4
  • 83
    • 12344314253 scopus 로고    scopus 로고
    • Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells
    • I.S. Song, N. Savaraj, Z.H. Siddik, P. Liu, Y. Wei, C.J. Wu, and M.T. Kuo Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells Mol. Cancer Ther. 3 2004 1543 1549
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1543-1549
    • Song, I.S.1    Savaraj, N.2    Siddik, Z.H.3    Liu, P.4    Wei, Y.5    Wu, C.J.6    Kuo, M.T.7
  • 85
    • 0030656341 scopus 로고    scopus 로고
    • Lysosomal and cytosolic pH as regulators of exocytosis in mouse macrophages
    • R. Sundler Lysosomal and cytosolic pH as regulators of exocytosis in mouse macrophages Acta Physiol. Scand. 161 1997 553 556
    • (1997) Acta Physiol. Scand. , vol.161 , pp. 553-556
    • Sundler, R.1
  • 89
    • 84865584931 scopus 로고    scopus 로고
    • Genetic polymorphism of copper transporter protein 1 is related to platinum resistance in Chinese non-small cell lung carcinoma patients
    • X. Xu, L. Duan, B. Zhou, R. Ma, H. Zhou, and Z. Liu Genetic polymorphism of copper transporter protein 1 is related to platinum resistance in Chinese non-small cell lung carcinoma patients Clin. Exp. Pharmacol. Physiol. 39 2012 786 792
    • (2012) Clin. Exp. Pharmacol. Physiol. , vol.39 , pp. 786-792
    • Xu, X.1    Duan, L.2    Zhou, B.3    Ma, R.4    Zhou, H.5    Liu, Z.6
  • 90
    • 84887127352 scopus 로고    scopus 로고
    • P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration
    • T. Yamagishi, S. Sahni, D.M. Sharp, A. Arvind, P.J. Jansson, and D.R. Richardson P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration J. Biol. Chem. 288 2013 31761 31771
    • (2013) J. Biol. Chem. , vol.288 , pp. 31761-31771
    • Yamagishi, T.1    Sahni, S.2    Sharp, D.M.3    Arvind, A.4    Jansson, P.J.5    Richardson, D.R.6
  • 91
    • 84874728858 scopus 로고    scopus 로고
    • Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition
    • R.E. Yanes, D. Tarn, A.A. Hwang, D.P. Ferris, S.P. Sherman, C.R. Thomas, J. Lu, A.D. Pyle, J.I. Zink, and F. Tamanoi Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition Small 9 2013 697 704
    • (2013) Small , vol.9 , pp. 697-704
    • Yanes, R.E.1    Tarn, D.2    Hwang, A.A.3    Ferris, D.P.4    Sherman, S.P.5    Thomas, C.R.6    Lu, J.7    Pyle, A.D.8    Zink, J.I.9    Tamanoi, F.10
  • 92
    • 84921799144 scopus 로고    scopus 로고
    • Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance
    • B. Zhitomirsky, and Y.G. Assaraf Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Oncotarget 6 2015 1143 1156
    • (2015) Oncotarget , vol.6 , pp. 1143-1156
    • Zhitomirsky, B.1    Assaraf, Y.G.2
  • 93
    • 85019296770 scopus 로고    scopus 로고
    • The role of cytoplasmic-to-lysosomal pH gradient in hydrophobic weak base drug sequestration in lysosomes
    • B. Zhitomirsky, and Y.G. Assaraf The role of cytoplasmic-to-lysosomal pH gradient in hydrophobic weak base drug sequestration in lysosomes Cancer Cell Microenviron. 2 2015 e807
    • (2015) Cancer Cell Microenviron. , vol.2 , pp. e807
    • Zhitomirsky, B.1    Assaraf, Y.G.2
  • 94
    • 80051503951 scopus 로고    scopus 로고
    • Chemosensitization by phenothiazines in human lung cancer cells: Impaired resolution of gammaH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation
    • D. Zong, P. Haag, I. Yakymovych, R. Lewensohn, and K. Viktorsson Chemosensitization by phenothiazines in human lung cancer cells: impaired resolution of gammaH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation Cell Death Dis. 2 2011 e181
    • (2011) Cell Death Dis. , vol.2 , pp. e181
    • Zong, D.1    Haag, P.2    Yakymovych, I.3    Lewensohn, R.4    Viktorsson, K.5


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