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Volumn 5, Issue 3, 1999, Pages 621-627

Mechanisms of methotrexate resistance in osteosarcoma

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID; FOLINIC ACID; METHOTREXATE; TRIMETREXATE;

EID: 0033001234     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (147)

References (39)
  • 2
    • 0031861214 scopus 로고    scopus 로고
    • Intensification of preoperative chemotherapy for osteogenic sarcoma: The results of the Memorial Sloan-Kettering (T12) protocol
    • Meyers, P. A., Gorlick, R., Heller, G., Casper, E., Lane, J., Huvos, A., and Healey, J. Intensification of preoperative chemotherapy for osteogenic sarcoma: the results of the Memorial Sloan-Kettering (T12) protocol. J. Clin. Oncol., 16: 2452-2458, 1998.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2452-2458
    • Meyers, P.A.1    Gorlick, R.2    Heller, G.3    Casper, E.4    Lane, J.5    Huvos, A.6    Healey, J.7
  • 3
    • 0018091466 scopus 로고
    • High-dose methotrexate in osteogenic sarcoma: A 5-year experience
    • Jaffe, N., Frei, E., Watts, H., and Traggis, D. High-dose methotrexate in osteogenic sarcoma: a 5-year experience. Cancer Treat. Rep., 62: 259-264, 1978.
    • (1978) Cancer Treat. Rep. , vol.62 , pp. 259-264
    • Jaffe, N.1    Frei, E.2    Watts, H.3    Traggis, D.4
  • 4
    • 0026002081 scopus 로고
    • Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: A Scandinavian Sarcoma Group study
    • Saeter, G., Alvegard, T. A., Elomaa, I., Stenwig, A. E., Holmstrom, T., and Solheim, O. P. Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: a Scandinavian Sarcoma Group study. J. Clin. Oncol., 9: 1766-1775, 1991.
    • (1991) J. Clin. Oncol. , vol.9 , pp. 1766-1775
    • Saeter, G.1    Alvegard, T.A.2    Elomaa, I.3    Stenwig, A.E.4    Holmstrom, T.5    Solheim, O.P.6
  • 5
    • 0027351189 scopus 로고
    • Karnofsky memorial lecture. Ode to methotrexate
    • Bertino, J. R. Karnofsky memorial lecture. Ode to methotrexate. J. Clin. Oncol., 11: 5-14, 1993.
    • (1993) J. Clin. Oncol. , vol.11 , pp. 5-14
    • Bertino, J.R.1
  • 8
    • 0030948473 scopus 로고    scopus 로고
    • Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression
    • Gorlick, R., Goker, E., Trippett, T., Steinherz, P., Elisseyeff, Y., Mazumdar, M., Flintoff, W. F., and Bertino, J. R. Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. Blood, 89: 1013-1018, 1996.
    • (1996) Blood , vol.89 , pp. 1013-1018
    • Gorlick, R.1    Goker, E.2    Trippett, T.3    Steinherz, P.4    Elisseyeff, Y.5    Mazumdar, M.6    Flintoff, W.F.7    Bertino, J.R.8
  • 9
    • 0029075026 scopus 로고
    • Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations
    • Goker, E., Waltham, M., Kheradpour, A., Trippett, T., Mazumdar, M., Elisseyeff, Y., Schnieders, B., Steinherz, P., Tan, C., Berman, E., and Bertino, J. R. Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations. Blood, 86: 677-684, 1995.
    • (1995) Blood , vol.86 , pp. 677-684
    • Goker, E.1    Waltham, M.2    Kheradpour, A.3    Trippett, T.4    Mazumdar, M.5    Elisseyeff, Y.6    Schnieders, B.7    Steinherz, P.8    Tan, C.9    Berman, E.10    Bertino, J.R.11
  • 11
    • 0027297862 scopus 로고
    • Serum methotrexate (MTX) concentrations and prognosis in patients with osteosarcoma of the extremities treated with a multidrug neoadjuvant regimen
    • Ferrari, S., Sassoli, V., Orlandi, M., Strazzari, S., Puggiolo, C., Battistini, A., and Bacci, G. Serum methotrexate (MTX) concentrations and prognosis in patients with osteosarcoma of the extremities treated with a multidrug neoadjuvant regimen. J. Chemother, 5: 135-141, 1993.
    • (1993) J. Chemother , vol.5 , pp. 135-141
    • Ferrari, S.1    Sassoli, V.2    Orlandi, M.3    Strazzari, S.4    Puggiolo, C.5    Battistini, A.6    Bacci, G.7
  • 12
    • 0031943038 scopus 로고    scopus 로고
    • Predictive factors of histologic response to primary chemotherapy in osteosarcoma of the extremity: Study of 272 patients preoperatively treated with high-dose methotrexate, doxorubicin, and cisplatin
    • Bacci, G., Ferrari, S., Delepine, N., Bertoni, F., Picci, P., Mercuri, M., Bacchini, P., Brach del Prever, A., Tienghi, A., Comandone, A., and Campanacci, M. Predictive factors of histologic response to primary chemotherapy in osteosarcoma of the extremity: study of 272 patients preoperatively treated with high-dose methotrexate, doxorubicin, and cisplatin. J. Clin. Oncol., 16: 658-663, 1998.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 658-663
    • Bacci, G.1    Ferrari, S.2    Delepine, N.3    Bertoni, F.4    Picci, P.5    Mercuri, M.6    Bacchini, P.7    Brach Del Prever, A.8    Tienghi, A.9    Comandone, A.10    Campanacci, M.11
  • 13
    • 0029861534 scopus 로고    scopus 로고
    • Influence of methotrexate dose intensity on outcome of patients with high grade osteogenic sarcoma
    • Delepine, N., Delepine, G., Bacci, G., Rosen, G., and Desbois, J. C. Influence of methotrexate dose intensity on outcome of patients with high grade osteogenic sarcoma. Cancer (Phila.), 78: 2127-2135, 1996.
    • (1996) Cancer (Phila.) , vol.78 , pp. 2127-2135
    • Delepine, N.1    Delepine, G.2    Bacci, G.3    Rosen, G.4    Desbois, J.C.5
  • 14
    • 0031058728 scopus 로고    scopus 로고
    • Prognostic significance of chemotherapy dosage characteristic in children with osteogenic sarcoma
    • Leung, S., Marshall, G. M., Al Mahr, M., Tobias, V., Lee, D. B., and Hughes, D. O. Prognostic significance of chemotherapy dosage characteristic in children with osteogenic sarcoma. Med. Pediatr. Oncol., 28: 179-182, 1997.
    • (1997) Med. Pediatr. Oncol. , vol.28 , pp. 179-182
    • Leung, S.1    Marshall, G.M.2    Al Mahr, M.3    Tobias, V.4    Lee, D.B.5    Hughes, D.O.6
  • 15
    • 0025036839 scopus 로고
    • Accumulation, intracellular metabolism, and antitumor activity of high- and low-dose methotrexate in human osteosarcoma xenografts
    • Meyer, W. H., Loftin, S. K., Houghton, J. A., and Houghton, P. J. Accumulation, intracellular metabolism, and antitumor activity of high- and low-dose methotrexate in human osteosarcoma xenografts. Cancer Commun., 2: 219-229, 1990.
    • (1990) Cancer Commun. , vol.2 , pp. 219-229
    • Meyer, W.H.1    Loftin, S.K.2    Houghton, J.A.3    Houghton, P.J.4
  • 17
    • 0017655886 scopus 로고
    • Primary osteogenic sarcoma. Pathologic aspects in 20 patients after treatment with chemotherapy, en bloc resection and prosthetic bone replacement
    • Huvos, A. G., Rosen, G., and Marcove, R. C. Primary osteogenic sarcoma. Pathologic aspects in 20 patients after treatment with chemotherapy, en bloc resection and prosthetic bone replacement. Arch. Pathol. Lab. Med., 101: 14-18, 1977.
    • (1977) Arch. Pathol. Lab. Med. , vol.101 , pp. 14-18
    • Huvos, A.G.1    Rosen, G.2    Marcove, R.C.3
  • 18
    • 0020059356 scopus 로고
    • Preoperative chemotherapy for osteogenic sarcoma: Selection of post-operative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy
    • Rosen, G., Caparros, B., Huvos, A. G., Kosloff, C., Nirenberg, A., Cacavio, A., Marcove, R. C., Lane, J. M., Mehta, B., and Urban, C. Preoperative chemotherapy for osteogenic sarcoma: selection of post-operative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer (Phila.), 49: 1221-1230, 1982.
    • (1982) Cancer (Phila.) , vol.49 , pp. 1221-1230
    • Rosen, G.1    Caparros, B.2    Huvos, A.G.3    Kosloff, C.4    Nirenberg, A.5    Cacavio, A.6    Marcove, R.C.7    Lane, J.M.8    Mehta, B.9    Urban, C.10
  • 19
    • 0001279038 scopus 로고    scopus 로고
    • Preparation of genomic DNA from mammalian tissue
    • F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhi (eds.), New York: John Wiley & Sons, Inc.
    • Ausubel, F. M., Brent, R., and Kingston, R. E. Preparation of genomic DNA from mammalian tissue. In: F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhi (eds.), Current Protocols in Molecular Biology, Vol. 2, pp. 2.1-2.2.2. New York: John Wiley & Sons, Inc., 1996.
    • (1996) Current Protocols in Molecular Biology , vol.2 , pp. 21-222
    • Ausubel, F.M.1    Brent, R.2    Kingston, R.E.3
  • 21
    • 0016700864 scopus 로고
    • Detection of specific sequences among DNA fragments separated by gel electrophoresis
    • Southern, E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol., 98: 503-508, 1975.
    • (1975) J. Mol. Biol. , vol.98 , pp. 503-508
    • Southern, E.M.1
  • 28
    • 0031051550 scopus 로고    scopus 로고
    • Accumulation of E2F-4. DP-1 DNA binding complexes with induction of dhfr gene expression during the G1 to S phase transition
    • Wells, J. M., Illenye, S., Magae, J., Wu, C. L., and Heintz, N. H. Accumulation of E2F-4. DP-1 DNA binding complexes with induction of dhfr gene expression during the G1 to S phase transition. J. Biol. Chem., 272: 4483-4492, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4483-4492
    • Wells, J.M.1    Illenye, S.2    Magae, J.3    Wu, C.L.4    Heintz, N.H.5
  • 30
    • 0030970016 scopus 로고    scopus 로고
    • Functional roles of E2F in cell cycle regulation
    • Fan, J. G., and Bertino, J. R. Functional roles of E2F in cell cycle regulation. Oncogene, 14: 1191-1200, 1997.
    • (1997) Oncogene , vol.14 , pp. 1191-1200
    • Fan, J.G.1    Bertino, J.R.2
  • 31
    • 0030610390 scopus 로고    scopus 로고
    • Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells
    • Li, W. W., Fan, J. G., Hochhauser, D., and Bertino, J. R. Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. Cancer Res. 57: 2193-2199, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 2193-2199
    • Li, W.W.1    Fan, J.G.2    Hochhauser, D.3    Bertino, J.R.4
  • 36
    • 0021032114 scopus 로고
    • Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate
    • Diddens, H., Niethammer, D., and Jackson, R. C. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate. Cancer Res., 43: 5286-5292, 1983.
    • (1983) Cancer Res. , vol.43 , pp. 5286-5292
    • Diddens, H.1    Niethammer, D.2    Jackson, R.C.3
  • 37
    • 0027050422 scopus 로고
    • Inability of leucovorin to rescue a naturally methotrexate resistance human soft tissue sarcoma cell line from trimetrexate cytotoxicity
    • Li, W. W., and Bertino, J. R. Inability of leucovorin to rescue a naturally methotrexate resistance human soft tissue sarcoma cell line from trimetrexate cytotoxicity. Cancer Res., 52: 6866-6870, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 6866-6870
    • Li, W.W.1    Bertino, J.R.2
  • 38
    • 0029053314 scopus 로고
    • Selective treatment of SCID mice bearing methotrexate transport-resistant human acute lymphoblastic leukemia tumors with trimetrexate and leucovorin protection
    • Lacerda, J. F., Goker, E., Kheradpour, A., Dennig, D., Elisseyeff, Y., Jagiello, C., O'Reilly, R. J., and Bertino, J. R. Selective treatment of SCID mice bearing methotrexate transport-resistant human acute lymphoblastic leukemia tumors with trimetrexate and leucovorin protection. Blood, 85: 2675-2679, 1995.
    • (1995) Blood , vol.85 , pp. 2675-2679
    • Lacerda, J.F.1    Goker, E.2    Kheradpour, A.3    Dennig, D.4    Elisseyeff, Y.5    Jagiello, C.6    O'Reilly, R.J.7    Bertino, J.R.8
  • 39
    • 0006087075 scopus 로고    scopus 로고
    • Trimetrexate (TMTX) oral bioavailability and lack of cross resistance with HD-MTX in patients with recurrent osteosarcoma
    • Tkaczewski, L., Tong, W. P., Spriggs, D., Bertino, J. R., Capizzi, R. L., and Kamen, B. A. Trimetrexate (TMTX) oral bioavailability and lack of cross resistance with HD-MTX in patients with recurrent osteosarcoma. Proc. Am. Soc. Clin. Oncol., 15: 1504, 1996.
    • (1996) Proc. Am. Soc. Clin. Oncol. , vol.15 , pp. 1504
    • Tkaczewski, L.1    Tong, W.P.2    Spriggs, D.3    Bertino, J.R.4    Capizzi, R.L.5    Kamen, B.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.