Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression

Blood

Volumn 89, Issue 3, 1997, Pages 1013-1018

  Gorlick, Richard ^b   Goker, Erdem ^b   Trippett, Tanya ^b   Steinherz, Peter ^b   Elisseyeff, Yaroslav ^b   Mazumdar, Madhu ^b   Flintoff, Wayne F ^b   Bertino, Joseph R ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; FOLIC ACID; METHOTREXATE;

ACUTE LYMPHOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RECURRENCE; CHILD; DRUG TRANSPORT; DRUG UPTAKE; GENE EXPRESSION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MEMBRANE TRANSPORT; MULTIDRUG RESISTANCE; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0030948473     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.3.1013     Document Type: Article

References (38)

1. Jolivet J, Cowan KH, Curt GA, Clendeninn NJ, Chabner BA: The pharmacology and clinical use of methotrexate. N Engl J Med 309:1094, 1983
2. Bertino JR: Ode to methotrexate. J Clin Oncol 11:5, 1993
3. Bertino JR, Goker E: Drug resistance in acute leukemia. Leuk Lymph 11:37, 1993
4. Allegra CJ: Antifolates, in Chabner BA, Collins JM (eds): Cancer Chemotherapy: Principles and Practice. Philadelphia, PA, Lippincott, 1990, p 110
5. Schweitzer BI, Dicker AP, Bertino JR: Dihydrofolate reductase as a therapeutic target. FASEB J 4:2441, 1990
6. Goker E, Waltham M, Kheradpour A, Trippett T, Mazumdar M, Elisseyeff Y, Schnieders B, Steinherz P, Tan C, Berman E, Bertino JR: Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia and is correlated with p53 gene mutations. Blood 86:677, 1995
7. Trippett T, Schlemmer S, Elisseyeff Y, Goker E, Wachter M, Steinherz P, Tan C, Berman E, Wright JE, Rosowsky A, Schweitzer B, Bertino JR: Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia. Blood 80:1158, 1992
8. Matherly LH, Taub JE, Ravindranath Y, Proefke SA, Wong SC, Gimotty P, Buck S, Wright JE, Rosowsky A: Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphocytic leukemia. Blood 85:500, 1995
9. Williams FMR, Flintoff WF: Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J Biol Chem 270:2987, 1995
10. Moscow JA, Gong M, He R, Sgagias MK, Dixon KH, Anzick SL, Meltzer PS, Cowan KH: Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res 55:3790, 1995
11. Wong SC, Proefke SA, Bhushan A, Matherly LH: Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J Biol Chem 270:17468, 1995
12. Prasad PD, Ramamoorthy S, Leibach FH, Ganapathy V: Molecular cloning of the human placental folate transporter. Biochem Biophys Res Commun 206:681, 1995
13. Gaynon PS, Steinherz PG, Bleyer AW, Ablin AR, Albo VC, Finkelstein JZ, Grossman NJ, Novak LJ, Pysemany AF, Reaman GH, Chappell RJ, Sather HN, Hammond GD: Improved therapy for children with acute lymphoblastic leukemia and unfavorable presenting features: A follow-up report of the Children's Cancer Group study CCG-106. J Clin Oncol 11:2234, 1993
14. Steinherz PG, Redner A, Steinherz L, Meyers P, Tan C, Heller G: Development of a new intensive therapy for acute lymphoblastic leukemia in children at increased risk of early relapse. Cancer 72:3120, 1993
15. Berman E, Weiss M, Kempin S, Gee T, Bertino J, Clarkson B: Intensive therapy for adult acute lymphoblastic leukemia. Semin Hematol 28:72, 1991
16. Rosowsky A, Wright JE, Shapiro H, Beardsley GP, Lazarus H: A new fluorescent dihydrofolate reductase probe for studies of methotrexate resistance. J Biol Chem 257:14162, 1982
17. Rosowsky A, Wright JE, Cucchi CA, Boeheim K, Frei E III: Transport of a fluorescent antifolate by methotrexate-sensitive and methotrexate-resistant human leukemic lymphoblasts. Biochem Pharmacol 35:356, 1986
18. Assaraf YG, Feder JN, Sharma RC, Wright JE, Rosowsky A, Shane B, Schimke RT: Characterization of the coexisting multiple mechanisms of methotrexate resistance in mouse 3T6 R50 fibroblasts. J Biol Chem 267:5776, 1992
19. Thomas PS: Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci USA 77:5201, 1980
20. Laborda, J: 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res 19:3998, 1991
21. Horikoshi T, Danenberg KD, Stadlbauer THW, Volkenandt M, Shea LCC, Aigner K, Gustavsson B, Leichman L, Frosing R, Ray M, Gibson NW, Spears CP, Danenberg PV: Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res 52:108, 1992
22. Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV, Leichman L: Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 55:1407, 1995
23. Fleiss JL: Statistical Methods for Rates and Proportions (ed 2). New York, NY, Wiley Interscience, 1981
24. McCloskey DE, McGuire JJ, Russell CA, Rowan BG, Bertino JR, Pizzorno G, Mini E: Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines. J Biol Chem 266:6181, 1991
25. Spinella MJ, Brigle KE, Sierra EE, Goldman ID: Distinguishing between folate receptor mediated transport and reduced folate carrier mediated transport in L1210 leukemia cells. J Biol Chem 270:7842, 1995
26. Westerhof GR, Rijnbout S, Schornagel JH, Pinedo HM, Peters GJ, Jansen G: Functional activity of the reduced folate carrier in KB, MA104 and IGROV-1 cells expressing folate binding protein. Cancer Res 55:3996, 1995
27. Williams FMR, Murray RC, Underhill TM, Flintoff WF: Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake. J Biol Chem 269:5810, 1994
28. Dixon KH, Lanpher BC, Chiu J, Kelley K, Cowan KH: A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J Biol Chem 269:17, 1994
29. Klohs WD, Steinkampf RW, Besserer JA, Fry DW: Cross-resistance of pleiotropically resistant P388 leukemia cells to the lipophilic antifolates trimetrexate and BW 301U. Cancer Lett 31:253, 1986
30. Assaraf YG, Molina A, Schimke RT: Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype. J Natl Cancer Inst 81:290, 1989
31. Spencer HT, Sorrentino BP, Pui CH, Chunduru SK, Sleep SE, Blakley RL: Mutations in the gene for human dihydrofolate reductase: An unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate. Leukemia 10:439, 1996
32. Connolly T, Myers TG, Paull KD, Cowan KH, Moscow JA: RFC1 expression and resistance to methotrexate and trimetrexate in transfected and non-selected cell lines. Proc Am Assoc Cancer Res 37:498, 1996 (abstr)
33. Brigle KE, Spinella MJ, Sierra EE, Goldman ID: Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line. J Biol Chem 270:22974, 1995
34. Lin JT, Tong WP, Trippett TM, Niedzwiecki D, Tao Y, Tan C, Steinherz P, Schweitzer BI, Bertino JR: Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemia. Leuk Res 15:1191, 1991
35. Goker E, Kheradpour A, Waltham M, Banerjee D, Tong WP, Elisseyeff Y, Bertino JR: Acute monocytic leukemia: A myeloid subset that may be sensitive to methotrexate. Leukemia 9:274, 1995
36. Zochbauer S, Gaur A, Brunner R, Kyrle PA, Lechner K, Pirker R: P-glycoprotein expression as unfavorable prognostic factor in acute myeloid leukemia. Leukemia 8:974, 1994
37. Paietta A, Andersen J, Racevskis J, Gallagher R, Bennett J, Yunis J, Cassileth P, Wiernik PH: Significantly lower p-glycoprotein expression in acute promyelocytic leukemia than in other types of acute myeloid leukemia: Immunological, molecular and functional analyses. Leukemia 8:968, 1994
38. Lacerda JF, Goker E, Kheradpour A, Dennig D, Elisseyeff Y, Jagiello C, O'Reilly RJ, Bertino JR: Selective treatment of SCID mice bearing methotrexate-transport resistant human acute leukemia tumors with trimetrexate and leucovorin protection. Blood 85:2675, 1995