-
1
-
-
34548149961
-
1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxiainducible factor 1α
-
1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxiainducible factor 1α. J Biol Chem 282: 23572–23580, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 23572-23580
-
-
Baek, J.H.1
Liu, Y.V.2
McDonald, K.R.3
Wesley, J.B.4
Hubbi, M.E.5
Byun, H.6
Semenza, G.L.7
-
2
-
-
36348938850
-
Spermidine/spermine N1-acetyltransferase-1 binds to hypoxia-inducible factor-1α (HIF-1α) and RACK1 and promotes ubiquitination and degradation of HIF-1α
-
Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL. Spermidine/spermine N1-acetyltransferase-1 binds to hypoxia-inducible factor-1α (HIF-1α) and RACK1 and promotes ubiquitination and degradation of HIF-1α. J Biol Chem 282: 33358–33366, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 33358-33366
-
-
Baek, J.H.1
Liu, Y.V.2
McDonald, K.R.3
Wesley, J.B.4
Zhang, H.5
Semenza, G.L.6
-
3
-
-
13944276440
-
OS-9 interacts with hypoxia inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α
-
Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL. OS-9 interacts with hypoxia inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α. Mol Cell 17: 503–512, 2005.
-
(2005)
Mol Cell
, vol.17
, pp. 503-512
-
-
Baek, J.H.1
Mahon, P.C.2
Oh, J.3
Kelly, B.4
Krishnamachary, B.5
Pearson, M.6
Chan, D.A.7
Giaccia, A.J.8
Semenza, G.L.9
-
4
-
-
64249107059
-
Evidence for cardiomyocyte renewal in humans
-
Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisen J. Evidence for cardiomyocyte renewal in humans. Science 324: 98–102, 2009.
-
(2009)
Science
, vol.324
, pp. 98-102
-
-
Bergmann, O.1
Bhardwaj, R.D.2
Bernard, S.3
Zdunek, S.4
Barnabe-Heider, F.5
Walsh, S.6
Zupicich, J.7
Alkass, K.8
Buchholz, B.A.9
Druid, H.10
Jovinge, S.11
Frisen, J.12
-
5
-
-
61349088682
-
The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF
-
Beyer S, Kristensen MM, Jensen KS, Johansen JV, Staller P. The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J Biol Chem 283: 36542–36552, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 36542-36552
-
-
Beyer, S.1
Kristensen, M.M.2
Jensen, K.S.3
Johansen, J.V.4
Staller, P.5
-
6
-
-
77951043486
-
Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds
-
Biswas S, Roy S, Banerjee J, Hussain SR, Khanna S, Meenakshisundaram G, Kuppusamy P, Friedman A, Sen CK. Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds. Proc Natl Acad Sci USA 107: 6976–6981, 2010.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 6976-6981
-
-
Biswas, S.1
Roy, S.2
Banerjee, J.3
Hussain, S.R.4
Khanna, S.5
Meenakshisundaram, G.6
Kuppusamy, P.7
Friedman, A.8
Sen, C.K.9
-
7
-
-
84934908244
-
Oxygen regulates proliferation of neural stem cells through Wnt/β-catenin signalling
-
Braunschweig L, Meyer AK, Wagenführ L, Storch A. Oxygen regulates proliferation of neural stem cells through Wnt/β-catenin signalling. Mol Cell Neurosci 67: 84–92, 2015.
-
(2015)
Mol Cell Neurosci
, vol.67
, pp. 84-92
-
-
Braunschweig, L.1
Meyer, A.K.2
Wagenführ, L.3
Storch, A.4
-
8
-
-
84924811108
-
Human ventricular unloading induces cardiomyocyte proliferation
-
Canseco DC, Kimura W, Garg S, Mukherjee S, Bhattacharya S, Abdisalaam S, Das S, Asaithamby A, Mammen PP, Sadek HA. Human ventricular unloading induces cardiomyocyte proliferation. J Am Coll Cardiol 65: 892–900, 2015.
-
(2015)
J am Coll Cardiol
, vol.65
, pp. 892-900
-
-
Canseco, D.C.1
Kimura, W.2
Garg, S.3
Mukherjee, S.4
Bhattacharya, S.5
Abdisalaam, S.6
Das, S.7
Asaithamby, A.8
Mammen, P.P.9
Sadek, H.A.10
-
9
-
-
0032581277
-
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis
-
Carmeliet P, Dor Y, Herbert JM, Fukumara D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis. Nature 394: 485, 1998.
-
(1998)
Nature
, vol.394
, pp. 485
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumara, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshert, E.16
-
10
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME, Capla JM, Galiano RD, Levine JP, Gurtner GC. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10: 858–864, 2004.
-
(2004)
Nat Med
, vol.10
, pp. 858-864
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
Tepper, O.M.4
Bastidas, N.5
Kleinman, M.E.6
Capla, J.M.7
Galiano, R.D.8
Levine, J.P.9
Gurtner, G.C.10
-
11
-
-
0037022387
-
Analysis of Cdc6 function in the assembly of mammalian prereplication complexes
-
Cook JG, Park CH, Burke TW, Leone G, DeGregori J, Engel A, Nevins JR. Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc Natl Acad Sci USA 99: 1347–1352, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 1347-1352
-
-
Cook, J.G.1
Park, C.H.2
Burke, T.W.3
Leone, G.4
Degregori, J.5
Engel, A.6
Nevins, J.R.7
-
12
-
-
31144478127
-
Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis
-
Corn PG, Ricci MS, Scata KA, Arsham AM, Simon MC, Dicker DT, El-Deiry WS. Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biol Ther 4: 1285–1294, 2005.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 1285-1294
-
-
Corn, P.G.1
Ricci, M.S.2
Scata, K.A.3
Arsham, A.M.4
Simon, M.C.5
Dicker, D.T.6
El-Deiry, W.S.7
-
13
-
-
55949123655
-
The interplay between MYC and HIF in the Warburg effect
-
Dang CV. The interplay between MYC and HIF in the Warburg effect. Ernst Schering Found Symp Proc 8: 35–53, 2007.
-
(2007)
Ernst Schering Found Symp Proc
, vol.8
, pp. 35-53
-
-
Dang, C.V.1
-
14
-
-
84922302149
-
MCM paradox: Abundance of eukaryotic replicative helicases and genomic integrity
-
Das M, Singh S, Pradhan S, Narayan G. MCM paradox: abundance of eukaryotic replicative helicases and genomic integrity. Mol Biol Int 2014: 574850, 2014.
-
(2014)
Mol Biol Int
, vol.2014
-
-
Das, M.1
Singh, S.2
Pradhan, S.3
Narayan, G.4
-
15
-
-
34547232986
-
Non-transcriptional control of DNA replication by c-Myc
-
Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favera R. Non-transcriptional control of DNA replication by c-Myc. Nature 448: 445–451, 2007.
-
(2007)
Nature
, vol.448
, pp. 445-451
-
-
Dominguez-Sola, D.1
Ying, C.Y.2
Grandori, C.3
Ruggiero, L.4
Chen, B.5
Li, M.6
Galloway, D.A.7
Gu, W.8
Gautier, J.9
Dalla-Favera, R.10
-
16
-
-
84863376354
-
HIF-1Α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency
-
Du J, Chen Y, Li Q, Han X, Cheng C, Wang Z, Danielpour D, Dunwoodie SL, Bunting KD, Yang YC. HIF-1Α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. Blood 119: 2789–2798, 2012.
-
(2012)
Blood
, vol.119
, pp. 2789-2798
-
-
Du, J.1
Chen, Y.2
Li, Q.3
Han, X.4
Cheng, C.5
Wang, Z.6
Danielpour, D.7
Dunwoodie, S.L.8
Bunting, K.D.9
Yang, Y.C.10
-
17
-
-
0028294605
-
WAF1/ CIP1 Is Induced in p53 -mediated G1 arrest and apoptosis
-
El-Deiry WS, Harper JW, Connor PMO, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW, Vogelstein B. WAF1/ CIP1 Is Induced in p53 -mediated G1 arrest and apoptosis. Cancer Res 54: 1169–1174, 1994.
-
(1994)
Cancer Res
, vol.54
, pp. 1169-1174
-
-
El-Deiry, W.S.1
Harper, J.W.2
Connor, P.3
Velculescu, V.E.4
Canman, C.E.5
Jackman, J.6
Pietenpol, J.A.7
Burrell, M.8
Hill, D.E.9
Wang, Y.10
Wiman, K.G.11
Mercer, W.E.12
Kastan, M.B.13
Kohn, K.W.14
Elledge, S.J.15
Kinzler, K.W.16
Vogelstein, B.17
-
18
-
-
73949121249
-
The hematopoietic stem cell niche: Low in oxygen but a nice place to be
-
Eliasson P, Jönsson JI. The hematopoietic stem cell niche: low in oxygen but a nice place to be. J Cell Physiol 222: 17–22, 2010.
-
(2010)
J Cell Physiol
, vol.222
, pp. 17-22
-
-
Eliasson, P.1
Jönsson, J.I.2
-
19
-
-
77950860807
-
Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture
-
Eliasson P, Rehn M, Hammar P, Larsson P, Sirenko O, Flippin LA, Cammenga J, Jönsson JI. Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture. Exp Hematol 38: 301–310, 2010.
-
(2010)
Exp Hematol
, vol.38
, pp. 301-310
-
-
Eliasson, P.1
Rehn, M.2
Hammar, P.3
Larsson, P.4
Sirenko, O.5
Flippin, L.A.6
Cammenga, J.7
Jönsson, J.I.8
-
20
-
-
33747152561
-
Matrix elasticity directs stem cell lineage specification
-
Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 126: 677–689, 2006.
-
(2006)
Cell
, vol.126
, pp. 677-689
-
-
Engler, A.J.1
Sen, S.2
Sweeney, H.L.3
Discher, D.E.4
-
21
-
-
17944375360
-
C. Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, Mcneill LA, Hewitson KS, Rourke JO, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian Y, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107: 43–54, 2001.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
Rourke, J.O.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
22
-
-
84884315657
-
STUB1/CHIP is required for HIF-1Α degradation by chaperone- mediated autophagy
-
Ferreira JV, Fofo H, Bejarano E, Bento CF, Ramalho JS, Girao H, Pereira P. STUB1/CHIP is required for HIF-1Α degradation by chaperone- mediated autophagy. Autophagy 9: 1349–1366, 2013.
-
(2013)
Autophagy
, vol.9
, pp. 1349-1366
-
-
Ferreira, J.V.1
Fofo, H.2
Bejarano, E.3
Bento, C.F.4
Ramalho, J.S.5
Girao, H.6
Pereira, P.7
-
23
-
-
61849173573
-
Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation
-
Francis LI, Randell JCW, Takara TJ, Uchima L, Bell SP. Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. Genes Dev 23: 643–654, 2009.
-
(2009)
Genes Dev
, vol.23
, pp. 643-654
-
-
Francis, L.I.1
Randell, J.C.W.2
Takara, T.J.3
Uchima, L.4
Bell, S.P.5
-
24
-
-
0035896558
-
Hypoxia Inhibits G1/S transition through regulation of p27 expression
-
Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL, Dang CV. Hypoxia Inhibits G1/S transition through regulation of p27 expression. J Biol Chem 276: 7919–7926, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 7919-7926
-
-
Gardner, L.B.1
Li, Q.2
Park, M.S.3
Flanagan, W.M.4
Semenza, G.L.5
Dang, C.V.6
-
25
-
-
37249025795
-
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress
-
Ge XQ, Jackson DA, Blow JJ. Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev 21: 3331–3341, 2007.
-
(2007)
Genes Dev
, vol.21
, pp. 3331-3341
-
-
Ge, X.Q.1
Jackson, D.A.2
Blow, J.J.3
-
26
-
-
0037214282
-
Hypoxia-inducible factor 1α is essential for cell cycle arrest during hypoxia
-
Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson RS. Hypoxia-inducible factor 1α is essential for cell cycle arrest during hypoxia. Mol Cell Biol 23: 359–369, 2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 359-369
-
-
Goda, N.1
Ryan, H.E.2
Khadivi, B.3
McNulty, W.4
Rickert, R.C.5
Johnson, R.S.6
-
27
-
-
34047156190
-
HIF-2 α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity
-
Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2 α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity. Cancer Cell 11: 335–347, 2007.
-
(2007)
Cancer Cell
, vol.11
, pp. 335-347
-
-
Gordan, J.D.1
Bertout, J.A.2
Hu, C.J.3
Diehl, J.A.4
Simon, M.C.5
-
28
-
-
56849096837
-
HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
-
Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, Greenberg RA, Flaherty KT, Rathmell WK, Keith B, Simon MC, Nathanson KL. HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 14: 435–446, 2008.
-
(2008)
Cancer Cell
, vol.14
, pp. 435-446
-
-
Gordan, J.D.1
Lal, P.2
Dondeti, V.R.3
Letrero, R.4
Parekh, K.N.5
Oquendo, C.E.6
Greenberg, R.A.7
Flaherty, K.T.8
Rathmell, W.K.9
Keith, B.10
Simon, M.C.11
Nathanson, K.L.12
-
29
-
-
27644561755
-
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
-
Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M. Hypoxia requires Notch signaling to maintain the undifferentiated cell state. Dev Cell 9: 617–628, 2005.
-
(2005)
Dev Cell
, vol.9
, pp. 617-628
-
-
Gustafsson, M.V.1
Zheng, X.2
Pereira, T.3
Gradin, K.4
Jin, S.5
Lundkvist, J.6
Ruas, J.L.7
Poellinger, L.8
Lendahl, U.9
Bondesson, M.10
-
30
-
-
65949084702
-
HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia
-
Hackenbeck T, Knaup KX, Schietke R, Schödel J, Willam C, Wu X, Warnecke C, Eckardt KU, Wiesener MS. HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia. Cell Cycle 8: 1386–1395, 2009.
-
(2009)
Cell Cycle
, vol.8
, pp. 1386-1395
-
-
Hackenbeck, T.1
Knaup, K.X.2
Schietke, R.3
Schödel, J.4
Willam, C.5
Wu, X.6
Warnecke, C.7
Eckardt, K.U.8
Wiesener, M.S.9
-
31
-
-
77956259261
-
Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1Α-regulated VEGF signaling
-
Harms KM, Li L, Cunningham LA. Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1Α-regulated VEGF signaling. PLoS One 5, e9767, 2010.
-
(2010)
Plos One
, vol.5
-
-
Harms, K.M.1
Li, L.2
Cunningham, L.A.3
-
32
-
-
0027496935
-
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
-
Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805–816, 1993.
-
(1993)
Cell
, vol.75
, pp. 805-816
-
-
Harper, J.W.1
Adami, G.R.2
Wei, N.3
Keyomarsi, K.4
Elledge, S.J.5
-
34
-
-
84905976385
-
Cyclin-dependent kinases regulate lysosomal degradation of hypoxiainducible factor 1α to promote cell-cycle progression
-
Hubbi ME, Gilkes DM, Hu H, Kshitiz Ahmed I, Semenza GL. Cyclin-dependent kinases regulate lysosomal degradation of hypoxiainducible factor 1α to promote cell-cycle progression. Proc Natl Acad Sci USA 111: E3325–E3334, 2014.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. E3325-E3334
-
-
Hubbi, M.E.1
Gilkes, D.M.2
Hu, H.3
Kshitiz Ahmed, I.4
Semenza, G.L.5
-
35
-
-
84876266454
-
Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation
-
Hubbi ME, Hu H, Kshitiz Ahmed I, Levchenko A, Semenza GL. Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation. J Biol Chem 288: 10703–10714, 2013.
-
(2013)
J Biol Chem
, vol.288
, pp. 10703-10714
-
-
Hubbi, M.E.1
Hu, H.2
Kshitiz Ahmed, I.3
Levchenko, A.4
Semenza, G.L.5
-
36
-
-
84880558721
-
Sirtuin-7 inhibits the activity of hypoxia-inducible factors
-
Hubbi ME, Hu H, Kshitiz Gilkes DM, Semenza GL. Sirtuin-7 inhibits the activity of hypoxia-inducible factors. J Biol Chem 288: 20768–20775, 2013.
-
(2013)
J Biol Chem
, vol.288
, pp. 20768-20775
-
-
Hubbi, M.E.1
Hu, H.2
Kshitiz Gilkes, D.M.3
Semenza, G.L.4
-
37
-
-
84874227153
-
A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication
-
Hubbi ME, Kshitiz Gilkes DM, Rey S, Wong CC, Luo W, Kim DH, Dang CV, Levchenko A, Semenza GL. A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. Sci Signal 6: 10, 2013.
-
(2013)
Sci Signal
, vol.6
, pp. 10
-
-
Hubbi, M.E.1
Kshitiz Gilkes, D.M.2
Rey, S.3
Wong, C.C.4
Luo, W.5
Kim, D.H.6
Dang, C.V.7
Levchenko, A.8
Semenza, G.L.9
-
38
-
-
79958023043
-
MCM proteins are negative regulators of hypoxia-inducible factor 1
-
Hubbi ME, Luo W, Baek JH, Semenza GL. MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell 42: 700–712, 2011.
-
(2011)
Mol Cell
, vol.42
, pp. 700-712
-
-
Hubbi, M.E.1
Luo, W.2
Baek, J.H.3
Semenza, G.L.4
-
39
-
-
84943750048
-
An essential role for chaperone-mediated autophagy in cell cycle progression
-
Hubbi ME, Semenza GL. An essential role for chaperone-mediated autophagy in cell cycle progression. Autophagy 11: 850–851, 2015.
-
(2015)
Autophagy
, vol.11
, pp. 850-851
-
-
Hubbi, M.E.1
Semenza, G.L.2
-
40
-
-
0037319618
-
Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem
-
Hyrien O, Marheineke K, Goldar A. Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem. BioEssays 25: 116–125, 2003.
-
(2003)
Bioessays
, vol.25
, pp. 116-125
-
-
Hyrien, O.1
Marheineke, K.2
Goldar, A.3
-
41
-
-
48249084972
-
Proteins protect human cells from replicative stress by licensing backup origins of replication
-
Ibarra A, Schwob E, Méndez J. Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Natl Acad Sci USA 105: 8956–8961, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 8956-8961
-
-
Ibarra, A.1
Schwob, E.2
Méndez, J.3
Excess, M.4
-
42
-
-
74749095240
-
Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins
-
Ilves I, Petojevic T, Pesavento JJ, Botchan MR. Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. Mol Cell 37: 247–258, 2010.
-
(2010)
Mol Cell
, vol.37
, pp. 247-258
-
-
Ilves, I.1
Petojevic, T.2
Pesavento, J.J.3
Botchan, M.R.4
-
43
-
-
0035917313
-
HIFα targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
2 sensing. Science 292: 464–468, 2001.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin, W.G.10
-
44
-
-
0035917808
-
Targeting of HIF-α to the von Hippel- Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292: 468–472, 2001.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim Av Hebestreit, H.F.7
Mukherji, M.8
Schofield, C.J.9
Maxwell, P.H.10
Pugh, C.W.11
Ratcliffe, P.J.12
-
45
-
-
0032994432
-
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
-
Jiang W, Wells NJ, Hunter T. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc Natl Acad Sci USA 96: 6193–6198, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6193-6198
-
-
Jiang, W.1
Wells, N.J.2
Hunter, T.3
-
46
-
-
0037015059
-
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
-
Jin K, Zhu Y, Sun Y, Mao XO, Xie L, Greenberg DA. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci USA 99: 11946–11950, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11946-11950
-
-
Jin, K.1
Zhu, Y.2
Sun, Y.3
Mao, X.O.4
Xie, L.5
Greenberg, D.A.6
-
47
-
-
84871315072
-
Hypoxia induces myocardial regeneration in zebrafish
-
Jopling C, Suñé G, Faucherre A, Fabregat C, Izpisua Belmonte JC. Hypoxia induces myocardial regeneration in zebrafish. Circulation 126: 3017–3027, 2012.
-
(2012)
Circulation
, vol.126
, pp. 3017-3027
-
-
Jopling, C.1
Suñé, G.2
Faucherre, A.3
Fabregat, C.4
Izpisua Belmonte, J.C.5
-
48
-
-
84864318195
-
Chaperone-mediated autophagy: A unique way to enter the lysosome world
-
Kaushik S, Cuervo AM. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol 22: 407–417, 2012.
-
(2012)
Trends Cell Biol
, vol.22
, pp. 407-417
-
-
Kaushik, S.1
Cuervo, A.M.2
-
49
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
Kim J, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 27: 7381–7393, 2007.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7381-7393
-
-
Kim, J.1
Gao, P.2
Liu, Y.C.3
Semenza, G.L.4
Dang, C.V.5
-
50
-
-
84938069663
-
Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart
-
Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, Abdulrahman Y, Chen R, Garcia JA, Shelton JM, Richardson JA, Ashour AM, Asaithamby A, Liang H, Xing C, Lu Z, Zhang CC, Sadek HA. Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature 523: 226–230, 2015.
-
(2015)
Nature
, vol.523
, pp. 226-230
-
-
Kimura, W.1
Xiao, F.2
Canseco, D.C.3
Muralidhar, S.4
Thet, S.5
Zhang, H.M.6
Abdulrahman, Y.7
Chen, R.8
Garcia, J.A.9
Shelton, J.M.10
Richardson, J.A.11
Ashour, A.M.12
Asaithamby, A.13
Liang, H.14
Xing, C.15
Lu, Z.16
Zhang, C.C.17
Sadek, H.A.18
-
51
-
-
17844408765
-
Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1α
-
Kirito K, Fox N, Komatsu N, Kaushansky K. Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1α. Hematopoiesis 105: 4258–4263, 2005.
-
(2005)
Hematopoiesis
, vol.105
, pp. 4258-4263
-
-
Kirito, K.1
Fox, N.2
Komatsu, N.3
Kaushansky, K.4
-
52
-
-
57349136768
-
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1α, leading to its oxygen-independent degradation
-
Koh MY, Darnay BG, Powis G. Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1α, leading to its oxygen-independent degradation. Mol Cell Biol 28: 7081–7095, 2008.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 7081-7095
-
-
Koh, M.Y.1
Darnay, B.G.2
Powis, G.3
-
53
-
-
81455128769
-
Chaperone-mediated autophagy is required for tumor growth
-
Kon M, Kiffin R, Koga H, Chapochnick J, Macian F, Varticovski L, Cuervo AM. Chaperone-mediated autophagy is required for tumor growth. Sci Transl Med 3: 109–117, 2011.
-
(2011)
Sci Transl Med
, vol.3
, pp. 109-117
-
-
Kon, M.1
Kiffin, R.2
Koga, H.3
Chapochnick, J.4
Macian, F.5
Varticovski, L.6
Cuervo, A.M.7
-
54
-
-
3142631736
-
HIF-1α induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1α induces cell cycle arrest by functionally counteracting Myc. EMBO J 23: 1949–1956, 2004.
-
(2004)
EMBO J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
55
-
-
84862128771
-
Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors
-
Kshitiz Hubbi ME, Ahn EH, Downey J, Afzal J, Kim DH, Rey S, Chang C, Kundu A, Semenza GL, Abraham RM, Levchenko A. matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Sci Signal 5: 41, 2012.
-
(2012)
Sci Signal
, vol.5
, pp. 41
-
-
Kshitiz Hubbi, M.E.1
Ahn, E.H.2
Downey, J.3
Afzal, J.4
Kim, D.H.5
Rey, S.6
Chang, C.7
Kundu, A.8
Semenza, G.L.9
Abraham, R.M.10
Levchenko, A.11
-
56
-
-
0034595448
-
Uninterrupted MCM2-7 function required for DNA replication fork progression
-
Labib K, Tercero J, Diffley JF. Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 288: 1643–1647, 2000.
-
(2000)
Science
, vol.288
, pp. 1643-1647
-
-
Labib, K.1
Tercero, J.2
Diffley, J.F.3
-
57
-
-
84896388770
-
RUNX3 inhibits hypoxiainducible factor-1α protein stability by interacting with prolyl hydroxylases in gastric cancer cells
-
Lee SH, Bae SC, Kim KW, Lee YM. RUNX3 inhibits hypoxiainducible factor-1α protein stability by interacting with prolyl hydroxylases in gastric cancer cells. Oncogene 33: 1458–1467, 2014.
-
(2014)
Oncogene
, vol.33
, pp. 1458-1467
-
-
Lee, S.H.1
Bae, S.C.2
Kim, K.W.3
Lee, Y.M.4
-
58
-
-
0031435940
-
Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
-
Lei M, Kawasaki Y, Young MR, Kihara M, Sugino A. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev 11: 3365–3374, 1997.
-
(1997)
Genes Dev
, vol.11
, pp. 3365-3374
-
-
Lei, M.1
Kawasaki, Y.2
Young, M.R.3
Kihara, M.4
Sugino, A.5
-
59
-
-
33751072389
-
Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1α
-
Lim JH, Park JW, Kim MS, Park SK, Johnson RS, Chun YS. Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1α. Mol Pharmacol 70: 1856–1865, 2006.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1856-1865
-
-
Lim, J.H.1
Park, J.W.2
Kim, M.S.3
Park, S.K.4
Johnson, R.S.5
Chun, Y.S.6
-
61
-
-
37549028456
-
Calcineurin promotes hypoxia-inducible factor 1α expression by dephosphorylating RACK1 and blocking RACK1 dimerization
-
Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL. Calcineurin promotes hypoxia-inducible factor 1α expression by dephosphorylating RACK1 and blocking RACK1 dimerization. J Biol Chem 282: 37064–37073, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 37064-37073
-
-
Liu, Y.V.1
Hubbi, M.E.2
Pan, F.3
McDonald, K.R.4
Mansharamani, M.5
Cole, R.N.6
Liu, J.O.7
Semenza, G.L.8
-
62
-
-
84870608916
-
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
-
Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proc Natl Acad Sci USA 109: E3367–E3376, 2012.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. E3367-E3376
-
-
Luo, W.1
Chang, R.2
Zhong, J.3
Pandey, A.4
Semenza, G.L.5
-
63
-
-
77950473770
-
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxiainducible factor (HIF)-1α but not HIF-2α
-
Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxiainducible factor (HIF)-1α but not HIF-2α. J Biol Chem 285: 3651–3663, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 3651-3663
-
-
Luo, W.1
Zhong, J.2
Chang, R.3
Hu, H.4
Pandey, A.5
Semenza, G.L.6
-
64
-
-
18944376218
-
Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27
-
Mack FA, Patel JH, Biju MP, Haase VH, Simon MC. Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol 25: 4565–4578, 2005.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4565-4578
-
-
Mack, F.A.1
Patel, J.H.2
Biju, M.P.3
Haase, V.H.4
Simon, M.C.5
-
65
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam a Poellinger L. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414: 550–554, 2001.
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
Bertilsson, G.4
Asman, M.5
Tanaka, H.6
Cao, Y.7
Berkenstam A Poellinger, L.8
-
66
-
-
60749109846
-
Cell cycle, CDKs and cancer: A changing paradigm
-
Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 9: 153–166, 2009.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 153-166
-
-
Malumbres, M.1
Barbacid, M.2
-
67
-
-
77957584397
-
O2 regulates stem cells through Wnt/β-catenin signalling
-
2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol 12: 1007–1013, 2010.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 1007-1013
-
-
Mazumdar, J.1
O’Brien, W.T.2
Johnson, R.S.3
Lamanna, J.C.4
Chavez, J.C.5
Klein, P.S.6
Simon, M.C.7
-
68
-
-
84863982875
-
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
-
Montagner M, Enzo E, Forcato M, Zanconato F, Parenti A, Rampazzo E, Basso G, Leo G, Rosato A, Bicciato S, Cordenonsi M, Piccolo S. SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature 487: 380–384, 2012.
-
(2012)
Nature
, vol.487
, pp. 380-384
-
-
Montagner, M.1
Enzo, E.2
Forcato, M.3
Zanconato, F.4
Parenti, A.5
Rampazzo, E.6
Basso, G.7
Leo, G.8
Rosato, A.9
Bicciato, S.10
Cordenonsi, M.11
Piccolo, S.12
-
69
-
-
0034307432
-
Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells
-
Morrison SJ, Csete M, Groves AK, Melega W, Wold B, Anderson DJ. Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells. J Neurosci 20: 7370–7376, 2000.
-
(2000)
J Neurosci
, vol.20
, pp. 7370-7376
-
-
Morrison, S.J.1
Csete, M.2
Groves, A.K.3
Melega, W.4
Wold, B.5
Erson, D.J.6
-
70
-
-
84883029966
-
PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein cep192
-
Moser S, Bensaddek D, Ortmann B, Maure JF, Mudie S, Blow JJ, Lamond A, Swedlow J, Rocha S. PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein cep192. Dev Cell 26: 381–392, 2013.
-
(2013)
Dev Cell
, vol.26
, pp. 381-392
-
-
Moser, S.1
Bensaddek, D.2
Ortmann, B.3
Maure, J.F.4
Mudie, S.5
Blow, J.J.6
Lamond, A.7
Swedlow, J.8
Rocha, S.9
-
71
-
-
84923259951
-
Therapeutic targeting of autophagy in cancer. Part I. Molecular pathways controlling autophagy
-
Nagelkerke A, Sweep FCGJ, Geurts-Moespot A, Bussink J, Span PN. Therapeutic targeting of autophagy in cancer. Part I. Molecular pathways controlling autophagy. Semin Cancer Biol 31: 89–98, 2014.
-
(2014)
Semin Cancer Biol
, vol.31
, pp. 89-98
-
-
Nagelkerke, A.1
Sweep, F.C.G.J.2
Geurts-Moespot, A.3
Bussink, J.4
Span, P.N.5
-
72
-
-
84900331122
-
A proliferative burst during preadolescence establishes the final cardiomyocyte number
-
Naqvi N, Li M, Calvert JW, Tejada T, Lambert JP, Wu J, Kesteven SH, Holman SR, Matsuda T, Lovelock JD, Howard WW, Iismaa SE, Chan AY, Crawford BH, Wagner MB, Martin DIK, Lefer DJ, Graham RM, Husain A. A proliferative burst during preadolescence establishes the final cardiomyocyte number. Cell 157: 795–807, 2014.
-
(2014)
Cell
, vol.157
, pp. 795-807
-
-
Naqvi, N.1
Li, M.2
Calvert, J.W.3
Tejada, T.4
Lambert, J.P.5
Wu, J.6
Kesteven, S.H.7
Holman, S.R.8
Matsuda, T.9
Lovelock, J.D.10
Howard, W.W.11
Iismaa, S.E.12
Chan, A.Y.13
Crawford, B.H.14
Wagner, M.B.15
Martin, D.16
Lefer, D.J.17
Graham, R.M.18
Husain, A.19
-
73
-
-
84877575509
-
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment
-
Nombela-Arrieta C, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol 15: 533–543, 2013.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 533-543
-
-
Nombela-Arrieta, C.1
Pivarnik, G.2
Winkel, B.3
Canty, K.J.4
Harley, B.5
Mahoney, J.E.6
Park, S.Y.7
Lu, J.8
Protopopov, A.9
Silberstein, L.E.10
-
74
-
-
0030831599
-
CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication
-
Owens JC, Detweiler CS, Li JJ. CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication. Proc Natl Acad Sci USA 94: 12521–12526, 1997.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 12521-12526
-
-
Owens, J.C.1
Detweiler, C.S.2
Li, J.J.3
-
75
-
-
34248359065
-
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
-
Parmar K, Mauch P, Vergilio JA, Sackstein R, Down JD. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci USA 104: 5431–5436, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5431-5436
-
-
Parmar, K.1
Mauch, P.2
Vergilio, J.A.3
Sackstein, R.4
Down, J.D.5
-
76
-
-
54449090771
-
Stem cell factor induces HIF-1α at normoxia in hematopoietic cells
-
Pedersen M, Löfstedt T, Sun J, Holmquist-Mengelbier L, Påhlman S, Rönnstrand L. Stem cell factor induces HIF-1α at normoxia in hematopoietic cells. Biochem Biophys Res Commun 377: 98–103, 2008.
-
(2008)
Biochem Biophys Res Commun
, vol.377
, pp. 98-103
-
-
Pedersen, M.1
Löfstedt, T.2
Sun, J.3
Holmquist-Mengelbier, L.4
Påhlman, S.5
Rönnstrand, L.6
-
77
-
-
0033556238
-
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
-
Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J 18: 396–410, 1999.
-
(1999)
EMBO J
, vol.18
, pp. 396-410
-
-
Petersen, B.O.1
Lukas, J.2
Sørensen, C.S.3
Bartek, J.4
Helin, K.5
-
78
-
-
34347226670
-
Oxygen tension controls the expansion of human CNS precursors and the generation of astrocytes and oligodendrocytes
-
Pistollato F, Chen HL, Schwartz PH, Basso G, Panchision DM. Oxygen tension controls the expansion of human CNS precursors and the generation of astrocytes and oligodendrocytes. Mol Cell Neurosci 35: 424–435, 2007.
-
(2007)
Mol Cell Neurosci
, vol.35
, pp. 424-435
-
-
Pistollato, F.1
Chen, H.L.2
Schwartz, P.H.3
Basso, G.4
Panchision, D.M.5
-
79
-
-
58949097017
-
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
-
Pollard PJ, Loenarz C, Mole DR, McDonough M, Gleadle JM, Schofield CJ, Ratcliffe PJ. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α. Biochem J 416: 387–394, 2008.
-
(2008)
Biochem J
, vol.416
, pp. 387-394
-
-
Pollard, P.J.1
Loenarz, C.2
Mole, D.R.3
McDonough, M.4
Gleadle, J.M.5
Schofield, C.J.6
Ratcliffe, P.J.7
-
80
-
-
0028176483
-
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
-
Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massagué J. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78: 59–66, 1994.
-
(1994)
Cell
, vol.78
, pp. 59-66
-
-
Polyak, K.1
Lee, M.H.2
Erdjument-Bromage, H.3
Koff, A.4
Roberts, J.M.5
Tempst, P.6
Massagué, J.7
-
81
-
-
84864131464
-
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
-
Prabhakar NR, Semenza GL. Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92: 967–1003, 2012.
-
(2012)
Physiol Rev
, vol.92
, pp. 967-1003
-
-
Prabhakar, N.R.1
Semenza, G.L.2
-
82
-
-
84899533827
-
The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response
-
Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 157: 565–579, 2014.
-
(2014)
Cell
, vol.157
, pp. 565-579
-
-
Puente, B.N.1
Kimura, W.2
Muralidhar, S.A.3
Moon, J.4
Amatruda, J.F.5
Phelps, K.L.6
Grinsfelder, D.7
Rothermel, B.A.8
Chen, R.9
Garcia, J.A.10
Santos, C.X.11
Thet, S.12
Mori, E.13
Kinter, M.T.14
Rindler, P.M.15
Zacchigna, S.16
Mukherjee, S.17
Chen, D.J.18
Mahmoud, A.I.19
Giacca, M.20
Rabinovitch, P.S.21
Aroumougame, A.22
Shah, A.M.23
Szweda, L.I.24
Sadek, H.A.25
more..
-
83
-
-
0031921561
-
Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase
-
Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol 18: 2758–2767, 1998.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2758-2767
-
-
Saha, P.1
Chen, J.2
Thome, K.C.3
Lawlis, S.J.4
Hou, Z.H.5
Hendricks, M.6
Parvin, J.D.7
Dutta, A.8
-
84
-
-
34547952048
-
Cdk1 is sufficient to drive the mammalian cell cycle
-
Santamaría D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K, Cáceres JF, Dubus P, Malumbres M, Barbacid M. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448: 811–815, 2007.
-
(2007)
Nature
, vol.448
, pp. 811-815
-
-
Santamaría, D.1
Barrière, C.2
Cerqueira, A.3
Hunt, S.4
Tardy, C.5
Newton, K.6
Cáceres, J.F.7
Dubus, P.8
Malumbres, M.9
Barbacid, M.10
-
85
-
-
77649084546
-
Mild hypoxia enhances proliferation and multipotency of human neural stem cells
-
Santilli G, Lamorte G, Carlessi L, Ferrari D, Nodari LR, Binda E, Delia D, Vescovi AL, De Filippis L. Mild hypoxia enhances proliferation and multipotency of human neural stem cells. PLoS One 5: e8575, 2010.
-
(2010)
Plos One
, vol.5
-
-
Santilli, G.1
Lamorte, G.2
Carlessi, L.3
Ferrari, D.4
Nodari, L.R.5
Binda, E.6
Delia, D.7
Vescovi, A.L.8
De Filippis, L.9
-
86
-
-
84897019542
-
Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
-
Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol Mech Dis 9: 47–71, 2014.
-
(2014)
Annu Rev Pathol Mech Dis
, vol.9
, pp. 47-71
-
-
Semenza, G.L.1
-
87
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12: 5447–5454, 1992.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
88
-
-
80052565462
-
Hypoxiainducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis
-
Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC. Hypoxiainducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Mol Cell Biol 31: 3885–3895, 2011.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 3885-3895
-
-
Sengupta, T.1
Abraham, G.2
Xu, Y.3
Clurman, B.E.4
Minella, A.C.5
-
89
-
-
0037126303
-
Cell culture Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage
-
Seonane J, Le HV, Massague J. Cell culture Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419: 729–734, 2002.
-
(2002)
Nature
, vol.419
, pp. 729-734
-
-
Seonane, J.1
Le, H.V.2
Massague, J.3
-
90
-
-
73849129578
-
The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
-
Sheu Y, Stillman B. The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature 463: 113–117, 2010.
-
(2010)
Nature
, vol.463
, pp. 113-117
-
-
Sheu, Y.1
Stillman, B.2
-
91
-
-
0035894847
-
Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells
-
Shingo T, Sorokan ST, Shimazaki T, Weiss S. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci 21: 9733–9743, 2001.
-
(2001)
J Neurosci
, vol.21
, pp. 9733-9743
-
-
Shingo, T.1
Sorokan, S.T.2
Shimazaki, T.3
Weiss, S.4
-
92
-
-
77956205122
-
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
-
Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, Schneider JW, Zhang CC, Sadek HA. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 7: 380–390, 2010.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 380-390
-
-
Simsek, T.1
Kocabas, F.2
Zheng, J.3
Deberardinis, R.J.4
Mahmoud, A.I.5
Olson, E.N.6
Schneider, J.W.7
Zhang, C.C.8
Sadek, H.A.9
-
93
-
-
84900342698
-
Direct measurement of local oxygen concentration in the bone marrow of live animals
-
Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, Zaher W, Mortensen LJ, Alt C, Turcotte R, Yusuf R, Côté D, Vinogradov SA, Scadden DT, Lin CP. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 508: 269–273, 2014.
-
(2014)
Nature
, vol.508
, pp. 269-273
-
-
Spencer, J.A.1
Ferraro, F.2
Roussakis, E.3
Klein, A.4
Wu, J.5
Runnels, J.M.6
Zaher, W.7
Mortensen, L.J.8
Alt, C.9
Turcotte, R.10
Yusuf, R.11
Côté, D.12
Vinogradov, S.A.13
Scadden, D.T.14
Lin, C.P.15
-
94
-
-
0034307725
-
Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen
-
Studer L, Csete M, Lee SH, Kabbani N, Walikonis J, Wold B, McKay R. Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J Neurosci 20: 7377–7383, 2000.
-
(2000)
J Neurosci
, vol.20
, pp. 7377-7383
-
-
Studer, L.1
Csete, M.2
Lee, S.H.3
Kabbani, N.4
Walikonis, J.5
Wold, B.6
McKay, R.7
-
95
-
-
80053916176
-
Metabolic regulation of hematopoietic stem cells in the hypoxic niche
-
Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 9: 298–310, 2011.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 298-310
-
-
Suda, T.1
Takubo, K.2
Semenza, G.L.3
-
96
-
-
77956217067
-
Regulation of the HIF-1α level is essential for hematopoietic stem cells
-
Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T. Regulation of the HIF-1α level is essential for hematopoietic stem cells. Cell Stem Cell 7: 391–402, 2010.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 391-402
-
-
Takubo, K.1
Goda, N.2
Yamada, W.3
Iriuchishima, H.4
Ikeda, E.5
Kubota, Y.6
Shima, H.7
Johnson, R.S.8
Hirao, A.9
Suematsu, M.10
Suda, T.11
-
97
-
-
0031020884
-
Domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1: 72–82, 1997.
-
(1997)
Genes Dev
, vol.1
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
Endothelial, P.4
-
98
-
-
0028363519
-
P27, A novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
-
Toyoshima H, Hunter T. p27, A novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78: 67–74, 1994.
-
(1994)
Cell
, vol.78
, pp. 67-74
-
-
Toyoshima, H.1
Hunter, T.2
-
99
-
-
32844454603
-
Histone demethylation by a family of JmjC domain-containing proteins
-
Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y. Histone demethylation by a family of JmjC domain-containing proteins. Nature 439: 811–816, 2006.
-
(2006)
Nature
, vol.439
, pp. 811-816
-
-
Tsukada, Y.1
Fang, J.2
Erdjument-Bromage, H.3
Warren, M.E.4
Borchers, C.H.5
Tempst, P.6
Zhang, Y.7
-
100
-
-
0028816847
-
Purification and characterization of hypoxiainducible factor 1
-
Wang GL, Semenza GL. Purification and characterization of hypoxiainducible factor 1. J Biol Chem 270: 1230–1237, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
101
-
-
84891953688
-
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism
-
Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin Y, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ, Wang WC. JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism. Proc Natl Acad Sci USA 111: 279–84, 2014.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 279-284
-
-
Wang, H.J.1
Hsieh, Y.J.2
Cheng, W.C.3
Lin, C.P.4
Lin, Y.5
Yang, S.F.6
Chen, C.C.7
Izumiya, Y.8
Yu, J.S.9
Kung, H.J.10
Wang, W.C.11
-
102
-
-
84890293880
-
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth
-
Warfel NA, Dolloff NG, Dicker DT, Malysz J, El-Deiry WS. CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth. Cell Cycle 12: 3689–3701, 2013.
-
(2013)
Cell Cycle
, vol.12
, pp. 3689-3701
-
-
Warfel, N.A.1
Dolloff, N.G.2
Dicker, D.T.3
Malysz, J.4
El-Deiry, W.S.5
-
103
-
-
77649253431
-
Hemodynamic support by left ventricular assist devices reduces cardiomyocyte DNA content in the failing human heart
-
Wohlschlaeger J, Levkau B, Brockhoff G, Schmitz KJ, Von Winterfeld M, Takeda A, Takeda N, Stypmann J, Vahlhaus C, Schmid C, Pomjanski N, Böcking A, Baba HA. Hemodynamic support by left ventricular assist devices reduces cardiomyocyte DNA content in the failing human heart. Circulation 121: 989–996, 2010.
-
(2010)
Circulation
, vol.121
, pp. 989-996
-
-
Wohlschlaeger, J.1
Levkau, B.2
Brockhoff, G.3
Schmitz, K.J.4
Von Winterfeld, M.5
Takeda, A.6
Takeda, N.7
Stypmann, J.8
Vahlhaus, C.9
Schmid, C.10
Pomjanski, N.11
Böcking, A.12
Baba, H.A.13
-
105
-
-
33747432986
-
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress
-
Woodward AM, Göhler T, Luciani MG, Oehlmann M, Ge X, Gartner A, Jackson DA, Blow JJ. Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J Cell Biol 173: 673–683, 2006.
-
(2006)
J Cell Biol
, vol.173
, pp. 673-683
-
-
Woodward, A.M.1
Göhler, T.2
Luciani, M.G.3
Oehlmann, M.4
Ge, X.5
Gartner, A.6
Jackson, D.A.7
Blow, J.J.8
-
106
-
-
63449103705
-
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
-
Xia X, Lemieux ME, Li W, Carroll JS, Brown M, Liu XS, Kung AL. Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci USA 106: 4260–4265, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 4260-4265
-
-
Xia, X.1
Lemieux, M.E.2
Li, W.3
Carroll, J.S.4
Brown, M.5
Liu, X.S.6
Kung, A.L.7
-
107
-
-
0035967099
-
Repression of transcription of the p27(Kip1) cyclindependent kinase inhibitor gene by c-Myc
-
Yang W, Shen J, Wu M, Arsura M, FitzGerald M, Suldan Z, Kim DW, Hofmann CS, Pianetti S, Romieu-Mourez R, Freedman LP, Sonenshein GE. Repression of transcription of the p27(Kip1) cyclindependent kinase inhibitor gene by c-Myc. Oncogene 20: 1688–1702, 2001.
-
(2001)
Oncogene
, vol.20
, pp. 1688-1702
-
-
Yang, W.1
Shen, J.2
Wu, M.3
Arsura, M.4
Fitzgerald, M.5
Suldan, Z.6
Kim, D.W.7
Hofmann, C.S.8
Pianetti, S.9
Romieu-Mourez, R.10
Freedman, L.P.11
Sonenshein, G.E.12
-
108
-
-
0035859692
-
HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu F, White SB, Zhao Q, Lee FS. HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 98: 9630–9635, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
-
109
-
-
84940891882
-
RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect
-
Zhang CS, Liu Q, Li M, Lin SY, Peng Y, Wu D, Li TY, Fu Q, Jia W, Wang X, Ma T, Zong Y, Cui J, Pu C, Lian G, Guo H, Ye Z, Lin SC. RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect. Cell Res 25: 1025–1042, 2015.
-
(2015)
Cell Res
, vol.25
, pp. 1025-1042
-
-
Zhang, C.S.1
Liu, Q.2
Li, M.3
Lin, S.Y.4
Peng, Y.5
Wu, D.6
Li, T.Y.7
Fu, Q.8
Jia, W.9
Wang, X.10
Ma, T.11
Zong, Y.12
Cui, J.13
Pu, C.14
Lian, G.15
Guo, H.16
Ye, Z.17
Lin, S.C.18
-
110
-
-
76549126781
-
JNK1 mediates degradation HIF-1α by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70
-
Zhang D, Li J, Costa M, Gao J, Huang C. JNK1 mediates degradation HIF-1α by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res 70: 813–823, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 813-823
-
-
Zhang, D.1
Li, J.2
Costa, M.3
Gao, J.4
Huang, C.5
-
111
-
-
34247614521
-
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
-
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 11: 407–420, 2007.
-
(2007)
Cancer Cell
, vol.11
, pp. 407-420
-
-
Zhang, H.1
Gao, P.2
Fukuda, R.3
Kumar, G.4
Krishnamachary, B.5
Zeller, K.I.6
Dang, C.V.7
Semenza, G.L.8
-
112
-
-
84897042356
-
Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia
-
Zhang P, Yao Q, Lu L, Li Y, Chen PJ, Duan C. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep 6: 1110–1121, 2014.
-
(2014)
Cell Rep
, vol.6
, pp. 1110-1121
-
-
Zhang, P.1
Yao, Q.2
Lu, L.3
Li, Y.4
Chen, P.J.5
Duan, C.6
-
113
-
-
70350507985
-
Control of cyclin D1 and breast tumorigenesis by the Egln2 prolyl hydroxylase
-
Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG, Bommi-Reddy A. Control of cyclin D1 and breast tumorigenesis by the Egln2 prolyl hydroxylase. Cancer Cell 16: 413–424, 2009.
-
(2009)
Cancer Cell
, vol.16
, pp. 413-424
-
-
Zhang, Q.1
Gu, J.2
Li, L.3
Liu, J.4
Luo, B.5
Cheung, H.W.6
Boehm, J.S.7
Ni, M.8
Geisen, C.9
Root, D.E.10
Polyak, K.11
Brown, M.12
Richardson, A.L.13
Hahn, W.C.14
Kaelin, W.G.15
Bommi-Reddy, A.16
-
114
-
-
84939815593
-
The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia
-
Zhao L, Oliver E, Maratou K, Atanur SS, Dubois OD, Cotroneo E, Chen C, Wang L, Arce C, Chabosseau PL, Ponsa-Cobas J, Frid MG, Moyon B, Webster Z, Aldashev A, Ferrer J, Rutter GA, Stenmark KA, Aitman TJ, Wilkins MR. The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Nature 524: 356–360, 2015.
-
(2015)
Nature
, vol.524
, pp. 356-360
-
-
Zhao, L.1
Oliver, E.2
Maratou, K.3
Atanur, S.S.4
Dubois, O.D.5
Cotroneo, E.6
Chen, C.7
Wang, L.8
Arce, C.9
Chabosseau, P.L.10
Ponsa-Cobas, J.11
Frid, M.G.12
Moyon, B.13
Webster, Z.14
Aldashev, A.15
Ferrer, J.16
Rutter, G.A.17
Stenmark, K.A.18
Aitman, T.J.19
Wilkins, M.R.20
more..
-
115
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases 1
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases 1 Cancer Res 59: 5830–5835, 1999.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
|