Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis

Genes and Development

Volumn 11, Issue 24, 1997, Pages 3365-3374

  Lei, Ming ^a   Kawasaki, Yasuo ^a,b   Young, Michael R ^a,c   Kihara, Makoto ^b   Sugino, Akio ^b   Tye, Bik K ^a  

^a Department of Obstetrics Gynecology   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

Cdc7 Dbf4 kinase; DNA replication; Mcm proteins

Indexed keywords

CYCLIN DEPENDENT KINASE; DNA; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CELL CYCLE S PHASE; DNA REPLICATION ORIGIN; DNA SYNTHESIS; ENZYME ACTIVITY; GENE MUTATION; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SUPPRESSOR GENE;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0031435940     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.24.3365     Document Type: Article

References (53)

1. Adams, A.E.M., D. Botstein, and D.G. Drubin. 1989. A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation. Nature 243: 231-233.
2. Aparicio, O.M., D.M. Weinstein, and S.P. Bell. 1997. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase. Cell 91: 59-69.
3. Axelrod, A. and J. Rine. 1991. A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae. Mol. Cell. Biol. 11: 1080-1091.
4. Bell, S. and B. Stillman. 1992. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357: 128-134.
5. Brewer, B.J. and W.L. Fangman. 1987. The localization of replication origins on ARS plasmids in S. cerevisiae. Cell 51: 463-471.
6. Chong, J., H.M. Mahbubani, C.Y. Khoo, and J.J. Blow. 1995. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375: 418-421.
7. Cocker, J.H., S. Piatti, C. Santocanale, K. Nasmyth, and J.F.X. Diffley. 1996. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379: 180-182.
8. Coleman, T.R., P.B. Carpenter, and W.G. Dunphy. 1996. The Xenopus Cdc6 Protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87: 53-63.
9. Coue, M., S.E. Kearsey, and M. Mechali. 1996. Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication. EMBO J. 15: 1085-1097.
10. Diffley, J.F.X. 1996. Once and only once upon a time: Specifying and regulating origins of DNA replication in eukaryotic cells. Genes & Dev. 10: 2819-2830.
11. Diffley, J.F.X., J.H. Cocker, S.J. Dowell, and A. Rowley. 1994. Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78: 303-316.
12. Dijkwel, P.A., J.P. Vaughn, and J.L. Hamlin. 1991. Mapping of replication initiation sites in mammalian genomes by two-dimensional gel analysis: Stabilization and enrichment of replication intermediates by isolation on the nuclear matrix. Mol. Cell. Biol. 11: 3850-3859.
13. Donovan, S., J. Harwood, L.S. Drury, and J.F.X. Diffley. 1997. Cdc6p-dependent loading of Mem proteins onto pre-replicative chromatin in budding yeast. Proc. Natl. Acad. Sci. 94: 5611-5616.
14. Dowell, S.J., P. Romanoski, and J.F.X. Diffley. 1994. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 265: 1243-1246.
15. Elsasser, S., F. Lou, B. Wang, J. Campbell, and A. Jong. 1996. Interaction between yeast Cdc6 protein and B-type cyclin/ Cdc28 kinases. Mol. Biol. Cell 7: 1723-1735.
16. Fields, S. and O.K. Song. 1989. A novel genetic system to detect protein-protein interaction. Proc. Natl. Acad. Sci. 340: 245-246.
17. Gibson, S.I. 1989. "Analysis of Mcm3, a minichromosome maintenance mutant of yeast with a cell division cycle arrest phenotype," Ph.D. thesis, Cornell University, Ithaca, NY.
18. Hardy, C.F.J. and A. Pautz. 1996. A novel role for Cdc5p in DNA replication. Mol. Cell Biol. 16: 6775-6782.
19. Hardy, C.F.J., O. Dryga, P.M.B. Pahl, and R.A. Sclafani. 1997. mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc. Natl. Acad. Sci. 94: 3151-3155.
20. Hartwell, L.H. 1976. Sequential function of gene products relative to DNA synthesis in the yeast cell cycle. J. Mol. Biol. 104: 803-817.
21. Hendrickson, M., M. Madine, S. Dalton, and J. Gautier. 1996. Phosphorylation of MCM4 by cdc2 proteins kinase inhibits the activity of the minichromosome maintenance complex. Proc. Natl. Acad. Sci. 93: 12223-12228.
22. Hennessy, K.M., A. Lee, E. Chen, and D. Botstein. 1991. A group of interacting yeast DNA replication genes. Genes & Dev. 5: 958-969.
23. Hereford, L. and L. Hartwell. 1974. Sequential gene function in the initiation of S. cerevisiae DNA synthesis. J. Mol. Biol. 84: 445-461.
24. Hollingsworth, R.E. and R. Sclafani. 1992. Molecular genetic studies of the Cdc7 protein kinase and induced mutagenesis in yeast. Genetics 132: 53-62.
25. Hutter, K.J. and H.E. Eipel. 1978. Flow cytometric determinations of cellular substances in algae, bacteria, molds and yeasts. J. Microbiol. Ser. 44: 269-282.
26. Jackson, A.L., P.M.B. Pahl, K. Harrison, J. Rosamond, and R.A. Sclafani. 1993. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol. Cell Biol. 13: 2899-2908.
27. Johnston, L.H. and A.P.M. Thomas. 1982. The isolation of new DNA synthesis mutants in the yeast Saccharomyces cerevisiae. Mol. & Gen. Genet. 186: 445-448.
28. Kearsey, S.E., D. Maiorano, E.G. Holmes, and I. Todorov. 1995. The role of MCM proteins in the control of genome duplication. BioEssays 18: 183-189.
29. Kitada, K., L. Johnston, T. Sugino, and A. Sugino. 1992. Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition. Genetics 131: 21-29.
30. Kitada, K., A.L. Johnson, L.H. Johnston, and A. Sugino. 1993. A multipcopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. Mol. Cell. Biol. 13: 4445-4457.
31. Kubota, Y., S. Mimura, S.-i. Nishimoto, H. Takisawa, and H. Nojima. 1995. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell 81: 601-610.
32. Leatherwood, J., A. Lopez-Girona, and P. Russell. 1996. Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein. Nature 379: 360-363.
33. Lei, M., Y. Kawasaki, and B.K. Tye. 1996. Physical interactions among Mem proteins and effects of Mcm dosage on DNA replication in S. cerevisiae. Mol. Cell. Biol. 16: 5081-5090.
34. Madine, M.A., C.-Y. Khoo, A.D. Mills, and R.A. Laskey. 1995. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature 375: 421-424.
35. Maine, G.T., P. Sinha, and B.K. Tye. 1984. Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106: 365-385.
36. Masai, H., T. Miyake, and K. Arai. 1995. Hsk1(+), a Sachizosac-charomyces pombe gene related to Saccharomyces cerevisiae Cdc7, is required for chromosomal replication. EMBO J. 14: 3094-3104.
37. Merchant, A.M., Y. Kawasaki, Y. Chen, M. Lei, and B.K. Tye. 1997. A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in S. cerevisiae. Mol. Cell. Biol. 17: 3261-3271.
38. Nasmyth, K. 1996. Viewpoints: Putting the cell cycle in order. Science 274: 1643-1645.
39. Pringle, J.R. and L.H. Hartwell. 1981. The Saccharomyces cerevisiae cell cycle. In the molecular biology of the yeast Saccharomyces, (ed. J.N. Strathern, E.W. Jones, and J.R. Broach) pp. 97-142. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
40. Sato, N., K.-i. Arai, and H. Masai. 1997. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: In vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. EMBO J. 16: 4340-4351.
41. Schild, D. and B. Byers. 1978. Meiotic effects of DNA-defective cell division cycle mutations of Saccharomyces cerevisiae. Chromosoma 70: 109-130.
42. Sherman, F. and P. Wakem. 1991. Mapping yeast genes. Meth. Enzymol. 194: 38-57.
43. Simchen, G. 1974. Are mitotic functions required in meiosis? Genetics 114: 753-767.
44. Stillman, B. 1996. Cell cycle control of DNA replication. Science 274: 1659-1663.
45. Tanaka, T., D. Knapp, and K. Nasmyth. 1997. Loading of an Mem protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90: 649-660.
46. Thommes, P., Y. Kubota, H. Takisawa, and J.J. Blow. 1997. The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides. EMBO J. 16: 3312-3319.
47. Todorov, I.T., A. Attaran, and S.E. Kearsey. 1995. BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication. J. Cell Biol. 129: 1433-1445.
48. Treisman, J.E., P.J. Follette, P.H. O'Farrell, and G.M. Rubin. 1995. Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. Genes & Dev. 9: 1709-1715.
49. Tye, B.K. 1994. The Mcm2-3-5 proteins: Are they replication licensing factors? Trends Cell Biol. 4: 160-166.
50. Yan, H., S. Gibson, and B.K. Tye. 1991. Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function. Genes & Dev. 5: 944-957.
51. Yan, H., A.M. Merchant, and B.K. Tye. 1993. Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes & Dev. 7: 2149-2160.
52. Young, M. and B.K. Tye. 1997. Mcm2 and Mcm3 are constitutive nuclear proteins which exhibit distinct isoforms and bind chromatin during specific cell cycle stages of S. cerevisiae. Mol. Biol. Cell 8: 1587-1601.
53. Young, M., K. Suzuki, H. Yan, S. Gibson, and B.K. Tye. 1997. Nuclear accumulation of S. cerevisiae Mcm3 is dependent on its nuclear localization sequence. Genes Cells (in press).