Uninterrupted MCH2-7 function required for DNA replication fork progression

Science

Volumn 288, Issue 5471, 2000, Pages 1643-1647

  Labib, Karim ^a   Tercero, José Antonio ^a   Diffley, John F X ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; CDC54 PROTEIN, S CEREVISIAE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; FUNGAL DNA; FUNGAL PROTEIN; HYBRID PROTEIN; LIGASE; MCM2 PROTEIN, FUNGAL; MCM6 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; UBIQUITIN PROTEIN LIGASE; UBR1 PROTEIN, S CEREVISIAE;

ARTICLE; CELL CYCLE; CHROMOSOME REPLICATION; DNA REPLICATION; ENZYME ACTIVITY; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; BIOSYNTHESIS; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CHROMOSOME; GENETICS; METABOLISM; MITOSIS; MUTATION; REPLICON; TEMPERATURE;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

CELL CYCLE PROTEINS; CHROMOSOMES, FUNGAL; DNA REPLICATION; DNA, FUNGAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; G1 PHASE; G2 PHASE; LIGASES; MITOSIS; MUTATION; RECOMBINANT FUSION PROTEINS; REPLICON; S PHASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TEMPERATURE; UBIQUITIN-PROTEIN LIGASES;

EID: 0034595448     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5471.1643     Document Type: Article

References (28)

1. S. E. Kearsey and K. Labib, Biochim. Biophys. Acta 1398, 113 (1998).
2. B. K. Tye, Annu. Rev. Biochem. 68, 649 (1999).
3. Y. Ishimi, J. Biol. Chem. 272, 24508 (1997).
4. Z. You, Y. Komamura, Y. Ishimi, Mol. Cell. Biol. 19, 8003 (1999).
5. Z. Kelman, J. K. Lee, J. Hurwitz, Proc. Natl. Acad. Sci. U.S.A. 96, 14783 (1999).
6. J. P. Chong, M. K. Hayashi, M. N. Simon, R. M. Xu, B. Stillman, Proc. Natl. Acad. Sci. U.S.A. 97, 1530 (2000).
7. O. M. Aparicio, D. M. Weinstein, S. P. Bell, Cell 91, 59 (1997).
8. K. M. Hennessy, C. D. Clark, D. Botstein, Genes Dev. 4, 2252 (1990).
9. K. Nasmyth and P. Nurse, Mol. Gen. Genet. 182, 119 (1981).
10. R. J. Dohmen, P. Wu, A. Varshavsky, Science 263, 1273 (1994).
11. Web figure 1 and information on methods are available at Science Online at www.sciencemag.org/ features/data/1048585/shl.
12. K. Labib, J. A. Tercero, J. F. X. Diffley, data not shown.
13. K. Bousset and J. F. X. Diffley, Genes Dev. 12, 480 (1998).
14. A. D. Donaldson et al., Mol. Cell 2, 173 (1998).
15. K. Labib and J. F. X. Diffley, data not shown.
16. J. A. Tercero, K. Labib, J. F. X. Diffley, EMBO J. 19, 2082 (2000).
17. S. Donovan, J. Harwood, L. S. Drury, J. F. X. Diffley, Proc. Natl. Acad. Sci. U.S.A. 94, 5611 (1997).
18. C. Liang and B. Stillman, Genes Dev. 11, 3375 (1997).
19. M. R. Young and B. K. Tye, Mol. Biol. Cell 8, 1587 (1997).
20. M. Weinreich, C. Liang, B. Stillman, Proc. Natl. Acad. Sci. U.S.A. 96, 441 (1999).
21. T. Tanaka, D. Knapp, K. Nasmyth, Cell 90, 649 (1997).
22. K. Labib, J. F. X. Diffley, S. E. Kearsey, Nature Cell Biol. 1, 415 (1999).
23. V. Q. Nguyen, C. Co, K. Irie, J. J. Li, Curr. Biol. 10, 195 (2000).
24. B. J. Brewer and W. L. Fangman, Cell 55, 637 (1988).
25. S. A. Greenfeder and C. S. Newlon, Mol. Cell. Biol. 12, 4056 (1992).
26. A. M. Deshpande and C. S. Newlon, Science 272, 1030 (1996).
27. C. Santocanale and J. F. X. Diffley, Nature 395, 615 (1998).
28. We thank L. Johnston and A. Varshavsky for providing plasmids, K. Bousset for advice concerning density transfer experiments, and T. Lindahl for helpful comments on the manuscript. Supported by the Imperial Cancer Research Fund, and a postdoctoral fellowship from the Human Frontier Science Programme (J.A.T.).