메뉴 건너뛰기




Volumn 9, Issue 9, 2013, Pages 1349-1366

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

Author keywords

Autophagy; CHIP; CMA; HIF1A; Hypoxia; Metabolism; Starvation; STUB1; Tumor growth; Ubiquitin

Indexed keywords

CHAPERONE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1A; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE STUB1; UNCLASSIFIED DRUG;

EID: 84884315657     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.25190     Document Type: Article
Times cited : (142)

References (65)
  • 2
    • 0029051439 scopus 로고
    • Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • PMID:7539918;
    • Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 1995; 92: 5510-4; PMID:7539918; http://dx.doi.org/10.1073/ pnas.92.12.5510
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 3
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • DOI 10.1074/jbc.272.36.22642
    • Salceda S, Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redoxinduced changes. J Biol Chem 1997; 272: 22642-7; PMID:9278421; http://dx.doi.org/10.1074/jbc.272.36. 22642 (Pubitemid 27386079)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.36 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 7
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • PMID:1448077
    • Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992; 12: 5447-54; PMID:1448077
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 8
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: Upstream and downstream of cancer metabolism
    • PMID:19942427;
    • Semenza GL. HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 2010; 20: 51-6; PMID:19942427; http://dx.doi.org/10.1016/j.gde. 2009.10.009
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 51-56
    • Semenza, G.L.1
  • 9
    • 33846254999 scopus 로고    scopus 로고
    • 2-independent and HSP90 inhibitor-induced degradation of HIF-1α
    • DOI 10.1016/j.molcel.2007.01.001, PII S1097276507000020
    • Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)- independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell 2007; 25: 207-17; PMID:17244529; http://dx.doi.org/10.1016/j.molcel.2007.01.001 (Pubitemid 46109612)
    • (2007) Molecular Cell , vol.25 , Issue.2 , pp. 207-217
    • Liu, Y.V.1    Baek, J.H.2    Zhang, H.3    Diez, R.4    Cole, R.N.5    Semenza, G.L.6
  • 10
    • 78649753203 scopus 로고    scopus 로고
    • The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxal
    • PMID:21124777
    • Bento CF, Fernandes R, Ramalho J, Marques C, Shang F, Taylor A, et al. The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxal. PLoS One 2010; 5:e15062; PMID:21124777; http://dx.doi.org/10.1371/journal.pone.0015062
    • (2010) PLoS One , vol.5
    • Bento, C.F.1    Fernandes, R.2    Ramalho, J.3    Marques, C.4    Shang, F.5    Taylor, A.6
  • 11
    • 77950473770 scopus 로고    scopus 로고
    • Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha
    • PMID:19940151;
    • Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. J Biol Chem 2010; 285: 3651-63; PMID:19940151; http://dx.doi.org/10.1074/jbc.M109.068577
    • (2010) J Biol Chem , vol.285 , pp. 3651-3663
    • Luo, W.1    Zhong, J.2    Chang, R.3    Hu, H.4    Pandey, A.5    Semenza, G.L.6
  • 12
    • 67649933387 scopus 로고    scopus 로고
    • 15-Deoxy- Delta 12, 14)-prostaglandin-J(2) reveals a new pVHL-independent lysosomal-dependent mechanism of HIF-1alpha degradation
    • PMID:19458911
    • Olmos G, Arenas MI, Bienes R, Calzada MJ, Aragonés J, Garcia-Bermejo ML, et al. 15-Deoxy- Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. Cell Mol Life Sci 2009; 66: 2167-80; PMID:19458911; http://dx.doi.org/10.1007/ s00018-009-0039-x
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2167-2180
    • Olmos, G.1    Arenas, M.I.2    Bienes, R.3    Calzada, M.J.4    Aragonés, J.5    Garcia-Bermejo, M.L.6
  • 13
    • 84876266454 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation
    • PMID:23457305;
    • Hubbi ME, Hu H, Kshitiz, Ahmed I, Levchenko A, Semenza GL. Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation. J Biol Chem 2013; 288: 10703-14; PMID:23457305; http://dx.doi.org/10.1074/jbc. M112.414771
    • (2013) J Biol Chem , vol.288 , pp. 10703-10714
    • Hubbi, M.E.1    Hu, H.2    Kshitiz Ahmed, I.3    Levchenko, A.4    Semenza, G.L.5
  • 14
    • 0029837453 scopus 로고    scopus 로고
    • A receptor for the selective uptake and degradation of proteins by lysosomes
    • Cuervo AM, Dice JF. A receptor for the selective uptake and degradation of proteins by lysosomes. Science 1996; 273: 501-3; PMID:8662539; http://dx.doi.org/10.1126/science.273.5274.501 (Pubitemid 26286451)
    • (1996) Science , vol.273 , Issue.5274 , pp. 501-503
    • Cuervo, A.M.1    Dice, J.F.2
  • 15
    • 0024975155 scopus 로고
    • A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins
    • PMID:2799391;
    • Chiang HL, Terlecky SR, Plant CP, Dice JF. A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science 1989; 246: 382-5; PMID:2799391; http://dx.doi.org/10.1126/science.2799391
    • (1989) Science , vol.246 , pp. 382-385
    • Chiang, H.L.1    Terlecky, S.R.2    Plant, C.P.3    Dice, J.F.4
  • 16
    • 27944495299 scopus 로고    scopus 로고
    • Chaperoned ubiquitylation - Crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex
    • DOI 10.1016/j.molcel.2005.09.023, PII S1097276505016448
    • Zhang M, Windheim M, Roe SM, Peggie M, Cohen P, Prodromou C, et al. Chaperoned ubiquitylation- -crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Mol Cell 2005; 20: 525-38; PMID:16307917; http://dx.doi.org/10.1016/j.molcel.2005.09.023 (Pubitemid 41668638)
    • (2005) Molecular Cell , vol.20 , Issue.4 , pp. 525-538
    • Zhang, M.1    Windheim, M.2    Roe, S.M.3    Peggie, M.4    Cohen, P.5    Prodromou, C.6    Pearl, L.H.7
  • 17
    • 44349182079 scopus 로고    scopus 로고
    • Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
    • PMID:18485199
    • Xu Z, Kohli E, Devlin KI, Bold M, Nix JC, Misra S. Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes. BMC Struct Biol 2008; 8: 26; PMID:18485199; http://dx.doi.org/10.1186/1472-6807-8- 26
    • (2008) BMC Struct Biol , vol.8 , pp. 26
    • Xu, Z.1    Kohli, E.2    Devlin, K.I.3    Bold, M.4    Nix, J.C.5    Misra, S.6
  • 18
    • 0035684430 scopus 로고    scopus 로고
    • CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein
    • DOI 10.1093/embo-reports/kve246
    • Murata S, Minami Y, Minami M, Chiba T, Tanaka K. CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein. EMBO Rep 2001; 2: 1133-8; PMID:11743028; http://dx.doi.org/10.1093/embo-reports/kve246 (Pubitemid 34055961)
    • (2001) EMBO Reports , vol.2 , Issue.12 , pp. 1133-1138
    • Murata, S.1    Minami, Y.2    Minami, M.3    Chiba, T.4    Tanaka, K.5
  • 19
    • 0346727127 scopus 로고    scopus 로고
    • Protein degradation and protection against misfolded or damaged proteins
    • DOI 10.1038/nature02263
    • Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature 2003; 426: 895-9; PMID:14685250; http://dx.doi.org/10. 1038/nature02263 (Pubitemid 38056882)
    • (2003) Nature , vol.426 , Issue.6968 , pp. 895-899
    • Goldberg, A.L.1
  • 20
    • 0035142877 scopus 로고    scopus 로고
    • The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
    • DOI 10.1038/35050509
    • Meacham GC, Patterson C, Zhang W, Younger JM, Cyr DM. The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol 2001; 3: 100-5; PMID:11146634; http://dx.doi.org/10.1038/35050509 (Pubitemid 32114840)
    • (2001) Nature Cell Biology , vol.3 , Issue.1 , pp. 100-105
    • Meacham, G.C.1    Patterson, C.2    Zhang, W.3    Younger, J.M.4    Cyr, D.M.5
  • 21
    • 0036789884 scopus 로고    scopus 로고
    • Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
    • PMID:12239347
    • Xu W, Marcu M, Yuan X, Mimnaugh E, Patterson C, Neckers L. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. Proc Natl Acad Sci U S A 2002; 99: 12847- 52; PMID:12239347; http://dx.doi.org/10.1073/pnas.202365899
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12847-12852
    • Xu, W.1    Marcu, M.2    Yuan, X.3    Mimnaugh, E.4    Patterson, C.5    Neckers, L.6
  • 22
    • 21244499845 scopus 로고    scopus 로고
    • The Co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates α-synuclein degradation decisions between proteasomal and lysosomal pathways
    • DOI 10.1074/jbc.M503326200
    • Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ. The co-chaperone carboxyl terminus of Hsp70- interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J Biol Chem 2005; 280: 23727-34; PMID:15845543; http://dx.doi.org/10.1074/jbc.M503326200 (Pubitemid 40884855)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.25 , pp. 23727-23734
    • Shin, Y.1    Klucken, J.2    Patterson, C.3    Hyman, B.T.4    McLean, P.J.5
  • 23
    • 33947157845 scopus 로고    scopus 로고
    • Influence of dissolved oxygen concentration on intracellular pH for regulation of Aspergillus niger growth rate during citric acid fermentation in a stirred tank bioreactor
    • PMID:15951848
    • Haq IU, Ali S, Qadeer MA. Influence of dissolved oxygen concentration on intracellular pH for regulation of Aspergillus niger growth rate during citric acid fermentation in a stirred tank bioreactor. Int J Biol Sci 2005; 1: 34-41; PMID:15951848
    • (2005) Int J Biol Sci , vol.1 , pp. 34-41
    • Haq, I.U.1    Ali, S.2    Qadeer, M.A.3
  • 25
    • 77949328788 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy: Selectivity pays off
    • PMID:19857975;
    • Cuervo AM. Chaperone-mediated autophagy: selectivity pays off. Trends Endocrinol Metab 2010; 21: 142-50; PMID:19857975; http://dx.doi.org/10.1016/j. tem.2009.10.003
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 142-150
    • Cuervo, A.M.1
  • 26
    • 51349130544 scopus 로고    scopus 로고
    • The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
    • PMID:18644871
    • Bandyopadhyay U, Kaushik S, Varticovski L, Cuervo AM. The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol Cell Biol 2008; 28: 5747- 63; PMID:18644871; http://dx.doi.org/10.1128/MCB.02070-07
    • (2008) Mol Cell Biol , vol.28 , pp. 5747-5763
    • Bandyopadhyay, U.1    Kaushik, S.2    Varticovski, L.3    Cuervo, A.M.4
  • 27
    • 79960330523 scopus 로고    scopus 로고
    • A photoconvertible fluorescent reporter to track chaperone-mediated autophagy
    • PMID:21750540
    • Koga H, Martinez-Vicente M, Macian F, Verkhusha VV, Cuervo AM. A photoconvertible fluorescent reporter to track chaperone-mediated autophagy. Nat Commun 2011; 2: 386; PMID:21750540; http://dx.doi.org/10.1038/ncomms1393
    • (2011) Nat Commun , vol.2 , pp. 386
    • Koga, H.1    Martinez-Vicente, M.2    MacIan, F.3    Verkhusha, V.V.4    Cuervo, A.M.5
  • 28
    • 48249091611 scopus 로고    scopus 로고
    • Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy
    • PMID:18337468;
    • Kaushik S, Massey AC, Mizushima N, Cuervo AM. Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell 2008; 19: 2179-92; PMID:18337468; http://dx.doi.org/10.1091/mbc.E07-11-1155
    • (2008) Mol Biol Cell , vol.19 , pp. 2179-2192
    • Kaushik, S.1    Massey, A.C.2    Mizushima, N.3    Cuervo, A.M.4
  • 29
    • 0027944153 scopus 로고
    • Selective binding and uptake of ribonuclease A and glyceraldehyde-3- phosphate dehydrogenase by isolated rat liver lysosomes
    • PMID:7929357
    • Cuervo AM, Terlecky SR, Dice JF, Knecht E. Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes. J Biol Chem 1994; 269: 26374-80; PMID:7929357
    • (1994) J Biol Chem , vol.269 , pp. 26374-26380
    • Cuervo, A.M.1    Terlecky, S.R.2    Dice, J.F.3    Knecht, E.4
  • 30
    • 43949117436 scopus 로고    scopus 로고
    • Early cellular changes after blockage of chaperone-mediated autophagy
    • Massey AC, Follenzi A, Kiffin R, Zhang C, Cuervo AM. Early cellular changes after blockage of chaperone- mediated autophagy. Autophagy 2008; 4: 442- 56; PMID:18253088 (Pubitemid 351705141)
    • (2008) Autophagy , vol.4 , Issue.4 , pp. 442-456
    • Massey, A.C.1    Follenzi, A.2    Kiffin, R.3    Zhang, C.4    Cuervo, A.M.5
  • 31
    • 0033585496 scopus 로고    scopus 로고
    • AHIF: A natural antisense transcript overexpressed in human renal cancer and during hypoxia
    • Thrash-Bingham CA, Tartof KD. aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia. J Natl Cancer Inst 1999; 91: 143-51; PMID:9923855; http://dx.doi.org/10.1093/jnci/91.2.143 (Pubitemid 29042691)
    • (1999) Journal of the National Cancer Institute , vol.91 , Issue.2 , pp. 143-151
    • Thrash-Bingham, C.A.1    Tartof, K.D.2
  • 32
    • 2442544693 scopus 로고    scopus 로고
    • Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)- 1alpha and HIF-2alpha expression in lung epithelial cells: Implication of natural antisense HIF-1alpha
    • PMID:14744852;
    • Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)- 1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem 2004; 279: 14871-8; PMID:14744852; http://dx.doi.org/10.1074/jbc.M400461200
    • (2004) J Biol Chem , vol.279 , pp. 14871-14878
    • Uchida, T.1    Rossignol, F.2    Matthay, M.A.3    Mounier, R.4    Couette, S.5    Clottes, E.6
  • 33
    • 0032523239 scopus 로고    scopus 로고
    • Inhibitory function of p21(Cip1/WAF1) in differentiation of primary mouse keratinocytes independent of cell cycle control
    • DOI 10.1126/science.280.5366.1069
    • Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, Seth PK, et al. Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science 1998; 280: 1069-72; PMID:9582119; http://dx.doi.org/10.1126/science.280.5366.1069 (Pubitemid 28234947)
    • (1998) Science , vol.280 , Issue.5366 , pp. 1069-1072
    • Di Cunto, F.1    Topley, G.2    Calautti, E.3    Hsiao, J.4    Ong, L.5    Seth, P.K.6    Dotto, G.P.7
  • 34
    • 0032510269 scopus 로고    scopus 로고
    • Expression of a novel form of p21(Cip1/Waf1) in UV-irradiated and transformed cells
    • Poon RY, Hunter T. Expression of a novel form of p21Cip1/Waf1 in UV-irradiated and transformed cells. Oncogene 1998; 16: 1333-43; PMID:9546435; http://dx.doi.org/10.1038/sj.onc.1201897 (Pubitemid 28138206)
    • (1998) Oncogene , vol.16 , Issue.10 , pp. 1333-1343
    • Poon, R.Y.C.1    Hunter, T.2
  • 35
    • 0033013126 scopus 로고    scopus 로고
    • Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
    • Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, et al. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol 1999; 19: 4535- 45; PMID:10330192 (Pubitemid 29242026)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.6 , pp. 4535-4545
    • Ballinger, C.A.1    Connell, P.2    Wu, Y.3    Hu, Z.4    Thompson, L.J.5    Yin, L.-Y.6    Patterson, C.7
  • 36
    • 0035146685 scopus 로고    scopus 로고
    • The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
    • DOI 10.1038/35050618
    • Connell P, Ballinger CA, Jiang J, Wu Y, Thompson LJ, Höhfeld J, et al. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol 2001; 3: 93-6; PMID:11146632; http://dx.doi.org/10.1038/35050618 (Pubitemid 32114838)
    • (2001) Nature Cell Biology , vol.3 , Issue.1 , pp. 93-96
    • Connell, P.1    Ballinger, C.A.2    Jiang, J.3    Wu, Y.4    Thompson, L.J.5    Hohfeld, J.6    Patterson, C.7
  • 38
    • 0028848119 scopus 로고
    • Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation
    • Cuervo AM, Knecht E, Terlecky SR, Dice JF. Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. Am J Physiol 1995; 269:C1200-8; PMID:7491910 (Pubitemid 3005885)
    • (1995) The American journal of physiology , vol.269 , Issue.51
    • Cuervo, A.M.1    Knecht, E.2    Terlecky, S.R.3    Dice, J.F.4
  • 40
    • 0031016301 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: Evidence against a regulatory role for Src kinase
    • Gleadle JM, Ratcliffe PJ. Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase. Blood 1997; 89: 503-9; PMID:9002952 (Pubitemid 27051685)
    • (1997) Blood , vol.89 , Issue.2 , pp. 503-509
    • Gleadle, J.M.1    Ratcliffe, P.J.2
  • 42
    • 33646248422 scopus 로고    scopus 로고
    • Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells
    • PMID:16611993;
    • Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol 2006; 26: 3514-26; PMID:16611993; http://dx.doi.org/10.1128/MCB.26.9.3514-3526.2006
    • (2006) Mol Cell Biol , vol.26 , pp. 3514-3526
    • Hu, C.J.1    Iyer, S.2    Sataur, A.3    Covello, K.L.4    Chodosh, L.A.5    Simon, M.C.6
  • 43
    • 4344578534 scopus 로고    scopus 로고
    • The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator
    • DOI 10.1091/mbc.E04-04-0293
    • Alberti S, Böhse K, Arndt V, Schmitz A, Höhfeld J. The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell 2004; 15: 4003-10; PMID:15215316; http://dx.doi.org/10.1091/mbc.E04-04-0293 (Pubitemid 39122006)
    • (2004) Molecular Biology of the Cell , vol.15 , Issue.9 , pp. 4003-4010
    • Alberti, S.1    Bohse, K.2    Arndt, V.3    Schmitz, A.4    Hohfeld, J.5
  • 44
    • 0037195907 scopus 로고    scopus 로고
    • Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome
    • DOI 10.1074/jbc.M204196200
    • Alberti S, Demand J, Esser C, Emmerich N, Schild H, Hohfeld J. Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome. J Biol Chem 2002; 277: 45920-7; PMID:12297498; http://dx.doi.org/10.1074/jbc.M204196200 (Pubitemid 35417574)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.48 , pp. 45920-45927
    • Alberti, S.1    Demand, J.2    Esser, C.3    Emmerich, N.4    Schild, H.5    Hohfeld, J.6
  • 45
    • 28644442088 scopus 로고    scopus 로고
    • BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP
    • DOI 10.1091/mbc.E05-07-0660
    • Arndt V, Daniel C, Nastainczyk W, Alberti S, Höhfeld J. BAG-2 acts as an inhibitor of the chaperone- associated ubiquitin ligase CHIP. Mol Biol Cell 2005; 16: 5891-900; PMID:16207813; http://dx.doi.org/10.1091/mbc.E05-07- 0660 (Pubitemid 41752235)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.12 , pp. 5891-5900
    • Arndt, V.1    Daniel, C.2    Nastainczyk, W.3    Alberti, S.4    Hohfeld, J.5
  • 46
    • 72149124383 scopus 로고    scopus 로고
    • IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
    • PMID:20026656
    • Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, et al. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol 2009; 187: 1083- 99; PMID:20026656; http://dx.doi.org/10.1083/jcb.200909067
    • (2009) J Cell Biol , vol.187 , pp. 1083-1099
    • Thompson, L.M.1    Aiken, C.T.2    Kaltenbach, L.S.3    Agrawal, N.4    Illes, K.5    Khoshnan, A.6
  • 47
    • 70349666552 scopus 로고    scopus 로고
    • Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways
    • PMID:19509306
    • Liu H, Wang P, Song W, Sun X. Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways. FASEB J 2009; 23: 3383- 92; PMID:19509306; http://dx.doi.org/10.1096/fj.09-134296
    • (2009) FASEB J , vol.23 , pp. 3383-3392
    • Liu, H.1    Wang, P.2    Song, W.3    Sun, X.4
  • 48
    • 66149128366 scopus 로고    scopus 로고
    • Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy
    • PMID:19433452;
    • Shen S, Zhang P, Lovchik MA, Li Y, Tang L, Chen Z, et al. Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy. J Cell Biol 2009; 185: 629-39; PMID:19433452; http://dx.doi.org/10.1083/jcb.200810183
    • (2009) J Cell Biol , vol.185 , pp. 629-639
    • Shen, S.1    Zhang, P.2    Lovchik, M.A.3    Li, Y.4    Tang, L.5    Chen, Z.6
  • 49
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
    • DOI 10.1126/science.1101738
    • Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D. Impaired degradation of mutant alphasynuclein by chaperone-mediated autophagy. Science 2004; 305: 1292-5; PMID:15333840; http://dx.doi.org/10.1126/science.1101738 (Pubitemid 39129234)
    • (2004) Science , vol.305 , Issue.5688 , pp. 1292-1295
    • Cuervo, A.M.1    Stafanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 50
    • 0031595780 scopus 로고    scopus 로고
    • IκB is a substrate for a selective pathway of lysosomal proteolysis
    • Cuervo AM, Hu W, Lim B, Dice JF. IkappaB is a substrate for a selective pathway of lysosomal proteolysis. Mol Biol Cell 1998; 9: 1995-2010; PMID:9693362 (Pubitemid 28373620)
    • (1998) Molecular Biology of the Cell , vol.9 , Issue.8 , pp. 1995-2010
    • Cuervo, A.M.1    Hu, W.2    Lim, B.3    Dice, J.F.4
  • 51
    • 74549133523 scopus 로고    scopus 로고
    • Chaperone-assisted selective autophagy is essential for muscle maintenance
    • PMID:20060297;
    • Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, et al. Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol 2010; 20: 143-8; PMID:20060297; http://dx.doi.org/10.1016/j.cub.2009.11. 022
    • (2010) Curr Biol , vol.20 , pp. 143-148
    • Arndt, V.1    Dick, N.2    Tawo, R.3    Dreiseidler, M.4    Wenzel, D.5    Hesse, M.6
  • 52
    • 0031041902 scopus 로고    scopus 로고
    • A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins
    • DOI 10.1074/jbc.272.9.5606
    • Cuervo AM, Dice JF, Knecht E. A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins. J Biol Chem 1997; 272: 5606-15; PMID:9038169; http://dx.doi.org/10.1074/jbc.272.9. 5606 (Pubitemid 27102386)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.9 , pp. 5606-5615
    • Cuervo, A.M.1    Dice, J.F.2    Knecht, E.3
  • 54
    • 2542479834 scopus 로고    scopus 로고
    • Modulation of glucokinase expression by hypoxia-inducible factor 1 and upstream stimulatory factor 2 in primary rat hepatocytes
    • DOI 10.1515/BC.2004.018
    • Roth U, Jungermann K, Kietzmann T. Modulation of glucokinase expression by hypoxia-inducible factor 1 and upstream stimulatory factor 2 in primary rat hepatocytes. Biol Chem 2004; 385: 239- 47; PMID:15134337; http://dx.doi.org/10. 1515/BC.2004.018 (Pubitemid 38679069)
    • (2004) Biological Chemistry , vol.385 , Issue.3-4 , pp. 239-247
    • Roth, U.1    Jungermann, K.2    Kietzmann, T.3
  • 55
    • 1642576082 scopus 로고    scopus 로고
    • The Transcription Factors HIF-1 and HNF-4 and the Coactivator p300 Are Involved in Insulin-regulated Glucokinase Gene Expression via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
    • DOI 10.1074/jbc.M308391200
    • Roth U, Curth K, Unterman TG, Kietzmann T. The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2004; 279: 2623-31; PMID:14612449; http://dx.doi.org/10. 1074/jbc.M308391200 (Pubitemid 38114249)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.4 , pp. 2623-2631
    • Roth, U.1    Curth, K.2    Unterman, T.G.3    Kietzmann, T.4
  • 56
    • 34047264834 scopus 로고    scopus 로고
    • Von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase
    • PMID:17203215
    • Park SK, Haase VH, Johnson RS. von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase. Int J Oncol 2007; 30: 341-8; PMID:17203215
    • (2007) Int J Oncol , vol.30 , pp. 341-348
    • Park, S.K.1    Haase, V.H.2    Johnson, R.S.3
  • 57
    • 0033233243 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1
    • DOI 10.1146/annurev.cellbio.15.1.551
    • Semenza GL. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 1999; 15: 551-78; PMID:10611972; http://dx.doi.org/10.1146/annurev.cellbio.15.1.551 (Pubitemid 32250386)
    • (1999) Annual Review of Cell and Developmental Biology , vol.15 , pp. 551-578
    • Semenza, G.L.1
  • 58
    • 78651272137 scopus 로고    scopus 로고
    • Hormonal regulation of gluconeogenic gene transcription in the liver
    • PMID:20826956;
    • Yabaluri N, Bashyam MD. Hormonal regulation of gluconeogenic gene transcription in the liver. J Biosci 2010; 35: 473-84; PMID:20826956; http://dx.doi.org/10.1007/s12038-010-0052-0
    • (2010) J Biosci , vol.35 , pp. 473-484
    • Yabaluri, N.1    Bashyam, M.D.2
  • 59
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • DOI 10.1126/science.1104819
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62; PMID:15637262; http://dx.doi.org/10.1126/science.1104819 (Pubitemid 40093472)
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 60
    • 23844485492 scopus 로고    scopus 로고
    • Reduced expression of hypoxia-inducible factor-1α in perinecrotic regions of solid tumors
    • DOI 10.1158/0008-5472.CAN-04-4480
    • Sobhanifar S, Aquino-Parsons C, Stanbridge EJ, Olive P. Reduced expression of hypoxia-inducible factor- 1alpha in perinecrotic regions of solid tumors. Cancer Res 2005; 65: 7259-66; PMID:16103077; http://dx.doi.org/10.1158/ 0008-5472.CAN-04-4480 (Pubitemid 41161257)
    • (2005) Cancer Research , vol.65 , Issue.16 , pp. 7259-7266
    • Sobhanifar, S.1    Aquino-Parsons, C.2    Stanbridge, E.J.3    Olive, P.4
  • 61
    • 79959371914 scopus 로고    scopus 로고
    • Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
    • PMID:21700219;
    • Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, et al. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell 2011; 42: 719-30; PMID:21700219; http://dx.doi.org/10.1016/j.molcel.2011.04.025
    • (2011) Mol Cell , vol.42 , pp. 719-730
    • Lv, L.1    Li, D.2    Zhao, D.3    Lin, R.4    Chu, Y.5    Zhang, H.6
  • 62
    • 81455128769 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy is required for tumor growth
    • PMID:22089453;
    • Kon M, Kiffin R, Koga H, Chapochnick J, Macian F, Varticovski L, et al. Chaperone-mediated autophagy is required for tumor growth. Sci Transl Med 2011; 3:ra117; PMID:22089453; http://dx.doi.org/10.1126/scitranslmed.3003182
    • (2011) Sci Transl Med , vol.3
    • Kon, M.1    Kiffin, R.2    Koga, H.3    Chapochnick, J.4    MacIan, F.5    Varticovski, L.6
  • 63
    • 0348134741 scopus 로고    scopus 로고
    • Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1α
    • DOI 10.1126/science.1088805
    • Hagen T, Taylor CT, Lam F, Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science 2003; 302: 1975-8; PMID:14671307; http://dx.doi.org/10.1126/science.1088805 (Pubitemid 37523507)
    • (2003) Science , vol.302 , Issue.5652 , pp. 1975-1978
    • Hagen, T.1    Taylor, C.T.2    Lam, F.3    Moncada, S.4
  • 64
    • 0018184182 scopus 로고
    • Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient
    • Wattiaux R, Wattiaux-De Coninck S, Ronveauxdupal MF, Dubois F. Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient. J Cell Biol 1978; 78: 349-68; PMID:211139; http://dx.doi.org/10.1083/jcb.78.2.349 (Pubitemid 8403877)
    • (1978) Journal of Cell Biology , vol.78 , Issue.2 , pp. 349-368
    • Wattiaux, R.1    Wattiaux-De Coninck, S.2    Ronveaux-Dupal, M.F.3    Dubois, F.4
  • 65
    • 0027280820 scopus 로고
    • Uptake and degradation of glyceraldehyde-3-phosphate dehydrogenase by rat liver lysosomes
    • Aniento F, Roche E, Cuervo AM, Knecht E. Uptake and degradation of glyceraldehyde-3-phosphate dehydrogenase by rat liver lysosomes. J Biol Chem 1993; 268: 10463-70; PMID:8486700 (Pubitemid 23150232)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.14 , pp. 10463-10470
    • Aniento, F.1    Roche, E.2    Cuervo, A.M.3    Knecht, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.