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Volumn 12, Issue 23, 2013, Pages 3689-3701

CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth

Author keywords

Angiogenesis; CDK1; Cell cycle; HIF 1 ; Hypoxia

Indexed keywords

ALSTERPAULLONE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIN B; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 4; FLAVOPIRIDOL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PALBOCICLIB; PURVALANOL A; RO 3306; ROSCOVITINE; SERINE; UNCLASSIFIED DRUG;

EID: 84890293880     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.26930     Document Type: Article
Times cited : (85)

References (46)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • PMID:21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0034663989 scopus 로고    scopus 로고
    • HIF-1 and human disease: One highly involved factor
    • PMID:10950862
    • Semenza GL. HIF-1 and human disease: one highly involved factor. Genes Dev 2000; 14:1983-91; PMID:10950862
    • (2000) Genes Dev , vol.14 , pp. 1983-1991
    • Semenza, G.L.1
  • 3
    • 35148828429 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 (HIF-1) pathway
    • PMID:17925579
    • Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007; 2007:cm8; PMID:17925579; http://dx.doi.org/10.1126/stke.4072007cm8
    • (2007) Sci STKE , vol.2007
    • Semenza, G.L.1
  • 4
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • PMID:11902584
    • Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2:38-47; PMID:11902584; http://dx.doi.org/10.1038/nrc704
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 5
    • 56149089262 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and cancer pathogenesis
    • PMID:18506846
    • Semenza GL. Hypoxia-inducible factor 1 and cancer pathogenesis. IUBMB Life 2008; 60:591-7; PMID:18506846; http://dx.doi.org/10.1002/iub.93
    • (2008) IUBMB Life , vol.60 , pp. 591-597
    • Semenza, G.L.1
  • 6
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • PMID:7539918
    • Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 1995; 92:5510-4; PMID:7539918; http://dx.doi.org/10.1073/ pnas.92.12.5510
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 7
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • (Bethesda) PMID:15304631
    • Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 2004; 19:176-82; PMID:15304631; http://dx.doi.org/10.1152/physiol.00001.2004
    • (2004) Physiology , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 8
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • PMID:11598268
    • Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001; 294:1337-40; PMID:11598268; http://dx.doi.org/10.1126/ science.1066373
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 9
    • 0035917313 scopus 로고    scopus 로고
    • HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
    • PMID:11292862
    • Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001; 292:464-8; PMID:11292862; http://dx.doi.org/10.1126/science.1059817
    • (2001) Science , vol.292 , pp. 464-468
    • Ivan, M.1    Kondo, K.2    Yang, H.3    Kim, W.4    Valiando, J.5    Ohh, M.6    Salic, A.7    Asara, J.M.8    Lane, W.S.9    Kaelin Jr., W.G.10
  • 11
    • 31444444162 scopus 로고    scopus 로고
    • Integration of oxygen signaling at the consensus HRE
    • PMID:16234508
    • Wenger RH, Stiehl DP, Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci STKE 2005; 2005:re12; PMID:16234508
    • (2005) Sci STKE , vol.2005
    • Wenger, R.H.1    Stiehl, D.P.2    Camenisch, G.3
  • 12
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in tumorigenesis
    • PMID:18259193
    • Rankin EB, Giaccia AJ. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 2008; 15:678-85; PMID:18259193; http://dx.doi.org/10.1038/cdd.2008.21
    • (2008) Cell Death Differ , vol.15 , pp. 678-685
    • Rankin, E.B.1    Giaccia, A.J.2
  • 14
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • PMID:10749120
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000; 60:1541-5; PMID:10749120
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 15
    • 0032725554 scopus 로고    scopus 로고
    • p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    • PMID:10551817
    • Richard DE, Berra E, Gothié E, Roux D, Pouysségur J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem 1999; 274:32631-7; PMID:10551817; http://dx.doi.org/10.1074/jbc.274.46. 32631
    • (1999) J Biol Chem , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothié, E.3    Roux, D.4    Pouysségur, J.5
  • 16
    • 33845403070 scopus 로고    scopus 로고
    • Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha
    • PMID:16954218
    • Mylonis I, Chachami G, Samiotaki M, Panayotou G, Paraskeva E, Kalousi A, Georgatsou E, Bonanou S, Simos G. Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha. J Biol Chem 2006; 281:33095-106; PMID:16954218; http://dx.doi.org/10.1074/jbc.M605058200
    • (2006) J Biol Chem , vol.281 , pp. 33095-33106
    • Mylonis, I.1    Chachami, G.2    Samiotaki, M.3    Panayotou, G.4    Paraskeva, E.5    Kalousi, A.6    Georgatsou, E.7    Bonanou, S.8    Simos, G.9
  • 17
    • 34247583794 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner
    • PMID:17325032
    • Flügel D, Görlach A, Michiels C, Kietzmann T. Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner. Mol Cell Biol 2007; 27:3253-65; PMID:17325032; http://dx.doi.org/10.1128/MCB.00015-07
    • (2007) Mol Cell Biol , vol.27 , pp. 3253-3265
    • Flügel, D.1    Görlach, A.2    Michiels, C.3    Kietzmann, T.4
  • 18
    • 0037119415 scopus 로고    scopus 로고
    • Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
    • PMID:12052835
    • Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem 2002; 277:29936-44; PMID:12052835; http://dx.doi.org/10.1074/jbc.M204733200
    • (2002) J Biol Chem , vol.277 , pp. 29936-29944
    • Isaacs, J.S.1    Jung, Y.J.2    Mimnaugh, E.G.3    Martinez, A.4    Cuttitta, F.5    Neckers, L.M.6
  • 19
    • 78649814934 scopus 로고    scopus 로고
    • Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha
    • PMID:20889502
    • Xu D, Yao Y, Lu L, Costa M, Dai W. Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. J Biol Chem 2010; 285:38944-50; PMID:20889502; http://dx.doi.org/10. 1074/jbc.M110.160325
    • (2010) J Biol Chem , vol.285 , pp. 38944-38950
    • Xu, D.1    Yao, Y.2    Lu, L.3    Costa, M.4    Dai, W.5
  • 20
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • PMID:12086860
    • Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002; 1:237-46; PMID:12086860; http://dx.doi.org/10.1016/S1535-6108(02) 00043-0
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin Jr., W.G.5
  • 21
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • PMID:8266103
    • van den Heuvel S, Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 1993; 262:2050-4; PMID:8266103; http://dx.doi.org/10.1126/science.8266103
    • (1993) Science , vol.262 , pp. 2050-2054
    • Van Den Heuvel, S.1    Harlow, E.2
  • 22
    • 0033166064 scopus 로고    scopus 로고
    • Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal
    • PMID:10395539
    • Hagting A, Jackman M, Simpson K, Pines J. Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal. Curr Biol 1999; 9:680-9; PMID:10395539; http://dx.doi.org/10.1016/S0960- 9822(99)80308-X
    • (1999) Curr Biol , vol.9 , pp. 680-689
    • Hagting, A.1    Jackman, M.2    Simpson, K.3    Pines, J.4
  • 23
    • 36349030360 scopus 로고    scopus 로고
    • Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase
    • PMID:17893151
    • Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. J Biol Chem 2007; 282:33776-87; PMID:17893151; http://dx.doi.org/10.1074/jbc.M703320200
    • (2007) J Biol Chem , vol.282 , pp. 33776-33787
    • Chen, D.1    Gould, C.2    Garza, R.3    Gao, T.4    Hampton, R.Y.5    Newton, A.C.6
  • 24
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • PMID:14645546
    • Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003; 23:9361-74; PMID:14645546; http://dx.doi.org/10. 1128/MCB.23.24.9361-9374.2003
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 25
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • PMID:16517406
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006; 3:187-97; PMID:16517406; http://dx.doi.org/10. 1016/j.cmet.2006.01.012
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 26
    • 80755125565 scopus 로고    scopus 로고
    • Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
    • PMID:22037377
    • Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol 2011; 29:1039-45; PMID:22037377; http://dx.doi.org/10.1038/nbt.2017
    • (2011) Nat Biotechnol , vol.29 , pp. 1039-1045
    • Anastassiadis, T.1    Deacon, S.W.2    Devarajan, K.3    Ma, H.4    Peterson, J.R.5
  • 27
    • 84860406130 scopus 로고    scopus 로고
    • Spectral imaging-based methods for quantifying autophagy and apoptosis
    • PMID:21757995
    • Dolloff NG, Ma X, Dicker DT, Humphreys RC, Li LZ, El-Deiry WS. Spectral imaging-based methods for quantifying autophagy and apoptosis. Cancer Biol Ther 2011; 12:349-56; PMID:21757995; http://dx.doi.org/10.4161/cbt.12.4.17175
    • (2011) Cancer Biol Ther , vol.12 , pp. 349-356
    • Dolloff, N.G.1    Ma, X.2    Dicker, D.T.3    Humphreys, R.C.4    Li, L.Z.5    El-Deiry, W.S.6
  • 29
  • 31
    • 33645802169 scopus 로고    scopus 로고
    • Cyclin-dependent kinase pathways as targets for cancer treatment
    • PMID:16603719
    • Shapiro GI. Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 2006; 24:1770-83; PMID:16603719; http://dx.doi.org/10. 1200/JCO.2005.03.7689
    • (2006) J Clin Oncol , vol.24 , pp. 1770-1783
    • Shapiro, G.I.1
  • 33
    • 84857047339 scopus 로고    scopus 로고
    • PhosphoSitePlus: A comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse
    • PMID:22135298
    • Hornbeck PV, Kornhauser JM, Tkachev S, Zhang B, Skrzypek E, Murray B, Latham V, Sullivan M. PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res 2012; 40(Database issue):D261-70; PMID:22135298; http://dx.doi.org/10.1093/nar/gkr1122
    • (2012) Nucleic Acids Res , vol.40 , Issue.DATABASE ISSUE
    • Hornbeck, P.V.1    Kornhauser, J.M.2    Tkachev, S.3    Zhang, B.4    Skrzypek, E.5    Murray, B.6    Latham, V.7    Sullivan, M.8
  • 35
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • PMID:10934146
    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157:411-21; PMID:10934146; http://dx.doi.org/10. 1016/S0002-9440(10)64554-3
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, A.L.7
  • 36
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • PMID:17418410
    • Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007; 11:335-47; PMID:17418410; http://dx.doi.org/10.1016/j.ccr.2007.02.006
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.J.3    Diehl, J.A.4    Simon, M.C.5
  • 37
    • 0037214282 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia
    • PMID:12482987
    • Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson RS. Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol 2003; 23:359-69; PMID:12482987; http://dx.doi.org/10. 1128/MCB.23.1.359-369.2003
    • (2003) Mol Cell Biol , vol.23 , pp. 359-369
    • Goda, N.1    Ryan, H.E.2    Khadivi, B.3    McNulty, W.4    Rickert, R.C.5    Johnson, R.S.6
  • 38
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • PMID:15611513
    • Kim WY, Kaelin WG. Role of VHL gene mutation in human cancer. J Clin Oncol 2004; 22:4991-5004; PMID:15611513; http://dx.doi.org/10.1200/JCO.2004.05. 061
    • (2004) J Clin Oncol , vol.22 , pp. 4991-5004
    • Kim, W.Y.1    Kaelin, W.G.2
  • 39
    • 1342267616 scopus 로고    scopus 로고
    • The clinical significance of Cyclin B1 and Wee1 expression in non-small-cell lung cancer
    • PMID:14760118
    • Yoshida T, Tanaka S, Mogi A, Shitara Y, Kuwano H. The clinical significance of Cyclin B1 and Wee1 expression in non-small-cell lung cancer. Ann Oncol 2004; 15:252-6; PMID:14760118; http://dx.doi.org/10.1093/annonc/mdh073
    • (2004) Ann Oncol , vol.15 , pp. 252-256
    • Yoshida, T.1    Tanaka, S.2    Mogi, A.3    Shitara, Y.4    Kuwano, H.5
  • 40
    • 0036300779 scopus 로고    scopus 로고
    • Significance of cyclin B1 expression as an independent prognostic indicator of patients with squamous cell carcinoma of the esophagus
    • PMID:11895914
    • Nozoe T, Korenaga D, Kabashima A, Ohga T, Saeki H, Sugimachi K. Significance of cyclin B1 expression as an independent prognostic indicator of patients with squamous cell carcinoma of the esophagus. Clin Cancer Res 2002; 8:817-22; PMID:11895914
    • (2002) Clin Cancer Res , vol.8 , pp. 817-822
    • Nozoe, T.1    Korenaga, D.2    Kabashima, A.3    Ohga, T.4    Saeki, H.5    Sugimachi, K.6
  • 41
    • 0031046787 scopus 로고    scopus 로고
    • WAF1 expression and p53 mutations in human colorectal cancers
    • PMID:9030251
    • Wang A, Yoshimi N, Ino N, Tanaka T, Mori H. WAF1 expression and p53 mutations in human colorectal cancers. J Cancer Res Clin Oncol 1997; 123:118-23; PMID:9030251; http://dx.doi.org/10.1007/BF01269890
    • (1997) J Cancer Res Clin Oncol , vol.123 , pp. 118-123
    • Wang, A.1    Yoshimi, N.2    Ino, N.3    Tanaka, T.4    Mori, H.5
  • 43
    • 77952751368 scopus 로고    scopus 로고
    • Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition
    • PMID:20360007
    • Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I. Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition. J Biol Chem 2010; 285:16978-90; PMID:20360007; http://dx.doi.org/10. 1074/jbc.M109.096552
    • (2010) J Biol Chem , vol.285 , pp. 16978-16990
    • Timofeev, O.1    Cizmecioglu, O.2    Settele, F.3    Kempf, T.4    Hoffmann, I.5
  • 44
    • 34250865564 scopus 로고    scopus 로고
    • CDC25 phosphatases in cancer cells: Key players? Good targets?
    • PMID:17568790
    • Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer 2007; 7:495-507; PMID:17568790; http://dx.doi.org/10.1038/nrc2169
    • (2007) Nat Rev Cancer , vol.7 , pp. 495-507
    • Boutros, R.1    Lobjois, V.2    Ducommun, B.3
  • 46
    • 34447117505 scopus 로고    scopus 로고
    • Review: Implications of in vitro research on the effect of radiotherapy and chemotherapy under hypoxic conditions
    • PMID:17602059
    • Wouters A, Pauwels B, Lardon F, Vermorken JB. Review: implications of in vitro research on the effect of radiotherapy and chemotherapy under hypoxic conditions. Oncologist 2007; 12:690-712; PMID:17602059; http://dx.doi.org/10. 1634/theoncologist.12-6-690
    • (2007) Oncologist , vol.12 , pp. 690-712
    • Wouters, A.1    Pauwels, B.2    Lardon, F.3    Vermorken, J.B.4


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