RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect

Cell Research

Volumn 25, Issue 9, 2015, Pages 1025-1042

  Zhang, Chen Song ^a   Liu, Qi ^a   Li, Mengqi ^a   Lin, Shu Yong ^a   Peng, Yongying ^a   Wu, Di ^a   Li, Terytty Yang ^a   Fu, Qiang ^b   Jia, Weiping ^b   Wang, Xinjun ^a   Ma, Teng ^a   Zong, Yue ^a   Cui, Jiwen ^a   Pu, Chengfei ^a   Lian, Guili ^a   Guo, Huiling ^a   Ye, Zhiyun ^a   Lin, Sheng Cai ^a  

^a XIAMEN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

HIF; hydroxylation; PHD; RHOBTB3; the Warburg effect; ubiquitination; VHL

Indexed keywords

COBALT; COBALT CHLORIDE; EGLN1 PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; LIM PROTEIN; LIMD1 PROTEIN, HUMAN; PROTEASOME; PROTEIN BINDING; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOBTB3 PROTEIN, HUMAN; SIGNAL PEPTIDE; SMALL INTERFERING RNA; VHL PROTEIN, HUMAN; VON HIPPEL LINDAU PROTEIN;

ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CARCINOMA, RENAL CELL; CELL CULTURE; CHEMISTRY; DOWN REGULATION; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HUMAN; HYDROXYLATION; KIDNEY NEOPLASMS; KNOCKOUT MOUSE; MALE; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; XENOGRAFT;

ANIMALS; CARCINOMA, RENAL CELL; CELLS, CULTURED; COBALT; DOWN-REGULATION; HEK293 CELLS; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY NEOPLASMS; LIM DOMAIN PROTEINS; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, NUDE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; RHO GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84940891882     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2015.90     Document Type: Article

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