Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 32, 2014, Pages

  Hubbi, Maimon E ^a   Gilkes, Daniele M ^a,b   Hu, Hongxia ^a   Kshitiz, K ^c   Ahmed, Ishrat ^a   Semenza, Gregg L ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c Yale University   (United States)

Author keywords

Cell proliferation; Chaperone mediated autophagy; Lysosome

Indexed keywords

BAFILOMYCIN; CHLOROQUINE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; HELICASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ROSCOVITINE;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL FUNCTION; CELL PROLIFERATION; CHAPERONE-MEDIATED AUTOPHAGY; CONTROLLED STUDY; DEGRADATION; DNA REPLICATION; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOPRECIPITATION; LYSOSOME; MINICHROMOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY;

CELL PROLIFERATION; CHAPERONE MEDIATED AUTOPHAGY; LYSOSOME;

ANIMALS; CDC2 PROTEIN KINASE; CELL CYCLE CHECKPOINTS; CELL LINE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 2; G1 PHASE CELL CYCLE CHECKPOINTS; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYSOSOMES; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; PROTEOLYSIS;

EID: 84905976385     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412840111     Document Type: Article

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