-
2
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
-
An, W. G., M. Kanekal, M. C. Simon, E. Maltepe, M. V. Blagosklonny, and L. M. Neckers. 1998. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 392:405-408.
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
Kanekal, M.2
Simon, M.C.3
Maltepe, E.4
Blagosklonny, M.V.5
Neckers, L.M.6
-
3
-
-
0032524285
-
p53 inhibits hypoxia-inducible factor-stimulated transcription
-
Blagosklonny, M. V., W. G. An, L. Y. Romanova, J. Trepel, T. Fojo, and L. Neckers. 1998. p53 inhibits hypoxia-inducible factor-stimulated transcription. J. Biol. Chem. 273:11995-11998.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11995-11998
-
-
Blagosklonny, M.V.1
An, W.G.2
Romanova, L.Y.3
Trepel, J.4
Fojo, T.5
Neckers, L.6
-
4
-
-
0035432151
-
Hypoxia-inducible factor: Achilles' heel of anti-angiogenic cancer therapy
-
Blagosklonny, M. V. 2001. Hypoxia-inducible factor: Achilles' heel of anti-angiogenic cancer therapy. Int. J. Oncol. 19:257-262.
-
(2001)
Int. J. Oncol.
, vol.19
, pp. 257-262
-
-
Blagosklonny, M.V.1
-
5
-
-
0032581277
-
Role of H1F-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet, P., Y. Dor, J. M. Herbert, D. Fukumura, K. Brusselmans, M. Dewerchin, M. Neeman, F. Bono, R. Abramovitch, P. Maxwell, C. J. Koch, P. Ratcliffe, L. Moons, R. K. Jain, D. Collen, E. Keshert, and E. Keshet. 1998. Role of H1F-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394:485-490.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshert, E.16
Keshet, E.17
-
6
-
-
0035937715
-
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
-
Chen, C., N. Pore, A. Behrooz, F. Ismail-Beigi, and A. Maity. 2001. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J. Biol. Chem. 276:9519-9525.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9519-9525
-
-
Chen, C.1
Pore, N.2
Behrooz, A.3
Ismail-Beigi, F.4
Maity, A.5
-
7
-
-
0034682783
-
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
Cockman, M. E., N. Masson, D. R. Mole, P. Jaakkola, G. W. Chang, S. C. Clifford, E. R. Maher, C. W. Pugh, P. J. Ratcliffe, and P. H. Maxwell. 2000. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275:25733-25741.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
Jaakkola, P.4
Chang, G.W.5
Clifford, S.C.6
Maher, E.R.7
Pugh, C.W.8
Ratcliffe, P.J.9
Maxwell, P.H.10
-
8
-
-
0035129209
-
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation
-
de Alboran, I. M., R. C. O'Hagan, F. Gartner, B. Malynn, L. Davidson, R. Rickert, K. Rajewsky, R. A. DePinho, and F. W. Alt. 2001. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity 14:45-55.
-
(2001)
Immunity
, vol.14
, pp. 45-55
-
-
De Alboran, I.M.1
O'Hagan, R.C.2
Gartner, F.3
Malynn, B.4
Davidson, L.5
Rickert, R.6
Rajewsky, K.7
DePinho, R.A.8
Alt, F.W.9
-
9
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe, J. A., B. H. Jiang, N. V. Iyer, F. Agani, S. W. Leung, R. D. Koos, and G. L. Semenza. 1996. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16:4604-4613.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
12
-
-
0035145591
-
Kip1 regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest
-
Kip1 regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Mol. Cell. Biol. 21:1196-1206.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1196-1206
-
-
Green, S.L.1
Freiberg, R.A.2
Giaccia, A.J.3
-
13
-
-
0036179376
-
Hypoxia links ATR and p53 through replication arrest
-
Hammond, E. M., N. C. Denko, M. J. Dorie, R. T. Abraham, and A. J. Giaccia. 2002. Hypoxia links ATR and p53 through replication arrest. Mol. Cell. Biol. 22:1834-1843.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1834-1843
-
-
Hammond, E.M.1
Denko, N.C.2
Dorie, M.J.3
Abraham, R.T.4
Giaccia, A.J.5
-
14
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1 alpha
-
2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 12:149-162.
-
(1998)
Genes Dev.
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, K.L.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
15
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
-
Jiang, B. H., E. Rue, G. L. Wang, R. Roe, and G. L. Semenza. 1996. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J. Biol. Chem. 271:17771-17778.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.L.3
Roe, R.4
Semenza, G.L.5
-
16
-
-
0032487925
-
Hypoxia-induced pRB hypophosphorylation results from downregulation of CDK and upregulation of PP1 activities
-
Krtolica, A., N. A. Krucher, and J. W. Ludlow. 1998. Hypoxia-induced pRB hypophosphorylation results from downregulation of CDK and upregulation of PP1 activities. Oncogene 17:2295-2304.
-
(1998)
Oncogene
, vol.17
, pp. 2295-2304
-
-
Krtolica, A.1
Krucher, N.A.2
Ludlow, J.W.3
-
17
-
-
0032771749
-
Molecular analysis of selected cell cycle regulatory proteins during aerobic and hypoxic maintenance of human ovarian carcinoma cells
-
Krtolica, A., N. A. Krucher, and J. W. Ludlow. 1999. Molecular analysis of selected cell cycle regulatory proteins during aerobic and hypoxic maintenance of human ovarian carcinoma cells. Br. J. Cancer 80:1875-1883.
-
(1999)
Br. J. Cancer
, vol.80
, pp. 1875-1883
-
-
Krtolica, A.1
Krucher, N.A.2
Ludlow, J.W.3
-
18
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
Lando, D., D. J. Peet, D. A. Whelan, J. J. Gorman, and M. L. Whitelaw. 2002. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295:858-861.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
19
-
-
0024341665
-
The biosynthetic pathway of pyrimidine (deoxy)nucleotides: A sensor of oxygen tension necessary for maintaining cell proliferation?
-
Loffier, M. 1989. The biosynthetic pathway of pyrimidine (deoxy)nucleotides: A sensor of oxygen tension necessary for maintaining cell proliferation? Exp. Cell Res. 182:673-680.
-
(1989)
Exp. Cell Res.
, vol.182
, pp. 673-680
-
-
Loffier, M.1
-
20
-
-
0035979247
-
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
-
Loonstra, A., M. Vooijs, H. B. Beverloo, B. A. Allak, E. van Drunen, R. Kanaar, A. Berns, and J. Jonkers. 2001. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc. Natl. Acad. Sci. USA 98:9209-9214.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9209-9214
-
-
Loonstra, A.1
Vooijs, M.2
Beverloo, H.B.3
Allak, B.A.4
Van Drunen, E.5
Kanaar, R.6
Berns, A.7
Jonkers, J.8
-
21
-
-
0027518447
-
Hypoxic stress induces reversible hypophosphorylation of pRB and reduction in cyclin A abundance independent of cell cycle progression
-
Ludlow, J. W., R. Howell, and H. C. Smith. 1993. Hypoxic stress induces reversible hypophosphorylation of pRB and reduction in cyclin A abundance independent of cell cycle progression. Oncogene 8:331-339.
-
(1993)
Oncogene
, vol.8
, pp. 331-339
-
-
Ludlow, J.W.1
Howell, R.2
Smith, H.C.3
-
22
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
-
Masson, N., C. Willam, P. H. Maxwell, C. W. Pugh, and P. J. Ratcliffe. 2001. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J. 20:5197-5206.
-
(2001)
EMBO J.
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
23
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P. H., M. Wiesener, G. W. Chang, S. C. Clifford, E. C. Vaux, M. E. Cockman, C. C. Wykoff, C. W. Pugh, E. R. Maher, and P. J. Ratcliffe. 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
24
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
Ravi, R., B. Mookerjee, Z. M. Bhujwalla, C. H. Sutter, D. Artemov, Q. Zeng, L. E. Dillehay, A. Madan, G. L. Semenza, and A. Bedi. 2000. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 14:34-44.
-
(2000)
Genes Dev.
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
25
-
-
0030818183
-
B lymphocyte-specific, Cremediated mutagenesis in mice
-
Rickert, R. C., J. Rose, and K. Rajewsky. 1997. B lymphocyte-specific, Cremediated mutagenesis in mice. Nucleic Acids Res. 25:1317-1318.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 1317-1318
-
-
Rickert, R.C.1
Rose, J.2
Rajewsky, K.3
-
26
-
-
0032100732
-
HIF-1 alpha is required for solid tumor formation and embryonic vascularization
-
Ryan, H. E., J. Lo, and R. S. Johnson. 1998. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17:3005-3015.
-
(1998)
EMBO J.
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
27
-
-
0033870727
-
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth
-
Ryan, H. E., M. Poloni, W. McNulty, D. Elson, M. Gassmann, J. M. Arbeit, and R. S. Johnson. 2000. Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res. 60:4010-4015.
-
(2000)
Cancer Res.
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
Johnson, R.S.7
-
28
-
-
0034667433
-
Hyper-inducibility of hypoxia-responsive genes without p53/p21-dependent check-point in aggressive prostate cancer
-
Salnikow, K., M. Costa, W. D. Figg, and M. V. Blagosklonny. 2000. Hyper-inducibility of hypoxia-responsive genes without p53/p21-dependent check-point in aggressive prostate cancer. Cancer Res. 60:5630-5634.
-
(2000)
Cancer Res.
, vol.60
, pp. 5630-5634
-
-
Salnikow, K.1
Costa, M.2
Figg, W.D.3
Blagosklonny, M.V.4
-
29
-
-
0035499204
-
Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
-
Schipani, E., H. Ryan, S. Didrickson, T. Kobayashi, M. Knight, and R. S. Johnson. 2001. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 15:2865-2876.
-
(2001)
Genes Dev.
, vol.15
, pp. 2865-2876
-
-
Schipani, E.1
Ryan, H.2
Didrickson, S.3
Kobayashi, T.4
Knight, M.5
Johnson, R.S.6
-
30
-
-
0031918244
-
Regulation of proliferation-survival decisions during tumor cell hypoxia
-
Schmaltz, C., P. H. Hardenbergh, A. Wells, and D. E. Fisher. 1998. Regulation of proliferation-survival decisions during tumor cell hypoxia. Mol. Cell. Biol. 18:2845-2854.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 2845-2854
-
-
Schmaltz, C.1
Hardenbergh, P.H.2
Wells, A.3
Fisher, D.E.4
-
31
-
-
0035027828
-
Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells
-
Seagroves, T. N., H. Ryan, H. Lu, B. G. Wouters, M. Knapp, P. Thibault, K. Laderoute, and R. S. Johnson. 2001. Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol. Cell. Biol. 21:3436-3444.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
Ryan, H.2
Lu, H.3
Wouters, B.G.4
Knapp, M.5
Thibault, P.6
Laderoute, K.7
Johnson, R.S.8
-
32
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza, G. L., P. H. Roth, H. M. Fang, and G. L. Wang. 1994. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269:23757-23763.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
33
-
-
0034682721
-
Cellular senescence: Mitotic clock or culture shock?
-
Sherr, C. J., and R. A. DePinho. 2000. Cellular senescence: Mitotic clock or culture shock? Cell 102:407-410.
-
(2000)
Cell
, vol.102
, pp. 407-410
-
-
Sherr, C.J.1
DePinho, R.A.2
-
34
-
-
0028950645
-
Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL
-
Shimizu, S., Y. Eguchi, H. Kosaka, W. Kamiike, H. Matsuda, and Y. Tsujimoto. 1995. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 374:811-813.
-
(1995)
Nature
, vol.374
, pp. 811-813
-
-
Shimizu, S.1
Eguchi, Y.2
Kosaka, H.3
Kamiike, W.4
Matsuda, H.5
Tsujimoto, Y.6
-
35
-
-
0026485002
-
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
-
Shweiki, D., A. Itin, D. Soffer, and E. Keshet. 1992. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843-845.
-
(1992)
Nature
, vol.359
, pp. 843-845
-
-
Shweiki, D.1
Itin, A.2
Soffer, D.3
Keshet, E.4
-
36
-
-
10144241685
-
Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes
-
Solvason, N., W. W. Wu, N. Kabra, X. Wu, E. Lees, and M. C. Howard. 1996. Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes. J. Exp. Med. 184:407-417.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 407-417
-
-
Solvason, N.1
Wu, W.W.2
Kabra, N.3
Wu, X.4
Lees, E.5
Howard, M.C.6
-
37
-
-
0035855668
-
Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia
-
Suzuki, H., A. Tomida, and T. Tsuruo. 2001. Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Oncogene 20:5779-5788.
-
(2001)
Oncogene
, vol.20
, pp. 5779-5788
-
-
Suzuki, H.1
Tomida, A.2
Tsuruo, T.3
-
38
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
-
Tanimoto, K., Y. Makino, T. Pereira, and L. Poellinger. 2000. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J. 19:4298-4309.
-
(2000)
EMBO J.
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
Poellinger, L.4
-
39
-
-
0021099095
-
Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: Possible regulation mechanism
-
Thelander, L., A. Graslund, and M. Thelander. 1983. Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: Possible regulation mechanism. Biochem. Biophys. Res. Commun. 110:859-865.
-
(1983)
Biochem. Biophys. Res. Commun.
, vol.110
, pp. 859-865
-
-
Thelander, L.1
Graslund, A.2
Thelander, M.3
-
41
-
-
0027210562
-
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
-
Wang, G. L., and G. L. Semenza. 1993. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc. Natl. Acad. Sci. USA 90:4304-4308.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 4304-4308
-
-
Wang, G.L.1
Semenza, G.L.2
-
42
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang, G. L., and G. L. Semenza. 1995. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270:1230-1237.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
|