메뉴 건너뛰기




Volumn 31, Issue 18, 2011, Pages 3885-3895

Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; EGLN 1 PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MEMBRANE PROTEIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

EID: 80052565462     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.05089-11     Document Type: Article
Times cited : (15)

References (53)
  • 1
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova, J., et al. 2005. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434:864-870.
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1
  • 2
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova, J., et al. 2006. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444:633-637.
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1
  • 3
    • 0038152755 scopus 로고    scopus 로고
    • Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase
    • Bornstein, G., et al. 2003. Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J. Biol. Chem. 278:25752-25757.
    • (2003) J. Biol. Chem. , vol.278 , pp. 25752-25757
    • Bornstein, G.1
  • 4
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet, P., et al. 1998. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394:485-490.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1
  • 5
    • 0036745763 scopus 로고    scopus 로고
    • CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells
    • Chen, Z., V. B. Indjeian, M. McManus, L. Wang, and B. D. Dynlacht. 2002. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev. Cell 3:339-350.
    • (2002) Dev. Cell , vol.3 , pp. 339-350
    • Chen, Z.1    Indjeian, V.B.2    McManus, M.3    Wang, L.4    Dynlacht, B.D.5
  • 6
    • 72449177341 scopus 로고    scopus 로고
    • E2F1-3 switch from activities in progenitor cells to repressors in differentiating cells
    • Chong, J. L., et al. 2009. E2F1-3 switch from activities in progenitor cells to repressors in differentiating cells. Nature 462:930-934.
    • (2009) Nature , vol.462 , pp. 930-934
    • Chong, J.L.1
  • 7
    • 0029957947 scopus 로고    scopus 로고
    • Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation
    • Clurman, B. E., R. J. Sheaff, K. Thress, M. Groudine, and J. M. Roberts. 1996. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev. 10:1979-1990.
    • (1996) Genes Dev. , vol.10 , pp. 1979-1990
    • Clurman, B.E.1    Sheaff, R.J.2    Thress, K.3    Groudine, M.4    Roberts, J.M.5
  • 8
    • 25444443688 scopus 로고    scopus 로고
    • Modelling glandular epithelial cancers in three-dimensional cultures
    • Debnath, J., and J. S. Brugge. 2005. Modelling glandular epithelial cancers in three-dimensional cultures. Nat. Rev. Cancer 5:675-688.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 675-688
    • Debnath, J.1    Brugge, J.S.2
  • 9
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • Debnath, J., S. K. Muthuswamy, and J. S. Brugge. 2003. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30:256-268.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 10
    • 33845269825 scopus 로고    scopus 로고
    • Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    • Di Micco, R., et al. 2006. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444:638-642.
    • (2006) Nature , vol.444 , pp. 638-642
    • Di Micco, R.1
  • 11
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri, G. P., et al. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U. S. A. 92:9363-9367.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 9363-9367
    • Dimri, G.P.1
  • 12
    • 3042687608 scopus 로고    scopus 로고
    • Deregulation of cyclin E in human cells interferes with prereplication complex assembly
    • Ekholm-Reed, S., et al. 2004. Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J. Cell Biol. 165:789-800.
    • (2004) J. Cell Biol. , vol.165 , pp. 789-800
    • Ekholm-Reed, S.1
  • 13
    • 0035896558 scopus 로고    scopus 로고
    • Hypoxia inhibits G1/S transition through regulation of p27 expression
    • Gardner, L. B., et al. 2001. Hypoxia inhibits G1/S transition through regulation of p27 expression. J. Biol. Chem. 276:7919-7926.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7919-7926
    • Gardner, L.B.1
  • 14
    • 0042528364 scopus 로고    scopus 로고
    • Cyclin E ablation in the mouse
    • Geng, Y., et al. 2003. Cyclin E ablation in the mouse. Cell 114:431-443.
    • (2003) Cell , vol.114 , pp. 431-443
    • Geng, Y.1
  • 15
    • 0037214282 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia
    • Goda, N., et al. 2003. Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol. Cell. Biol. 23:359-369.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 359-369
    • Goda, N.1
  • 16
    • 45349091765 scopus 로고    scopus 로고
    • Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase
    • Grim, J. E., et al. 2008. Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. J. Cell Biol. 181:913-920.
    • (2008) J. Cell Biol. , vol.181 , pp. 913-920
    • Grim, J.E.1
  • 17
    • 0026802989 scopus 로고
    • Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
    • Hinds, P. W., et al. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993-1006.
    • (1992) Cell , vol.70 , pp. 993-1006
    • Hinds, P.W.1
  • 18
    • 33750032892 scopus 로고    scopus 로고
    • CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage
    • Huang, H., K. M. Regan, Z. Lou, J. Chen, and D. J. Tindall. 2006. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314:294-297.
    • (2006) Science , vol.314 , pp. 294-297
    • Huang, H.1    Regan, K.M.2    Lou, Z.3    Chen, J.4    Tindall, D.J.5
  • 19
    • 18344381018 scopus 로고    scopus 로고
    • Cyclin E in normal and neoplastic cell cycles
    • Hwang, H. C., and B. E. Clurman. 2005. Cyclin E in normal and neoplastic cell cycles. Oncogene 24:2776-2786.
    • (2005) Oncogene , vol.24 , pp. 2776-2786
    • Hwang, H.C.1    Clurman, B.E.2
  • 20
    • 0035917313 scopus 로고    scopus 로고
    • 2 sensing
    • 2 sensing. Science 292:464-468.
    • (2001) Science , vol.292 , pp. 464-468
    • Ivan, M.1
  • 21
    • 0035917808 scopus 로고    scopus 로고
    • 2-regulated prolyl hydroxylation
    • 2-regulated prolyl hydroxylation. Science 292: 468-472.
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1
  • 22
    • 67649331662 scopus 로고    scopus 로고
    • An algorithm for identifying novel targets of transcription factor families: application to hypoxia-inducible factor 1 targets
    • Jiang, Y., et al. 2009. An algorithm for identifying novel targets of transcription factor families: application to hypoxia-inducible factor 1 targets. Cancer Inform. 7:75-89.
    • (2009) Cancer Inform. , vol.7 , pp. 75-89
    • Jiang, Y.1
  • 23
    • 0344643474 scopus 로고    scopus 로고
    • Cyclin E is a more powerful predictor of breast cancer outcome than proliferation
    • Keyomarsi, K., S. L. Tucker, and I. Bedrosian. 2003. Cyclin E is a more powerful predictor of breast cancer outcome than proliferation. Nat. Med. 9:152.
    • (2003) Nat. Med. , vol.9 , pp. 152
    • Keyomarsi, K.1    Tucker, S.L.2    Bedrosian, I.3
  • 24
    • 0037079027 scopus 로고    scopus 로고
    • Cyclin E and survival in patients with breast cancer
    • Keyomarsi, K., et al. 2002. Cyclin E and survival in patients with breast cancer. N. Engl. J. Med. 347:1566-1575.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1566-1575
    • Keyomarsi, K.1
  • 25
    • 0035812709 scopus 로고    scopus 로고
    • Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
    • Koepp, D. M., et al. 2001. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294:173-177.
    • (2001) Science , vol.294 , pp. 173-177
    • Koepp, D.M.1
  • 26
    • 3142631736 scopus 로고    scopus 로고
    • HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
    • Koshiji, M., et al. 2004. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J. 23:1949-1956.
    • (2004) EMBO J. , vol.23 , pp. 1949-1956
    • Koshiji, M.1
  • 27
    • 34547214508 scopus 로고    scopus 로고
    • Cell shape regulates global histone acetylation in human mammary epithelial cells
    • Le Beyec, J., et al. 2007. Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp. Cell Res. 313:3066-3075.
    • (2007) Exp. Cell Res. , vol.313 , pp. 3066-3075
    • Le Beyec, J.1
  • 28
    • 34247864012 scopus 로고    scopus 로고
    • Three-dimensional culture models of normal and malignant breast epithelial cells
    • Lee, G. Y., P. A. Kenny, E. H. Lee, and M. J. Bissell. 2007. Three-dimensional culture models of normal and malignant breast epithelial cells. Nat. Methods 4:359-365.
    • (2007) Nat. Methods , vol.4 , pp. 359-365
    • Lee, G.Y.1    Kenny, P.A.2    Lee, E.H.3    Bissell, M.J.4
  • 29
    • 2342442851 scopus 로고    scopus 로고
    • Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation
    • Liu, E., X. Li, F. Yan, Q. Zhao, and X. Wu. 2004. Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J. Biol. Chem. 279: 17283-17288.
    • (2004) J. Biol. Chem. , vol.279 , pp. 17283-17288
    • Liu, E.1    Li, X.2    Yan, F.3    Zhao, Q.4    Wu, X.5
  • 30
    • 22244492318 scopus 로고    scopus 로고
    • A mouse model for cyclin E-dependent genetic instability and tumorigenesis
    • Loeb, K. R., et al. 2005. A mouse model for cyclin E-dependent genetic instability and tumorigenesis. Cancer Cell 8:35-47.
    • (2005) Cancer Cell , vol.8 , pp. 35-47
    • Loeb, K.R.1
  • 31
    • 34247185765 scopus 로고    scopus 로고
    • Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas
    • Ma, Y., et al. 2007. Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas. Proc. Natl. Acad. Sci. U. S. A. 104:4089-4094.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 4089-4094
    • Ma, Y.1
  • 32
    • 25144525540 scopus 로고    scopus 로고
    • CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis
    • Mailand, N., and J. F. Diffley. 2005. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell 122:915-926.
    • (2005) Cell , vol.122 , pp. 915-926
    • Mailand, N.1    Diffley, J.F.2
  • 33
    • 48449092237 scopus 로고    scopus 로고
    • A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression
    • Majumder, P. K., et al. 2008. A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell 14:146-155.
    • (2008) Cancer Cell , vol.14 , pp. 146-155
    • Majumder, P.K.1
  • 34
    • 34547928992 scopus 로고    scopus 로고
    • p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability
    • Minella, A. C., J. E. Grim, M. Welcker, and B. E. Clurman. 2007. p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability. Oncogene 26:6948-6953.
    • (2007) Oncogene , vol.26 , pp. 6948-6953
    • Minella, A.C.1    Grim, J.E.2    Welcker, M.3    Clurman, B.E.4
  • 35
    • 45349089427 scopus 로고    scopus 로고
    • Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo
    • Minella, A. C., et al. 2008. Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev. 22:1677-1689.
    • (2008) Genes Dev. , vol.22 , pp. 1677-1689
    • Minella, A.C.1
  • 36
    • 0037195268 scopus 로고    scopus 로고
    • p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation
    • Minella, A. C., et al. 2002. p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation. Curr. Biol. 12:1817-1827.
    • (2002) Curr. Biol. , vol.12 , pp. 1817-1827
    • Minella, A.C.1
  • 37
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima, N., T. Yoshimori, and B. Levine. 2010. Methods in mammalian autophagy research. Cell 140:313-326.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 38
    • 0034977277 scopus 로고    scopus 로고
    • Apaf-1 is a transcriptional target for E2F and p53
    • Moroni, M. C., et al. 2001. Apaf-1 is a transcriptional target for E2F and p53. Nat. Cell Biol. 3:552-558.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 552-558
    • Moroni, M.C.1
  • 40
    • 0034730321 scopus 로고    scopus 로고
    • Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication
    • Okuda, M., et al. 2000. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103:127-140.
    • (2000) Cell , vol.103 , pp. 127-140
    • Okuda, M.1
  • 41
    • 3242878193 scopus 로고    scopus 로고
    • ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes
    • Ovcharenko, I., M. A. Nobrega, G. G. Loots, and L. Stubbs. 2004. ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes. Nucleic Acids Res. 32:W280-W286.
    • (2004) Nucleic Acids Res. , vol.32
    • Ovcharenko, I.1    Nobrega, M.A.2    Loots, G.G.3    Stubbs, L.4
  • 42
    • 55549103719 scopus 로고    scopus 로고
    • E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites
    • Rabinovich, A., V. X. Jin, R. Rabinovich, X. Xu, and P. J. Farnham. 2008. E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res. 18:1763-1777.
    • (2008) Genome Res , vol.18 , pp. 1763-1777
    • Rabinovich, A.1    Jin, V.X.2    Rabinovich, R.3    Xu, X.4    Farnham, P.J.5
  • 43
    • 1542377277 scopus 로고    scopus 로고
    • Inactivation of hCDC4 can cause chromosomal instability
    • Rajagopalan, H., et al. 2004. Inactivation of hCDC4 can cause chromosomal instability. Nature 428:77-81.
    • (2004) Nature , vol.428 , pp. 77-81
    • Rajagopalan, H.1
  • 44
    • 0042510099 scopus 로고    scopus 로고
    • Inactivation of E2F3 results in centrosome amplification
    • Saavedra, H. I., et al. 2003. Inactivation of E2F3 results in centrosome amplification. Cancer Cell 3:333-346.
    • (2003) Cancer Cell , vol.3 , pp. 333-346
    • Saavedra, H.I.1
  • 45
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza, G. L. 2010. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29:625-634.
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 47
    • 33751329698 scopus 로고    scopus 로고
    • Deregulated cyclin E promotes p53 loss of heterozygosity and tumorigenesis in the mouse mammary gland
    • Smith, A. P., et al. 2006. Deregulated cyclin E promotes p53 loss of heterozygosity and tumorigenesis in the mouse mammary gland. Oncogene 25:7245-7259.
    • (2006) Oncogene , vol.25 , pp. 7245-7259
    • Smith, A.P.1
  • 48
    • 0035921849 scopus 로고    scopus 로고
    • Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
    • Strohmaier, H., et al. 2001. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413:316-322.
    • (2001) Nature , vol.413 , pp. 316-322
    • Strohmaier, H.1
  • 49
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles
    • Subramanian, A., et al. 2005. Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U. S. A. 102:15545-15550.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 50
    • 10344237022 scopus 로고    scopus 로고
    • Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma
    • Thomas, D. M., et al. 2004. Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. J. Cell Biol. 167:925-934.
    • (2004) J. Cell Biol. , vol.167 , pp. 925-934
    • Thomas, D.M.1
  • 51
    • 38549086019 scopus 로고    scopus 로고
    • FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
    • Welcker, M., and B. E. Clurman. 2008. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat. Rev. Cancer 8:83-94.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 83-94
    • Welcker, M.1    Clurman, B.E.2
  • 52
    • 0141591688 scopus 로고    scopus 로고
    • Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation
    • Welcker, M., et al. 2003. Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol. Cell 12:381-392.
    • (2003) Mol. Cell , vol.12 , pp. 381-392
    • Welcker, M.1
  • 53
    • 0034665757 scopus 로고    scopus 로고
    • NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
    • Zhao, J., et al. 2000. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev. 14:2283-2297.
    • (2000) Genes Dev. , vol.14 , pp. 2283-2297
    • Zhao, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.