Chaperone-mediated autophagy targets hypoxia-inducible factor-1β(HIF- 1β) for lysosomal degradation

Journal of Biological Chemistry

Volumn 288, Issue 15, 2013, Pages 10703-10714

  Hubbi, Maimon E ^a   Hu, Hongxia ^a   Kshitiz, ^a   Ahmed, Ishrat ^a   Levchenko, Andre ^a   Semenza, Gregg L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE-MEDIATED AUTOPHAGY; GENETIC APPROACH; HYPOXIA-INDUCIBLE FACTOR 1; LYSOSOMAL DEGRADATION; PROTEASOMAL DEGRADATION; THERAPEUTIC TARGETS;

BIOCHEMISTRY;

BIOLOGY;

6 AMINONICOTINAMIDE; 9 (2 HYDROXY 3 NONYL)ADENINE; ACRIFLAVINE; AMMONIUM CHLORIDE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BLEOMYCIN; CHLOROQUINE; DIGOXIN; HEAT SHOCK COGNATE PROTEIN 70; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CANCER CELL; CHAPERONE-MEDIATED AUTOPHAGY; CONTROLLED STUDY; DEGRADATION; EMBRYO; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HSC70 GENE; HUMAN; HUMAN CELL; HYPOXIA; LYSOSOME; MACROAUTOPHAGY; MOUSE; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; STARVATION; UPREGULATION;

ANIMALS; ANTIRHEUMATIC AGENTS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL HYPOXIA; CHLOROQUINE; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HSC70 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYSOSOMES; MICE; PROTEOLYSIS;

EID: 84876266454     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.414771     Document Type: Article

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