-
1
-
-
8544271638
-
Hypoxia-inducible factors and hypoxic cell death in tumour physiology
-
Bacon AL and Harris AL (2004) Hypoxia-inducible factors and hypoxic cell death in tumour physiology. Ann Med 36:530-539.
-
(2004)
Ann Med
, vol.36
, pp. 530-539
-
-
Bacon, A.L.1
Harris, A.L.2
-
2
-
-
0034282518
-
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
-
Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, and Oberhuber G (2000) Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60:4693-4696.
-
(2000)
Cancer Res
, vol.60
, pp. 4693-4696
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Plank, C.4
Breitenecker, G.5
Oberhuber, G.6
-
3
-
-
0041382820
-
The hypoxic response of tumors is dependent on their microenvironment
-
Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, Johnson RS, and Bergers G (2003) The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4:133-146.
-
(2003)
Cancer Cell
, vol.4
, pp. 133-146
-
-
Blouw, B.1
Song, H.2
Tihan, T.3
Bosze, J.4
Ferrara, N.5
Gerber, H.P.6
Johnson, R.S.7
Bergers, G.8
-
4
-
-
4043065767
-
The bafilomycin/concanamycin binding site in subunit c of the V-ATPases from Neurospora crassa and Saccharomyces cerevisiae
-
Bowman EJ, Graham LA, Stevens TH, and Bowman BJ (2004) The bafilomycin/concanamycin binding site in subunit c of the V-ATPases from Neurospora crassa and Saccharomyces cerevisiae. J Biol Chem 279:33131-33138.
-
(2004)
J Biol Chem
, vol.279
, pp. 33131-33138
-
-
Bowman, E.J.1
Graham, L.A.2
Stevens, T.H.3
Bowman, B.J.4
-
5
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, et al. (1998) Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature (Lond) 394:485-490.
-
(1998)
Nature (Lond)
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
-
6
-
-
0035205085
-
A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses
-
Chun YS, Choi E, Yeo EJ, Lee JH, Kim MS, and Park JW (2001) A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses. J Cell Sci 114:4051-4061.
-
(2001)
J Cell Sci
, vol.114
, pp. 4051-4061
-
-
Chun, Y.S.1
Choi, E.2
Yeo, E.J.3
Lee, J.H.4
Kim, M.S.5
Park, J.W.6
-
7
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, et al. (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
-
8
-
-
0024389333
-
Structure and function of vacuolar class of ATP-driven proton pumps
-
Forgac M (1989) Structure and function of vacuolar class of ATP-driven proton pumps. Physiol Rev 69:765-796.
-
(1989)
Physiol Rev
, vol.69
, pp. 765-796
-
-
Forgac, M.1
-
9
-
-
0037330625
-
Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes
-
Gartel AL and Shchors K (2003) Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes. Exp Cell Res 283:17-21.
-
(2003)
Exp Cell Res
, vol.283
, pp. 17-21
-
-
Gartel, A.L.1
Shchors, K.2
-
10
-
-
0037214282
-
Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia
-
Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, and Johnson RS (2003) Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol 23:359-369.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 359-369
-
-
Goda, N.1
Ryan, H.E.2
Khadivi, B.3
McNulty, W.4
Rickert, R.C.5
Johnson, R.S.6
-
11
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science (Wash DC) 292:468-472.
-
(2001)
Science (Wash DC)
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.V.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
-
12
-
-
23444449093
-
STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells
-
Jung JE, Lee HG, Cho IH, Chung DH, Yoon SH, Yang YM, Lee JW, Choi S, Park JW, Ye SK, et al. (2005) STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB J 19:1296-1298.
-
(2005)
FASEB J
, vol.19
, pp. 1296-1298
-
-
Jung, J.E.1
Lee, H.G.2
Cho, I.H.3
Chung, D.H.4
Yoon, S.H.5
Yang, Y.M.6
Lee, J.W.7
Choi, S.8
Park, J.W.9
Ye, S.K.10
-
13
-
-
0037088576
-
Heat induction of the unphosphorylated form of hypoxia-inducible factor-1α is dependent on heat shock protein-90 activity
-
Katschinski DM, Le L, Heinrich D, Wagner KF, Hofer T, Schindler SG, and Wenger RH (2002) Heat induction of the unphosphorylated form of hypoxia-inducible factor-1α is dependent on heat shock protein-90 activity. J Biol Chem 277:9262-9267.
-
(2002)
J Biol Chem
, vol.277
, pp. 9262-9267
-
-
Katschinski, D.M.1
Le, L.2
Heinrich, D.3
Wagner, K.F.4
Hofer, T.5
Schindler, S.G.6
Wenger, R.H.7
-
14
-
-
0030601899
-
Bafilomycin A1 induces apoptosis in PC12 cells independently of intracellular pH
-
Kinoshita K, Waritani T, Noto M, Takizawa K, Minemoto Y, Nishikawa A, and Ohkuma S (1996) Bafilomycin A1 induces apoptosis in PC12 cells independently of intracellular pH. FEBS Lett 398:61-66.
-
(1996)
FEBS Lett
, vol.398
, pp. 61-66
-
-
Kinoshita, K.1
Waritani, T.2
Noto, M.3
Takizawa, K.4
Minemoto, Y.5
Nishikawa, A.6
Ohkuma, S.7
-
15
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, and Huang LE (2004) HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO (Eur Mol Biol Organ) J 23:1949-1956.
-
(2004)
EMBO (Eur Mol Biol Organ) J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
16
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, and Bruick RK (2002) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16:1466-1471.
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
17
-
-
18944376218
-
Decreased growth of Vhl-/- Fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27
-
Mack FA, Patel JH, Biju MP, Haase VH, and Simon MC (2005) Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol 25:4565-4578.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4565-4578
-
-
Mack, F.A.1
Patel, J.H.2
Biju, M.P.3
Haase, V.H.4
Simon, M.C.5
-
18
-
-
0038383678
-
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
-
Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, and Simon MC (2003) Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell 3:75-88.
-
(2003)
Cancer Cell
, vol.3
, pp. 75-88
-
-
Mack, F.A.1
Rathmell, W.K.2
Arsham, A.M.3
Gnarra, J.4
Keith, B.5
Simon, M.C.6
-
20
-
-
0142026431
-
Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1
-
Nakashima S, Hiraku Y, Tada-Oikawa S, Hishita T, Gabazza EC, Tamaki S, Imoto I, Adachi Y, and Kawanishi S (2003) Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1. J Biochem (Tokyo) 134:359-364.
-
(2003)
J Biochem (Tokyo)
, vol.134
, pp. 359-364
-
-
Nakashima, S.1
Hiraku, Y.2
Tada-Oikawa, S.3
Hishita, T.4
Gabazza, E.C.5
Tamaki, S.6
Imoto, I.7
Adachi, Y.8
Kawanishi, S.9
-
22
-
-
0031595031
-
Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-1
-
Ohta T, Arakawa H, Futagami F, Fushida S, Kitagawa H, Kayahara M, Nagakawa T, Miwa K, Kurashima K, Numata M, et al. (1998) Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-1. J Pathol 185:324-330.
-
(1998)
J Pathol
, vol.185
, pp. 324-330
-
-
Ohta, T.1
Arakawa, H.2
Futagami, F.3
Fushida, S.4
Kitagawa, H.5
Kayahara, M.6
Nagakawa, T.7
Miwa, K.8
Kurashima, K.9
Numata, M.10
-
23
-
-
0033870727
-
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth
-
Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM, and Johnson RS (2000) Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res 60:4010-4015.
-
(2000)
Cancer Res
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
Johnson, R.S.7
-
24
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3:721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
25
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang GL and Semenza GL (1995) Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270:1230-1237.
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
26
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo EJ, Chun YS, Cho YS, Kim J, Lee JC, Kim MS, and Park JW (2003) YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 95:516-525.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 516-525
-
-
Yeo, E.J.1
Chun, Y.S.2
Cho, Y.S.3
Kim, J.4
Lee, J.C.5
Kim, M.S.6
Park, J.W.7
-
27
-
-
0034213146
-
Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression
-
Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, and Semenza GL (2000) Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer 88:2606-2618.
-
(2000)
Cancer
, vol.88
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzitti, J.M.3
Laughner, E.4
Simons, J.W.5
Semenza, G.L.6
-
28
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, and Simons JW (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
|